Albert C Ludolph

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. doi request reprint Amyotrophic lateral sclerosis
    Albert C Ludolph
    Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany
    Curr Opin Neurol 25:530-5. 2012
  2. pmc Implementation of a population-based epidemiological rare disease registry: study protocol of the amyotrophic lateral sclerosis (ALS)--registry Swabia
    Gabriele Nagel
    Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr, 22, Ulm 89081, Germany
    BMC Neurol 13:22. 2013
  3. pmc A biochemical marker panel in MRI-proven hyperacute ischemic stroke-a prospective study
    Carolin Knauer
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89075 Ulm, Germany
    BMC Neurol 12:14. 2012
  4. pmc A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1
    Anissa Fergani
    INSERM U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F 67085 France
    Mol Neurodegener 6:26. 2011
  5. pmc Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tuebingen, Germany
    J Neurol 256:1337-42. 2009
  6. pmc Cardiac involvement in patients with Becker muscular dystrophy: new diagnostic and pathophysiological insights by a CMR approach
    Ali Yilmaz
    Division of Cardiology, Robert Bosch Krankenhaus, Stuttgart, Germany
    J Cardiovasc Magn Reson 10:50. 2008
  7. ncbi request reprint Preclinical trials--an update on translational research in ALS
    Albert C Ludolph
    Department of Neurology, University of Ulm, Ulm, Germany
    Neurodegener Dis 2:215-9. 2005
  8. ncbi request reprint Matrix metalloproteinases--a conceptional alternative for disease-modifying strategies in ALS/MND?
    Albert C Ludolph
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, Ulm, Germany
    Exp Neurol 201:277-80. 2006
  9. pmc Evidence-based drug treatment in amyotrophic lateral sclerosis and upcoming clinical trials
    Albert C Ludolph
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Ther Adv Neurol Disord 2:319-26. 2009
  10. pmc Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
    A C Ludolph
    Department of Neurology, University of Ulm, Ulm, Germany
    Eur J Neurol 16:297-309. 2009

Detail Information

Publications111 found, 100 shown here

  1. doi request reprint Amyotrophic lateral sclerosis
    Albert C Ludolph
    Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany
    Curr Opin Neurol 25:530-5. 2012
    ..The field of amyotrophic lateral sclerosis (ALS) has seen a number of remarkable advances during recent years that will be summarized in this review...
  2. pmc Implementation of a population-based epidemiological rare disease registry: study protocol of the amyotrophic lateral sclerosis (ALS)--registry Swabia
    Gabriele Nagel
    Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr, 22, Ulm 89081, Germany
    BMC Neurol 13:22. 2013
    ..The objective of this work is to describe the study protocol and the implementation steps of the amyotrophic lateral sclerosis (ALS) registry Swabia, located in the South of Germany...
  3. pmc A biochemical marker panel in MRI-proven hyperacute ischemic stroke-a prospective study
    Carolin Knauer
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89075 Ulm, Germany
    BMC Neurol 12:14. 2012
    ..Our aim was to prove whether the panel is a reliable indicating device for the diagnosis of ischemic stroke in a time window of 6 h to fasten the pre- and intrahospital pathway to fibrinolysis...
  4. pmc A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1
    Anissa Fergani
    INSERM U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F 67085 France
    Mol Neurodegener 6:26. 2011
    ..abstract:..
  5. pmc Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tuebingen, Germany
    J Neurol 256:1337-42. 2009
    ....
  6. pmc Cardiac involvement in patients with Becker muscular dystrophy: new diagnostic and pathophysiological insights by a CMR approach
    Ali Yilmaz
    Division of Cardiology, Robert Bosch Krankenhaus, Stuttgart, Germany
    J Cardiovasc Magn Reson 10:50. 2008
    ..Cardiovascular magnetic resonance (CMR) has the potential to detect cardiac involvement by depicting early scar formation that may appear before onset of wall motion abnormalities...
