Martin H. Maurer

Summary

Affiliation: University of Heidelberg
Location: Heidelberg, Germany

Publications

  1. doi Genomic and proteomic advances in autism research
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Electrophoresis 33:3653-8. 2012
  2. doi Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study
    Robert E Feldmann
    Division of Systems Physiology, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Stress 11:134-47. 2008
  3. ncbi Screening the brain: molecular fingerprints of neural stem cells
    Martin H Maurer
    Dept of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Curr Stem Cell Res Ther 1:65-77. 2006
  4. pmc Protein expression differs between neural progenitor cells from the adult rat brain subventricular zone and olfactory bulb
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    BMC Neurosci 9:7. 2008
  5. pmc Transplantation of adult neural progenitor cells transfected with vascular endothelial growth factor rescues grafted cells in the rat brain
    Martin H Maurer
    Department of Physiology, Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Int J Biol Sci 4:1-7. 2008
  6. ncbi Alterations in cerebral metabolomics and proteomic expression during sepsis
    Jochen Hinkelbein
    Clinic for Anesthesiology and Intensive Care Medicine, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    Curr Neurovasc Res 4:280-8. 2007
  7. ncbi Neuroprotection by pravastatin in acute ischemic stroke in rats
    Christian Berger
    Department of Neurology, University of Heidelberg, Germany
    Brain Res Rev 58:48-56. 2008
  8. ncbi Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656
    Eberhard P Scholz
    Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 376:275-84. 2007
  9. pmc The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemia
    Dieter Newrzella
    Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Genomics 8:370. 2007
  10. ncbi Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2
    Daniel Scherer
    Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 375:311-22. 2007

