Beat Lutz

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. doi request reprint Endocannabinoid signals in the control of emotion
    Beat Lutz
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Curr Opin Pharmacol 9:46-52. 2009
  2. pmc Development of a species-specific RNA polymerase I-based shRNA expression vector
    M S Brenz Verca
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Nucleic Acids Res 35:e10. 2007
  3. pmc The endocannabinoid system in anxiety, fear memory and habituation
    S Ruehle
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    J Psychopharmacol 26:23-39. 2012
  4. pmc Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration
    Martin Häring
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS ONE 6:e26617. 2011
  5. ncbi request reprint The endocannabinoid system and extinction learning
    Beat Lutz
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, D 55099 Mainz, Germany
    Mol Neurobiol 36:92-101. 2007
  6. doi request reprint Soothing the seizures of children
    Beat Lutz
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Nat Med 14:721-2. 2008
  7. doi request reprint Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions
    Sabine Ruehle
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany
    J Neurosci 33:10264-77. 2013
  8. pmc Alterations in the hippocampal endocannabinoid system in diet-induced obese mice
    Federico Massa
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, D 55099 Mainz, Germany
    J Neurosci 30:6273-81. 2010
  9. pmc Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS Biol 5:e269. 2007
  10. pmc The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuron 51:455-66. 2006

Detail Information

Publications62

  1. doi request reprint Endocannabinoid signals in the control of emotion
    Beat Lutz
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Curr Opin Pharmacol 9:46-52. 2009
    ....
  2. pmc Development of a species-specific RNA polymerase I-based shRNA expression vector
    M S Brenz Verca
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Nucleic Acids Res 35:e10. 2007
    ..As Pol I-dependent transcription is highly species-specific, Pol I-based system provides an important biosafety advantage with respect to silencing of genes with unknown functions...
  3. pmc The endocannabinoid system in anxiety, fear memory and habituation
    S Ruehle
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    J Psychopharmacol 26:23-39. 2012
    ..Thus, both for anxiety and fear memory processing, endocannabinoid signalling may ensure an appropriate reaction to stressful events. Therefore, the ECS can be considered as a regulatory buffer system for emotional responses...
  4. pmc Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration
    Martin Häring
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS ONE 6:e26617. 2011
    ..In addition, the results could explain the contradictory findings of previous pharmacological studies and could further suggest a possibility to readjust an imbalance in exploratory behaviour observed in psychiatric disorders...
  5. ncbi request reprint The endocannabinoid system and extinction learning
    Beat Lutz
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, D 55099 Mainz, Germany
    Mol Neurobiol 36:92-101. 2007
    ..This review summarizes the current data on the role of the endocannabinoid system in the modulation of extinction learning...
  6. doi request reprint Soothing the seizures of children
    Beat Lutz
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Nat Med 14:721-2. 2008
  7. doi request reprint Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions
    Sabine Ruehle
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany
    J Neurosci 33:10264-77. 2013
    ..Our data pave the way to a better understanding of neuronal networks in the context of behavior, by fine-tuned interference with synaptic transmission processes...
  8. pmc Alterations in the hippocampal endocannabinoid system in diet-induced obese mice
    Federico Massa
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, D 55099 Mainz, Germany
    J Neurosci 30:6273-81. 2010
    ..Our results show that DIO-induced changes in the eCB system affect not only tissues directly involved in the metabolic regulation but also brain regions mediating hedonic aspects of eating and influencing cognitive processes...
  9. pmc Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS Biol 5:e269. 2007
    ....
  10. pmc The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuron 51:455-66. 2006
    ..The direct endocannabinoid-mediated control of hippocampal glutamatergic neurotransmission may constitute a promising therapeutic target for the treatment of disorders associated with excessive excitatory neuronal activity...
  11. doi request reprint Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus
    Frauke Steindel
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    J Neurochem 124:795-807. 2013
    ..This selective signalling mechanism raises the possibility of designing novel cannabinoid ligands that differentially activate only a subset of physiological effects of CB1 stimulation, thereby optimizing therapeutic action...
