Nikolaus Marx

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA®)
    Nikolaus Marx
    Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany
    Diab Vasc Dis Res 12:164-74. 2015
  2. pmc C-peptide levels are associated with mortality and cardiovascular mortality in patients undergoing angiography: the LURIC study
    Nikolaus Marx
    Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany
    Diabetes Care 36:708-14. 2013
  3. ncbi request reprint Renin-angiotensin-aldosterone system antagonists and the prevention of type 2 diabetes mellitus
    Robert Stöhr
    Department of Internal Medicine I Cardiology, University Hospital Aachen, Pauwelsstrasse 30, 74 Aachen, Germany
    Curr Pharm Des 18:958-62. 2012
  4. pmc PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice
    Anna Foryst-Ludwig
    Center for Cardiovascular Research, Institute of Pharmacology Charité Universitätsmedizin Berlin, Germany
    Cardiovasc Diabetol 9:64. 2010
  5. doi request reprint Glucagon-like peptide-1(1-37) inhibits chemokine-induced migration of human CD4-positive lymphocytes
    Nikolaus Marx
    Department of Internal Medicine I Cardiology, University of Aachen, Pauwelstr 30, Aachen, Germany
    Cell Mol Life Sci 67:3549-55. 2010
  6. doi request reprint Predictors and incidence of stent edge dissections in patients with type 2 diabetes as determined by optical coherence tomography
    Sebastian Reith
    Department of Internal Medicine I, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Int J Cardiovasc Imaging 29:1237-47. 2013
  7. doi request reprint Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe⁻/⁻ mice
    Mathias Burgmaier
    Department of Internal Medicine I, University Hospital of the RWTH Aachen, Pauwelsstrase 30, D 52074 Aachen, Germany
    Atherosclerosis 231:427-35. 2013
  8. doi request reprint Serum levels of C-peptide are associated with coronary artery calcification in patients with rheumatoid arthritis
    Mathias Burgmaier
    Department of Internal Medicine I Cardiology, University Hospital of the RWTH Aachen, Pauwelstr 30, 52074, Aachen, Germany
    Rheumatol Int 35:1541-7. 2015
  9. doi request reprint Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism
    Corinna Lebherz
    Department of Internal Medicine I, University Hospital Aachen, Pauwelsstrase 30, 52074, Aachen, Germany
    Cardiovasc Diabetol 15:21. 2016
  10. doi request reprint Correlation between optical coherence tomography-derived intraluminal parameters and fractional flow reserve measurements in intermediate grade coronary lesions: a comparison between diabetic and non-diabetic patients
    Sebastian Reith
    Department of Cardiology, Medical Clinic I, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Clin Res Cardiol 104:59-70. 2015

