Wolfgang Maier

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc The German MultiCare-study: Patterns of multimorbidity in primary health care - protocol of a prospective cohort study
    Ingmar Schafer
    Department of Primary Medical Care, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BMC Health Serv Res 9:145. 2009
  2. ncbi request reprint The dichotomy of schizophrenia and affective disorders in extended pedigrees
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105, Bonn, Germany
    Schizophr Res 57:259-66. 2002
  3. ncbi request reprint Special feature: family-genetic research strategies for personality disorders
    W Maier
    Department of Psychiatry, University of Bonn, FRG
    J Pers Disord 12:262-76. 1998
  4. ncbi request reprint Family and genetic studies on the relationship of schizophrenia to affective disorders
    W Maier
    Klinik fur Psychiatrie und Psychotherapie, Universitat Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 249:57-61. 1999
  5. ncbi request reprint [Genetics of schizophrenic disorders. New concepts and findings]
    W Maier
    Klinik für Psychiatrie und Psychotherapie der Universität Bonn
    Nervenarzt 70:955-69. 1999
  6. ncbi request reprint The epidemiology of comorbidity between depression, anxiety disorders and somatic diseases
    W Maier
    Department of Psychiatry, University of Bonn, Germany
    Int Clin Psychopharmacol 14:S1-6. 1999
  7. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
  8. doi request reprint Association analysis of Rgs7 variants with panic disorder
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Neural Transm 116:1523-8. 2009
  9. ncbi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
  10. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010

Collaborators

Detail Information

Publications143 found, 100 shown here

  1. pmc The German MultiCare-study: Patterns of multimorbidity in primary health care - protocol of a prospective cohort study
    Ingmar Schafer
    Department of Primary Medical Care, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BMC Health Serv Res 9:145. 2009
    ..As a consequence, there is little help for GPs in adjusting care for these patients, even though studies suggest that adhering to present clinical practice guidelines in the care of patients with multimorbidity may have adverse effects...
  2. ncbi request reprint The dichotomy of schizophrenia and affective disorders in extended pedigrees
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105, Bonn, Germany
    Schizophr Res 57:259-66. 2002
    ..In relatives, the risk of schizophrenia was maximal in absence of a family history of affective disorder. This constellation holds true even if only families of index cases without any affective syndrome during lifetime are considered...
  3. ncbi request reprint Special feature: family-genetic research strategies for personality disorders
    W Maier
    Department of Psychiatry, University of Bonn, FRG
    J Pers Disord 12:262-76. 1998
    ..Gene-oriented approaches seem to be particularly promising. This strategy is illustrated for personality disorders in obligate carriers of mutations in the fragile-X gene...
  4. ncbi request reprint Family and genetic studies on the relationship of schizophrenia to affective disorders
    W Maier
    Klinik fur Psychiatrie und Psychotherapie, Universitat Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 249:57-61. 1999
    ..Several of these candidate regions for schizophrenia are overlapping with candidate regions for bipolar disorder. Thus, the hypothesis of an etiological dichotomy of schizophrenia and affective disorders faces a new challenge...
  5. ncbi request reprint [Genetics of schizophrenic disorders. New concepts and findings]
    W Maier
    Klinik für Psychiatrie und Psychotherapie der Universität Bonn
    Nervenarzt 70:955-69. 1999
    ..Given these findings, polygenic transmission has now become very likely. The candidate regions are currently being narrowed down by various promising techniques...
  6. ncbi request reprint The epidemiology of comorbidity between depression, anxiety disorders and somatic diseases
    W Maier
    Department of Psychiatry, University of Bonn, Germany
    Int Clin Psychopharmacol 14:S1-6. 1999
    ..Recognition of comorbidity is essential for improvement of treatment...
  7. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
    ..We also investigated the association of the SNPs to treatment response, but did not get significant results. In sum, our results argue for only a minor role of TPH2 in schizophrenia...
  8. doi request reprint Association analysis of Rgs7 variants with panic disorder
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Neural Transm 116:1523-8. 2009
    ..Our results argue against a major role of Rgs7 gene variants in the pathogenesis of PD, but are consistent with a minor gender-specific effect on PD, particularly PDAgP...
