M A Mall

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
  2. doi request reprint Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    J Aerosol Med Pulm Drug Deliv 21:13-24. 2008
  3. doi request reprint Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Exp Physiol 94:171-4. 2009
  4. pmc Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice
    Marcus A Mall
    Division of Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    J Biol Chem 285:26945-55. 2010
  5. doi request reprint Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice
    Zhe Zhou
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    Am J Respir Crit Care Med 178:1245-56. 2008
  6. doi request reprint In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography
    M O Wielpütz
    Dept of Radiology, German Cancer Research Center, Heidelberg, Germany
    Eur Respir J 38:1060-70. 2011
  7. doi request reprint Initial evaluation of a biochemical cystic fibrosis newborn screening by sequential analysis of immunoreactive trypsinogen and pancreatitis-associated protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern European population
    Olaf Sommerburg
    Division of Paediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Paediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany
    J Inherit Metab Dis 33:S263-71. 2010
  8. doi request reprint Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice
    P Anagnostopoulou
    Division of Paediatric Pulmonology and Cystic Fibrosis Center, Dept of Paediatrics III, University of Heidelberg, Heidelberg, Germany
    Eur Respir J 36:1436-47. 2010
  9. doi request reprint Use of a new-generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung
    Julia Duerr
    Division of Pediatric Pulmonology, Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Am J Respir Cell Mol Biol 44:244-54. 2011
  10. doi request reprint Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation
    Amanda Cobos-Correa
    1 Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany 2 Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany
    Nat Chem Biol 5:628-30. 2009

Collaborators

Detail Information

Publications10

  1. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
    ..Previous studies have shown that airway surface dehydration in beta-epithelial Na(+) channel (betaENaC)-overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors...
  2. doi request reprint Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    J Aerosol Med Pulm Drug Deliv 21:13-24. 2008
    ....
  3. doi request reprint Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Exp Physiol 94:171-4. 2009
    ..These results support a critical role of ENaC in the in vivo pathogenesis of CF lung disease and suggest that amiloride may be an effective preventive therapy for CF patients...
  4. pmc Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice
    Marcus A Mall
    Division of Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    J Biol Chem 285:26945-55. 2010
    ..We conclude that the capacity to regulate Na(+) transport and ASL volume, not absolute Na(+) transport rates in Ussing chambers, is the key physiologic function protecting airways from dehydration-induced lung disease...
  5. doi request reprint Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice
    Zhe Zhou
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    Am J Respir Crit Care Med 178:1245-56. 2008
    ..However, inhalation therapy with the ENaC blocker amiloride did not have therapeutic benefits in patients with CF with established lung disease...
  6. doi request reprint In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography
    M O Wielpütz
    Dept of Radiology, German Cancer Research Center, Heidelberg, Germany
    Eur Respir J 38:1060-70. 2011
    ....
  7. doi request reprint Initial evaluation of a biochemical cystic fibrosis newborn screening by sequential analysis of immunoreactive trypsinogen and pancreatitis-associated protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern European population
    Olaf Sommerburg
    Division of Paediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Paediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany
    J Inherit Metab Dis 33:S263-71. 2010
    ....
  8. doi request reprint Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice
    P Anagnostopoulou
    Division of Paediatric Pulmonology and Cystic Fibrosis Center, Dept of Paediatrics III, University of Heidelberg, Heidelberg, Germany
    Eur Respir J 36:1436-47. 2010
    ....
  9. doi request reprint Use of a new-generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung
    Julia Duerr
    Division of Pediatric Pulmonology, Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Am J Respir Cell Mol Biol 44:244-54. 2011
    ....
  10. doi request reprint Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation
    Amanda Cobos-Correa
    1 Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany 2 Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany
    Nat Chem Biol 5:628-30. 2009
    ..In bronchoalveolar lavages from a mouse model of pulmonary inflammation, LaRee1 detected MMP12 activity at the surface of activated macrophages. LaRee1 may become a powerful tool for monitoring lung disease...