  12. ncbi request reprint Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
    Fabricio A Moreira
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, D 55099 Mainz, Germany
    Neuropharmacology 54:141-50. 2008
    ..In addition, it indicates an increased activation of CB1 receptors as a mechanism underlying the effects of FAAH inhibition in two models of anxiety...
  13. pmc Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission
    Alejandro Aparisi Rey
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Neuropsychopharmacology 37:2624-34. 2012
    ....
  14. doi request reprint The endocannabinoid system: emotion, learning and addiction
    Fabricio A Moreira
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Addict Biol 13:196-212. 2008
    ..Further understanding of the temporal, spatial and functional characteristics of this system is necessary to clarify its role in emotional responses and will promote advances in its therapeutic exploitation...
  15. doi request reprint Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression
    Fabricio A Moreira
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Best Pract Res Clin Endocrinol Metab 23:133-44. 2009
    ..The present review discusses these side-effects, which have to be taken into account in the therapeutic exploitation of the endocannabinoid system...
  16. pmc AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity
    Stephan Guggenhuber
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 5:e15707. 2010
    ..Our data provide further evidence for a role of increased CB1 signaling in pyramidal hippocampal neurons as a safeguard against the adverse effects of excessive excitatory network activity...
  17. doi request reprint Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
    Christoph Stumm
    Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Neurobiol Aging 34:2574-84. 2013
    ..Furthermore, the findings indicate that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target...
  18. pmc Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice
    Michel A Steiner
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 33:54-67. 2008
    ..We conclude that pharmacological blockade of CB1 signaling shares antidepressant-like behavioral effects with desipramine, but reveals opposite effects on HPA axis activity...
  19. ncbi request reprint The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract
    Federico Massa
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    J Mol Med (Berl) 83:944-54. 2005
    ....
  20. ncbi request reprint Embryonic stem cells stably expressing BDNF-GFP exhibit a BDNF-release-dependent enhancement of neuronal differentiation
    Julia Leschik
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, D 55128 Mainz, Germany
    J Cell Sci 126:5062-73. 2013
    ..Thus, our study describes the generation of ESCs stably overexpressing BDNF-GFP, which are ideally suited to investigate the ameliorating effects of BDNF in cell transplantation studies of various neuropathological conditions...
  21. ncbi request reprint The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    Uberto Pagotto
    Endocrinology Unit, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Bologna, Italy, and Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Germany
    Endocr Rev 27:73-100. 2006
    ..The relevance of the system is further strenghtened by the notion that drugs interfering with the activity of the endocannabinoid system are considered as promising candidates for the treatment of various diseases, including obesity...
  22. doi request reprint Genetic models of the endocannabinoid system
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, D 55099, Mainz, Germany
    Curr Top Behav Neurosci 1:111-39. 2009
    ....
  23. ncbi request reprint Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system
    Nadhim Bayatti
    Department of Pathobiochemistry, Johannes Gutenberg University Mainz Medical School, 55099 Mainz, Germany
    Endocrinology 146:1205-13. 2005
    ..Thus, these data highlight an interaction between the CRH and the cannabinoid system in the regulation of BDNF expression by influencing cAMP and Ca2+ signaling pathways...
  24. ncbi request reprint Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants
    Anne Gaëlle Corbillé
    INSERM, U839, F 75005 Paris, France
    J Neurosci 27:6937-47. 2007
    ....
  25. pmc Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    Nitin Agarwal
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld, Heidelberg, 69120 Germany
    Nat Neurosci 10:870-9. 2007
    ....
  26. pmc Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
    Jan Mulder
    Department of Neuroscience, Retzius vag 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles vag 1, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:8760-5. 2008
    ..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis...
  27. ncbi request reprint Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity
    Henrik H Hansen
    Department of Pediatric Neurology and Neuroscience Research Center, Humboldt University, Berlin, Germany
    Ann Neurol 64:42-52. 2008
    ..Neurocognitive deficits have been reported in children whose mothers used marijuana during pregnancy. Maternal consumption of ethanol is known to cause serious developmental deficits..
  28. doi request reprint Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008
    ..We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation...
