Wolfgang Maier

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint Common risk genes for affective and schizophrenic psychoses
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strabe 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:37-40. 2008
  2. ncbi request reprint [Neurocognitive disorders in DSM-5: pervasive changes in the diagnostics of dementia]
    W Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat Bonn, Sigmund Freud Str 25, 53115, Bonn, Deutschland
    Nervenarzt 85:564-70. 2014
  3. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  4. pmc Influence of social support on cognitive change and mortality in old age: results from the prospective multicentre cohort study AgeCoDe
    Marion Eisele
    Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    BMC Geriatr 12:9. 2012
  5. pmc Copy number variation of the SELENBP1 gene in schizophrenia
    Shirly Amar
    Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    Behav Brain Funct 6:40. 2010
  6. pmc The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Psychiatry 10:91. 2010
  7. pmc Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
    Richard Delorme
    INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
    BMC Med Genet 11:100. 2010
  8. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
  9. pmc Specialist involvement and referral patterns in ambulatory medical care for patients with dementia in Germany: results of a claims data based case-control study
    Hendrik van den Bussche
    Institute of Primary Medical Care, University Medical Center Hamburg Eppendorf, Germany
    BMC Health Serv Res 11:148. 2011
  10. ncbi request reprint Schizophrenia and bipolar disorder: differences and overlaps
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Curr Opin Psychiatry 19:165-70. 2006

Collaborators

Detail Information

Publications196 found, 100 shown here

  1. doi request reprint Common risk genes for affective and schizophrenic psychoses
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strabe 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:37-40. 2008
    ..The new levels of evidence enrich the classical continuity/discontinuity debate on the relationship between both groups of disorders...
  2. ncbi request reprint [Neurocognitive disorders in DSM-5: pervasive changes in the diagnostics of dementia]
    W Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat Bonn, Sigmund Freud Str 25, 53115, Bonn, Deutschland
    Nervenarzt 85:564-70. 2014
    ..The subsequent more extensive concept of NCD also allows the diagnosis of etiological-specific prodromal states of cognitive impairments. The changes from DSM-IV to DSM-5 are critically discussed...
  3. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  4. pmc Influence of social support on cognitive change and mortality in old age: results from the prospective multicentre cohort study AgeCoDe
    Marion Eisele
    Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    BMC Geriatr 12:9. 2012
    ..This study aims to investigate the influence of perceived social support, understood as the emotional component of social support, on cognition and mortality in old age as part of a prospective longitudinal multicentre study in Germany...
  5. pmc Copy number variation of the SELENBP1 gene in schizophrenia
    Shirly Amar
    Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    Behav Brain Funct 6:40. 2010
    ..We hypothesized that CN mutations in the SELENBP1 locus could associate with the disorder and that these mutations could alter the gene product's activity in patients...
  6. pmc The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Psychiatry 10:91. 2010
    ..This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia...
  7. pmc Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
    Richard Delorme
    INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
    BMC Med Genet 11:100. 2010
    ..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients...
  8. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
    ..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment...
  9. pmc Specialist involvement and referral patterns in ambulatory medical care for patients with dementia in Germany: results of a claims data based case-control study
    Hendrik van den Bussche
    Institute of Primary Medical Care, University Medical Center Hamburg Eppendorf, Germany
    BMC Health Serv Res 11:148. 2011
    ..To analyze the referral processes from general practitioners to specialists and among specialists for dementia patients in the time periods before, during and after the diagnosis in Germany...
  10. ncbi request reprint Schizophrenia and bipolar disorder: differences and overlaps
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Curr Opin Psychiatry 19:165-70. 2006
    ..Following the recent progress mainly in the fields of genetics and neurobiology, the validity of the diagnostic distinction between schizophrenia and bipolar disorder is increasingly challenged...
  11. ncbi request reprint Meta-analyses: a method to maximise the evidence from clinical studies?
