R Maas

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia
    Renke Maas
    Clinical Pharmacology Unit, Institute for Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Atherosclerosis 191:211-9. 2007
  2. ncbi request reprint Old and new cardiovascular risk factors: from unresolved issues to new opportunities
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Atheroscler Suppl 4:5-17. 2003
  3. ncbi request reprint Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA)
    Renke Maas
    Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    Vasc Med 10:S49-57. 2005
  4. ncbi request reprint Elevation of asymmetrical dimethylarginine (ADMA) and coronary artery disease in men with erectile dysfunction
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Germany
    Eur Urol 48:1004-11; discussion 1011-2. 2005
  5. ncbi request reprint A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue
    Renke Maas
    Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:220-8. 2007
  6. ncbi request reprint Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery
    Renke Maas
    University Hospital Hamburg Eppendorf, Institute of Experimental and Clinical Pharmacology and Toxicology, Hamburg, Germany
    Crit Care Med 35:1876-81. 2007
  7. ncbi request reprint Antihypertensive therapy: special focus on drug interactions
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie, Universitätsklinikum HamburgEppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Expert Opin Drug Saf 2:549-79. 2003
  8. ncbi request reprint The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Vasc Med 7:213-25. 2002
  9. pmc Syncope, driving recommendations, and clinical reality: survey of patients
    Renke Maas
    Clinical Pharmacology Unit, Department of Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    BMJ 326:21. 2003
  10. ncbi request reprint Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension
    Milica Bajcetic
    Institute of Experimental and Clinical Pharmacology and Toxicology, Clinical Pharmacology Unit, University Hospital Hamburg Eppendorf, Martinistrasse 521, D 20246 Hamburg
    J Clin Pharmacol 47:295-304. 2007

Detail Information

Publications63

  1. ncbi request reprint Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia
    Renke Maas
    Clinical Pharmacology Unit, Institute for Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Atherosclerosis 191:211-9. 2007
    ..To investigate the association of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and coronary endothelial function...
  2. ncbi request reprint Old and new cardiovascular risk factors: from unresolved issues to new opportunities
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Atheroscler Suppl 4:5-17. 2003
    ..With several new risk factors and substantial changes in lifestyle and treatment patterns on the horizon major changes in the hierarchy of risk factors may be inevitable...
  3. ncbi request reprint Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA)
    Renke Maas
    Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    Vasc Med 10:S49-57. 2005
    ..As impairment of DDAH activity or capacity is associated with substantial increases in plasma ADMA concentrations, DDAH is likely to emerge as a prime target for specific therapeutic interventions...
  4. ncbi request reprint Elevation of asymmetrical dimethylarginine (ADMA) and coronary artery disease in men with erectile dysfunction
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Germany
    Eur Urol 48:1004-11; discussion 1011-2. 2005
    ....
  5. ncbi request reprint A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue
    Renke Maas
    Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:220-8. 2007
    ..9% and 10% for mouse kidney and liver, respectively. The present DDAH activity assay allows for the first time to simultaneously determine DDAH activity and endogenous formation of ADMA, SDMA, and L-arginine in tissue...
  6. ncbi request reprint Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery
    Renke Maas
    University Hospital Hamburg Eppendorf, Institute of Experimental and Clinical Pharmacology and Toxicology, Hamburg, Germany
    Crit Care Med 35:1876-81. 2007
    ..We aimed to investigate elevated plasma ADMA concentrations as a prospective risk marker for adverse events in patients undergoing noncardiac surgery...
  7. ncbi request reprint Antihypertensive therapy: special focus on drug interactions
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie, Universitätsklinikum HamburgEppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Expert Opin Drug Saf 2:549-79. 2003
    ..In this respect, the authors discuss controversial viewpoints on the overall clinical relevance of drug interactions occurring at the level of cytochrome P450 metabolism...
  8. ncbi request reprint The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Vasc Med 7:213-25. 2002
    ..Likewise, the role of endothelium-derived factors mediating NO-independent pathways is evaluated...
