C Maihofner

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi request reprint Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia
    Frank Seifert
    Department of Neurology, University Hospital Erlangen, 91054 Erlangen, Germany
    J Neurosci 29:6167-75. 2009
  2. ncbi request reprint [Neuropathic pain and neuroplasticity in functional imaging studies]
    C Maihofner
    Neurologische Klinik der Universität Erlangen Nürnberg, Schwabachanlage 6, 91054, Erlangen, Deutschland
    Schmerz 24:137-45. 2010
  3. doi request reprint Prospective, non-interventional study on the tolerability and analgesic effectiveness over 12 weeks after a single application of capsaicin 8% cutaneous patch in 1044 patients with peripheral neuropathic pain: first results of the QUEPP study
    C Maihofner
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany
    Curr Med Res Opin 29:673-83. 2013
  4. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
  5. ncbi request reprint [Complex regional pain syndromes: new aspects on pathophysiology and therapy]
    C Maihofner
    Neurologische Klinik mit Poliklinik der Universität Erlangen Nürnberg, Schwabachanlage, Erlangen
    Fortschr Neurol Psychiatr 75:331-42. 2007
  6. ncbi request reprint Complex regional pain syndromes: new pathophysiological concepts and therapies
    C Maihofner
    Department of Neurology, University Hospital Erlangen, Schwabachanlage, Erlangen, Germany
    Eur J Neurol 17:649-60. 2010
  7. doi request reprint Activation of central sympathetic networks during innocuous and noxious somatosensory stimulation
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroimage 55:216-24. 2011
  8. ncbi request reprint Brain imaging of analgesic and antihyperalgesic effects of cyclooxygenase inhibition in an experimental human pain model: a functional MRI study
    Christian Maihofner
    Department of Neurology, Schwabachanlage 6, D91054 Erlangen, University Hospital Erlangen, Germany
    Eur J Neurosci 26:1344-56. 2007
  9. ncbi request reprint The motor system shows adaptive changes in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, Institute for Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 130:2671-87. 2007
  10. doi request reprint Cortical processing of mechanical hyperalgesia: a MEG study
    Christian Maihofner
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Pain 14:64-70. 2010

Collaborators

Detail Information

Publications56

  1. doi request reprint Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia
    Frank Seifert
    Department of Neurology, University Hospital Erlangen, 91054 Erlangen, Germany
    J Neurosci 29:6167-75. 2009
    ..We conclude that activity in mPFC correlates inversely with individual extent of central hyperalgesia and predicts individual pharmacological antihyperalgesic treatment response...
  2. ncbi request reprint [Neuropathic pain and neuroplasticity in functional imaging studies]
    C Maihofner
    Neurologische Klinik der Universität Erlangen Nürnberg, Schwabachanlage 6, 91054, Erlangen, Deutschland
    Schmerz 24:137-45. 2010
    ..Finally, advanced methods of structural brain imaging (voxel-based morphometry, VBM) show significant structural changes suggesting that chronic pain syndromes may be associated with neurodegeneration...
  3. doi request reprint Prospective, non-interventional study on the tolerability and analgesic effectiveness over 12 weeks after a single application of capsaicin 8% cutaneous patch in 1044 patients with peripheral neuropathic pain: first results of the QUEPP study
    C Maihofner
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany
    Curr Med Res Opin 29:673-83. 2013
    ..Reversible defunctionalisation of nociceptors by the TRPV1 agonist capsaicin in high concentration is an emerging new concept for the treatment of peripheral neuropathic pain...
  4. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
    ..To test the hypothesis whether isolated appearance of individual AMRF syndrome features could be related to heterozygote SCARB2 mutations, we screened for SCARB2 mutations in unrelated patients showing isolated AMRF features...
  5. ncbi request reprint [Complex regional pain syndromes: new aspects on pathophysiology and therapy]
    C Maihofner
    Neurologische Klinik mit Poliklinik der Universität Erlangen Nürnberg, Schwabachanlage, Erlangen
    Fortschr Neurol Psychiatr 75:331-42. 2007
    ..Sympathetic blocks are useful for the treatment of sympathetically maintained pain. Invasive therapeutic concepts include implantation of spinal cord stimulators. This review covers new aspects of pathophysiology and therapy of CRPS...