    Wolfgang Maier
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University, Sigmund Freud Str 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:17-23. 2010
    ..Thus, meta-analyses are primarily a method to generate hypotheses through an a posteriori analysis of treatment effects...
  12. doi request reprint Contribution of allelic variations to the phenotype of response to antidepressants and antipsychotics
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund Freud Str 25, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:12-20. 2008
    ..Although specific results transferable into clinical practice were not yet obtained in this respect, the proof of principle could be demonstrated...
  13. ncbi request reprint Transition to schizophrenia and related disorders: toward a taxonomy of risk
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Germany
    Schizophr Bull 29:693-701. 2003
    ....
  14. ncbi request reprint Genetic models of schizophrenia and bipolar disorder: overlapping inheritance or discrete genotypes?
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 255:159-66. 2005
    ..g., COMT, BDNF). There is room for speculation about other common susceptibility genes, given the overlap between candidate regions for schizophrenia and those for bipolar disorder emerging from linkage studies...
  15. ncbi request reprint Genetics of schizophrenia and affective disorders
    W Maier
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Pharmacopsychiatry 36:S195-202. 2003
    ....
  16. doi request reprint From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-3. 2008
    ....
  17. ncbi request reprint [Meta-analyses. A tool for maximizing therapy study evidence?]
    W Maier
    Klinik für Psychiatrie und Psychotherapie der Rheinischen Friedrich Wilhelms Universität, Sigmund Freud Strasse 25, 53105, Bonn
    Nervenarzt 78:1028-36. 2007
    ..Instead, meta-analyses are useful tools for generating hypotheses in a posteriori analysis...
  18. ncbi request reprint [Genetics of depression. Current knowledge and perspectives]
    W Maier
    Universitat Bonn, Bonn
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:487-92. 2004
    ..Complicating factors are gene--environmental interaction, only small to modest effects of disposition genes, and putative epigenetic mechanisms...
  19. pmc Clinical impact of recently detected susceptibility genes for schizophrenia
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Dialogues Clin Neurosci 8:79-84. 2006
    ..Strong associations are also obtained on a symptomatic level, not only on a diagnostic level. The pathophysiological role of these hot candidate genes is currently under intensive study...
  20. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  21. ncbi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
    ..Based on these findings, we consider NPS as a promising target for antipsychotic drug development...
  22. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
    ..We also investigated the association of the SNPs to treatment response, but did not get significant results. In sum, our results argue for only a minor role of TPH2 in schizophrenia...
  23. ncbi request reprint Association analysis of Rgs7 variants with panic disorder
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Neural Transm 116:1523-8. 2009
    ..Our results argue against a major role of Rgs7 gene variants in the pathogenesis of PD, but are consistent with a minor gender-specific effect on PD, particularly PDAgP...
  24. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  25. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  26. ncbi request reprint Association of SORL1 gene variants with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Brain Res 1264:1-6. 2009
    ..Thus, our data support a role of SORL1 polymorphisms in AD...
  27. ncbi request reprint Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    J Neural Transm 116:897-903. 2009
    ..Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans...
  28. pmc Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early--and additional memory dysfunction in the late--prodromal state
    Ingo Frommann
    Department of Psychiatry, University Hospital of Bonn, Sigmund Freud Street 25, Bonn, Germany
    Schizophr Bull 37:861-73. 2011
    ..Memory deficits were associated with the onset of psychotic symptoms indicating further disease progression in the trajectory to psychosis and, thus, may be useful in predicting psychosis and targeting early intervention...
  29. ncbi request reprint Neuregulin-1 haplotype HAP(ICE) is associated with lower hippocampal volumes in schizophrenic patients and in non-affected family members
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    J Psychiatr Res 43:1-6. 2008
    ..This preliminary evidence may help to guide further research into the pathophysiological pathways that underlie this genetic susceptibility for schizophrenia...
  30. doi request reprint Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, D 40629 Düsseldorf, Germany
    J Clin Psychiatry 72:205-18. 2011
    ..The current study was therefore designed to compare prospectively the relapse preventive efficacy of further maintenance treatment and targeted intermittent treatment in patients with ICD-10-diagnosed first-episode schizophrenia...
  31. doi request reprint Remission and recovery and their predictors in schizophrenia spectrum disorder: results from a 1-year follow-up naturalistic trial
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Psychiatr Q 83:187-207. 2012
    ..0113) were found to be significantly predictive of recovery. Our results underline the need to implement more specific treatment strategies to improve long-term outcome...
  32. ncbi request reprint Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Germany
    Eur Neuropsychopharmacol 18:768-72. 2008
    ..008). Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia...
  33. doi request reprint Auditory P300 in individuals clinically at risk for psychosis
    Ingo Frommann
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    Int J Psychophysiol 70:192-205. 2008
    ..The aim of this study was to assess the amplitude, latency, and topography of the P300 in individuals at clinical high risk for psychosis...
  34. ncbi request reprint Unipolar depression and hippocampal volume: impact of DNA sequence variants of the glucocorticoid receptor gene
    Astrid Zobel
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:836-43. 2008
    ..Unipolar depression is associated with DNA variants of the NR3C1 gene in our population. Neurobiological underpinnings of depression as volumetric reductions of the hippocampus may also be mediated by variants in this gene...
  35. ncbi request reprint Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:151-8. 2004
    ..The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD...
  36. ncbi request reprint Harm avoidance in subjects with obsessive-compulsive disorder and their families
    Susan Ettelt
    Department of Psychiatry and Psychotherapy, University of Greifswald, Germany
    J Affect Disord 107:265-9. 2008
    ..HA is considered to be a genetically influenced personality trait with an increasingly understood neuroanatomical basis...
  37. doi request reprint Predictors of relapse in the year after hospital discharge among patients with schizophrenia
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstreet 7, 80336 Munich, Germany
    Psychiatr Serv 63:87-90. 2012
    ..Relapse and its predictors were examined among patients with schizophrenia in the year after hospital discharge...
  38. ncbi request reprint Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: comparing treatment with risperidone and haloperidol
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 13:30-8. 2012
    ..To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol...
  39. doi request reprint Early onset of obsessive-compulsive disorder and associated comorbidity
    Deborah Janowitz
    Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    Depress Anxiety 26:1012-7. 2009
    ..This study was undertaken to discriminate the subtypes of OCD in different AOO levels and to test the hypothesis that different AOO bands are associated with a differential pattern of comorbidity...
  40. doi request reprint Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychobiology 63:131-6. 2011
    ..Thus, we hypothesized that the disease-associated C allele of the rs9960767 polymorphism of the TCF4 gene led to impaired VDM functioning in schizophrenia patients...
  41. doi request reprint Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression
    Holger Brockmann
    Department of Nuclear Medicine, University Bonn, Bonn, Germany
    J Psychiatr Res 45:442-51. 2011
    ..While the clinical impact of these findings will need to be further investigated in larger cohort studies, the necessity to monitor and to account for individual 5-HTTLPR-status in future MDD imaging studies is highly recommended...
  42. doi request reprint A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Eur Neuropsychopharmacol 20:414-20. 2010
    ..This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia...
  43. ncbi request reprint Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Gen Psychiatry 67:414-22. 2010
    ..Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD)...
  44. ncbi request reprint Executive performance of depressed suicide attempters: the role of suicidal ideation
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:414-21. 2008
    ..Yet it remains unclear if a distinct cognitive suicidal phenotype does exist. The aim of the present study was to further investigate the role of suicidal thinking for the neuropsychological performance in depressive suicide attempters...
  45. ncbi request reprint Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:766-73. 2008
    ..To test this assumption, we investigated PPI of ASR in individuals with prodromal symptoms of schizophrenia and patients with first-episode schizophrenia...
  46. doi request reprint Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:91-4. 2009
    ..003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms...
