M A Mall

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Early cystic fibrosis lung disease: Role of airway surface dehydration and lessons from preventive rehydration therapies in mice
    Marcus A Mall
    Department of Translational Pulmonology and Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Translational Lung Research Center Heidelberg TLRC, Member of the German Center for Lung Research DZL, University of Heidelberg, Heidelberg, Germany Electronic address
    Int J Biochem Cell Biol 52:174-9. 2014
  2. pmc Pulmonary emphysema in cystic fibrosis detected by densitometry on chest multidetector computed tomography
    Mark O Wielpütz
    Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e73142. 2013
  3. pmc CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice
    Bjarki Johannesson
    Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e44059. 2012
  4. pmc The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
    Eva K Roth
    Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e24445. 2011
  5. pmc Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice
    Marcus A Mall
    Division of Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    J Biol Chem 285:26945-55. 2010
  6. doi request reprint Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Exp Physiol 94:171-4. 2009
  7. doi request reprint Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    J Aerosol Med Pulm Drug Deliv 21:13-24. 2008
  8. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
  9. ncbi request reprint Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice
    Zhe Zhou
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    Am J Respir Crit Care Med 178:1245-56. 2008
  10. doi request reprint In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography
    M O Wielpütz
    Dept of Radiology, German Cancer Research Center, Heidelberg, Germany
    Eur Respir J 38:1060-70. 2011

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Early cystic fibrosis lung disease: Role of airway surface dehydration and lessons from preventive rehydration therapies in mice
    Marcus A Mall
    Department of Translational Pulmonology and Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Translational Lung Research Center Heidelberg TLRC, Member of the German Center for Lung Research DZL, University of Heidelberg, Heidelberg, Germany Electronic address
    Int J Biochem Cell Biol 52:174-9. 2014
    ..These results support clinical testing of preventive/early rehydration strategies in infants and young children with CF. ..
  2. pmc Pulmonary emphysema in cystic fibrosis detected by densitometry on chest multidetector computed tomography
    Mark O Wielpütz
    Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e73142. 2013
    ..In the present study, we used computationally generated density masks based on multidetector computed tomography (MDCT) of the chest for non-invasive characterization and quantification of emphysema in CF...
  3. pmc CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice
    Bjarki Johannesson
    Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e44059. 2012
    ....
  4. pmc The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
    Eva K Roth
    Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e24445. 2011
    ..However, the effects of 1-EBIO on wild-type and mutant CFTR function in native human colonic tissues remain unknown...
  5. pmc Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice
    Marcus A Mall
    Division of Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    J Biol Chem 285:26945-55. 2010
    ..We conclude that the capacity to regulate Na(+) transport and ASL volume, not absolute Na(+) transport rates in Ussing chambers, is the key physiologic function protecting airways from dehydration-induced lung disease...
  6. doi request reprint Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Exp Physiol 94:171-4. 2009
    ..These results support a critical role of ENaC in the in vivo pathogenesis of CF lung disease and suggest that amiloride may be an effective preventive therapy for CF patients...
  7. doi request reprint Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    J Aerosol Med Pulm Drug Deliv 21:13-24. 2008
    ....
  8. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
    ..Previous studies have shown that airway surface dehydration in beta-epithelial Na(+) channel (betaENaC)-overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors...
  9. ncbi request reprint Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice
    Zhe Zhou
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    Am J Respir Crit Care Med 178:1245-56. 2008
    ..However, inhalation therapy with the ENaC blocker amiloride did not have therapeutic benefits in patients with CF with established lung disease...
  10. doi request reprint In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography
    M O Wielpütz
    Dept of Radiology, German Cancer Research Center, Heidelberg, Germany
    Eur Respir J 38:1060-70. 2011
    ....
  11. doi request reprint Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice
    P Anagnostopoulou
    Division of Paediatric Pulmonology and Cystic Fibrosis Center, Dept of Paediatrics III, University of Heidelberg, Heidelberg, Germany
    Eur Respir J 36:1436-47. 2010
    ....
  12. doi request reprint Initial evaluation of a biochemical cystic fibrosis newborn screening by sequential analysis of immunoreactive trypsinogen and pancreatitis-associated protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern European population
    Olaf Sommerburg
    Division of Paediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Paediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany
    J Inherit Metab Dis 33:S263-71. 2010
    ....
  13. doi request reprint Use of a new-generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung
    Julia Duerr
    Division of Pediatric Pulmonology, Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Am J Respir Cell Mol Biol 44:244-54. 2011
    ....
  14. doi request reprint Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation
    Amanda Cobos-Correa
    1 Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany 2 Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany
    Nat Chem Biol 5:628-30. 2009
    ..In bronchoalveolar lavages from a mouse model of pulmonary inflammation, LaRee1 detected MMP12 activity at the surface of activated macrophages. LaRee1 may become a powerful tool for monitoring lung disease...