  29. pmc Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala
    Shahnaz Christina Azad
    Max Planck Institute of Psychiatry, Clinical Neuropharmacology, 80804 Munich, Germany
    Learn Mem 15:143-52. 2008
    ..These findings suggest that CB1 expressed on either glutamatergic or GABAergic neurons play a differential role in the control of synaptic transmission and plasticity...
  30. pmc Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes
    Laura Tedesco
    Integrated Laboratories Network, Center for Study and Research on Obesity, Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan, Italy
    Diabetes 57:2028-36. 2008
    ..This study was undertaken to test whether CB1 receptor blockade increases the espression of eNOS and mitochondrial biogenesis in white adipocytes...
  31. doi request reprint Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors
    Martin A Storr
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Mol Med (Berl) 86:925-36. 2008
    ..In conclusion, drugs targeting EC degradation offer therapeutic potential in the treatment of inflammatory bowel diseases. Furthermore, reduction of FAAH mRNA expression is involved in the pathophysiological response to colitis...
  32. pmc Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
    Douglas Osei-Hyiaman
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA
    J Clin Invest 118:3160-9. 2008
    ....
  33. ncbi request reprint Hardwiring the brain: endocannabinoids shape neuronal connectivity
    Paul Berghuis
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    Science 316:1212-6. 2007
    ....
  34. ncbi request reprint Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1
    Giovanni Marsicano
    Department of Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 80:448-56. 2002
    ..The results strongly suggest that CB1 is not involved in the cellular antioxidant neuroprotective effects of cannabinoids...
  35. pmc CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice
    Astrid Cannich
    Groups of Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Learn Mem 11:625-32. 2004
    ..We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner...
  36. ncbi request reprint Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling
    Shahnaz C Azad
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:9953-61. 2004
    ..This disinhibition increases the activity of common output neurons and could provide a prerequisite for extinction by formation of new memory...
  37. ncbi request reprint Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity
    Leonid G Khaspekov
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Eur J Neurosci 19:1691-8. 2004
    ....
  38. ncbi request reprint Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task
    Sabine M Holter
    Max Planck Institut fur Psychiatrie, AG Neuronale Plastizität Mausverhalten, Kraepelinstr 2, D 80804 München, Germany
    Eur J Pharmacol 510:69-74. 2005
    ..These data demonstrate that the cannabinoid CB1 receptor is not essential for extinction of the stimulus-response association in an appetitively-motivated learning task...
  39. ncbi request reprint CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  40. pmc The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    Daniela Cota
    Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Invest 112:423-31. 2003
    ....
  41. ncbi request reprint The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Neurosci 26:1551-61. 2006
    ..These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function...
  42. ncbi request reprint Protective activation of the endocannabinoid system during ischemia in dopamine neurons
    Miriam Melis
    Centre of Excellence Neurobiology of Addiction, University of Cagliari, Italy
    Neurobiol Dis 24:15-27. 2006
    ..Lastly, they point to CB1 receptors as valuable targets in protection of DA neurons against ischemic injury and emphasize the need for a better understanding of endocannabinoid actions in the fine control of DA transmission...
  43. ncbi request reprint Molecular biology of cannabinoid receptors
    Beat Lutz
    Group Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Prostaglandins Leukot Essent Fatty Acids 66:123-42. 2002
    ....
  44. ncbi request reprint Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice
    Rudolph Marsch
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 27:832-9. 2007
    ..Our data provide first evidence for fear-promoting effects of TRPV1 with respect to both innate and conditioned fear and for a decisive role of this receptor in synaptic plasticity...
  45. ncbi request reprint Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function
    Daniela Cota
    Group of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 148:1574-81. 2007
    ....
  46. pmc The endogenous cannabinoid system protects against colonic inflammation
    Federico Massa
    Group Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Invest 113:1202-9. 2004
    ..Our results indicate that the endogenous cannabinoid system represents a promising therapeutic target for the treatment of intestinal disease conditions characterized by excessive inflammatory responses...