  47. ncbi request reprint Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 59:536-45. 2006
    ..Thus, we compared the effects of a combined 5-HT2A/D2 and a pure D2/D3 antagonist on PPI and habituation of ASR in patients with schizophrenia...
  48. ncbi request reprint Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
    ..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
  49. doi request reprint Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease
    Julius Popp
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Alzheimers Dis 18:819-28. 2009
    ..The results suggest that alteration of the homocysteine metabolism is related to increased accumulation of phosphorylated tau and may contribute to the neurofibrillary pathology in normal aging and in AD...
  50. ncbi request reprint Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia
    Frank Jessen
    Department of Psychiatry, University of Bonn Sigmund Freud Str 25 53105 Bonn, Germany
    Schizophr Res 87:81-8. 2006
    ....
  51. doi request reprint Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  52. pmc Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
    ..In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia...
  53. doi request reprint PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 14:237-45. 2011
    ..Our results point to a moderating role of PCLO SNP rs2522833 on HPA regulation during antidepressant treatment, which may represent a neurobiological feature of stability of clinical response...
  54. ncbi request reprint Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  55. pmc The German Research Network on Schizophrenia--impact on the management of schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Postbox 12 05 10, D 40605 Düsseldorf, Germany
    Dialogues Clin Neurosci 8:115-21. 2006
    ....
  56. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
    ..These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia...
  57. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 16:1951-8. 2013
    ..In agreement with preclinical research, we suggest that NPS may be a promising pharmacological candidate with anti-obsessional properties...
  58. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
    ..In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD...
  59. ncbi request reprint Evaluating depressive symptoms in schizophrenia: a psychometric comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Psychopathology 45:276-85. 2012
    ....
  60. ncbi request reprint Akathisia and suicidal ideation in first-episode schizophrenia
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    J Clin Psychopharmacol 32:694-8. 2012
    ..The allocated treatment, anxiety, and nervousness had no influence. The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES...
  61. doi request reprint A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:117-24. 2012
    ..Our findings suggest a role of SHANK1 in working memory deficits in schizophrenia, which may arise from neurodevelopmental changes to prefrontal cortical areas...
  62. doi request reprint Response trajectories in "real-world" naturalistically treated schizophrenia patients
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 139:218-24. 2012
    ..To date, research has identified distinct antipsychotic response trajectories yet focussing on data from randomized-controlled trials (RCTs). Therefore, the heterogeneity of response in "real-world" schizophrenia patients is still unknown...
  63. doi request reprint Association of amygdala volumes with cortisol secretion in unipolar depressed patients
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Psychiatry Res 202:96-103. 2012
    ....
  64. ncbi request reprint Normal prepulse inhibition and habituation of acoustic startle response in suicidal depressive patients without psychotic symptoms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    J Affect Disord 92:299-303. 2006
    ..Thus, we investigated PPI and habituation of ASR in suicidal patients with depressive disorders as potential biological markers for suicidal behavior...
  65. ncbi request reprint Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression
    Schamim Schahab
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 22:95-8. 2006
    ..These data suggest the presence of a putative risk gene for major depression at chromosome 12...
  66. ncbi request reprint Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia
    Sibylle G Schwab
    Department of Psychiatry, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Schizophr Res 65:19-25. 2003
    ..3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]...
  67. ncbi request reprint Patterns of subjective memory impairment in the elderly: association with memory performance
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 37:1753-62. 2007
    ..However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline...
  68. doi request reprint Prediction of psychosis by mismatch negativity
    Mitja Bodatsch
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Biol Psychiatry 69:959-66. 2011
    ..To this aim, mismatch negativity (MMN) was investigated in a sample clinically at high risk, comparing individuals with and without subsequent conversion to psychosis...
  69. doi request reprint No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression
    Frank Jessen
    Departments of aPsychiatry bRadiology, University of Bonn, Germany
    Psychiatr Genet 19:99-101. 2009
    ..There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants...
