J Luttges

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas
    J Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 26:466-71. 2002
  2. ncbi Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas
    Nobuyuki Ohike
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer Lett 199:193-200. 2003
  3. ncbi [Pancreatic ductal adenocarcinoma and its precursors]
    J Luttges
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:12-7. 2005
  4. ncbi The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Am J Surg Pathol 25:942-8. 2001
  5. ncbi Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status
    Jutta Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreas 27:e57-62. 2003
  6. ncbi Where and when does pancreatic carcinoma start?
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Med Klin (Munich) 99:191-5. 2004
  7. ncbi The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation
    J Luttges
    Department of Pathology, University of Kiel, Germany
    J Pathol 191:154-61. 2000
  8. ncbi Pancreatic mucinous noncystic (colloid) carcinomas and intraductal papillary mucinous carcinomas are usually microsatellite stable
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 16:537-42. 2003
  9. ncbi Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution
    J Luttges
    Department of Pathology, University of Kiel, Michaelisstrasse 11, D 24105 Kiel, Germany
    Virchows Arch 435:461-8. 1999
  10. ncbi Recommendation for the examination of pancreaticoduodenectomy specimens removed from patients with carcinoma of the exocrine pancreas. A proposal for a standardized pathological staging of pancreaticoduodenectomy specimens including a checklist
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Dig Surg 16:291-6. 1999