Collaborators

Detail Information

Publications31

  1. pmc Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA®)
    Nikolaus Marx
    Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany
    Diab Vasc Dis Res 12:164-74. 2015
    ..The results of CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes may influence the decision-making process for selecting a second glucose-lowering agent after metformin in type 2 diabetes. ..
  2. pmc C-peptide levels are associated with mortality and cardiovascular mortality in patients undergoing angiography: the LURIC study
    Nikolaus Marx
    Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany
    Diabetes Care 36:708-14. 2013
    ..Recent data suggest that C-peptide could play a causal role in the pathophysiology of vascular disease, but nothing is known about the prognostic value of C-peptide concentrations in the circulation...
  3. ncbi request reprint Renin-angiotensin-aldosterone system antagonists and the prevention of type 2 diabetes mellitus
    Robert Stöhr
    Department of Internal Medicine I Cardiology, University Hospital Aachen, Pauwelsstrasse 30, 74 Aachen, Germany
    Curr Pharm Des 18:958-62. 2012
    ....
  4. pmc PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice
    Anna Foryst-Ludwig
    Center for Cardiovascular Research, Institute of Pharmacology Charité Universitätsmedizin Berlin, Germany
    Cardiovasc Diabetol 9:64. 2010
    ....
  5. doi request reprint Glucagon-like peptide-1(1-37) inhibits chemokine-induced migration of human CD4-positive lymphocytes
    Nikolaus Marx
    Department of Internal Medicine I Cardiology, University of Aachen, Pauwelstr 30, Aachen, Germany
    Cell Mol Life Sci 67:3549-55. 2010
    ..This effect provides a potential novel mechanism for how GLP-1(1-37) may modulate vascular disease...
  6. doi request reprint Predictors and incidence of stent edge dissections in patients with type 2 diabetes as determined by optical coherence tomography
    Sebastian Reith
    Department of Internal Medicine I, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Int J Cardiovasc Imaging 29:1237-47. 2013
    ....
  7. doi request reprint Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe⁻/⁻ mice
    Mathias Burgmaier
    Department of Internal Medicine I, University Hospital of the RWTH Aachen, Pauwelsstrase 30, D 52074 Aachen, Germany
    Atherosclerosis 231:427-35. 2013
    ..We therefore investigated the actions of GLP-1(7-37), GLP-1(9-37) as well as GLP-1(28-37) on vascular lesion formation in a mouse model of atherosclerosis...
  8. doi request reprint Serum levels of C-peptide are associated with coronary artery calcification in patients with rheumatoid arthritis
    Mathias Burgmaier
    Department of Internal Medicine I Cardiology, University Hospital of the RWTH Aachen, Pauwelstr 30, 52074, Aachen, Germany
    Rheumatol Int 35:1541-7. 2015
    ..In conclusion, C-peptide serum levels are independently associated with the presence of CAC in patients with RA. These data suggest a potential role of C-peptide in cardiovascular disease in patients with RA...
  9. doi request reprint Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism
    Corinna Lebherz
    Department of Internal Medicine I, University Hospital Aachen, Pauwelsstrase 30, 52074, Aachen, Germany
    Cardiovasc Diabetol 15:21. 2016
    ..This study was performed to elucidate, whether a direct link exists between inflammation and GLP-1 secretion in humans...
  10. doi request reprint Correlation between optical coherence tomography-derived intraluminal parameters and fractional flow reserve measurements in intermediate grade coronary lesions: a comparison between diabetic and non-diabetic patients
    Sebastian Reith
    Department of Cardiology, Medical Clinic I, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Clin Res Cardiol 104:59-70. 2015
    ..This study aimed at comparing the diagnostic value of intraluminal parameters as determined by OCT to predict FFR ≤0.8 in lesions of patients with versus without DM...
  11. doi request reprint Impact of aortic valve calcification severity and impaired left ventricular function on 3-year results of patients undergoing transcatheter aortic valve replacement
    Ralf Koos
    Department of Cardiology, University Hospital RWTH Aachen, RWTH University Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Eur Radiol 23:3253-61. 2013
    ..To evaluate clinical pre-interventional predictors of 3-year outcome and mortality in high-risk patients with severe aortic valve stenosis treated with transcatheter aortic valve implantation (TAVI)...
  12. doi request reprint Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA
    Erol Saygili
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    J Mol Cell Cardiol 49:79-87. 2010
    ..In summary, this study provides evidence that high-rate electrical stimulation of sympathetic neurons mediates nerve sprouting by an increase in NGF expression that targets the TrkA receptor in an autocrine/paracrine manner...
  13. ncbi request reprint Electrocardiographic and imaging predictors for permanent pacemaker requirement after transcatheter aortic valve implantation
    Ralf Koos
    Department of Cardiology, University Hospital RWTH Aachen, RWTH University Aachen, Aachen, Germany
    J Heart Valve Dis 20:83-90. 2011
    ..Pacemaker (PM) implantation is a possible requirement after transcatheter aortic valve implantation (TAVI). The study aim was to evaluate the electrocardiographic and imaging predictors of the need for PM implantation after TAVI...
  14. doi request reprint Acetylcholine as an age-dependent non-neuronal source in the heart
    Obaida R Rana
    Department of Cardiology, RWTH Aachen University, Aachen, 52074, Germany
    Auton Neurosci 156:82-9. 2010
    ..This finding may provide new physiological/pathological aspects in the communication between cardiomyocytes and other cell types in the myocardium, e.g. fibrocytes, neurocytes or endothelial cells...
  15. doi request reprint The right ventricular response to high afterload: comparison between healthy persons and patients with transposition of the great arteries: a 2D strain study
    Michael Becker
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Echocardiography 27:1256-62. 2010
    ..To evaluate the contraction pattern of the systemic right ventricle (RV) in comparison to healthy controls...
  16. doi request reprint Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion
    Erol Saygili
    Department of Cardiology, Medical Clinic I, RWTH Aachen University, Germany
    Cell Mol Neurobiol 31:17-25. 2011
    ..In summary, specific MMP-2 blockade prevents sympathetic nerve sprouting (SNS) by inhibition of pro-NGF conversion while losartan abolishes HFES-induced SNS by reducing total NGF, MMP-2 and MT1-MMP expression...