  9. pmc Syncope, driving recommendations, and clinical reality: survey of patients
    Renke Maas
    Clinical Pharmacology Unit, Department of Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    BMJ 326:21. 2003
  10. ncbi request reprint Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension
    Milica Bajcetic
    Institute of Experimental and Clinical Pharmacology and Toxicology, Clinical Pharmacology Unit, University Hospital Hamburg Eppendorf, Martinistrasse 521, D 20246 Hamburg
    J Clin Pharmacol 47:295-304. 2007
    ..Larger crossover trials will have to establish these observations and investigate whether interaction of both drugs affects telmisartan efficacy and tolerability in clinical use...
  11. doi request reprint Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease
    R H Boger
    Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Intern Med 269:349-61. 2011
    ..Symmetric dimethylarginine (SDMA) does not inhibit NO synthases. Peripheral arterial disease (PAD) is a systemic indication of atherosclerosis...
  12. doi request reprint Predicting recurrence of vasovagal syncope: a simple risk score for the clinical routine
    Muhammet A Aydin
    Department of Cardiology, University Heart Center, Hamburg, Germany
    J Cardiovasc Electrophysiol 20:416-21. 2009
    ..Predictors for recurrence of syncope are lacking in patients with vasovagal syncope. The aim of this study was to identify risk factors for recurrence of syncope and develop a simple prognostic risk score of clinical value...
  13. doi request reprint L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides
    Friedrich Schulze
    Center for Experimental Medicine, Institute for Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany
    Nutr Res 29:291-7. 2009
    ..We conclude from our data that L-arginine enhances the effects of simvastatin on lipid metabolism, but it has no triglyceride-lowering effects when given alone...
  14. doi request reprint Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke
    Friedrich Schulze
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Atherosclerosis 208:518-23. 2010
    ..ADMA is a predictor of cardiovascular events and mortality in diverse populations...
  15. ncbi request reprint Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine
    Gerhild I Böger
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, Hamburg, Germany
    J Am Coll Cardiol 49:2274-82. 2007
    ..We hypothesized that the level of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide (NO) synthase (eNOS), might determine the endothelial effects of statins...
  16. ncbi request reprint Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Regi
    Renke Maas
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Chem 53:693-701. 2007
    ..We investigated the association between plasma concentrations of ADMA and risk in initially healthy smoking and nonsmoking men...
  17. ncbi request reprint Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects
    F Schulze
    University Hospital Hamburg Eppendorf, Centre for Experimental Medicine, Institute of Experimental and Clinical Pharmacology and Toxicology, Clinical Pharmacology Unit, Hamburg, Germany
    Eur J Clin Invest 35:622-6. 2005
    ..Asymmetric dimethylarginine (ADMA) acts as an endogenous inhibitor of NO-synthase. In the last years ADMA has emerged as a cardiovascular risk factor. The aim of this study was to determine a reference value for ADMA...
  18. ncbi request reprint Event-recorder monitoring in the diagnosis of atrial fibrillation in symptomatic patients: subanalysis of the SOPAT trial
    Monica Patten
    Universitäres Herzzentrum, Kardiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Cardiovasc Electrophysiol 17:1216-20. 2006
    ..Furthermore, patients' symptoms are not a reliable surrogate parameter for the prevalence of AF...
  19. pmc Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community
    Rainer H Boger
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Circulation 119:1592-600. 2009
    ..Although elevated ADMA has been associated with an increased risk of cardiovascular disease events and death in referral samples, the prognostic significance of ADMA in the community has not been adequately evaluated...
  20. ncbi request reprint High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma
    Edzard Schwedhelm
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:211-9. 2007
    ..37+/-0.07 microM in healthy humans (n=85), respectively, and 44+/-14, 0.72+/-0.23, and 0.19+/-0.06 microM in C57BL/6 mice. Also, the molar ratios of arginine to ADMA were different in man and mice, i.e. 166+/-50 and 85+/-22, respectively...
  21. ncbi request reprint Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study
    Friedrich Schulze
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, Center of Experimental Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Am Heart J 152:493.e1-8. 2006
    ..It has been shown that ADMA predicts cardiovascular mortality in patients who have coronary heart disease (CHD). However, the question whether ADMA is an independent risk factor for CHD still remains unresolved...
  22. doi request reprint Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Dement Geriatr Cogn Disord 26:58-64. 2008
    ..Concerning Alzheimer's disease (AD), there are reports on altered cerebral NO metabolism, but only few studies on ADMA concentrations in plasma and cerebrospinal fluid (CSF)...