Detail Information

Publications34

  1. ncbi The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas
    J Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 26:466-71. 2002
    ....
  2. ncbi Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas
    Nobuyuki Ohike
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer Lett 199:193-200. 2003
    ....
  3. ncbi [Pancreatic ductal adenocarcinoma and its precursors]
    J Luttges
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:12-7. 2005
    ..With the definition of ductal lesions as pancreatic intraepithelial neoplasia, a progression model for pancreatic ductal carcinoma has been developed and corresponding gene alterations have been detected...
  4. ncbi The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Am J Surg Pathol 25:942-8. 2001
    ..The second group seems to be related to ductal carcinoma because of its MUC1 positivity in the absence or very weak MUC2 staining. The third group shows focal MUC1/MUC2 expression and is characterized by oncocytic histology...
  5. ncbi Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status
    Jutta Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreas 27:e57-62. 2003
    ..The question is addressed whether mutated K-ras interferes with the regulation of apoptosis or proliferation...
  6. ncbi Where and when does pancreatic carcinoma start?
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Med Klin (Munich) 99:191-5. 2004
    ..Molecular studies revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma...
  7. ncbi The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation
    J Luttges
    Department of Pathology, University of Kiel, Germany
    J Pathol 191:154-61. 2000
    ..Criteria that relate to cellular and structural differentiation seem to be more predictive than those related to proliferation...
  8. ncbi Pancreatic mucinous noncystic (colloid) carcinomas and intraductal papillary mucinous carcinomas are usually microsatellite stable
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 16:537-42. 2003
    ..The data suggest that pancreatic carcinomas with a mucinous phenotype (MUC2+/MUC1-) do not appear to normally exhibit mutations in the mismatch repair genes and therefore differ in their carcinogenesis from those in other organs...
  9. ncbi Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution
    J Luttges
    Department of Pathology, University of Kiel, Michaelisstrasse 11, D 24105 Kiel, Germany
    Virchows Arch 435:461-8. 1999
    ..Hyperplastic/metaplastic duct changes of the pancreas increase with age, but their distribution pattern in the pancreas differs from that of ductal carcinomas...
  10. ncbi Recommendation for the examination of pancreaticoduodenectomy specimens removed from patients with carcinoma of the exocrine pancreas. A proposal for a standardized pathological staging of pancreaticoduodenectomy specimens including a checklist
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Dig Surg 16:291-6. 1999
    ....
  11. ncbi Solitary fibrous tumour of the pancreas: a new member of the small group of mesenchymal pancreatic tumours
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 435:37-42. 1999
    ..Other mesenchymal tumours that may occur in the pancreas include tumours of the peripheral nerve sheath, fibrous histiocytic tumours and rare vascular tumours...
  12. ncbi Rare ductal adenocarcinoma of the pancreas in patients younger than age 40 years
    Jutta Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer 100:173-82. 2004
    ..The objective of the current study was to determine whether the features of PDACs in patients age < 40 years differ from those in older patients. The authors reviewed the literature and their own files...
  13. ncbi Update on the pathology and genetics of exocrine pancreatic tumors with ductal phenotype: precursor lesions and new tumor entities
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Dig Dis 19:15-23. 2001
    ....
  14. ncbi [Solid pseudopapillary neoplasms. Enigmatic entity with female preponderance]
    M Kosmahl
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:41-5. 2005
    ..Predicting malignancy histologically is not yet possible. The most important differential diagnosis to consider is neuroendocrine tumor of the pancreas. The etiology and pathogenesis of SPN are obscure...
  15. ncbi [Cystic pancreas tumors and their classification: features old and new]
    M Kosmahl
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:22-30. 2005
    ..This review discusses the most important cystic tumors and tumor-like lesions, presents a new classification, and summarizes the immunohistochemical differential diagnosis...
  16. ncbi Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis
    J Luttges
    Departments of Pathology and Surgery, University of Kiel, Kiel University of Bochum, Bochum, Germany
    Am J Pathol 158:1677-83. 2001
    ....
  17. ncbi Expression of the tumor suppressor gene Maspin in human pancreatic cancers
    N Maass
    Department of Gynecologic Oncology, University of Kiel, 24105 Kiel, Germany
    Clin Cancer Res 7:812-7. 2001
    ..In addition, the detection of maspin in pancreatic tumor tissues and its lack of expression in all normal pancreatic tissues suggests that maspin may be a useful marker of primary human pancreatic cancer...
  18. ncbi [Intraductal neoplasms of the pancreas: cystic and common]
    G Kloppel
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:31-6. 2005
    ..Currently, IPMNs have advanced to the most commonly resected cystic tumor of the pancreas. Recent studies have shown that IPMNs may be distinguished into different types showing a different biology according to their mucin pattern...
  19. ncbi Genetic imbalances in precursor lesions of endometrial cancer detected by comparative genomic hybridization
    M Kiechle
    Departments of Gynecology and Obstetrics and Pathology, University of Kiel, Germany
    Am J Pathol 156:1827-33. 2000
    ..This analysis provides evidence that tumorigenesis proceeds through the accumulation of a series of genetic alterations and suggests a stepwise mode of tumorigenesis...
  20. ncbi [Spectrum of chronic pancreatitis. On the way to etiological classification]
    G Kloppel
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:59-66. 2005
    ..A catalog of five criteria is presented for distinguishing chronic pancreatitis from ductal adenocarcinoma of the pancreas...
  21. ncbi Radiation exposure to the personnel in the operating room and in the pathology due to SLN detection with Tc-99m-nanocolloid in breast cancer patients
    W Brenner
    Kliniken für Nuklearmedizin, Christian Albrechts Universitat zu Kiel
    Nuklearmedizin 39:142-5. 2000
    ..AIM of this study was to assess the radiation exposure for the personnel in the operating room and in the pathology laboratories caused by radioguided SLN localization in breast cancer...
  22. ncbi [Lymph scintigraphy and pre- and intraoperative gamma probe measurements for localization of sentinel lymph nodes (SLN) in breast cancer]
    W Brenner
    Kliniken für Nuklearmedizin, Christian Albrechts Universitat zu Kiel
    Nuklearmedizin 39:82-7. 2000
    ..Aim of this study was to prove the clinical value of nuclear medicine procedures to detect the sentinel lymph node (SLN) for SLN biopsy...
  23. ncbi Autoimmune pancreatitis: pathological, clinical, and immunological features
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreas 27:14-9. 2003
    ..Hence, the term autoimmune pancreatitis has been introduced and will be used in this review...
  24. ncbi Recurrence of primary biliary cirrhosis after orthotopic liver transplantation
    Roland Kurdow
    Clinic for General and Thoracic Surgery, University Clinic, Christian Albrechts University, Arnold Heller Str 7, 24105 Kiel, Germany
    Hepatogastroenterology 50:322-5. 2003
    ....
  25. ncbi Autoimmune pancreatitis: pathological findings
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    JOP 6:97-101. 2005
    ..Autoimmune pancreatitis most commonly involves the head of the pancreas and the distal bile duct. Occasionally, masses are formed and it has been described as an inflammatory myofibroblastic tumor...
  26. ncbi The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Curr Gastroenterol Rep 6:111-8. 2004
    ..Molecular studies have revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma...
  27. ncbi WHO-classification 2000: exocrine pancreatic tumors
    G Kloppel
    Department of Pathology, University of Kiel
    Verh Dtsch Ges Pathol 85:219-28. 2001
    ....
  28. ncbi Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal
    M Kosmahl
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 445:168-78. 2004
    ..This classification is easy to handle and enables a distinction on the basis of clinical behavior and prognosis...
  29. ncbi Primary orbital leiomyoma and leiomyosarcoma
    B Wiechens
    Department of Ophthalmology, Head and Neck Surgery, Orbital Center, Kiel, Germany
    Ophthalmologica 213:159-64. 1999
    ..After exenteration histologic examination showed a dedifferentiated highly malignant soft tissue tumor which expressed desmin and smooth muscle actin but was negative for myoglobin, S-100 and HMB-45...
  30. ncbi The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis)
    E Stuber
    I Medizinische Universitätsklinik, Kiel, Germany
    Eur J Clin Invest 30:594-9. 2000
    ..g. celiac disease, Crohn's disease, ulcerative colitis) we investigated, in a first line of experiments, the expression of OX40 in biopsy specimens of patients suffering from these diseases...
  31. ncbi Idiosyncratic drug allergic phenprocoumon-induced hepatitis with subacute liver failure initially misdiagnosed as autoimmune hepatitis
    H Hinrichsen
    First Dept of Medicine, Christian Albrechts University, Kiel, Germany
    Scand J Gastroenterol 36:780-3. 2001
    ..Coumarin anticoagulants are known to cause hepatotoxicity, but only a few cases have been reported. Coumarins are usually administered following cardiovascular surgery and the differential diagnosis is post-transfusion hepatitis...
  32. ncbi Precursor lesions of invasive breast cancer
    Ingrid Schreer
    Breast Center, University Hospital Kiel, Kiel, Germany
    Eur J Radiol 54:62-71. 2005
    ..The clinical importance of the various grades has to be assessed. Intimate cooperation between diagnostic radiologist and pathologist is essential...
  33. ncbi Dentigerous cyst versus unicystic ameloblastoma--differential diagnosis in routine histology
    Anton Dunsche
    Department of Oral and Maxillofacial Surgery, University of Kiel, D-24105 Kiel, Germany
    J Oral Pathol Med 32:486-91. 2003
    ..Thus, unicystic ameloblastomas are not misdiagnosed if only two slides are prepared for routine diagnosis of DCs...
  34. ncbi Mucinous nonneoplastic cyst of the pancreas: a novel nonneoplastic cystic change?
    Markus Kosmahl
    Department of Pathology, University of Kiel, Kiel, Germany
    Mod Pathol 15:154-8. 2002
    ..Because they may represent a nonneoplastic cystic change of the pancreas, we propose the descriptive term mucinous nonneoplastic cyst for these tumors of unknown pathogenesis...