  17. doi request reprint GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering
    Florian Kahles
    Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany
    Diabetes 63:3221-9. 2014
    ..Consequently, GLP-1 provides a novel link between the immune system and the gut with strong relevance for metabolic regulation in context of inflammation. ..
  18. pmc Glucagon-like peptide-1(9-36) inhibits chemokine-induced migration of human CD4-positive lymphocytes
    Ana Liberman
    Department of Internal Medicine I Cardiology, University Hospital Aachen, Aachen, Germany
    PLoS ONE 8:e58445. 2013
    ..Thus, the present study examined the effect of GLP-1(9-36) on chemokine-induced CD4-positive lymphocyte migration as one of the early and critical steps in atherogenesis...
  19. doi request reprint Paclitaxel-eluting balloon versus everolimus-eluting stent for treatment of drug-eluting stent restenosis
    Mohammad Almalla
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 83:881-7. 2014
    ..This study compared the 1-year clinical outcome after the use of drug-eluting balloon (DEB) to second-generation everolimus-eluting stent (EES) for treatment of DES-ISR...
  20. pmc Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans
    Katja Piotrowski
    Department of Internal Medicine I, University Hospital Aachen, Pauwelsstrase 30, 52074, Aachen, Germany
    Cardiovasc Diabetol 12:117. 2013
    ..Despite these vasoprotective actions, associations between endogenous levels of GLP-1 and cardiovascular disease have yet not been investigated in humans which was the aim of the present study...
  21. doi request reprint Efficacy and safety of transcatheter coil embolization in congenital coronary artery fistulas guided by preinterventional cardiac computed tomography
    Sebastian Reith
    Department of Cardiology Medical Clinic I, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
    Coron Artery Dis 24:422-30. 2013
    ....
  22. doi request reprint Impact of type 2 diabetes mellitus and glucose control on fractional flow reserve measurements in intermediate grade coronary lesions
    Sebastian Reith
    Department of Cardiology, Medical Clinic I, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Clin Res Cardiol 103:191-201. 2014
    ..This study aimed to investigate the impact of DM and IGC on the relationship between FFR measurements and quantitative coronary angiography (QCA)-derived morphological parameters...
  23. doi request reprint Are patients with cardiac implants protected against electromagnetic interference in daily life and occupational environment?
    Andreas Napp
    Department of Internal Medicine I Cardiology, Angiology, Pneumology and Internal Intensive Care Medicine, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, Aachen 52074, Germany
    Eur Heart J 36:1798-804. 2015
    ....
  24. doi request reprint PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner
    Michael Lehrke
    Department of Internal Medicine I Cardiology, University Hospital Aachen, Pauwelsstrase 30, 52074 Aachen, Germany Electronic address
    J Mol Cell Cardiol 81:23-33. 2015
    ..PDE4 inhibition and Epac activation might represent novel approaches for the treatment of vascular diseases, including atherosclerosis and in-stent restenosis. ..
  25. doi request reprint Evaluation of a newly designed shirt-based ECG and breathing sensor for home-based training as part of cardiac rehabilitation for coronary artery disease
    Erik Skobel
    Clinic for Cardiac and Pulmonary Rehabilitation, Aachen, Germany RWTH University Hospital Aachen, Germany
    Eur J Prev Cardiol 21:1332-40. 2014
    ..New technological approaches are needed to provide sufficient supervision with respect to safety and performance of individual exercise programmes...
  26. doi request reprint Electromagnetic interference with implantable cardioverter-defibrillators at power frequency: an in vivo study
    Andreas Napp
    Department of Internal Medicine I Cardiology, Pneumology, Angiology A N, C K, M Z, B B, N M, P S and Research Center for Bioelectromagnetic Interaction at the Institute of Occupational Medicine former at the Institute of Hygiene and Environmental Medicine S J, D S, J S, University Hospital RWTH Aachen, Aachen, Germany and Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands C K
    Circulation 129:441-50. 2014
    ....
  27. doi request reprint Detection of coronary artery disease in postmenopausal women: the significance of integrated stress imaging tests in a 4-year prognostic study
    Michael Becker
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    Clin Res Cardiol 104:258-71. 2015
    ..In women non-invasive tests for detecting CAD are less accurate than in men, leading to a high proportion of unnecessary coronary angiographies (CAs)...
  28. doi request reprint Safety and Tolerability of Linagliptin in Patients With Type 2 Diabetes: A Comprehensive Pooled Analysis of 22 Placebo-controlled Studies
    Michael Lehrke
    Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany
    Clin Ther 36:1130-46. 2014
    ..Linagliptin, an orally administered DPP-4 inhibitor, has demonstrated favorable efficacy/safety in clinical trials. The aim of this post hoc pooled analysis was to expand current knowledge of the safety of linagliptin...
  29. ncbi request reprint Sclerostin as a potential novel biomarker for aortic valve calcification: an in-vivo and ex-vivo study
    Ralf Koos
    Department of Cardiology, University Hospital RWTH Aachen, RWTH University Aachen, Aachen, Germany
    J Heart Valve Dis 22:317-25. 2013
    ..The study aim was to evaluate serum sclerostin levels in patients with different degrees of AVC compared to a healthy control group, and to investigate local sclerostin expression in explanted calcified and non-calcified aortic valves...
  30. doi request reprint Beat to beat 3-dimensional intracardiac echocardiography: theoretical approach and practical experiences
    Daniel Stapf
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    Int J Cardiovasc Imaging 29:753-64. 2013
    ..However, shape and dimension of static and moving objects cannot always be displayed with necessary steadiness as needed in the clinical setting. As catheter depiction is also limited, clinical use seems impossible...
  31. doi request reprint Long-term outcome after angiographically proven coronary stent thrombosis
    Mohammad Almalla
    Department of Cardiology, Pneumology, Angiology, Intensive Care Medicine, University Hospital RWTH, Aachen, Germany
    Am J Cardiol 111:1289-94. 2013
    ..12, 95% CI 1.01 to 1.27, p = 0.0321). In conclusion, ST was associated with detrimental outcomes in the acute phase as well as the long-term phase. Recurrent ST was not infrequent...