  7. ncbi request reprint Preclinical trials--an update on translational research in ALS
    Albert C Ludolph
    Department of Neurology, University of Ulm, Ulm, Germany
    Neurodegener Dis 2:215-9. 2005
    ....
  8. ncbi request reprint Matrix metalloproteinases--a conceptional alternative for disease-modifying strategies in ALS/MND?
    Albert C Ludolph
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, Ulm, Germany
    Exp Neurol 201:277-80. 2006
  9. pmc Evidence-based drug treatment in amyotrophic lateral sclerosis and upcoming clinical trials
    Albert C Ludolph
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Ther Adv Neurol Disord 2:319-26. 2009
    ..We review treatment development in motor neuron disease and discuss the strengths and limitations of past as well as upcoming clinical trials...
  10. pmc Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
    A C Ludolph
    Department of Neurology, University of Ulm, Ulm, Germany
    Eur J Neurol 16:297-309. 2009
    ....
  11. doi request reprint Guidelines for preclinical animal research in ALS/MND: A consensus meeting
    Albert C Ludolph
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler 11:38-45. 2010
    ..A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott...
  12. doi request reprint MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS
    Lubin Fang
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol Sci 294:51-6. 2010
    ..Our data raises the question whether the skin may function as a biomarker for specific aspects of disease pathology in ALS...
  13. pmc Eye movement impairments in Parkinson's disease: possible role of extradopaminergic mechanisms
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    BMC Neurol 12:5. 2012
    ..However, the present study suggest that dopamine substitution is much less effective in improving oculomotor performance than it is in restoring skeletomotor abilities...
  14. pmc Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis
    Petra Steinacker
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 6:e23600. 2011
    ..We aimed to test whether soluble fragments of beta-amyloid precursor protein (sAPPα and sAPPß) correlated with clinical subtypes of ALS and were of prognostic value...
  15. doi request reprint Intersubject variability in the analysis of diffusion tensor images at the group level: fractional anisotropy mapping and fiber tracking techniques
    Hans Peter Müller
    Department of Neurology, University of Ulm, D 89081 Ulm, Germany
    Magn Reson Imaging 27:324-34. 2009
    ..The objective of the present study was to optimize technical approaches for this preservation of quantitative and directional information during spatial normalization in data analyses at the group level...
  16. doi request reprint The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes
    Marianne Stockmann
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neural Transm 120:785-98. 2013
    ..Our results suggest the presence of biological changes caused by some p150 mutants pointing to a potential pathogenetic significance as modifier of the phenotype of the human disease...
  17. doi request reprint Are amygdalar volume alterations in children with Tourette syndrome due to ADHD comorbidity?
    Andrea G Ludolph
    Department of Child and Adolescent Psychiatry, University of Ulm, Oberer Eselsberg 45, Ulm, Germany
    Dev Med Child Neurol 50:524-9. 2008
    ..Future studies should investigate if the involvement of the amygdala is due to TS or rather caused by the genetically-linked most frequent comorbidity ADHD...
  18. doi request reprint Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS)
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neurosci Lett 468:23-7. 2010
    ..We aimed to identify a characteristic CSF protein pattern that could provide new candidate biomarkers of disease progression in ALS...
  19. doi request reprint Functional connectivity within the default mode network is associated with saccadic accuracy in Parkinson's disease: a resting-state FMRI and videooculographic study
    Martin Gorges
    Department of Neurology, University of Ulm, Ulm, Germany
    Brain Connect 3:265-72. 2013
    ..These results suggest that PD-associated changes of DMN connectivity are correlated with PD-associated saccadic hypometria, in particular in the vertical direction...
  20. pmc The cerebro-morphological fingerprint of a progeroid syndrome: white matter changes correlate with neurological symptoms in xeroderma pigmentosum
    Jan Kassubek
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 7:e30926. 2012
    ..It has recently been shown that the underlying DNA repair defect plays a central role in the aging process. In addition to skin symptoms, various premature neurological abnormalities have been reported...