  6. ncbi request reprint Complex regional pain syndromes: new pathophysiological concepts and therapies
    C Maihofner
    Department of Neurology, University Hospital Erlangen, Schwabachanlage, Erlangen, Germany
    Eur J Neurol 17:649-60. 2010
    ..Invasive therapeutic concepts include implantation of spinal cord stimulators. This review covers new aspects of pathophysiology and therapy of CRPS...
  7. doi request reprint Activation of central sympathetic networks during innocuous and noxious somatosensory stimulation
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroimage 55:216-24. 2011
    ..Therefore, we here describe a cerebral network which may be engaged in the processing of the autonomic subdimension of the human pain experience...
  8. ncbi request reprint Brain imaging of analgesic and antihyperalgesic effects of cyclooxygenase inhibition in an experimental human pain model: a functional MRI study
    Christian Maihofner
    Department of Neurology, Schwabachanlage 6, D91054 Erlangen, University Hospital Erlangen, Germany
    Eur J Neurosci 26:1344-56. 2007
    ..Therefore, the results of the present study suggest that there is a difference in the brain areas modulated by analgesia and antihyperalgesia...
  9. ncbi request reprint The motor system shows adaptive changes in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, Institute for Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 130:2671-87. 2007
    ..In summary, the results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS...
  10. doi request reprint Cortical processing of mechanical hyperalgesia: a MEG study
    Christian Maihofner
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Pain 14:64-70. 2010
    ..We conclude that the S2 cortex may be involved for the processing of secondary mechanical hyperalgesia in the human brain. PPC activation may reflect higher attentional processing during mechanical hyperalgesia...
  11. doi request reprint [Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study]
    F Herrndobler
    Anästhesiologische Klinik, Universitatsklinikum Erlangen, Erlangen, Deutschland
    Schmerz 23:134-44. 2009
    ..Therefore, we sought to investigate the cerebral processing of hyperalgesia and acute pain using functional magnetic resonance imaging (fMRI) and pharmacological modulation with cyclooxygenase (COX) inhibitors...
  12. ncbi request reprint Brain correlates of short-term habituation to repetitive electrical noxious stimulation
    F T Nickel
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Pain 18:56-66. 2014
    ..Habituation to repetitive noxious stimuli is a well-known phenomenon. We investigated brain correlates of habituation to pain in a transdermal electrical pain model using functional magnetic resonance imaging (fMRI)...
  13. doi request reprint Central mechanisms of experimental and chronic neuropathic pain: findings from functional imaging studies
    F Seifert
    Department of Neurology, University of Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Cell Mol Life Sci 66:375-90. 2009
    ..In a third part of this review we discuss mechanisms of endogenous pain modulation...
  14. ncbi request reprint A functional magnetic resonance imaging navigated repetitive transcranial magnetic stimulation study of the posterior parietal cortex in normal pain and hyperalgesia
    F Seifert
    Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroscience 170:670-7. 2010
    ..05). We discuss the role of the PPC in central sensitization to pain, in spatial discrimination of pain stimuli and in spatial-attention to pain stimuli...
  15. doi request reprint Illusion of pain: pre-existing knowledge determines brain activation of 'imagined allodynia'
    Heidrun H Krämer
    Department of Neurology, University of Mainz, Mainz, Germany
    J Pain 9:543-51. 2008
    ..According to our results, the medial pain system is involved in the encoding of imagined allodynia...
  16. doi request reprint Quality discrimination for noxious stimuli in secondary somatosensory cortex: a MEG-study
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Eur J Pain 13:1048.e1-7. 2009
    ..Therefore, concerning the sensory dimension of the human pain experience we conclude that the S2 cortex is involved in the encoding of quality discrimination...
  17. ncbi request reprint Patterns of cortical reorganization in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 61:1707-15. 2003
    ..To use magnetoencephalography to assess possible cortical reorganization in the primary somatosensory cortex (S1) of patients with complex regional pain syndrome (CRPS)...
  18. ncbi request reprint Representation of UV-B-induced thermal and mechanical hyperalgesia in the human brain: a functional MRI study
    Frank Seifert
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Hum Brain Mapp 29:1327-42. 2008
    ..Finally, the data provide evidence for the existence of a common "sensitization network" consisting of ACC, bilateral anterior insula, and parts of the IFC...