  9. ncbi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
    ..Based on these findings, we consider NPS as a promising target for antipsychotic drug development...
  10. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  11. doi request reprint Association of SORL1 gene variants with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Brain Res 1264:1-6. 2009
    ..Thus, our data support a role of SORL1 polymorphisms in AD...
  12. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  13. doi request reprint Unipolar depression and hippocampal volume: impact of DNA sequence variants of the glucocorticoid receptor gene
    Astrid Zobel
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:836-43. 2008
    ..Unipolar depression is associated with DNA variants of the NR3C1 gene in our population. Neurobiological underpinnings of depression as volumetric reductions of the hippocampus may also be mediated by variants in this gene...
  14. ncbi request reprint Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    J Neural Transm 116:897-903. 2009
    ..Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans...
  15. doi request reprint Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychobiology 63:131-6. 2011
    ..Thus, we hypothesized that the disease-associated C allele of the rs9960767 polymorphism of the TCF4 gene led to impaired VDM functioning in schizophrenia patients...
  16. ncbi request reprint Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Germany
    Eur Neuropsychopharmacol 18:768-72. 2008
    ..008). Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia...
  17. pmc Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early--and additional memory dysfunction in the late--prodromal state
    Ingo Frommann
    Department of Psychiatry, University Hospital of Bonn, Sigmund Freud Street 25, Bonn, Germany
    Schizophr Bull 37:861-73. 2011
    ..Memory deficits were associated with the onset of psychotic symptoms indicating further disease progression in the trajectory to psychosis and, thus, may be useful in predicting psychosis and targeting early intervention...
  18. doi request reprint A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Eur Neuropsychopharmacol 20:414-20. 2010
    ..This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia...
  19. doi request reprint Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Gen Psychiatry 67:414-22. 2010
    ..Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD)...
  20. doi request reprint Executive performance of depressed suicide attempters: the role of suicidal ideation
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:414-21. 2008
    ..Yet it remains unclear if a distinct cognitive suicidal phenotype does exist. The aim of the present study was to further investigate the role of suicidal thinking for the neuropsychological performance in depressive suicide attempters...
  21. doi request reprint Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression
    Holger Brockmann
    Department of Nuclear Medicine, University Bonn, Bonn, Germany
    J Psychiatr Res 45:442-51. 2011
    ..While the clinical impact of these findings will need to be further investigated in larger cohort studies, the necessity to monitor and to account for individual 5-HTTLPR-status in future MDD imaging studies is highly recommended...
  22. ncbi request reprint Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 59:536-45. 2006
    ..Thus, we compared the effects of a combined 5-HT2A/D2 and a pure D2/D3 antagonist on PPI and habituation of ASR in patients with schizophrenia...
  23. doi request reprint Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:766-73. 2008
    ..To test this assumption, we investigated PPI of ASR in individuals with prodromal symptoms of schizophrenia and patients with first-episode schizophrenia...
  24. doi request reprint Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:91-4. 2009
    ..003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms...
  25. doi request reprint PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 14:237-45. 2011
    ..Our results point to a moderating role of PCLO SNP rs2522833 on HPA regulation during antidepressant treatment, which may represent a neurobiological feature of stability of clinical response...
  26. doi request reprint Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease
    Julius Popp
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Alzheimers Dis 18:819-28. 2009
    ..The results suggest that alteration of the homocysteine metabolism is related to increased accumulation of phosphorylated tau and may contribute to the neurofibrillary pathology in normal aging and in AD...
  27. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 16:1951-8. 2013
    ..In agreement with preclinical research, we suggest that NPS may be a promising pharmacological candidate with anti-obsessional properties...
  28. doi request reprint Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
    ..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
  29. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
    ..In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD...
  30. doi request reprint A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:117-24. 2012
    ..Our findings suggest a role of SHANK1 in working memory deficits in schizophrenia, which may arise from neurodevelopmental changes to prefrontal cortical areas...
  31. doi request reprint Association of amygdala volumes with cortisol secretion in unipolar depressed patients
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Psychiatry Res 202:96-103. 2012
    ....
  32. ncbi request reprint Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:151-8. 2004
    ..The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD...