  70. doi request reprint The relation of regional cerebral perfusion and atrophy in mild cognitive impairment (MCI) and early Alzheimer's dementia
    Christian Luckhaus
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Duesseldorf, Germany
    Psychiatry Res 183:44-51. 2010
    ..The data also support the concept of functional compensatory brain activation and the diaschisis hypothesis as relevant in incipient and early AD...
  71. doi request reprint The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:193-7. 2012
    ..41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions...
  72. doi request reprint Influencing factors and predictors of early improvement in the acute treatment of schizophrenia and schizophrenia spectrum disorder
    Rebecca Schennach-Wolff
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    J Psychiatr Res 45:1639-47. 2011
    ..To examine the influencing factors and predictors of early improvement in schizophrenia patients...
  73. doi request reprint Impact of TCF4 on the genetics of schizophrenia
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S161-5. 2011
    ..This indicates that TCF4 influences key mechanisms of information processing, which may contribute to the pathogenesis of schizophrenia...
  74. ncbi request reprint CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk
    Homeira Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strabetae 25, 53105 Bonn, Germany
    Brain Res 1232:1-6. 2008
    ..Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk...
  75. ncbi request reprint Is the clock drawing test appropriate for screening for mild cognitive impairment?--Results of the German study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
    Lena Ehreke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Dement Geriatr Cogn Disord 28:365-72. 2009
    ..Due to the fact that the Clock Drawing Test (CDT) is widely used to screen for dementia, it is questionable whether it is suited to screen for MCI...
  76. pmc Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families
    Sibylle G Schwab
    Molecular Genetics Laboratory, University of Bonn, Bonn, Germany
    Am J Hum Genet 72:185-90. 2003
    ....
  77. doi request reprint The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 11:1163-7. 2008
    ..Results suggest a possible role of 5-HT2A receptors in memory consolidation. Serotonergic drugs may have the potential to improve memory...
  78. doi request reprint Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes
    Britta Haenisch
    Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:1013-6. 2009
    ..In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression...
  79. doi request reprint Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response
    Wolfgang Block
    Department of Radiology, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 12:415-22. 2009
    ..This accounts in particular for those patients with low NAA and Cho baseline levels...
  80. pmc Noradrenergic enhancement of amygdala responses to fear
    Oezguer A Onur
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Soc Cogn Affect Neurosci 4:119-26. 2009
    ....
  81. ncbi request reprint Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 30:381-90. 2005
    ..Importantly, amisulpride was not inferior to olanzapine for any cognitive domain. Combined 5-HT(2A)/D2 receptor blockade is probably not necessary for cognitive improvement by SGAs...
  82. ncbi request reprint SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele
    Christian Spell
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:245-9. 2004
    ..This is the first report on a genetic factor which prevents the deleterious effect of the ApoE4 allele and thus reduces the risk of AD...
  83. doi request reprint Attitude towards adherence in patients with schizophrenia at discharge
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    J Psychiatr Res 43:1294-301. 2009
    ....
  84. doi request reprint Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Int J Neuropsychopharmacol 11:985-97. 2008
    ..Risperidone has better extrapyramidal tolerability and treatment retention rate than the equivalent dose of haloperidol in these patients...
  85. ncbi request reprint The hippocampus in families with schizophrenia in relation to obstetric complications
    Florian Ebner
    Department of Psychiatry, University of Bonn, Germany
    Schizophr Res 104:71-8. 2008
    ..The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications...
  86. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  87. ncbi request reprint Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)
    Tobias Luck
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Dement Geriatr Cogn Disord 24:307-16. 2007
    ..Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients of general practitioners (GPs)...
  88. pmc Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Psychopharmacology (Berl) 194:261-9. 2007
    ..This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol...
  89. pmc Basic symptoms and ultrahigh risk criteria: symptom development in the initial prodromal state
    Frauke Schultze-Lutter
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
    Schizophr Bull 36:182-91. 2010
    ..However, as regards the criteria, the results support the notion of BS as at least a complementary approach to the ultrahigh risk criteria, which may also allow for an earlier detection of psychosis...