  19. doi request reprint Differential endogenous pain modulation in complex-regional pain syndrome
    Frank Seifert
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 132:788-800. 2009
    ..Thus, we hypothesize that differential activity in endogenous pain modulating systems may be not only a result of CRPS, but a potential risk factor for its development...
  20. ncbi request reprint Neural activation during experimental allodynia: a functional magnetic resonance imaging study
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Eur J Neurosci 19:3211-8. 2004
    ..Furthermore, it demonstrates that the combined heat/capsaicin model can be used successfully in the exploration of brain processes underlying stimulus-evoked pain...
  21. ncbi request reprint Differential coding of hyperalgesia in the human brain: a functional MRI study
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neuroimage 28:996-1006. 2005
    ..We conclude that thermal and mechanical hyperalgesia produce substantially different brain activation patterns. This is linked to different psychophysical properties...
  22. ncbi request reprint Temporo-spatial analysis of cortical activation by phasic innocuous and noxious cold stimuli--a magnetoencephalographic study
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, Universitatsstrasse 17, D 91054 Erlangen, Germany
    Pain 100:281-90. 2002
    ..Furthermore, it supports the role of SII and the cingulate cortex in mediating freeze-pain. Therefore, these results suggest different processing of cold, freeze-pain and touch in the human brain...
  23. ncbi request reprint Cortical reorganization during recovery from complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 63:693-701. 2004
    ..To characterize reorganization of the primary somatosensory cortex (S1) during healing process in complex regional pain syndrome (CRPS)...
  24. doi request reprint Auditory hallucinations in schizophrenia - outcry of a diseased brain?
    Wolfgang Sperling
    Department of Psychiatry and Psychotherapy, University Clinic of Erlangen, Schwabachanlage 6, 91052 Erlangen, Germany
    Med Hypotheses 72:213-6. 2009
    ..If this hypothesis blurts out any measure of truth, the usual therapeutic algorithm will have to be re-evaluated...
  25. doi request reprint Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS)
    Kathrin Huehne
    Institute of Human Genetics, University Hospital Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Neurosci Lett 472:19-23. 2010
    ..No significant genetic association was observed. Thus, we conclude that the NEP gene does not seem to be a major risk factor for CRPS...
  26. doi request reprint Olfactory lateralization: odor intensity but not the hedonic estimation is lateralized
    Norbert Thuerauf
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurosci Lett 438:228-32. 2008
    ..For odor identification, however, a statistical tendency was observed. Based on our results we concluded that olfactory intensity estimates represent the most sensitive parameter of olfactory lateralization...
  27. doi request reprint Non-right-handedness and free serum testosterone levels in detoxified patients with alcohol dependence
    Wolfgang Sperling
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 45:237-40. 2010
    ..An increase in free serum testosterone levels has been found during and after the detoxification phase of patients with alcohol dependence...
  28. ncbi request reprint Centrally mediated sensory decline induced by differential C-fiber stimulation
    Roberto De Col
    Department of Neurology, Schwabachanlage 6, 91054 Erlangen, University Hospital Erlangen, Germany
    Pain 138:556-64. 2008
    ....
  29. doi request reprint Emotional reactivity to odors: olfactory sensitivity and the span of emotional evaluation separate the genders
    Norbert Thuerauf
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurosci Lett 456:74-9. 2009
    ..Investigating olfactory sensitivity females detected n-butanol and discriminated the 16 odors of the test significantly better than males. These results indicate that females possess higher olfactory sensitivity...
  30. ncbi request reprint Secondary somatosensory cortex is important for the sensory-discriminative dimension of pain: a functional MRI study
    Christian Maihofner
    Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    Eur J Neurosci 23:1377-83. 2006
    ..By contrast, corresponding scores for the affective-motivational pain dimension did not differ between both conditions. In summary, we conclude that S2 plays an important role in the sensory-discriminative dimension of pain...
  31. ncbi request reprint Mislocalization of tactile stimulation in patients with complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    J Neurol 253:772-9. 2006
    ..In contrast, in a healthy control group, no mislocalizations were found. Thus, our results further support the concept of pain-induced reorganization in the somatosensory system of CRPS patients...