  33. ncbi request reprint Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia
    Frank Jessen
    Department of Psychiatry, University of Bonn Sigmund Freud Str 25 53105 Bonn, Germany
    Schizophr Res 87:81-8. 2006
    ....
  34. ncbi request reprint Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression
    Schamim Schahab
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 22:95-8. 2006
    ..These data suggest the presence of a putative risk gene for major depression at chromosome 12...
  35. doi request reprint Auditory P300 in individuals clinically at risk for psychosis
    Ingo Frommann
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    Int J Psychophysiol 70:192-205. 2008
    ..The aim of this study was to assess the amplitude, latency, and topography of the P300 in individuals at clinical high risk for psychosis...
  36. doi request reprint No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression
    Frank Jessen
    Departments of aPsychiatry bRadiology, University of Bonn, Germany
    Psychiatr Genet 19:99-101. 2009
    ..There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants...
  37. ncbi request reprint Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:1473-81. 2013
    ..Instead, the findings likely represent genuine nicotine-induced enhancement of cognitive performance. ..
  38. pmc N-acetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) in patients with schizophrenia
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Schizophr Bull 39:197-205. 2013
    ..The signal of NAAG, however, largely overlaps with its precursor and degrading product N-acetylaspartate (NAA) that by itself does not act in glutamatergic neurotransmission...
  39. doi request reprint The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:193-7. 2012
    ..41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions...
  40. doi request reprint Impact of TCF4 on the genetics of schizophrenia
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S161-5. 2011
    ..This indicates that TCF4 influences key mechanisms of information processing, which may contribute to the pathogenesis of schizophrenia...
  41. doi request reprint Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response
    Wolfgang Block
    Department of Radiology, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 12:415-22. 2009
    ..This accounts in particular for those patients with low NAA and Cho baseline levels...
  42. ncbi request reprint Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia
    Sibylle G Schwab
    Department of Psychiatry, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Schizophr Res 65:19-25. 2003
    ..3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]...
  43. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
    ..These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia...
  44. doi request reprint Is the clock drawing test appropriate for screening for mild cognitive impairment?--Results of the German study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
    Lena Ehreke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Dement Geriatr Cogn Disord 28:365-72. 2009
    ..Due to the fact that the Clock Drawing Test (CDT) is widely used to screen for dementia, it is questionable whether it is suited to screen for MCI...
  45. doi request reprint Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes
    Britta Haenisch
    Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:1013-6. 2009
    ..In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression...
  46. doi request reprint CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk
    Homeira Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strabetae 25, 53105 Bonn, Germany
    Brain Res 1232:1-6. 2008
    ..Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk...
  47. doi request reprint The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 11:1163-7. 2008
    ..Results suggest a possible role of 5-HT2A receptors in memory consolidation. Serotonergic drugs may have the potential to improve memory...
  48. doi request reprint A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:83-90. 2013
    ..Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression...
  49. ncbi request reprint Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)
    Tobias Luck
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Dement Geriatr Cogn Disord 24:307-16. 2007
    ..Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients of general practitioners (GPs)...
  50. doi request reprint Cerebrospinal fluid markers for Alzheimer's disease over the lifespan: effects of age and the APOEε4 genotype
    Julius Popp
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Alzheimers Dis 22:459-68. 2010
    ..They also suggest that the decrease of Aβ1-42, but not the increase of pTau181 CSF levels is accelerated by the APOEε4 genotype in middle-aged and older adults with normal cognition...
  51. pmc Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Psychopharmacology (Berl) 194:261-9. 2007
    ..This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol...
  52. pmc Prediction of dementia in primary care patients
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    PLoS ONE 6:e16852. 2011
    ..AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting...
  53. pmc Noradrenergic enhancement of amygdala responses to fear
    Oezguer A Onur
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Soc Cogn Affect Neurosci 4:119-26. 2009
    ....
  54. doi request reprint CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Eur Psychiatry 24:183-90. 2009
    ..Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer's disease (AD) and results are contradictory...
