A Maelicke

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint [New theory! Galantamine and nicotinic-cholinergic transmission]
    Alfred Maelicke
    Institut für Physiologische Chemie und Pathobiochemie Johannes Gutenberg Universität Mainz Duesbergstrasse 6, 55099 Mainz
    Pharm Unserer Zeit 31:390-3. 2002
  2. ncbi request reprint Pharmacokinetic rationale for switching from donepezil to galantamine
    A Maelicke
    Laboratory of Molecular Neurobiology, Johannes Gutenberg University Medical School, Mainz, Germany
    Clin Ther 23:A8-12. 2001
  3. ncbi request reprint Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors
    Marek Samochocki
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Duesbergweg 6, D 55099 Mainz, Germany
    J Pharmacol Exp Ther 305:1024-36. 2003
  4. ncbi request reprint Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
    Dement Geriatr Cogn Disord 11:11-8. 2000
  5. ncbi request reprint Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, 6 Duesbergweg, D 55099, Mainz, Germany
    Eur J Pharmacol 393:165-70. 2000
  6. ncbi request reprint Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes-Gutenberg University Medical School, Mainz, Germany
    Biol Psychiatry 49:279-88. 2001
  7. ncbi request reprint Cloning of the human NCNF gene
    S Schneider-Hirsch
    Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg-University Medical School, Mainz, Germany
    J Recept Signal Transduct Res 18:1-13. 1998
  8. ncbi request reprint Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
    Behav Brain Res 113:199-206. 2000
  9. ncbi request reprint Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR
    M Samochocki
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz Germany
    Acta Neurol Scand Suppl 176:68-73. 2000
  10. ncbi request reprint Expression and renaturation of the N-terminal extracellular domain of torpedo nicotinic acetylcholine receptor alpha-subunit
    A Schrattenholz
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, 6 Duesbergweg, Johannes Gutenberg University Medical School, 55099 Mainz, Germany
    J Biol Chem 273:32393-9. 1998

Collaborators

  • A Schrattenholz
  • Edson X Albuquerque
  • W Knoll
  • T Herget
  • P J Groot Kormelink
  • E Neumann
  • Annette Nicke
  • Christina Zechel
  • Manickavasagom Alkondon
  • Edna F R Pereira
  • Yasco Aracava
  • Marek Samochocki
  • Mariton D Santos
  • Rodica V Popa
  • Takeshi Kihara
  • Ulrike Sattler
  • Luis E F Almeida
  • S Schneider-Hirsch
  • U M Bauer
  • R Heiermann
  • M Samochocki
  • M Rentrop
  • Cristiane Lopes
  • E K Schmidt
  • Tomoki Nakamizo
  • Hideyuki Sawada
  • Adriana L Camara
  • Hirofumi Yamashita
  • Shun Shimohama
  • Rie Kanki
  • Claudia Christner
  • Martin Radina
  • Andreas Fehrenbacher
  • Ruth Jostock
  • Hermann Lübbert
  • Anja Höffle
  • Christoph Ullmer
  • Marion Zerlin
  • Jurgen Ludwig
  • Howard M Eisenberg
  • Corey Hilmas
  • M Zerlin
  • R Jostock
  • W H Luyten
  • A Kukol
  • M Kreiter
  • R Naumann
  • T Liebermann
  • A Jonczyk
  • F Wang
  • T Pauly
  • S Reinhardt
  • A Maus
  • E Lang