  23. pmc Impact of atorvastatin treatment on platelet-activating factor acetylhydrolase and 15-F(2trans)-isoprostane in hypercholesterolaemic patients
    Ghainsom D Kom
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Br J Clin Pharmacol 63:672-9. 2007
    ..We investigated the effect of atorvastatin on PLA(2)s and PAF-AH activity and the urinary excretion of 15-F(2trans)-isoprostane (15-F(2t)-IsoP, 8-iso-PGF(2alpha), iPF(2alpha)-III)...
  24. doi request reprint Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency room
    Friedrich Schulze
    University Hospital Hamburg Eppendorf, Institute for Experimental and Clinical Pharmacology and Toxicology, Hamburg, Germany
    Clin Chim Acta 401:20-4. 2009
    ..We investigated the predictive value of asymmetric dimethylarginine (ADMA) in unselected patients attending an internal medicine ER regarding outcome of the patients and duration of stay in the hospital...
  25. ncbi request reprint Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia
    Renke Maas
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Clin Chem 54:292-300. 2008
    ..It was the aim of this study to directly estimate and compare whole-body NO production in normo- and hypercholesterolemia by applying a nonradioactive stable isotope dilution technique in vivo...
  26. ncbi request reprint Telmisartan improves endothelial function in patients with essential hypertension
    Ralf A Benndorf
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center, Hamburg Eppendorf, Germany
    J Cardiovasc Pharmacol 50:367-71. 2007
    ..We therefore investigated whether the new ARB telmisartan improves endothelial function and renal vascular resistance in patients with essential hypertension...
  27. pmc Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism
    Edzard Schwedhelm
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Centre Hamburg Eppendorf, Germany
    Br J Clin Pharmacol 65:51-9. 2008
    ..In contrast, L-citrulline is readily absorbed and at least in part converted to L-arginine. The aim of our study was to assess this metabolic conversion and its subsequent pharmacodynamic effects...
  28. ncbi request reprint Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial
    Tanja K Rudolph
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Am J Clin Nutr 86:334-40. 2007
    ..High-fat meals have negative effects on endothelial function, but vitamin-rich side orders may prevent these negative effects...
  29. ncbi request reprint Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension
    Ralf A Benndorf
    Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Metabolism 55:1159-64. 2006
    ..Future studies will demonstrate whether these telmisartan-induced effects may contribute to a blood pressure-independent reduction in cardiovascular morbidity...
  30. ncbi request reprint ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study
    Rainer H Boger
    Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    Vasc Med 10:S97-102. 2005
    ....
  31. ncbi request reprint Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study
    Edzard Schwedhelm
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    Circulation 109:843-8. 2004
    ..We tested the hypothesis that risk factors of CHD are associated with abundant systemic oxidative stress...
  32. ncbi request reprint Diagnostic yield of external electrocardiographic loop recorders in patients with recurrent syncope and negative tilt table test
    Andreas Schuchert
    Medical Clinic III, University Hospital Eppendorf, Hamburg, Germany
    Pacing Clin Electrophysiol 26:1837-40. 2003
    ....
  33. ncbi request reprint Effect of syncope-related traumatic injuries on the diagnostic evaluation and syncope recurrence of patients with syncope and apparently normal hearts
    Andreas Schuchert
    Medical Clinic III, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Am J Cardiol 95:1101-3. 2005
    ....
  34. ncbi request reprint A randomized and controlled pilot trial of beta-blockers for the treatment of recurrent syncope in patients with a positive or negative response to head-up tilt test
    Rodolfo Ventura
    Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany
    Pacing Clin Electrophysiol 25:816-21. 2002
    ..773). In conclusion, lipophilic beta-blockers appear efficacious in preventing recurrent syncope of suspected neurocardiogenic origin. The efficacy of therapy seems to be not predicted by HUT...
  35. ncbi request reprint Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma
    Edzard Schwedhelm
    Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    Clin Chem 51:1268-71. 2005
  36. doi request reprint Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk
    Rainer H Boger
    Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Germany
    Pharmacol Res 60:481-7. 2009
    ....
  37. ncbi request reprint Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality
    Rainer H Boger
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Chem Lab Med 43:1124-9. 2005
    ..Recently, advances have been made in the development of analytical methods that are reliable and fast enough to allow determination of ADMA in clinical routine...