  55. doi request reprint DNA sequence variants of the FKBP5 gene are associated with unipolar depression
    Astrid Zobel
    Department of Psychiatry, University of Bonn, Germany
    Int J Neuropsychopharmacol 13:649-60. 2010
    ..Furthermore, several of the investigated SNPs were associated with the disease status and the intermediate phenotype of hippocampal volume...
  56. ncbi request reprint Amygdala control of emotion-induced forgetting and remembering: evidence from Urbach-Wiethe disease
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Neuropsychologia 45:877-84. 2007
    ..Our findings implicate the amygdala in a neural circuitry that orchestrates rapid retrograde and anterograde regulation of episodic memory access upon criteria of behavioral significance...
  57. ncbi request reprint Normal prepulse inhibition and habituation of acoustic startle response in suicidal depressive patients without psychotic symptoms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    J Affect Disord 92:299-303. 2006
    ..Thus, we investigated PPI and habituation of ASR in suicidal patients with depressive disorders as potential biological markers for suicidal behavior...
  58. ncbi request reprint Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 30:381-90. 2005
    ..Importantly, amisulpride was not inferior to olanzapine for any cognitive domain. Combined 5-HT(2A)/D2 receptor blockade is probably not necessary for cognitive improvement by SGAs...
  59. doi request reprint Overnight deprivation from smoking disrupts amygdala responses to fear
    Oezguer A Onur
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Hum Brain Mapp 33:1407-16. 2012
    ..We suggest that aberrant amygdala reactivity in overnight-deprived smokers may reflect a pre-existing vulnerability to smoking and/or increase the risk of smoking relapse after a cessation attempt...
  60. doi request reprint Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder
    Thomas W Mühleisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Schizophr Res 138:69-73. 2012
    ..0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia...
  61. doi request reprint The hippocampus in families with schizophrenia in relation to obstetric complications
    Florian Ebner
    Department of Psychiatry, University of Bonn, Germany
    Schizophr Res 104:71-8. 2008
    ..The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications...
  62. ncbi request reprint Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Int J Mol Med 17:791-4. 2006
    ..Our data support the observation that ABCA1 polymorphisms influence cholesterol metabolism of the brain, but might not act as a major risk factor in AD...
  63. ncbi request reprint Patterns of subjective memory impairment in the elderly: association with memory performance
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 37:1753-62. 2007
    ..However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline...
  64. doi request reprint Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration
    Britta Schürmann
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    J Alzheimers Dis 25:421-4. 2011
    ..011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels...
  65. ncbi request reprint Population pharmacokinetic analysis of mirtazapine
    Katja Grasmäder
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53121 Bonn, Germany
    Eur J Clin Pharmacol 60:473-80. 2004
    ..While controlled clinical studies have evaluated the effect of individual covariates on the pharmacokinetics of mirtazapine, our analysis aims to identify covariates within a naturalistic clinical setting...
  66. doi request reprint Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Alzheimers Dis 27:393-9. 2011
    ..Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and Aβ42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production...
  67. doi request reprint Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
    ..The implementation of mixed effects models will enhance the power to detect treatment effects also with other classes of biological endpoints including molecular biomarkers of disease...
  68. ncbi request reprint Familiality of obsessive-compulsive disorder in nonclinical and clinical subjects
    Hans Joergen Grabe
    Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Klinikum der Hansestadt Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany
    Am J Psychiatry 163:1986-92. 2006
    ..This study compared the familial aggregation of OCD in first-degree relatives of community subjects with never-treated OCD, outpatients with OCD, and comparison subjects...
  69. ncbi request reprint The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder
    Barbara Hoefgen
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 57:247-51. 2005
    ..Consistently replicated evidence for an involvement of this polymorphism in the etiology of mood disorders, particularly in major depressive disorder (MDD), remains scant...
  70. ncbi request reprint SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele
    Christian Spell
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:245-9. 2004
    ..This is the first report on a genetic factor which prevents the deleterious effect of the ApoE4 allele and thus reduces the risk of AD...
  71. doi request reprint Startle cue-reactivity differentiates between light and heavy smokers
    Anne K Rehme
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Addiction 104:1757-64. 2009
    ..The goal of the present study was to investigate (i) whether smoking scenes induce appetitive cue effects in smokers, and (ii) whether smoking intensity is related to cue-reactivity...