  32. ncbi request reprint TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol
    Barbara Namer
    Department of Experimental Physiology and Pathophysiology, University of Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Neuroreport 16:955-9. 2005
    ..In contrast, TRPM8 activation by menthol produced no axon reflex reaction and resulted in cold hyperalgesia. We conclude that agonists of TRPA1 and TRPM8 channels produce strikingly different psychophysical patterns...
  33. ncbi request reprint Cortical activity associated with auditory hallucinations
    Axel Ropohl
    Departments of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroreport 15:523-6. 2004
    ..This activity was absent in healthy controls. We conclude that an increase in fast MEG activity in the auditory cortex is a neurophysiologic correlate for auditory hallucinations in schizophrenia...
  34. ncbi request reprint Decreased perceptual learning ability in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology and Institute for Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Eur J Pain 11:903-9. 2007
    ..Therefore, we provide further support for an involvement of the CNS in CRPS, which may have implications to future neurorehabilitation strategies for this disease...
  35. ncbi request reprint Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder
    Christian Maihofner
    Department of Neurology, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Brain Res 1129:200-5. 2007
    ..Therefore, we provide further functional neuroimaging evidence that the complex features of OCD have neural correlates, which may help in a future understanding of this disease...
  36. ncbi request reprint Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha?
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 65:311-3. 2005
    ..9 +/- 56.3 pg/mL) and controls (1,239.5 +/- 42.9 pg/mL). This study suggests involvement of TNF-alpha in mechanical hyperalgesia of CRPS...
  37. ncbi request reprint Functional imaging of allodynia in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, Institute for Experimental Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 66:711-7. 2006
    ..To investigate cerebral activations underlying touch-evoked pain (dynamic-mechanical allodynia) in patients with neuropathic pain...
  38. ncbi request reprint Cortical processing of brush-evoked allodynia
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroreport 14:785-9. 2003
    ..This study corroborates the concept of cortical reorganisation underlying chronic pain. Furthermore, it demonstrates that a remarkable early activation of the cingulate cortex may be involved in the cortical processing of allodynia...
  39. doi request reprint [Diagnostic guidelines for complex regional pain syndrome]
    E Peltz
    University of Erlangen, Department of Neurology, Erlangen
    Handchir Mikrochir Plast Chir 44:135-41. 2012
    ..Use of these diagnostic tools, even after achievement of normal findings, cannot exclude a CRPS and the decision for therapeutic initiation should not be influenced thereby...
  40. ncbi request reprint Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord
    C Maihofner
    Institut für Experimentelle Pharmakologie and Toxikologie, Universitat Erlangen, Universitätsstr 22, 91054, Erlangen, Germany
    Neuroscience 101:1093-108. 2000
    ..Intracellularly, cyclo-oxygenase-2 is bound to the membranes of the nucleus and endoplasmic reticulum, whereas neuronal nitric oxide synthase is found in the cytoplasm...
  41. doi request reprint Cortical control of thermoregulatory sympathetic activation
    M Fechir
    Department of Neurology, University Medical Center Mainz, Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur J Neurosci 31:2101-11. 2010
    ..These findings may represent reasonable explanations for sympathetic hyperactivity, which occurs, for example, after hemispheric stroke...
  42. ncbi request reprint Time perception in patients with major depressive disorder during vagus nerve stimulation
    T Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Friedrich Alexander University of Erlangen, Erlangen, Germany
    Pharmacopsychiatry 44:179-82. 2011
    ..Several studies have described time as a function of the frontal lobe. The activating eff ects of vagus nerve stimulation on the frontal lobe might also modulate time perception in patients with major depressive disorder (MDD)...
  43. ncbi request reprint Functional imaging of sensory decline and gain induced by differential noxious stimulation
    Tanja Stammler
    Department of Neurology, Schwabachanlage 6, 91054 Erlangen, University Hospital Erlangen, Germany
    Neuroimage 42:1151-63. 2008
    ..A potential neurobiological mechanism of secondary CNS-mediated hypoesthesia and hypoalgesia may involve modification of local inhibitory networks within somatosensory cortices...
  44. doi request reprint Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis
    Stefan P Renner
    Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany
    Gynecol Endocrinol 25:726-33. 2009
    ..Aim of this study was, therefore, to examine the effect of a single nucleotide polymorphism (SNP) of the NK1R gene on the susceptibility for endometriosis and the disease free survival (DFS) after surgery for endometriosis...