  21. doi request reprint Directional colour encoding of the human thalamus by diffusion tensor imaging
    Alexander Unrath
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    Neurosci Lett 434:322-7. 2008
    ..In summary, substantial neuroanatomical information can be gained for deep subcortical gray matter structures such as the thalamus with an improved detection and directional differentiation of voxel-specific tensors...
  22. ncbi request reprint Classification of phenotype characteristics in adult-onset spinal muscular atrophy
    Hans Jürgen Gdynia
    Department of Neurology, University of Ulm, Ulm, Germany
    Eur Neurol 58:170-6. 2007
    ..In a recently proposed classification, LMND were subdivided according to the clinical disease pattern and time course. This study was performed to investigate the clinical practicability of the classification...
  23. ncbi request reprint Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS)
    Dorothee Lule
    Department of Neurophysiology, University of Ulm, Albert Einstein Allee 47, 89081 Ulm, Germany
    J Neurol 254:519-27. 2007
    ..The reduction of activity in extrastriate visual areas might be similarly interpreted. The increased brain response in the right supramarginal area of ALS patients might represent an altered sensitivity to social-emotional cues...
  24. pmc Signal alterations of the basal ganglia in the differential diagnosis of Parkinson's disease: a retrospective case-controlled MRI data bank analysis
    Sarah Jesse
    Department of Neurology, University of Ulm, Germany
    BMC Neurol 12:163. 2012
    ....
  25. doi request reprint Differential diagnostic value of eye movement recording in PSP-parkinsonism, Richardson's syndrome, and idiopathic Parkinson's disease
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, Ulm, Germany
    J Neurol 255:1916-25. 2008
    ....
  26. doi request reprint Comparison of smooth pursuit eye movement deficits in multiple system atrophy and Parkinson's disease
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol 256:1438-46. 2009
    ..The differences in pursuit tracking between PD and MSA were large enough to warrant their use as ancillary diagnostic criteria for the distinction between these disorders...
  27. doi request reprint Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging
    Alexander Unrath
    Department of Neurology, University of Ulm, Ulm, Germany
    Mov Disord 23:1250-5. 2008
    ....
  28. ncbi request reprint Neurofilament heavy-chain NfH(SMI35) in cerebrospinal fluid supports the differential diagnosis of Parkinsonian syndromes
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Ulm, Germany
    Mov Disord 21:2224-7. 2006
    ..CSF NfH(SMI35) may therefore be of some value for the laboratory-supported differential diagnosis of atypical parkinsonian syndromes...
  29. doi request reprint Neuroanatomical patterns of cerebral white matter involvement in different motor neuron diseases as studied by diffusion tensor imaging analysis
    Hans Peter Müller
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler 13:254-64. 2012
    ..For potential future developments in MRI diagnostics in MND, a (perhaps multiparametric) ROI-based approach should include CST and the CC motor segment...
  30. doi request reprint Rate of change in early Huntington's disease: a clinicometric analysis
    Christina Meyer
    Department of Neurology, University of Ulm, Ulm, Germany
    Mov Disord 27:118-24. 2012
    ..It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies...
  31. pmc Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases
    Sarah Jesse
    Department of Neurology, University of Ulm, Steinhovelstr 1, 89075, Ulm, Germany
    J Neurol 258:1034-41. 2011
    ..Extensive elevation of routine parameters is not characteristic and should encourage a re-evaluation of the clinical diagnosis...
  32. doi request reprint Deep brain stimulation and behavioural changes: is comedication the most important factor?
    Dorothee Lule
    Department of Neurology, University of Ulm, Germany dorothee lule uni ulm de
    Neurodegener Dis 9:18-24. 2012
    ..Deep brain stimulation (DBS) is increasingly used for the treatment of parkinsonian motor symptoms, but the excellent efficacy of DBS contrasts with a growing number of reports that the treatment may result in behavioural complications...
  33. doi request reprint Proteome analysis of cerebrospinal fluid in amyotrophic lateral sclerosis (ALS)
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    Neurochem Res 33:2358-63. 2008
    ..Further evaluation of the candidate proteins identified here is necessary...