Collaborators

Detail Information

Publications56

  1. doi Genomic and proteomic advances in autism research
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Electrophoresis 33:3653-8. 2012
    ..In the current review, I will summarize the results of genomic and proteomic studies finding susceptibility genes and proteins for autism with regard to NSCs differentiation and maturation...
  2. doi Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study
    Robert E Feldmann
    Division of Systems Physiology, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Stress 11:134-47. 2008
    ..From this, we derive the preliminary hypothesis that PEBP1 may be a novel molecular mediator influencing cognitive integrity during chronic corticosterone exposure in rat hippocampus...
  3. ncbi Screening the brain: molecular fingerprints of neural stem cells
    Martin H Maurer
    Dept of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Curr Stem Cell Res Ther 1:65-77. 2006
    ..In conclusion, we suggest that stem cell properties can be specified by global gene or proteomic expression patterns rather than by the analysis of individual genes or proteins...
  4. pmc Protein expression differs between neural progenitor cells from the adult rat brain subventricular zone and olfactory bulb
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    BMC Neurosci 9:7. 2008
    ..In the current study, we therefore compared the cultured neurospheres for the fraction of GFAP-positive cells and their morphology of over a prolonged period of time...
  5. pmc Transplantation of adult neural progenitor cells transfected with vascular endothelial growth factor rescues grafted cells in the rat brain
    Martin H Maurer
    Department of Physiology, Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Int J Biol Sci 4:1-7. 2008
    ..Moreover, transplantation of VEGF-expressing NPCs supports angiogenesis in the brain, which may contribute to potential brain repair...
  6. ncbi Alterations in cerebral metabolomics and proteomic expression during sepsis
    Jochen Hinkelbein
    Clinic for Anesthesiology and Intensive Care Medicine, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    Curr Neurovasc Res 4:280-8. 2007
    ....
  7. ncbi Neuroprotection by pravastatin in acute ischemic stroke in rats
    Christian Berger
    Department of Neurology, University of Heidelberg, Germany
    Brain Res Rev 58:48-56. 2008
    ..In conclusion, a relatively high dose of pravastatin administered repetitively after stroke onset improved neurological outcome through various cholesterol-independent mechanisms...
  8. ncbi Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656
    Eberhard P Scholz
    Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 376:275-84. 2007
    ..In conclusion, we show that the anticholinergic agent orphenadrine is an antagonist at HERG channels. These results provide a novel molecular basis for the reported proarrhythmic side effects of orphenadrine...
  9. pmc The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemia
    Dieter Newrzella
    Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Genomics 8:370. 2007
    ..We have compared CA3 and CA1 gene expression in the uninjured brain, and after cerebral ischemia using laser microdissection (LMD), RNA amplification, and array hybridization...
  10. ncbi Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2
    Daniel Scherer
    Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 375:311-22. 2007
    ..2 subunits. This regulation may contribute to the hyperpolarizing effects of beta(3)-adrenoceptors in tissues that exhibit modulation by Kir2 channel function...
  11. ncbi The effects of sevoflurane anesthesia on rat brain proteins: a proteomic time-course analysis
    Armin Kalenka
    Department of Anesthesiology and Critical Care Medicine, University of Heidelberg, Mannheim, Germany
    Anesth Analg 104:1129-35, tables of contents. 2007
    ..In the present study, we investigated the existence of persisting changes on the proteome level after sevoflurane anesthesia that persisted for as long as 28 days after anesthesia...
  12. ncbi Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone
    Martin H Maurer
    Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    J Proteome Res 6:1198-208. 2007
    ....
  13. doi Acute anoxia stimulates proliferation in adult neural stem cells from the rat brain
    Heinrich F Bürgers
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Exp Brain Res 188:33-43. 2008
    ..Therefore, we conclude that NSCs are dying from glucose deprivation, not from hypoxic-ischemic damage...
  14. ncbi Old friends in new constellations--the hematopoetic growth factors G-CSF, GM-CSF, and EPO for the treatment of neurological diseases
    M H Maurer
    SYGNIS Bioscience GmbH and Co KG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Curr Med Chem 15:1407-11. 2008
    ..Additionally, we will describe the necessities for future research before such therapies can be envisioned...
  15. ncbi Expression of hemoglobin in rodent neurons
    Dominik W Schelshorn
    Division of Systems Physiology, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 29:585-95. 2009
    ..We propose that neuronal hemoglobin expression is connected to facilitated oxygen uptake in neurons, and hemoglobin might serve as oxygen capacitator molecule...
  16. pmc Proteomic definitions of mesenchymal stem cells
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Stem Cells Int 2011:704256. 2011
    ....
  17. doi Proteomics of human cerebral microdialysate: From detection of biomarkers to clinical application
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany Present address SYGNIS bioscience GmbH and Co KG, Heidelberg, Germany
    Proteomics Clin Appl 2:437-43. 2008
    ..In conclusion, proteomics of cerebral microdialysate may be used for diagnosis, disease monitoring, and therapeutic intervention of neurological patients...
