M Majores

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi Tumor recurrence and malignant progression of gangliogliomas
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Cancer 113:3355-63. 2008
  2. ncbi Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report
    M Majores
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Clin Neuropathol 26:311-6. 2007
  3. ncbi Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105, Bonn, Germany
    Acta Neuropathol 110:537-46. 2005
  4. ncbi The insulin gene VNTR polymorphism in Alzheimer's disease: results of a pilot study
    M Majores
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Federal Republic of Germany
    J Neural Transm 109:1029-34. 2002
  5. ncbi [Uniliteral wheezes as the first clinical sign of a bronchial carcinoid]
    U M Becher
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn
    Dtsch Med Wochenschr 135:390-3. 2010
  6. ncbi Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions
    V Schick
    Department of Neuropathology, University of Bonn Medical Centre, Bonn, Germany
    Neuropathol Appl Neurobiol 33:152-62. 2007
  7. ncbi Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Psychiatr Genet 14:97-100. 2004
  8. ncbi In situ-RT and immunolaser microdissection for mRNA analysis of individual cells isolated from epilepsy-associated glioneuronal tumors
    Jana Fassunke
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Lab Invest 84:1520-5. 2004
  9. ncbi Alterations of phosphatidylinositol 3-kinase pathway components in epilepsy-associated glioneuronal lesions
    Volker Schick
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 48:65-73. 2007
  10. ncbi Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 48:4-12. 2007

Collaborators

Detail Information

Publications16

  1. ncbi Tumor recurrence and malignant progression of gangliogliomas
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Cancer 113:3355-63. 2008
    ..Most gangliogliomas (GGs) are benign tumors, but tumor recurrence and malignant progression are observed in some patients...
  2. ncbi Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report
    M Majores
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Clin Neuropathol 26:311-6. 2007
    ..We report on a 46-year-old male patient with pharmacoresistant temporal lobe epilepsy (TLE). Based on ictal EEG patterns and MRI scans, Ammon's horn sclerosis (AHS) or an epilepsy-associated tumor was included in the differential diagnosis...
  3. ncbi Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105, Bonn, Germany
    Acta Neuropathol 110:537-46. 2005
    ..Aberrant expression of ERMs is, however, compatible with compromised PI3K-pathway signaling in glioneuronal lesions characterized by abnormal cellular differentiation and aberrant network formation...
  4. ncbi The insulin gene VNTR polymorphism in Alzheimer's disease: results of a pilot study
    M Majores
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Federal Republic of Germany
    J Neural Transm 109:1029-34. 2002
    ..002). Our preliminary results suggest, that genetically determined alterations of the INS/IGF-2 metabolism might modify the course of AD. Further studies are warranted to confirm these data in larger study samples...
  5. ncbi [Uniliteral wheezes as the first clinical sign of a bronchial carcinoid]
    U M Becher
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn
    Dtsch Med Wochenschr 135:390-3. 2010
    ..A 58-years-old non-smoking woman presented at our Thoracic Centre with increasing exertional dyspnea and on examination was found to have wheezing and decreased breath sounds over the left lung...
  6. ncbi Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions
    V Schick
    Department of Neuropathology, University of Bonn Medical Centre, Bonn, Germany
    Neuropathol Appl Neurobiol 33:152-62. 2007
    ..However, a potential functional significance of lower expression for the cell-size and cell-cycle regulators CDK1 and cyclinA2 in FCD(IIb) composed of large dysplastic neurones and balloon cells needs to be further resolved...
  7. ncbi Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Psychiatr Genet 14:97-100. 2004
    ..Since exploratory data suggest an involvement of the endosomal lysosomal system in major depression, further studies are warranted to investigate the biological role of the CD-MPR in major depression...
  8. ncbi In situ-RT and immunolaser microdissection for mRNA analysis of individual cells isolated from epilepsy-associated glioneuronal tumors
    Jana Fassunke
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Lab Invest 84:1520-5. 2004
    ..We consider that this in situ-RT/immuno-LCM protocol is of general applicability, whereby virtually any primary antibody can be used to facilitate capture of individual cells in tissue sections for molecular analysis...
  9. ncbi Alterations of phosphatidylinositol 3-kinase pathway components in epilepsy-associated glioneuronal lesions
    Volker Schick
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 48:65-73. 2007
    ..However, the underlying cause of PI3K-pathway activation and the functional relationship of PI3K-pathway activity to generation of seizures in epilepsy-associated glioneuronal lesions will need to be determined in the future...
  10. ncbi Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 48:4-12. 2007
    ..Here, we will discuss experimental approaches to unravel molecular-neuropathological aspects of TLE and highlight characteristics and potential of molecular studies in human and/or experimental TLE...
  11. ncbi Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells
    Volker Schick
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Brain Pathol 17:165-73. 2007
    ..balloon cells in FCD(IIb) and provides new implications for the development of treatment strategies for these cortical malformations...
  12. ncbi Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias
    Volker Schick
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105, Bonn, Germany
    Acta Neuropathol 112:715-25. 2006
    ..Future studies need to determine the origin of insulin pathway activation upstream of TSC1/TSC2 in FCD(IIb)...
  13. ncbi Molecular neuropathology of epilepsy-associated glioneuronal malformations
    Albert J Becker
    Department of Neuropathology, Bonn University Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Neuropathol Exp Neurol 65:99-108. 2006
    ....
  14. ncbi Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells
    Michael Majores
    Department of Neuropathology, Bonn University, Germany
    J Neuropathol Exp Neurol 64:629-37. 2005
    ..Our work is supported by DFG (SFB TR3 [AJB], DFG Bl 421/1-1 [IB]), BONFOR, and Deutsche Krebshilfe...
  15. ncbi Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Street 25, D-53105 Bonn, Germany
    Epilepsy Res 60:173-8. 2004
    ..In this review, we summarize recent data of gene expression profiles in human and experimental TLE and discuss the relevance of novel tools for bioinformatic analysis and data mining...
  16. ncbi Frequent recurrence and progression in pilocytic astrocytoma in adults
    Carsten Stuer
    Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany
    Cancer 110:2799-808. 2007
    ..To the authors' knowledge, the literature contains only scarce data regarding piloA in adults...