  34. doi request reprint Complementary image analysis of diffusion tensor imaging and 3-dimensional t1-weighted imaging: white matter analysis in amyotrophic lateral sclerosis
    Hans Peter Müller
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neuroimaging 21:24-33. 2011
    ..in order to obtain detailed information on disease-associated changes in the integrity of cerebral white matter (WM), complementary image analysis (CIA) was applied to patients with amyotrophic lateral sclerosis (ALS) and controls...
  35. ncbi request reprint Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: a voxel-based morphometric study
    Jan Kassubek
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler 8:328-36. 2007
    ..It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP...
  36. ncbi request reprint Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop
    Albert C Ludolph
    Department of Neurology, University of Ulm, Ulm, Germany
    Amyotroph Lateral Scler 8:217-23. 2007
    ..In this workshop, clinical and preclinical researchers established in the field of ALS/MND met in Holland in March 2006 in order to establish guidelines for the community for drug testing in mouse models...
  37. doi request reprint Whole brain-based analysis of regional white matter tract alterations in rare motor neuron diseases by diffusion tensor imaging
    Alexander Unrath
    Department of Neurology, University of Ulm, Ulm, Germany
    Hum Brain Mapp 31:1727-40. 2010
    ..Future advanced MRI-based investigations might help to provide a fingerprint-identification of MNDs...
  38. ncbi request reprint Cortical plasticity in amyotrophic lateral sclerosis: motor imagery and function
    Dorothee Lule
    Section of Neurophysiology, Univeristy of Ulm, Ulm, Germany
    Neurorehabil Neural Repair 21:518-26. 2007
    ..Cortical networks underlying motor imagery are functionally close to motor performance networks and can be activated by patients with severe motor disabilities...
  39. doi request reprint Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes
    Sigurd D Sussmuth
    Department of Neurology, University of Ulm, Ulm, Germany
    Mov Disord 25:1284-8. 2010
    ..In conclusion, this preliminary data show that changes in CSF tau and Abeta1-42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes...
  40. doi request reprint Amygdala size reduction is associated with memory deficits in complicated hereditary spastic paraparesis: an MRI study
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, Ulm, Germany
    Eur Neurol 64:117-23. 2010
    ..Our findings of disproportional amygdalar atrophy only in cHSP substantiate the association of morphologically assessable cerebral degeneration with cognitive impairment in cHSP...
  41. doi request reprint MRI allows for longitudinal quantitative analysis of body fat composition in rats: an analysis of sibutramine-associated changes at the group level
    Hans Peter Müller
    Department of Neurology, University of Ulm, Ulm, Germany
    Magn Reson Imaging 31:1150-5. 2013
    ..Standard T1-weighted (T1w) whole body MRI was used here to quantify different effects in the subcutaneous and visceral fat compartments in rats under treatment with an anorexiant...
  42. pmc Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    Ann Neurol 74:20-38. 2013
    ..To see whether the distribution patterns of phosphorylated 43kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages...
  43. pmc Diffusion tensor imaging and tractwise fractional anisotropy statistics: quantitative analysis in white matter pathology
    Hans Peter Mueller
    Department of Neurology, University of Ulm, Ulm, Germany
    Biomed Eng Online 6:42. 2007
    ..Information on anatomical connectivity in the brain by measurements of the diffusion of water in white matter tracts lead to quantification of local tract directionality and integrity...
  44. pmc A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons
    Kerstin E Braunstein
    Department of Neurology, University of Ulm, Ulm, Germany
    Hum Mol Genet 19:4385-98. 2010
    ..Our study supports a role for dynein dysfunction in the pathogenesis of neurodegenerative disorders of the basal ganglia, such as Perry syndrome and HD...
  45. pmc The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 5:e11986. 2010
    ....
  46. ncbi request reprint Biochemical markers in CSF of ALS patients
    Sigurd D Sussmuth
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, D 89081 Ulm, Germany
    Curr Med Chem 15:1788-801. 2008
    ..In this review, an updated overview is given on CSF biomarkers related to the pathomechanisms supposed to be participating in the complex disease process of ALS...