  90. doi request reprint CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Eur Psychiatry 24:183-90. 2009
    ..Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer's disease (AD) and results are contradictory...
  91. ncbi request reprint Population pharmacokinetic analysis of mirtazapine
    Katja Grasmäder
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53121 Bonn, Germany
    Eur J Clin Pharmacol 60:473-80. 2004
    ..While controlled clinical studies have evaluated the effect of individual covariates on the pharmacokinetics of mirtazapine, our analysis aims to identify covariates within a naturalistic clinical setting...
  92. ncbi request reprint Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene
    S Cichon
    Institute of Human Genetics, University of Bonn, Germany
    Psychiatr Genet 5:97-103. 1995
    ..We were unable to detect the deletion in patients with schizophrenia and bipolar affective disorder, nor in healthy controls...
  93. ncbi request reprint Antidepressive treatment in patients with temporal lobe epilepsy and major depression: a prospective study with three different antidepressants
    Kai Uwe Kuhn
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Epilepsy Behav 4:674-9. 2003
    ..At endpoint the dropout rate for mirtazapine was significantly higher than that for reboxetine or citalopram. Reboxetine showed a trend to be more efficacious than citalopram but not mirtazapine at Week 4...
  94. ncbi request reprint A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
    Hum Mol Genet 10:2933-44. 2001
    ..Putative paternally imprinted loci were identified in chromosomal regions 2p24-p21 and 2q31-q32. Maternally imprinted susceptibility genes may be located on 14q32 and 16q21-q23...
  95. pmc Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis
    S G Schwab
    Molecular Genetics Laboratory, Department of Psychiatry, University of Bon, Germany
    Am J Hum Genet 63:1139-52. 1998
    ..009). These results suggest the existence, on chromosome 18p, of a potential susceptibility locus for functional psychoses...
  96. ncbi request reprint hSKCa3: no association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia
    T Rohrmeier
    Department of Psychiatry, University of Regensburg, Germany
    Psychiatr Genet 9:169-75. 1999
    ..Thus, our data do not support the hypothesis that longer CAG repeats in the hSkCa3 gene contribute to the susceptibility for bipolar disorder and schizophrenia...
  97. ncbi request reprint Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease
    S Brune
    Department of Psychiatry, University of Bonn, Germany
    J Neural Transm 110:1041-50. 2003
    ..Cerebrospinal fluid amyloid-beta levels were influenced by PPAR-alpha L162V genotype. These results suggest, that PPAR-alpha polymorphism may be a risk factor for AD...
  98. ncbi request reprint Exonic variants of the GABA(B) receptor gene and panic disorder
    P G Sand
    Department of Psychiatry, University of Wurzburg, Germany
    Psychiatr Genet 10:191-4. 2000
    ..There was no indication of an increased vulnerability to panic disorder or agoraphobia with respect to the allelic variants under study...
  99. ncbi request reprint Outcome of suicidal patients with schizophrenia: results from a naturalistic study
    R Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Acta Psychiatr Scand 121:359-70. 2010
    ..Purpose was to assess suicidality before and at the time of admission in patients with schizophrenia and compare outcome differences...
  100. ncbi request reprint The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder
    Barbara Hoefgen
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 57:247-51. 2005
    ..Consistently replicated evidence for an involvement of this polymorphism in the etiology of mood disorders, particularly in major depressive disorder (MDD), remains scant...
  101. ncbi request reprint Polymorphic MAO-A and 5-HT-transporter genes: analysis of interactions in panic disorder
    P Sand
    Department of Psychiatry, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    World J Biol Psychiatry 1:147-50. 2000
    ..There was no significant difference in odds ratios, suggesting that the observed increase of genetic liability by the long MAO-A gene promoter allele is not modified by the 5-HTT gene promoter polymorphism...