  18. doi Neurons and neuronal stem cells survive in glucose-free lactate and in high glucose cell culture medium during normoxia and anoxia
    Sascha Wohnsland
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Neurochem Res 35:1635-42. 2010
    ....
  19. doi Isoflurane anesthesia elicits protein pattern changes in rat hippocampus
    Armin Kalenka
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg Anesthesiol 22:144-54. 2010
    ..These processes are also affected in AD. Results are discussed in view of AD, the toxicity mechanisms of isoflurane as well as the implications for our present understanding and conduction of clinical anesthesia...
  20. doi Alterations of the podocyte proteome in response to high glucose concentrations
    Sandra Schordan
    Department of Anatomy and Cell Biology, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
    Proteomics 9:4519-28. 2009
    ..Our data demonstrate that HG concentrations per se are sufficient to strongly modify the protein expression profile of podocytes, the analysis of which contributes to the identification of novel targets involved in diabetic nephropathy...
  21. doi Increased densities of monocarboxylate transport protein MCT1 after chronic administration of nicotine in rat brain
    Martin Canis
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    Neurosci Res 64:429-35. 2009
    ..It is concluded that MCT1 transporters were upregulated during chronic nicotine infusion at the level of brain substructures and, at least partially, independently of LCGU...
  22. doi Alterations in rat serum proteome and metabolome as putative disease markers in sepsis
    Jochen Hinkelbein
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Mannheim, Mannheim Medical Faculty of the University of Heidelberg, Mannheim, Germany
    J Trauma 66:1065-75. 2009
    ..This study investigated the changes in serum protein expression in a coecal ligature and puncture model of rat sepsis at 12, 24, and 48 hours after the induction of sepsis using differential proteomics...
  23. doi Increased densities of monocarboxylate transporter MCT1 after chronic hyperglycemia in rat brain
    Martin Canis
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, Heidelberg, Germany
    Brain Res 1257:32-9. 2009
    ..It is concluded that MCT1 transporters were up-regulated during chronic hyperglycemia at the level of brain substructures and independently of LCGU...
  24. doi Proteomics of brain extracellular fluid (ECF) and cerebrospinal fluid (CSF)
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Mass Spectrom Rev 29:17-28. 2010
    ..I will also discuss the needs for a transition of research-based experimental screening with mass spectrometry to fast and reliable diagnostic instrumentation for clinical use...
  25. ncbi Identification of early markers for symptomatic vasospasm in human cerebral microdialysate after subarachnoid hemorrhage: preliminary results of a proteome-wide screening
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 27:1675-83. 2007
    ..We conclude that GAPDH and HSP7C may be used as early markers indicating the later development of symptomatic vasospasm after SAH, enabling selective early therapeutic intervention in this high-risk group of patients...
  26. ncbi Changes in the serum proteome of patients with sepsis and septic shock
    Armin Kalenka
    Department of Anesthesiology and Critical Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Anesth Analg 103:1522-6. 2006
    ..Sepsis is still the leading cause of death in the intensive care unit. Our goal was to elucidate potential early differences in serum between survivors (SURV) and non-survivors (NON-SURV) on day 28...
  27. ncbi Adult neural stem cells express glucose transporters GLUT1 and GLUT3 and regulate GLUT3 expression
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    FEBS Lett 580:4430-4. 2006
    ..It is concluded that adult neural stem cells can transport glucose by GLUT1 and GLUT3 and can regulate their glucose transporter densities...
  28. ncbi Alterations in rat brain proteins after desflurane anesthesia
    Carsten D Fütterer
    of Anesthesiology and Critical Care Medicine, Faculty of Clinical Medicine Mannheim, Theodor Kutzer Ufer, 68167 Mannheim, Germany
    Anesthesiology 100:302-8. 2004
    ..Whether changes of protein expression persist in the brain for a longer period is not known. This study investigates the question of whether the expression of proteins is altered in the rat brain after the end of desflurane anesthesia...
  29. ncbi Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Neurosci Lett 355:105-8. 2004
    ..As local GLUT1 densities reflect local glucose metabolism in the brain, we conclude that local MCT1 densities are adjusted to local glucose metabolism and transport...
  30. ncbi Expression of vascular endothelial growth factor and its receptors in rat neural stem cells
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany
    Neurosci Lett 344:165-8. 2003
    ..The basal expression of VEGF and of several of its receptor mRNAs indicates a hitherto unknown angiogenic potential of neural stem cells...
  31. ncbi Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany
    Neurosci Lett 327:181-4. 2002
    ..In conclusion, components of oxidative metabolism pathways were activated at the level of transcription which could be related to neuroprotective effects of EPO or could indicate compromised tissue...
  32. ncbi Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent
    Krisztian J Kapinya
    Department of Experimental Neurology, Medical Faculty Charité, Humboldt University, Berlin, Germany
    Stroke 33:1889-98. 2002
    ..We tested whether volatile anesthetics induce neuroprotection that is maintained for a prolonged time...
  33. ncbi Correlation between local glucose transporter densities and local 3-O-methylglucose transport in rat brain
    R Duelli
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326 D 69120 Heidelberg, Germany