  47. doi request reprint MRI-based functional neuroimaging in ALS: an update
    Dorothee Lule
    Section of Neurophysiology, Department of Neurology, University of Ulm, Albert Einstein Allee 47, Ulm, Germany
    Amyotroph Lateral Scler 10:258-68. 2009
    ....
  48. doi request reprint PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis
    Judith Eschbach
    Neurology, Ulm University, 89081 Ulm, Germany
    Hum Mol Genet 22:3477-84. 2013
    ..In summary, we indentify PGC-1α as a novel and clinically relevant disease modifier of human and experimental ALS and report a sex-dependent effect of PGC-1α in this neurodegenerative disorder. ..
  49. doi request reprint Body fat distribution as a risk factor for cerebrovascular disease: an MRI-based body fat quantification study
    Hanna Sofia Karcher
    Department of Neurology, University of Ulm, Ulm, Germany
    Cerebrovasc Dis 35:341-8. 2013
    ....
  50. doi request reprint A novel optineurin truncating mutation and three glaucoma-associated missense variants in patients with familial amyotrophic lateral sclerosis in Germany
    Jochen H Weishaupt
    Department of Neurology, Ulm University, Ulm, Germany
    Neurobiol Aging 34:1516.e9-15. 2013
    ..Finally, our findings show that motoneurons and retinal ganglion cells, which are both projecting central nervous system neurons, might share common susceptibility factors...
  51. doi request reprint Signs of impaired selective attention in patients with amyotrophic lateral sclerosis
    Elmar H Pinkhardt
    Dept of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Neurol 255:532-8. 2008
    ..We conclude impaired selective attention reflects a subtle variant of frontotemporal dementia frequently observed in ALS patients at a relatively early stage of the disease...
  52. doi request reprint Intensified testing for attention-deficit hyperactivity disorder (ADHD) in girls should reduce depression and smoking in adult females and the prevalence of ADHD in the longterm
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, Germany
    Med Hypotheses 72:409-12. 2009
    ....
  53. doi request reprint Histopathological analysis of skeletal muscle in patients with Parkinson's disease and 'dropped head'/'bent spine' syndrome
    Hans Jürgen Gdynia
    University of Ulm, Dept of Neurology, Oberer Eselsberg 45, 89081 Ulm, Germany
    Parkinsonism Relat Disord 15:633-9. 2009
    ..Similar symptoms are known in patients with parkinsonian syndromes, but their pathophysiology remains unclear. One hypothesis is a relation between the movement disorder and the skeletal muscle pathology...
  54. doi request reprint The epidemiology of CuZn-SOD mutations in Germany: a study of 217 families
    Malessa Rabe
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Neurol 257:1298-302. 2010
    ..The L144F mutation, which is the most prevalent mutation in the Balkan countries, and the D90A mutation which is the most frequent SOD1 mutation globally, seem to be the second most common disease-causing mutations in Germany...
  55. doi request reprint Hypercapnia is a possible determinant of the function of the blood-cerebrospinal fluid barrier in amyotrophic lateral sclerosis
    Sigurd D Sussmuth
    Department of Neurology, Neurologische Klinik der Universität Ulm, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    Neurochem Res 35:1071-4. 2010
    ..In ALS, an important underlying mechanism might be the influence of the arterial pCO(2) which may alter the CSF flow...
  56. doi request reprint Neuroectodermally converted human mesenchymal stromal cells provide cytoprotective effects on neural stem cells and inhibit their glial differentiation
    Hans Jörg Habisch
    Department of Neurology, University of Ulm, Ulm, Germany
    Cytotherapy 12:491-504. 2010
    ..In recent years, bone marrow (BM)-derived mesenchymal stromal cells (MSC) have become a promising source for neuroregenerative therapies. We evaluated the trophic effects of neuroectodermally converted MSC (mNSC) on neural stem cells (NSC)...