  47. ncbi request reprint The endogenous cannabinoid system controls extinction of aversive memories
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nature 418:530-4. 2002
    ..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
  48. pmc Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse
    Shahnaz Christina Azad
    Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Learn Mem 10:116-28. 2003
    ..Our results indicate that the mechanisms underlying cannabinoid action in the LA partly resemble those observed in the nucleus accumbens and differ from those described for the hippocampus...
  49. ncbi request reprint Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes
    Kornelia Kamprath
    Neuronal Plasticity Mouse Behavior Group, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 26:6677-86. 2006
    ..Our findings underscore the importance of habituation as a determinant of fear extinction in mice and characterize the cannabinoid CB1 receptor as an essential molecular correlate of this process...
  50. ncbi request reprint An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples, Frederico II, Naples, Italy
    Gastroenterology 125:765-74. 2003
    ..In this study, we investigated the role of the endogenous cannabinoid system (i.e., the cannabinoid receptors and their endogenous ligands) in CT-induced fluid accumulation in the mouse small intestine...
  51. ncbi request reprint Reduced sensitivity to reward in CB1 knockout mice
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute for Mental Health, CIMH, University of Heidelberg, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 176:223-32. 2004
    ..Previous studies have demonstrated that the activation and blockade of the cannabinoid type 1 receptor (CB1) leads to an enhancement and decrease of the consumption of food and other orally ingested reinforcers, respectively...
  52. pmc Further evidence for the existence of a specific process for the membrane transport of anandamide
    Alessia Ligresti
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, Bldg 70, 80078 Pozzuoli NA, Italy
    Biochem J 380:265-72. 2004
    ..We suggest that at least one protein different from FAAH is required to facilitate AEA transport across the plasma membrane in a selective and bi-directional way...
  53. ncbi request reprint On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures
    Beat Lutz
    Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Biochem Pharmacol 68:1691-8. 2004
    ....
  54. ncbi request reprint The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:23892-8. 2007
    ..In summary, our results show the involvement of the CB1 cannabinoid receptor in NP proliferation and neurogenesis induced by excitotoxic injury and support a role for bFGF signaling in this process...
  55. ncbi request reprint The role of the amygdala in the extinction of conditioned fear
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 60:322-8. 2006
    ..Interpreted in the light of these findings, several recent in vitro electrophysiology studies in amygdala-containing brain slices are suggestive of potential synaptic and circuit bases of extinction learning...
  56. ncbi request reprint Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission
    Maria R Domenici
    Department of Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 26:5794-9. 2006
    ..The present data strongly indicate that excitatory synaptic transmission in forebrain areas is directly modulated by CB1 expressed on presynaptic axon terminals originating from glutamatergic neurons...
  57. ncbi request reprint Fatty acid amide hydrolase controls mouse intestinal motility in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 129:941-51. 2005
    ..The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo...
  58. ncbi request reprint The endocannabinoid system drives neural progenitor proliferation
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FASEB J 19:1704-6. 2005
    ..Our results demonstrate that endocannabinoids constitute a new group of signaling cues that regulate NP proliferation and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain...
  59. ncbi request reprint Pain killer without a high
    Krisztina Monory
    Nat Med 11:378-9. 2005
  60. ncbi request reprint Coexpression of the cannabinoid receptor type 1 with the corticotropin-releasing hormone receptor type 1 in distinct regions of the adult mouse forebrain
    Heike Hermann
    Group Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Neurosci Lett 375:13-8. 2005
    ..Colocalisation of CB1 and CRHR1 in hypothalamic regions strongly suggests functional interactions regarding the neuroendocrine homeostasis, including feeding behaviour...
  61. ncbi request reprint Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons
    Miriam Melis
    Center of Excellence Neurobiology of Addiction, Institute of Neuroscience, University of Cagliari, 09042 Monserrato, CA, Italy
    J Neurosci 24:10707-15. 2004
    ..This novel endocannabinoid-mediated self-regulatory role of dopamine neurons may bear relevance in the pathogenesis of neuropsychiatric disorders such as schizophrenia and addiction...
  62. ncbi request reprint Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    Katarzyna Maresz
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53226, USA
    Nat Med 13:492-7. 2007
    ..Together, our results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB(2) receptor...