  72. doi request reprint Resting-state perfusion in nonmedicated schizophrenic patients: a continuous arterial spin-labeling 3.0-T MR study
    Lukas Scheef
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    Radiology 256:253-60. 2010
    ..To determine whether well-described patterns of altered perfusion in schizophrenia can be identified by using continuous arterial spin labeling (CASL) with a whole-brain imaging sequence...
  73. ncbi request reprint Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 175:399-406. 2004
    ..Studies with rodents suggest that an increase or decrease in serotonin level in the brain alters several modalities of the ASR. So far, little is known about serotonergic and noradrenergic startle modulation in humans...
  74. pmc Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families
    Sibylle G Schwab
    Molecular Genetics Laboratory, University of Bonn, Bonn, Germany
    Am J Hum Genet 72:185-90. 2003
    ....
  75. doi request reprint Anticholinergic drug use and risk for dementia: target for dementia prevention
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S111-5. 2010
    ..In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition...
  76. ncbi request reprint Alterations of cholesterol precursor levels in Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Biochim Biophys Acta 1801:945-50. 2010
    ..These findings raise doubt on a beneficial effect of cholesterol lowering treatment in manifest AD...
  77. ncbi request reprint Mixed anxiety-depression in a 1 year follow-up study: shift to other diagnoses or remission?
    Katrin Barkow
    Department of Psychiatry, University of Bonn, Germany
    J Affect Disord 79:235-9. 2004
    ..However, a study examining the stability of this ICD-10-diagnosis is lacking. Our objective was to examine the 12 month outcome of MAD in comparison to the outcome of depression, anxiety, and comorbid depression and anxiety...
  78. ncbi request reprint Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Psychiatr Genet 14:97-100. 2004
    ..Since exploratory data suggest an involvement of the endosomal lysosomal system in major depression, further studies are warranted to investigate the biological role of the CD-MPR in major depression...
  79. ncbi request reprint Volume reduction of the entorhinal cortex in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurobiol Aging 27:1751-6. 2006
    ..The mean volume reduction of the hippocampus was 6% (SMI), 16% (MCI) and 19% (AD). Our results mirror the temporal sequence of neurodegeneration in AD and support the concept of SMI as the first clinical manifestation of dementia...
  80. ncbi request reprint Antidepressive treatment in patients with temporal lobe epilepsy and major depression: a prospective study with three different antidepressants
    Kai Uwe Kuhn
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Epilepsy Behav 4:674-9. 2003
    ..At endpoint the dropout rate for mirtazapine was significantly higher than that for reboxetine or citalopram. Reboxetine showed a trend to be more efficacious than citalopram but not mirtazapine at Week 4...
  81. ncbi request reprint Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis
    Micael Majores
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 9:185-7. 2002
    ..Thus, if sequence variations within the CTSD gene influence the risk for various diseases, the pathogenic mechanism is likely to be linked to the amino acid substitution in the profragment of CTSD...
  82. ncbi request reprint APOA1 polymorphism influences risk for early-onset nonfamiliar AD
    Heike Vollbach
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Ann Neurol 58:436-41. 2005
    ..No influence of the +83/84bp polymorphism on the risk for AD was observed. These results suggest that variants of APOA1 might influence the onset and the risk for AD...
  83. ncbi request reprint Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia
    Sibylle G Schwab
    Molecular Genetics Laboratory, Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 114:315-20. 2002
    ..Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31...
  84. ncbi request reprint Alexithymia in obsessive-compulsive disorder - results from a family study
    Hans Joergen Grabe
    Department of Psychiatry, University of Greifswald, Greifswald, Germany
    Psychother Psychosom 75:312-8. 2006
    ..This study investigates the hypotheses of an elevated level of alexithymia in subjects with OCD and their first-degree relatives compared to controls and their first-degree relatives...
  85. ncbi request reprint Response-dependent differences in regional cerebral blood flow changes with citalopram in treatment of major depression
    Alexius Y Joe
    Department of Nuclear Medicine University of Bonn, Bonn, Germany
    J Nucl Med 47:1319-25. 2006
    ..The aim of our study was to investigate differences of regional cerebral blood flow (rCBF) in MD between responders and nonresponders in the beginning and differences during the course of treatment...
