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Species | A MaelickeSummaryAffiliation: University of Mainz Country: Germany Publications
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Publications
[New theory! Galantamine and nicotinic-cholinergic transmission]Alfred Maelicke
, 55099 Mainz
Pharm Unserer Zeit 31:390-3. 2002- Pharmacokinetic rationale for switching from donepezil to galantamineA Maelicke
Laboratory of Molecular Neurobiology, Johannes Gutenberg University Medical School, Mainz, Germany
Clin Ther 23:A8-12. 2001..The switching protocol proposed here has been based on an analysis of mean plasma concentrations of donepezil following administration of a single dose and on the established pharmacokinetics of galantamine... - Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptorsMarek Samochocki
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Duesbergweg 6, D 55099 Mainz, Germany
J Pharmacol Exp Ther 305:1024-36. 2003..Galantamine's APL action directly addresses the nicotinic deficit in AD... - Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's diseaseA Maelicke
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
Dement Geriatr Cogn Disord 11:11-8. 2000..Galantamine's modulatory effects on nAChR may influence transcriptional regulation, resulting in an increased synthesis of nAChR. This may account for galantamine's sustained efficacy... - Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's diseaseA Maelicke
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, 6 Duesbergweg, D 55099, Mainz, Germany
Eur J Pharmacol 393:165-70. 2000.... - Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's diseaseA Maelicke
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes-Gutenberg University Medical School, Mainz, Germany
Biol Psychiatry 49:279-88. 2001.... - Cloning of the human NCNF geneS Schneider-Hirsch
Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg-University Medical School, Mainz, Germany
J Recept Signal Transduct Res 18:1-13. 1998..Based on the high level of sequence identity of human and murine NCNF, it is likely that also the human nuclear receptor is involved in the control of neurogenesis and gametogenesis... - Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's diseaseA Maelicke
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
Behav Brain Res 113:199-206. 2000..The potentiating effect of APL on nicotinic neurotransmission has been shown by whole-cell patch-clamp studies in natural murine and human neurons, and in murine and human cell lines expressing various subtypes of neuronal nAChR... - Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChRM Samochocki
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz Germany
Acta Neurol Scand Suppl 176:68-73. 2000..The possible benefits for therapy of AD of an APL action on nicotinic receptors is discussed... - Expression and renaturation of the N-terminal extracellular domain of torpedo nicotinic acetylcholine receptor alpha-subunitA Schrattenholz
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, 6 Duesbergweg, Johannes Gutenberg University Medical School, 55099 Mainz, Germany
J Biol Chem 273:32393-9. 1998..12 microM. The results demonstrate that the N-terminal extracellular region of the nAChR alpha-subunit forms a self-assembling domain that functionally expresses major elements of the ligand binding sites of the receptor... - Mapping of a binding site for ATP within the extracellular region of the Torpedo nicotinic acetylcholine receptor beta-subunitA Schrattenholz
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, 6 Duesbergweg, Johannes Gutenberg University Medical School, 55099 Mainz, Germany
Biochemistry 36:13333-40. 1997..The existence of an extracellular binding site for ATP confirms, on the molecular level, that this nucleotide can directly act on nicotinic receptors, as has been suggested from previous electrophysiological and biochemical studies... - Production of ceramides causes apoptosis during early neural differentiation in vitroT Herget
Laboratory of Molecular Neurobiology, University of Mainz, 55099 Mainz, Germany
J Biol Chem 275:30344-54. 2000..Expression of marker proteins shows that ceramide regulates apoptosis, rather than differentiation, during early neural differentiation... - Neuronal cell nuclear factor--a nuclear receptor possibly involved in the control of neurogenesis and neuronal differentiationU M Bauer
Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg-University Medical School, Mainz, Germany
Eur J Biochem 249:826-37. 1997..NCNF may induce neuronal differentiation by repressing the activity of genes that permit cell fates other than the neuronal one... - Incorporation of the acetylcholine receptor dimer from Torpedo californica in a peptide supported lipid membrane investigated by surface plasmon and fluorescence spectroscopyE K Schmidt
Max Planck Institute for Polymer Research, Mainz, Germany
Biosens Bioelectron 13:585-91. 1998..The latter was fluorescence labeled with Cy5. The different binding assays indicate the successful incorporation of the receptor in the lipid bilayer... - Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1R Heiermann
Laboratory of Molecular Neurobiology, Johannes Gutenberg University School of Medicine, Mainz, Germany
J Recept Res 13:693-709. 1993..The different patterns of derivatives produced by the variants upon exposure to RA therefore cannot be caused by somatic mutations in RAR genes of the tumor cell lines... - The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous systemMariton D Santos
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Mol Pharmacol 61:1222-34. 2002..In conclusion, the nicotinic APL action can be an important determinant of the therapeutic effectiveness of galantamine... - Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicityTakeshi Kihara
Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyoku, Kyoto 606-8507, Japan
Biochem Biophys Res Commun 325:976-82. 2004..Our data suggest that neuroprotection by galantamine is mediated, at least in part, by alpha7 nAChR-PI3K cascade... - The N-butylcarbamate derivative of galantamine acts as an allosteric potentiating ligand on alpha7 nicotinic receptors in hippocampal neurons: clinical implications for treatment of Alzheimer's diseaseRodica V Popa
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA
J Mol Neurosci 30:227-32. 2006..1998; Hejmadi et al., 2003; Kihara et al., 1997; Levin et al., 2006). Thus, increasing nAChR activity in the brain was proposed as a mechanism to slow down the progression of the disease (Maelicke and Albuquerque, 1996)... - Unconventional ligands and modulators of nicotinic receptorsEdna F R Pereira
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 W Baltimore St Baltimore, Maryland 21201, USA
J Neurobiol 53:479-500. 2002.... - Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptorsAnnette Nicke
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
FEBS Lett 554:219-23. 2003..These results indicate that as yet unidentified factors influence alpha-conotoxin pharmacology at native versus oocyte-expressed nAChRs... - Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulationLuis E F Almeida
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Bioorg Med Chem Lett 14:1879-87. 2004..These results indicate that naltrexone could be used as a smoking cessation aid... - The expression level of the orphan nuclear receptor GCNF (germ cell nuclear factor) is critical for neuronal differentiationUlrike Sattler
Institute of Physiological Biochemistry and Pathobiochemistry, Johannes Gutenberg University, Medical School, Duesberg Weg 6, 55099 Mainz, Germany
Mol Endocrinol 18:2714-26. 2004..Neuronal cells in the antisense cultures acquired functional competence, although with a significant delay. Our data propose that the level of GCNF is critical for differentiation and maturation of neuronal precursor cells... - Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neuronsYasco Aracava
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore St, Baltimore, MD 21201, USA
J Pharmacol Exp Ther 312:1195-205. 2005..It is suggested that blockade of alpha7(*) nAChRs by memantine could decrease its effectiveness for treatment of AD, particularly at early stages when the degrees of nAChR dysfunction and of cognitive decline correlate well...