Genomes and Genes
Affiliation: University of Ulm
- A genomewide linkage analysis for prostate cancer susceptibility genes in families from GermanyChristiane Maier
Abteilung Humangenetik, Universitat Ulm, Germany
Eur J Hum Genet 13:352-60. 2005..In the present study population, the MSR1 gene could play a significant role. Other conspicuous loci, like 1p31 and 8q13, need further investigation in order to verify their relevance and to identify candidate genes...
- Prostate cancer risk is not altered by TP53AIP1 germline mutations in a German case-control seriesManuel Luedeke
Department of Urology, University Hospital Ulm, Ulm, Germany
PLoS ONE 7:e34128. 2012..The large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition...
- Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) familiesJoan E Bailey-Wilson
Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
BMC Med Genet 13:46. 2012..Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive...
- Germline mutations of the MSR1 gene in prostate cancer families from GermanyChristiane Maier
Abteilung Humangenetik, Universitätsklinik Ulm, Germany
Hum Mutat 27:98-102. 2006..Nevertheless, the low frequencies of deleterious alleles, in addition to an apparently moderate penetrance, does not support MSR1 as a major susceptibility gene in this family sample...
- Editorial comment on: Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitorsChristiane Maier
Institut fur Humangenetik, Universitat Ulm, Ulm, Germany
Eur Urol 52:1088-9. 2007
- The prostate cancer risk locus at 10q11 is associated with DNA repair capacityAntje E Rinckleb
Department of Urology, University Hospital Ulm, 89075 Ulm, Germany
DNA Repair (Amst) 11:693-701. 2012..Based on the present observation, candidate genes from the contexts of DNA repair and apoptosis may be more promising targets for expression studies with respect to the rs10993994 genotype...
- Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genesManuel Luedeke
1Institute of Human Genetics, University Hospital Ulm, Ulm, Germany
Cancer Epidemiol Biomarkers Prev 18:3030-5. 2009..02; OR, 1.33; 95% CI, 1.04-1.70) in unselected PCa cases. The DNA repair genes POLI and ESCO1 are proposed as susceptibility genes for TMPRSS2-ERG fusion-positive PCa that warrant further investigation...
- Heritability of baseline and induced micronucleus frequenciesHarald Surowy
Institute of Human Genetics, University Hospital Ulm, Ulm, Germany
Mutagenesis 26:111-7. 2011....
- Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancerNatascha Bachmann
Department of Human Genetics, University of Ulm, Ulm, Germany
Prostate 65:252-9. 2005..This report details the results of the first mutation screen and association study of EZH2 (located at 7q35) as a potential candidate gene for the development of aggressive prostate cancer...
- POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinomaSilvia Kastler
Institute of Human Genetics, University of Ulm, Ulm, Germany
Prostate 70:666-74. 2010..The objective of this study was to investigate the POU5F1P1 expression in prostatic carcinoma and carcinoma surrounding prostatic tissue...
- Increased radiosensitivity as an indicator of genes conferring breast cancer susceptibilityDominic Varga
Department of Gynecology and Obstetrics, University of Ulm Medical School, Ulm, Germany
Strahlenther Onkol 183:655-60. 2007....
- Role of a CYP17 promoter polymorphism for familial prostate cancer risk in GermanyZorica Vesovic
Abteilung Humangenetik, Universitatsklinikum Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
Anticancer Res 25:1303-7. 2005..The purpose of the present study was to determine whether this correlation could be replicated in a European population...
- Baseline brain perfusion and the serotonin transporter promoter polymorphismRoberto Viviani
Department of Psychiatry and Psychotherapy III, University of Ulm, Germany
Biol Psychiatry 67:317-22. 2010..We reassess the findings of an increased baseline perfusion in the amygdala and ventral prefrontal areas in healthy carriers of the risk genotype in a much larger sample than in previous studies...
- On the difference of micronucleus frequencies in peripheral blood lymphocytes between breast cancer patients and controlsDominic Varga
Department of Human Genetics, University of Ulm, Ulm, Germany
Mutagenesis 21:313-20. 2006..73). We conclude that the G0 MNT may be a useful tool to substitute the phenotype breast cancer in association and linkage studies and that it may be possible to develop a test useful in the diagnosis or risk assessment for breast cancer...
- Genetic and environmental risk factors for submucous cleft palateRudolf Reiter
Section of Phoniatrics and Pedaudiology, Department of Otolaryngology, Head and Neck Surgery, University of Ulm, Ulm, Germany
Eur J Oral Sci 120:97-103. 2012..Our results indicate a potential role of maternal smoking during pregnancy for the formation of SMCP. The analysis of genetic variants hints at the contribution of TGFB3 and MN1 in the aetiology of SMCPs...
- Association of a CAV-1 haplotype to familial aggressive prostate cancerJuergen Haeusler
Department of Human Genetics, University of Ulm, Germany
Prostate 65:171-7. 2005..Mutation screening was performed as well as a case-control study to examine if polymorphisms in CAV-1 are associated with prostate cancer aggressiveness in a German population...
- Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer GeneticsDaniel J Schaid
Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Hum Genet 120:471-85. 2006..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
- A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer geneticsJianfeng Xu
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Hum Genet 77:219-29. 2005....
- Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancerScott J Hebbring
Mayo Clinic Rochester, 200 First Street Southwest, 920 Hilton Building, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 15:935-8. 2006..However, our data does suggest that mutations within NBS1, and in particular, 657del5, do not significantly contribute to the overall prostate cancer burden within our patient samples...
- Expression changes of CAV1 and EZH2, located on 7q31 approximately q36, are rarely related to genomic alterations in primary prostate carcinomaNatascha Bachmann
Department of Human Genetics, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
Cancer Genet Cytogenet 182:103-10. 2008..Through bisulfite sequencing of four tumor samples, CpG-hypermethylation was verified as an alternative mechanism for CAV1 silencing, as reported previously. Moreover, it could also be involved in the reactivation of EZH2...
- Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer GeneticsNicola J Camp
University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108, USA
Hum Mol Genet 16:1271-8. 2007..This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases...