Hugo H Marti

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Erythropoietin and the hypoxic brain
    Hugo H Marti
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Exp Biol 207:3233-42. 2004
  2. ncbi request reprint Delayed hyperbaric oxygenation is more effective than early prolonged normobaric hyperoxia in experimental focal cerebral ischemia
    Christopher Beynon
    Department of Neurology, University of Heidelberg, Germany
    Neurosci Lett 425:141-5. 2007
  3. ncbi request reprint Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 36:1679-83. 2005
  4. doi request reprint VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion
    Konstanze Plaschke
    Department of Anesthesiology, Medical Faculty, University of Heidelberg, Germany
    Exp Neurol 214:285-92. 2008
  5. ncbi request reprint Hyperbaric oxygen reduces basal lamina degradation after transient focal cerebral ischemia in rats
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1076:231-7. 2006
  6. doi request reprint Influenza virus infection aggravates stroke outcome
    Sajjad Muhammad
    Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Stroke 42:783-91. 2011
  7. ncbi request reprint Oxygen therapy in permanent brain ischemia: potential and limitations
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1107:185-91. 2006
  8. doi request reprint Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery
    Judith Lubjuhn
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Neurosci Methods 184:95-103. 2009
  9. pmc Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
    Alexander T Bauer
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 30:837-48. 2010
  10. doi request reprint Impaired hypoxic response in senescent mouse brain
    Tamer Rabie
    Institute of Physiology and Pathophysiology, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Dev Neurosci 29:655-61. 2011

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Erythropoietin and the hypoxic brain
    Hugo H Marti
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Exp Biol 207:3233-42. 2004
    ....
  2. ncbi request reprint Delayed hyperbaric oxygenation is more effective than early prolonged normobaric hyperoxia in experimental focal cerebral ischemia
    Christopher Beynon
    Department of Neurology, University of Heidelberg, Germany
    Neurosci Lett 425:141-5. 2007
    ..8+/-1.1). In conclusion, HBO is a more effective therapy than NBO in transient experimental ischemia even when accounting for delayed treatment-onset of HBO. The combination of NBO and HBO results in no additional benefit...
  3. ncbi request reprint Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 36:1679-83. 2005
    ..We examined the potential of HBO to reduce postischemic blood-brain barrier (BBB) damage and edema...
  4. doi request reprint VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion
    Konstanze Plaschke
    Department of Anesthesiology, Medical Faculty, University of Heidelberg, Germany
    Exp Neurol 214:285-92. 2008
    ....
  5. ncbi request reprint Hyperbaric oxygen reduces basal lamina degradation after transient focal cerebral ischemia in rats
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1076:231-7. 2006
    ..In conclusion, HBO therapy attenuates ischemic degradation of cerebral microvascular laminin-5 and blocks postischemic plasma MMP-9 upregulation...
  6. doi request reprint Influenza virus infection aggravates stroke outcome
    Sajjad Muhammad
    Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Stroke 42:783-91. 2011
    ..Stroke is triggered by several risk factors, including influenza and other respiratory tract infections. However, it is unknown how and in which way influenza infection affects stroke outcome...
  7. ncbi request reprint Oxygen therapy in permanent brain ischemia: potential and limitations
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1107:185-91. 2006
    ..The goals of the present study were to compare both oxygen therapies in 2 models of permanent ischemia, to study the effect of time window, and to evaluate the combination of both oxygen therapies...
  8. doi request reprint Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery
    Judith Lubjuhn
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Neurosci Methods 184:95-103. 2009
    ..The present study provides a basis to explore the potential of functional testing for neuroprotection and neuroregeneration after stroke...
  9. pmc Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
    Alexander T Bauer
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 30:837-48. 2010
    ..Therefore, inhibition of MMP-9 might provide the basis for therapeutic strategies to treat brain edema...
  10. doi request reprint Impaired hypoxic response in senescent mouse brain
    Tamer Rabie
    Institute of Physiology and Pathophysiology, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Dev Neurosci 29:655-61. 2011
    ....
  11. ncbi request reprint Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia
    Reiner Kunze
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Stroke 43:2748-56. 2012
    ..During normoxia, prolyl-4-hydroxylase domain (PHD) proteins hydroxylate HIF-α subunits, resulting in their degradation. We investigated the effect of neuronal deletion of PHD2, the most abundant isoform in brain, for stroke outcome...
  12. ncbi request reprint Massive inborn angiogenesis in the brain scarcely raises cerebral blood flow
    Johannes Vogel
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 24:849-59. 2004
    ..These findings suggest that attenuated CBF in transgenic mice during normocapnia is only partly due to a compensatory vasoconstriction, and that microvascular networks in transgenic brains might be ineffectively constructed...
  13. pmc Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke
    Stefan Reischl
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 9:e84767. 2014
    ..These results indicate that FG-4497 has the potential to prevent cerebral ischemic damage by neuroprotection and prevention of vascular leakage. ..
  14. doi request reprint Brain protection by erythropoietin: a manifold task
    Tamer Rabie
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Physiology (Bethesda) 23:263-74. 2008
    ..These functions make erythropoietin a good candidate for treating diseases associated with neuronal cell death...
  15. doi request reprint Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain
    Tamer Rabie
    Department of Physiology and Pathophysiology, University of Heidelberg Medical School, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany
    J Mol Neurosci 41:74-9. 2010
    ..Therefore, B-vitamin pre-treatment may attenuate the response to epileptic stimulation...
  16. doi request reprint Hyperbaric oxygen reduces tissue hypoxia and hypoxia-inducible factor-1 alpha expression in focal cerebral ischemia
    Li Sun
    Department of Neurology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Stroke 39:1000-6. 2008
    ..However, even the basic mechanisms underlying oxygen therapy are poorly understood. We investigated the effect of both oxygen therapies on tissue hypoxia and on the transcription factor hypoxia-inducible factor-1 alpha...