Detail Information

Publications23

  1. ncbi request reprint [New theory! Galantamine and nicotinic-cholinergic transmission]
    Alfred Maelicke
    Institut für Physiologische Chemie und Pathobiochemie Johannes Gutenberg Universität Mainz Duesbergstrasse 6, 55099 Mainz
    Pharm Unserer Zeit 31:390-3. 2002
  2. ncbi request reprint Pharmacokinetic rationale for switching from donepezil to galantamine
    A Maelicke
    Laboratory of Molecular Neurobiology, Johannes Gutenberg University Medical School, Mainz, Germany
    Clin Ther 23:A8-12. 2001
    ..The switching protocol proposed here has been based on an analysis of mean plasma concentrations of donepezil following administration of a single dose and on the established pharmacokinetics of galantamine...
  3. ncbi request reprint Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors
    Marek Samochocki
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Duesbergweg 6, D 55099 Mainz, Germany
    J Pharmacol Exp Ther 305:1024-36. 2003
    ..Galantamine's APL action directly addresses the nicotinic deficit in AD...
  4. ncbi request reprint Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
    Dement Geriatr Cogn Disord 11:11-8. 2000
    ..Galantamine's modulatory effects on nAChR may influence transcriptional regulation, resulting in an increased synthesis of nAChR. This may account for galantamine's sustained efficacy...
  5. ncbi request reprint Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, 6 Duesbergweg, D 55099, Mainz, Germany
    Eur J Pharmacol 393:165-70. 2000
    ....
  6. ncbi request reprint Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes-Gutenberg University Medical School, Mainz, Germany
    Biol Psychiatry 49:279-88. 2001
    ....
  7. ncbi request reprint Cloning of the human NCNF gene
    S Schneider-Hirsch
    Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg-University Medical School, Mainz, Germany
    J Recept Signal Transduct Res 18:1-13. 1998
    ..Based on the high level of sequence identity of human and murine NCNF, it is likely that also the human nuclear receptor is involved in the control of neurogenesis and gametogenesis...
  8. ncbi request reprint Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
    Behav Brain Res 113:199-206. 2000
    ..The potentiating effect of APL on nicotinic neurotransmission has been shown by whole-cell patch-clamp studies in natural murine and human neurons, and in murine and human cell lines expressing various subtypes of neuronal nAChR...
  9. ncbi request reprint Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR
    M Samochocki
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz Germany
    Acta Neurol Scand Suppl 176:68-73. 2000
    ..The possible benefits for therapy of AD of an APL action on nicotinic receptors is discussed...
  10. ncbi request reprint Expression and renaturation of the N-terminal extracellular domain of torpedo nicotinic acetylcholine receptor alpha-subunit
    A Schrattenholz
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, 6 Duesbergweg, Johannes Gutenberg University Medical School, 55099 Mainz, Germany
    J Biol Chem 273:32393-9. 1998
    ..12 microM. The results demonstrate that the N-terminal extracellular region of the nAChR alpha-subunit forms a self-assembling domain that functionally expresses major elements of the ligand binding sites of the receptor...
  11. ncbi request reprint Mapping of a binding site for ATP within the extracellular region of the Torpedo nicotinic acetylcholine receptor beta-subunit
    A Schrattenholz
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, 6 Duesbergweg, Johannes Gutenberg University Medical School, 55099 Mainz, Germany
    Biochemistry 36:13333-40. 1997
    ..The existence of an extracellular binding site for ATP confirms, on the molecular level, that this nucleotide can directly act on nicotinic receptors, as has been suggested from previous electrophysiological and biochemical studies...
  12. ncbi request reprint Production of ceramides causes apoptosis during early neural differentiation in vitro
    T Herget
    Laboratory of Molecular Neurobiology, University of Mainz, 55099 Mainz, Germany
    J Biol Chem 275:30344-54. 2000
    ..Expression of marker proteins shows that ceramide regulates apoptosis, rather than differentiation, during early neural differentiation...
  13. ncbi request reprint Neuronal cell nuclear factor--a nuclear receptor possibly involved in the control of neurogenesis and neuronal differentiation
    U M Bauer
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg-University Medical School, Mainz, Germany
    Eur J Biochem 249:826-37. 1997
    ..NCNF may induce neuronal differentiation by repressing the activity of genes that permit cell fates other than the neuronal one...
  14. ncbi request reprint Incorporation of the acetylcholine receptor dimer from Torpedo californica in a peptide supported lipid membrane investigated by surface plasmon and fluorescence spectroscopy
    E K Schmidt
    Max Planck Institute for Polymer Research, Mainz, Germany
    Biosens Bioelectron 13:585-91. 1998
    ..The latter was fluorescence labeled with Cy5. The different binding assays indicate the successful incorporation of the receptor in the lipid bilayer...
  15. ncbi request reprint Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1
    R Heiermann
    Laboratory of Molecular Neurobiology, Johannes Gutenberg University School of Medicine, Mainz, Germany
    J Recept Res 13:693-709. 1993
    ..The different patterns of derivatives produced by the variants upon exposure to RA therefore cannot be caused by somatic mutations in RAR genes of the tumor cell lines...
  16. ncbi request reprint The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system
    Mariton D Santos
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Pharmacol 61:1222-34. 2002
    ..In conclusion, the nicotinic APL action can be an important determinant of the therapeutic effectiveness of galantamine...
  17. ncbi request reprint Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity
    Takeshi Kihara
    Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyoku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 325:976-82. 2004
    ..Our data suggest that neuroprotection by galantamine is mediated, at least in part, by alpha7 nAChR-PI3K cascade...
  18. ncbi request reprint The N-butylcarbamate derivative of galantamine acts as an allosteric potentiating ligand on alpha7 nicotinic receptors in hippocampal neurons: clinical implications for treatment of Alzheimer's disease
    Rodica V Popa
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA
    J Mol Neurosci 30:227-32. 2006
    ..1998; Hejmadi et al., 2003; Kihara et al., 1997; Levin et al., 2006). Thus, increasing nAChR activity in the brain was proposed as a mechanism to slow down the progression of the disease (Maelicke and Albuquerque, 1996)...
  19. ncbi request reprint Unconventional ligands and modulators of nicotinic receptors
    Edna F R Pereira
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 W Baltimore St Baltimore, Maryland 21201, USA
    J Neurobiol 53:479-500. 2002
    ....
  20. ncbi request reprint Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors
    Annette Nicke
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    FEBS Lett 554:219-23. 2003
    ..These results indicate that as yet unidentified factors influence alpha-conotoxin pharmacology at native versus oocyte-expressed nAChRs...
  21. ncbi request reprint Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation
    Luis E F Almeida
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Bioorg Med Chem Lett 14:1879-87. 2004
    ..These results indicate that naltrexone could be used as a smoking cessation aid...
  22. ncbi request reprint The expression level of the orphan nuclear receptor GCNF (germ cell nuclear factor) is critical for neuronal differentiation
    Ulrike Sattler
    Institute of Physiological Biochemistry and Pathobiochemistry, Johannes Gutenberg University, Medical School, Duesberg Weg 6, 55099 Mainz, Germany
    Mol Endocrinol 18:2714-26. 2004
    ..Neuronal cells in the antisense cultures acquired functional competence, although with a significant delay. Our data propose that the level of GCNF is critical for differentiation and maturation of neuronal precursor cells...
  23. ncbi request reprint Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons
    Yasco Aracava
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore St, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 312:1195-205. 2005
    ..It is suggested that blockade of alpha7(*) nAChRs by memantine could decrease its effectiveness for treatment of AD, particularly at early stages when the degrees of nAChR dysfunction and of cognitive decline correlate well...