  86. ncbi request reprint Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Psychopharmacol 20:373-84. 2006
    ..These results suggest that the memory deficits of MDMA users are not only the result of a temporal or hippocampal dysfunction, but also of a dysfunction of regions within the frontal cortex...
  87. doi request reprint Facilitation of learning by social-emotional feedback in humans is beta-noradrenergic-dependent
    Yoan Mihov
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Neuropsychologia 48:3168-72. 2010
    ..Propranolol had no effect on learning during the nonsocial feedback condition. Our findings suggest that a facilitation of declarative learning by social-emotional feedback critically involves signaling via beta-noradrenergic receptors...
  88. doi request reprint Segregating intra-amygdalar responses to dynamic facial emotion with cytoarchitectonic maximum probability maps
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci Methods 172:13-20. 2008
    ..Our findings extend current models of facial emotion perception in humans by suggesting an intrinsic functional differentiation within the amygdala related to the extraction of value from facial expressions...
  89. ncbi request reprint Polymorphism in the BACE gene influences the risk for Alzheimer's disease
    Chartika M Kirschling
    Department of Psychiatry, University of Bonn, Germany
    Neuroreport 14:1243-6. 2003
    ..Furthermore, Abeta(42) CSF levels were influenced by BACE genotype. It appears that BACE polymorphism plays a more important role in the development of AD than previously assumed, possibly by influencing Abeta(42) levels...
  90. ncbi request reprint Pharmacogenetics of antidepressive treatment
    Astrid Zobel
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:407-17. 2010
    ..Despite of enormous research efforts, currently pharmacogenetics of therapeutic effects and of side effects of antidepressants are unable to guide decisions on the selection of the most beneficial drug for an individual patient...
  91. ncbi request reprint Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study
    Metin Bagli
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 253:44-8. 2003
    ..We conclude that plasma and CSF levels of sIL-6R are significantly increased in AD patients and that the magnitude of increase is determined by the IL-6 genotype...
  92. ncbi request reprint Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting
    Katja Grasmäder
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur J Clin Pharmacol 60:329-36. 2004
    ..Side effects and treatment response were analysed in an exploratory approach in poor and ultra-rapid metabolisers...
  93. ncbi request reprint Impairment of inhibitory control of the hypothalamic pituitary adrenocortical system in epilepsy
    Astrid Zobel
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 254:303-11. 2004
    ..Thus, epilepsies share with depression the deficiencies in the feedback mechanism of the HPA system, proposing common pathophysiological features of up to now unknown nature...
  94. doi request reprint From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-3. 2008
    ....
  95. ncbi request reprint Transition to schizophrenia and related disorders: toward a taxonomy of risk
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Germany
    Schizophr Bull 29:693-701. 2003
    ....
  96. pmc Clinical impact of recently detected susceptibility genes for schizophrenia
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Dialogues Clin Neurosci 8:79-84. 2006
    ..Strong associations are also obtained on a symptomatic level, not only on a diagnostic level. The pathophysiological role of these hot candidate genes is currently under intensive study...
  97. ncbi request reprint The temporal lobe in schizophrenia from uni- and multiply affected families
    Peter Falkai
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 325:25-8. 2002
    ..Comparing subjects from uni- and multiply affected families may be a useful strategy to reduce variability for future studies of environmental interactions with genetic risk for schizophrenia...
  98. ncbi request reprint Test-retest reliability of self-reported age at onset of selected psychiatric diagnoses in general health care
    Katrin Barkow
    Department of Psychiatry, University of Bonn, Germany
    Acta Psychiatr Scand 106:117-25. 2002
    ..To investigate reliability of self-reported age at onset of frequent mental disorders and its association with patient and disorder characteristics...
  99. ncbi request reprint No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
    Psychiatr Genet 15:195-8. 2005
    ..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder...
  100. ncbi request reprint Intact hippocampal gray matter in schizophrenia as revealed by automatized image analysis postmortem
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:513-7. 2005
    ..Results showed no significant differences between diagnostic groups with respect to the dependent variables, supporting the view that there is no primary alteration of hippocampal gray matter in schizophrenia...