  38. pmc Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort
    Edzard Schwedhelm
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Chem 55:1539-45. 2009
    ..Relatively small differences in ADMA concentrations between healthy individuals and those with disease underscore the need to formulate reference intervals that may aid risk stratification of individuals...
  39. ncbi request reprint Mobilization of putative high-proliferative-potential endothelial colony-forming cells during antihypertensive treatment in patients with essential hypertension
    Ralf A Benndorf
    Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Clinical Pharmacology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Stem Cells Dev 16:329-38. 2007
    ....
  40. ncbi request reprint Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial
    Monica Patten
    Herzzentrum, Kardiologie, Universitäts Klinikum Hamburg Eppendorf, Germany
    Eur Heart J 25:1395-404. 2004
    ..of spontaneous events of symptomatic PAF with and without anti-arrhythmic medication? (2) what is the prevalence of severe side-effects? and (3) is the fixed combination of Quinidine + Verapamil inferior to the efficacy of sotalol or not?..
  41. ncbi request reprint Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II
    F Kirchhoff
    Division of Nephrology, Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 73:643-50. 2008
    ..Our study describes a new model of hypertensive end-organ damage and repair in C57BL/6 mice...
  42. ncbi request reprint Psychiatric conditions in patients with recurrent unexplained syncope
    R Ventura
    Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany
    Europace 3:311-6. 2001
    ..The relationship between syncope and psychiatric disorders is little investigated. This study evaluated the prevalence of psychiatric diseases and prognostic outcome in patients with recurrent unexplained syncope...
  43. doi request reprint The role of nitric oxide synthase inhibition by asymmetric dimethylarginine in the pathophysiology of preeclampsia
    Rainer H Boger
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf Martinistrasse 52, DE 20246 Hamburg, Germany boeger uke uni hamburg de
    Gynecol Obstet Invest 69:1-13. 2010
    ..Recently, diagnostic assays for ADMA, e.g. by ELISA, have become available, which render ADMA a possible biomarker to identify pregnant women at risk of developing preeclampsia...
  44. doi request reprint Extensive characterization of the human DDAH1 transgenic mice
    Edzard Schwedhelm
    Institute of Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    Pharmacol Res 60:494-502. 2009
    ....
  45. ncbi request reprint Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events
    Tanja K Krempl
    Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Eur Heart J 26:1846-51. 2005
    ..We investigated the role of asymmetric dimethylarginine (ADMA) for clinical outcome of patients with unstable angina...
  46. doi request reprint Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension
    Renke Maas
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Pharmacol Res 60:488-93. 2009
    ..The mechanisms of this association need further investigation...
  47. doi request reprint Redox-generated isoprostanes are associated with residual platelet activity in aspirin-treated patients with stable coronary heart disease
    E Schwedhelm
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Thromb Haemost 8:2662-70. 2010
    ..We sought to investigate the prevalence of this phenomenon in patients with stable CHD and to study whether oxidative stress plays a role in its pathogenesis...
  48. doi request reprint [MR imaging of the Achilles tendon: evaluation of criteria for the differentiation of asymptomatic and symptomatic tendons]
    C Weber
    Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Rofo 183:631-40. 2011
    ..The purpose of this study was to develop quantitative and qualitative MRI criteria to differentiate between healthy and pathological Achilles tendons...
  49. ncbi request reprint The polyurethane nasolacrimal duct stent for lower tear duct obstruction: long-term success rate and complications
    U Schaudig
    Universitats Krankenhaus Eppendorf, Hamburg, Germany
    Graefes Arch Clin Exp Ophthalmol 238:733-7. 2000
    ..The polyurethane nasolacrimal duct stent is used as an alternative to conventional techniques for treatment of lower tear duct obstruction. The aim of this study was to evaluate the clinical success rate after a follow-up of 2 years...
  50. doi request reprint ADMA and the role of the genes: lessons from genetically modified animals and human gene polymorphisms
    Renke Maas
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Pharmacol Res 60:475-80. 2009
    ..Taken together, the current data suggest that ADMA-related pathology can largely but not completely be explained by impaired NO metabolism...