  57. ncbi request reprint Vacuolization correlates with spin-spin relaxation time in motor brainstem nuclei and behavioural tests in the transgenic G93A-SOD1 mouse model of ALS
    Selina Bucher
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Eur J Neurosci 26:1895-901. 2007
    ..Finally, our data suggest that MRI does not only resemble the findings of behavioural tests, but is potentially superior to behavioural studies...
  58. ncbi request reprint Severe sensorimotor neuropathy after intake of highest dosages of vitamin B6
    Hans Jürgen Gdynia
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neuromuscul Disord 18:156-8. 2008
    ..The unique aspect of this case is the muscle weakness and motor findings on electrophysiological testing in what is suggested by the literature to be a pure sensory neuronopathy...
  59. doi request reprint Full-length PGC-1α salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation
    Krisztina Ròna-Vörös
    Department of Neurology, Ulm University, 89081 Ulm, Germany
    Hum Mol Genet 22:5096-106. 2013
    ..NT-PGC-1α cannot fulfil this protective action. Activation of this endogenous salvage pathway might thus be a valuable therapeutic target for diseases involving mitochondrial dysfunction. ..
  60. pmc Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study
    Hans Peter Müller
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 8:e67630. 2013
    ..The objective of this study was to apply this DTI approach at the group level to β-amyloid precursor protein (APP) transgenic mice...
  61. pmc Fast diffusion tensor magnetic resonance imaging of the mouse brain at ultrahigh-field: aiming at cohort studies
    Hans Peter Müller
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 7:e53389. 2012
    ..It is the objective of this study to enable fast DTI of the mouse brain. In this context, CCRs appear attractive for SNR improvement...
  62. doi request reprint Parkinson's disease-like midbrain hyperechogenicity is frequent in amyotrophic lateral sclerosis
    Panteha Fathinia
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Neurol 260:454-7. 2013
    ..These findings are important for the diagnosis and differential diagnosis of PD and ALS alike...
  63. ncbi request reprint Global brain atrophy and corticospinal tract alterations in ALS, as investigated by voxel-based morphometry of 3-D MRI
    Jan Kassubek
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:213-20. 2005
    ..VBM might be a potential tool to visualize disease progression in future longitudinal studies...
  64. doi request reprint Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, Center for Clinical Research, University of Ulm, Germany
    Acta Neuropathol 122:577-89. 2011
    ..Moreover, the association of the GVD stages with those of AD-related pathology but not with other neurodegenerative disorders points to a possible role of GVD and the response to chronic stress in the pathogenesis of AD...
  65. doi request reprint Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
    ..This novel model is particularly suited to decipher the underlying mechanisms and to develop hopefully novel connective tissue-specific anti-aging strategies...
  66. doi request reprint Neuroimaging of multimodal sensory stimulation in amyotrophic lateral sclerosis
    Dorothee Lule
    Section of Neurophysiology, University of Ulm, Ulm, Germany
    J Neurol Neurosurg Psychiatry 81:899-906. 2010
    ..Structural and functional imaging techniques were combined to investigate sensory system function in amyotrophic lateral sclerosis (ALS)...
  67. doi request reprint Cerebrospinal fluid markers of idiopathic intracranial hypertension: is the renin-angiotensinogen system involved?
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, Ulm, Germany
    Cephalalgia 31:116-21. 2011
    ..The causes underlying idiopathic intracranial hypertension (IIH) are poorly understood...
  68. doi request reprint Whole brain-based computerized neuroimaging in ALS and other motor neuron disorders
    Julian Grosskreutz
    Department of Neurology, Friedrich Schiller University Jena, Jena, Germany
    Amyotroph Lateral Scler 9:238-48. 2008
    ..Here, the technical state-of-the-art and the results of VBM and DTI studies in MND as the current state are reviewed, and future perspectives for further neuroimaging applications are highlighted...
  69. ncbi request reprint Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study
    Alexander Unrath
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    J Neurol 254:1099-106. 2007
    ....