    Neurosci Lett 310:101-4. 2001
    ..Inasmuch as 3-O-MG is transported by the same transporter as glucose, these results indicate that the local densities of glucose transporters determine local glucose transport rates in the brain...
  34. ncbi Increased cerebral glucose utilization and decreased glucose transporter Glut1 during chronic hyperglycemia in rat brain
    R Duelli
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120, Heidelberg, Germany
    Brain Res 858:338-47. 2000
    ..2) The capacity to transport glucose is decreased during chronic hyperglycemia. (3) Increased LCGU and decreased densities of Glut1 are matched on a local level...
  35. ncbi Brain water content, glucose transporter densities and glucose utilization after 3 days of water deprivation in the rat
    R Duelli
    Department of Physiology, University of Heidelberg, Germany
    Neurosci Lett 271:13-6. 1999
    ..Densities of glucose transporters Glut1 and Glut3 increased in parallel to increased LCGU in some of the osmoregulatory structures indicating a long-term local adaptation of glucose transporters to LCGU...
  36. ncbi Decreased glucose transporter densities, rate constants and glucose utilization in visual structures of rat brain during chronic visual deprivation
    R Duelli
    Department of Physiology, University of Heidelberg, Germany
    Neurosci Lett 250:49-52. 1998
    ..These results indicate a moderate degree of downregulation of glucose transporters, LCGU and rate constants in the visual system during visual deprivation...
  37. ncbi [Cerebral microdialysis in stroke]
    C Berger
    Neurologische Universitatsklinik, Heidelberg
    Nervenarzt 75:113-23. 2004
    ....
  38. ncbi Comprehensive proteome expression profiling of undifferentiated versus differentiated neural stem cells from adult rat hippocampus
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Neurochem Res 29:1129-44. 2004
    ..These results suggest a massive reorganization of the stem cell proteomic profile upon differentiation and indicate potential cellular targets mediating the differentiation of neural stem cells...
  39. ncbi Reduced cerebral blood flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic mice with excessive erythrocytosis
    Thomas Frietsch
    Department of Anesthesiology and Critical Care Medicine, Faculty of Clinical Medicine Mannheim, Mannheim, Germany
    J Cereb Blood Flow Metab 27:469-76. 2007
    ..Hemodilution suggests that high blood viscosity is a cause of the decrease in CBF and partly of the increase in CMR(glc). Cerebral glucose metabolic rate may also be increased by a direct effect of Epo in the brain (tg-21 mice)...
  40. ncbi Spatial learning induces predominant downregulation of cytosolic proteins in the rat hippocampus
    N Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Genes Brain Behav 6:128-40. 2007
    ..These findings indicate that learning in the Morris water maze has a morphological correlate on the proteome level in the hippocampus...
  41. ncbi The heterogeneity of human mesenchymal stem cell preparations--evidence from simultaneous analysis of proteomes and transcriptomes
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Germany
    Exp Hematol 34:536-48. 2006
    ..Whereas surface antigen markers have failed to precisely define this population, a combination of proteomic data and microarray data provides a new dimension for the definition of MSC preparations...
  42. ncbi Volatile anesthetics evoke prolonged changes in the proteome of the left ventricule myocardium: defining a molecular basis of cardioprotection?
    A Kalenka
    Department of Anesthesiology and Critical Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Acta Anaesthesiol Scand 50:414-27. 2006
    ..Of those underlying molecular changes in gene and protein expression in the myocardium after exposure to volatile anesthetics that have been identified, some of them have been related to cardioprotection...
  43. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
    ..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...
  44. ncbi Stem cell proteomes: a profile of human mesenchymal stem cells derived from umbilical cord blood
    Robert E Feldmann
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Electrophoresis 26:2749-58. 2005
    ....
  45. ncbi FXTAS, SCA10, and SCA17 in American patients with movement disorders
    Ana I Seixas
    Am J Med Genet A 136:87-9. 2005
  46. ncbi Comparison of statistical approaches for the analysis of proteome expression data of differentiating neural stem cells
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Proteome Res 4:96-100. 2005
    ..Tools for the statistical analysis of proteome data should be implemented and documented in the existing 2DE software...
  47. ncbi The path to enlightenment: making sense of genomic and proteomic information
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany
    Genomics Proteomics Bioinformatics 2:123-31. 2004
    ..The article is a toolbox for researchers who have genomic or proteomic datasets and need to put their findings into a biological context...
  48. ncbi Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Neurochem 91:1007-17. 2004
    ..We propose that ee3 is a highly interesting new orphan GPCR with potential connections to erythropoietin and 5HT2a receptor signalling...
  49. ncbi Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration
    Ioana Potrovita
    Department of Neurology, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 24:8237-44. 2004
    ..In summary, our data show that TWEAK induces neuronal cell death and is involved in neurodegeneration in vivo...
  50. ncbi Simple method for three-dimensional representation of 2-DE spots using a spreadsheet program
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Germany
    J Proteome Res 3:665-6. 2004
    ..We describe an algorithm to visualize two-dimensional spot patterns in three dimensions using a spreadsheet program for surface plotting...