  17. ncbi request reprint Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis
    Jörg H W Distler
    Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Gloriastrasse 25, Zurich, Switzerland
    Arthritis Rheum 56:4203-15. 2007
    ..Based on the severely decreased oxygen levels in the skin of patients with SSc, we aimed to investigate the role of hypoxia in the pathogenesis of SSc...
  18. ncbi request reprint Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway
    Carsten Vogel
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    J Cell Physiol 212:236-43. 2007
    ....
  19. ncbi request reprint VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration
    Yaoming Wang
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci Res 85:740-7. 2007
    ....
  20. pmc Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice
    Yaoming Wang
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 27:304-7. 2007
    ..These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS...
  21. ncbi request reprint Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain
    Heike J Schoch
    Department of Molecular Cell Biology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Brain 125:2549-57. 2002
    ..In conclusion, our data show that VEGF is responsible for hypoxia-induced augmentation in vascular leakage following tissue hypoxia. Our findings might provide the basis for new therapeutic concepts for the treatment of cerebral oedema...
  22. ncbi request reprint Induction of HIF1alpha but not HIF2alpha in motoneurons after ventral funiculus axotomy-implication in neuronal survival strategies
    Mattias K Sköld
    Department of Neuroscience, Retzius Laboratory, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Exp Neurol 188:20-32. 2004
    ..We conclude that axotomized motoneurons in this model respond to injury by specific induction of HIF1alpha and VEGF expression that may provide an endogenous mechanism with the potential to promote motoneuron survival after injury...
  23. ncbi request reprint VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena
    Yaoming Wang
    Department of Neurology, University Hospital Zurich, Switzerland
    Brain 128:52-63. 2005
    ..g. by VEGF overexpression, may worsen rather than improve cerebral haemodynamics after stroke...
  24. ncbi request reprint Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis
    Hugo H Marti
    Max Planck Institute for Physiological and Clinical Research, Department of Molecular Cell Biology, D 61231 Bad Nauheim, Germany
    Mol Endocrinol 16:234-43. 2002
    ..Both the switch in transcript expression during spermiogenesis and the unexpected protein localization in mature sperm cells suggest a so far unrecognized function of HIF-1alpha...
  25. ncbi request reprint The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    FASEB J 20:1185-7. 2006
    ....
  26. ncbi request reprint Novel three-dimensional analysis tool for vascular trees indicates complete micro-networks, not single capillaries, as the angiogenic endpoint in mice overexpressing human VEGF(165) in the brain
    Stefan Heinzer
    Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
    Neuroimage 39:1549-58. 2008
    ....
  27. ncbi request reprint p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability
    Katja Issbrücker
    Department of Molecular Cell Biology, Max Planck Institute for Physiological and Clinical Research, 61231 Bad Nauheim, Germany
    FASEB J 17:262-4. 2003
    ..These dualistic properties of p38 MAPK are relevant not only for therapeutic angiogenesis but also for reducing edema formation and enhancing tissue repair in ischemic diseases...
  28. ncbi request reprint Vascular endothelial growth factor
    Hugo H Marti
    Max Planck Institute for Physiological and Clinical Research, Parkstrasse 1, D 61231 Bad Nauheim, Germany
    Adv Exp Med Biol 513:375-94. 2002
  29. ncbi request reprint Time- and cell type-specific induction of platelet-derived growth factor receptor-beta during cerebral ischemia
    Oliver Renner
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, D 61231 Bad Nauheim, Germany
    Brain Res Mol Brain Res 113:44-51. 2003
    ..Influencing the PDGF system therapeutically might improve angiogenesis, cellular protection, and edema inhibition...
  30. pmc Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN
    Dorthe M Katschinski
    Cell Physiology Group, Medical Faculty, Martin Luther University Halle, D 06112 Halle, Germany
    Mol Cell Biol 23:6780-9. 2003
    ..Indeed, Sds22 colocalized with the cell types expressing PASKIN in vivo, suggesting a functional role of protein phosphatase-1 in the regulation of PASKIN autophosphorylation...
  31. ncbi request reprint Simultaneous activation of several second messengers in hypoxia-induced hyperpermeability of brain derived endothelial cells
    Silvia Fischer
    Kerckhoff Clinic, Department of Anesthesiology and Intensive Care, Bad Nauheim, Germany
    J Cell Physiol 198:359-69. 2004
    ..These findings demonstrate that hypoxia and VEGF induce permeability through rearrangement of endothelial junctional proteins which involves activation of the PLCgamma and PI3-K/AKT pathway leading to the activation of PKG...
  32. ncbi request reprint Comments on Point-Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume"
    Leonhard Schaffer
    J Appl Physiol 100:366. 2006
  33. doi request reprint Vascular normalization in Rgs5-deficient tumours promotes immune destruction
    Juliana Hamzah
    Western Australian Institute for Medical Research, UWA Centre for Medical Research, Perth, Western Australia 6000, Australia
    Nature 453:410-4. 2008
    ....
  34. ncbi request reprint Preserved placental oxygenation and development during severe systemic hypoxia
    Leonhard Schaffer
    Department of Obstetrics, Division of Perinatal Physiology, University Hospital Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R844-51. 2006
    ..Our results show that placental oxygenation is preserved even during severe systemic hypoxia and imply that NOS-mediated mechanisms are involved to protect the placenta from maternal hypoxia...
  35. ncbi request reprint Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 26:12439-46. 2006
    ..In view that axotomy-induced RGC death occurs slowly and considering that RGCs are CNS-derived neurons, we predict the clinical implementation of VEGF in neurodegenerative diseases of both brain and retina...