  45. doi request reprint [Migraine - established concepts and new developments]
    V Speck
    Neurologische Klinik, Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen
    Fortschr Neurol Psychiatr 81:308-23. 2013
    ..Neuromodulative and neurostimulative procedures are promising but still experimental treatment options for patients with refractory migraine...
  46. doi request reprint [Symptoms and pathophysiological mechanisms of neuropathic pain syndromes]
    S Lanz
    Neurologische Klinik mit Poliklinik der Universität Erlangen Nürnberg, Erlangen, Germany
    Nervenarzt 80:430-44. 2009
    ..In coming years, several advances are expected in the basic and clinical sciences of neuropathic pain which will provide new and improved therapies for patients continuing to experience this sometimes very disabling condition...
  47. ncbi request reprint Simultaneous involvement of third and sixth cranial nerve in a patient with Lyme disease
    M Lell
    Division of Neuroradiology, Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, Germany
    Neuroradiology 45:85-7. 2003
    ..The patient was free of symptoms 1 month after completion of therapy, when thickening and contrast enhancement of the nerves were less pronounced...
  48. doi request reprint [33-year-old male patient with recurrent syncopes and orthostatic hypotension]
    H G Justl
    Medizinische Klinik 1, Friedrich Alexander Universitat Erlangen Nurnberg, Ulmenweg 18, Erlangen, Germany
    Internist (Berl) 51:788-92. 2010
    ..The clinical presentation und laboratory values confirmed the diagnosis of "pure autonomic failure". Finally, we describe the differential diagnosis of autonomic dysfunction...
  49. ncbi request reprint Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Pain 114:93-103. 2005
    ..The results of our study indicate a complex cortical network activated during pin-prick hyperalgesia in CRPS. The underlying neuronal matrix comprises areas not only involved in nociceptive, but also in cognitive and motor processing...
  50. ncbi request reprint Transient tetraplegia after cervical facet joint injection for chronic neck pain administered without imaging guidance
    Josef G Heckmann
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Clin Neurol Neurosurg 108:709-11. 2006
    ..It should be considered by any clinician performing "blind" zygapophysial joint injections in the cervical spine. Using imaging guidance should help prevent this type of complication...
  51. ncbi request reprint Effects of repetitive transcranial magnetic stimulation in depression: a magnetoencephalographic study
    Christian Maihofner
    Department of Neurology, University of Erlangen, Nuremberg, Erlangen, Germany
    Neuroreport 16:1839-42. 2005
    ..We conclude that therapeutic repetitive transcranial magnetic stimulation effects can be mirrored by changes of spontaneous magnetoencephalographic activity...
  52. doi request reprint Pain perception and detailed visual pain mapping in breast cancer survivors
    Sebastian M Jud
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Erlangen, Germany
    Breast Cancer Res Treat 119:105-10. 2010
    ..This study presents a method of visualizing pain areas and assigning them to a pictogram of the body in a sample of breast cancer patients. The method is easy to use and could help generate pain maps in several types of disease...
  53. ncbi request reprint Representation of cold allodynia in the human brain--a functional MRI study
    Frank Seifert
    Department of Experimental Physiology and Pathophysiology, University of Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Neuroimage 35:1168-80. 2007
    ....
  54. doi request reprint C-fiber axon reflex flare size correlates with epidermal nerve fiber density in human skin biopsies
    Andreas Bickel
    Department of Neurology, University of Erlangen Nuremberg, Germany
    J Peripher Nerv Syst 14:294-9. 2009
    ..We conclude that measurement of ARFS is a potential objective non-invasive diagnostic tool for analysis of C-fiber function in patients with small-fiber neuropathies...
  55. ncbi request reprint Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, Erlangen, Germany
    Eur J Neurosci 18:1527-34. 2003
    ..Selective COX-2 inhibition might therefore offer a new possibility in the treatment of human ALS. However, to determine the exact role of COX-2 in human ALS will require further research...
  56. doi request reprint High post surgical opioid requirements in Crohn's disease are not due to a general change in pain sensitivity
    Kathrin Huehne
    Institute of Human Genetics, University Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Eur J Pain 13:1036-42. 2009
    ..The results indicate that a more complex pathway is involved in the greater post operative opioid demand in CD. Therefore the presence of other, as yet unknown, genes could modulate opioid requirements in CD patients...