  51. ncbi request reprint Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress
    Edzard Schwedhelm
    Institute of Experimental and Clinical Pharmacology, Clinical Pharmacology Unit, University Hospital of Hamburg Eppendorf, Hamburg, Germany
    Clin Pharmacokinet 42:437-59. 2003
    ..Catechins are degraded to several gamma-valerolactone derivatives and phase II conjugates have also been identified. Only limited clinical pharmacokinetic data for other polyphenols such as resveratrol have been reported to date...
  52. doi request reprint A myeloperoxidase promoter polymorphism is independently associated with mortality in patients with impaired left ventricular function
    Volker Rudolph
    Department of Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany
    Free Radic Biol Med 47:1584-90. 2009
    ..The -463 G/A MPO polymorphism is linked to adverse clinical outcome of patients with impaired LV function. Further studies are needed to elucidate the value of this polymorphism for risk stratification...
  53. ncbi request reprint Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease
    Carmine Zoccali
    CNR Centre of Clinical Physiology and Renal Unit, Morelli Hospital, Reggio, Calabria, Italy
    J Am Soc Nephrol 13:490-6. 2002
    ..These data support the hypothesis that accumulation of this endogenous inhibitor of NO synthase is an important risk factor for cardiovascular disease in chronic renal failure and suggest a possible link between ADMA and inflammation...
  54. ncbi request reprint Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients
    Carmine Zoccali
    CNR, Division of Nephrology, Centre of Clinical Physiology and Renal Unit, Via Sbarre Inferiori 39, 89131 Reggio Calabria, Italy
    Kidney Int 62:339-45. 2002
    ..The endogenous inhibitor of nitric oxide (NO), asymmetric dimethylarginine (ADMA), is a strong predictor of adverse cardiovascular outcomes in patients with end-stage renal disease (ESRD)...
  55. ncbi request reprint Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections
    Carmine Zoccali
    CNR IBIM, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, c o Ki Point, Gransial SRL, Via Filippini n 85, 89100 Reggio Calabria, Italy
    Nephrol Dial Transplant 22:801-6. 2007
    ..We examined the evolution in the plasma concentration of ADMA measured at the clinical outset of acute inflammation and after its resolution in a series of 17 patients with acute bacterial infections...
  56. ncbi request reprint Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension
    Francesco Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    J Am Coll Cardiol 46:518-23. 2005
    ..We investigated the relationship between ADMA plasma levels and endothelium-dependent vasodilation in 36 never-treated essential hypertensives and in 8 normotensive healthy subjects...
  57. ncbi request reprint The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease
    Alessandra Testa
    CNR IBIM, National Research Council Institute of Biomedicine, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria and Department of Internal Medicine, Catania University, Catania, Italy
    J Hypertens 23:1825-30. 2005
    ..We evaluated the role of endothelial NOS (eNOS) gene polymorphisms and its interaction with plasma ADMA in the high cardiovascular complications rate of these patients...
  58. ncbi request reprint Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome
    Ronald G Garcia
    Int J Cardiol 122:176-8. 2007
    ..Ethnic-specific or environmental differences in the etiologic mechanisms of metabolic syndrome need to be elucidated in further studies...
  59. ncbi request reprint Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice
    Johannes Jacobi
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Physiol Heart Circ Physiol 294:H1058-66. 2008
    ..However, an overexpression of DDAH1 alleviates ANG II-induced renal interstitial fibrosis and vascular oxidative stress, suggesting a blood pressure-independent effect of ADMA on ANG II-induced target organ damage...
  60. ncbi request reprint Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia
    Renke Maas
    JAMA 291:823-4. 2004
  61. ncbi request reprint Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease
    Francesca Mallamaci
    CNR IBIM, Institute of Biomedicine, Clinical Epidemiology, and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy
    J Am Soc Nephrol 15:435-41. 2004
    ..Plasma NE and ADMA concentrations are strongly related among patients with ESRD. These two factors are likely to be involved in the same causal pathway leading to death and cardiovascular events among those patients...
  62. ncbi request reprint Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serum
    Friedrich Schulze
    J Chromatogr B Analyt Technol Biomed Life Sci 831:333. 2006
  63. ncbi request reprint Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease
    Belinda Spoto
    CNR IBIM, National Research Council Institute of Biomedicine, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio, Calabria, Italy
    Am J Hypertens 18:1549-55. 2005
    ....