  70. ncbi request reprint Primary progressive aphasia accompanied by environmental sound agnosia: a neuropsychological, MRI and PET study
    Ingo Uttner
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Psychiatry Res 146:191-7. 2006
    ..These neuropsychological findings were found to be associated with distinct focal alterations in functional and structural neuroimaging...
  71. ncbi request reprint Erythropoietin in cerebrospinal fluid: age-related reference values and relevance in neurological disease
    Karin Widl
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    Neurochem Res 32:1163-8. 2007
    ..The establishment of age-related reference values in a large cohort of controls will improve the interpretation of future CSF EPO evaluations in neurological diseases...
  72. doi request reprint Cerebrospinal fluid biomarkers of neurodegeneration in chronic neurological diseases
    Hayrettin Tumani
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Expert Rev Mol Diagn 8:479-94. 2008
    ..We review recent advances in CSF biomarkers research in CND and thereby focus on markers associated with neurodegeneration...
  73. pmc IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 4:e7638. 2009
    ..We aimed to evaluate the relevance of MRZR to predict conversion of patients with clinically isolated syndrome (CIS) to MS, and to compare it to oligoclonal bands (OCB) and MRI...
  74. doi request reprint Linking neuron and skin: matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)
    Lubin Fang
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Neurol Sci 285:62-6. 2009
    ..Our findings indicate a general upregulation of MMP-9 in ALS. MMP-9 seems to play a role in both neurodegeneration and skin changes in ALS and could thus be a common factor linking otherwise distant aspects of disease pathology...
  75. ncbi request reprint Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model
    Stefan Waibel
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    J Neurol 251:1080-4. 2004
    ..Therefore, we conclude that the combination of rasagiline and riluzole is a promising clinical combination for the improvement of current neuroprotective treatment strategies of ALS...
  76. doi request reprint Emotional adjustment in amyotrophic lateral sclerosis (ALS)
    Dorothee Lule
    Section of Neurophysiology, University of Ulm, Albert Einstein Allee 47, 89081, Ulm, Germany
    J Neurol 259:334-41. 2012
    ..Overall, in terminally ill patients the psychological response to the prognosis is not associated with neurobiological changes (e.g., associated with subclinical deficits in ALS) or with physical decline...
  77. pmc Amygdala size in amyotrophic lateral sclerosis without dementia: an in vivo study using MRI volumetry
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, Ulm, Germany
    BMC Neurol 6:48. 2006
    ..The aim of this study was to investigate possible alterations of amygdala volumes in vivo...
  78. doi request reprint Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD
    Elena Lebedeva
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany
    Neurobiol Aging 33:201.e9-18. 2012
    ..A better understanding of genetic influences on biomarkers like CSF Aβ42 might help to stratify patients and develop specific treatment strategies...
  79. ncbi request reprint Motor protein diseases of the nervous system
    C Oliver Hanemann
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:197-201. 2005
    ..This is likely to add to the understanding of motor neuron disease and may be relevant in terms of future therapeutic approaches...
  80. ncbi request reprint Cerebrospinal fluid erythropoietin (EPO) in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neurosci Lett 416:257-60. 2007
    ..Low concentrations of CSF EPO seem to point towards a rapid progression of disease that may be associated with a poorer prognosis...
  81. doi request reprint Candidate biomarkers of chronic inflammatory demyelinating polyneuropathy (CIDP): proteome analysis of cerebrospinal fluid
    Hayrettin Tumani
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neuroimmunol 214:109-12. 2009
    ..The pathophysiological role of these proteins remains to be clarified by further studies...
  82. doi request reprint Quantification of human body fat tissue percentage by MRI
    Hans Peter Müller
    Department of Neurology, University of Ulm, Ulm, Germany
    NMR Biomed 24:17-24. 2011
    ..The techniques presented in this study are likely to be of use in obesity-related investigations, as well as in the examination of longitudinal changes in weight during various medical conditions...
  83. doi request reprint Connective tissue disorders in dissections of the carotid or vertebral arteries
    Hans Jürgen Gdynia
    University of Ulm, Department of Neurology, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Clin Neurosci 15:489-94. 2008
    ..However, in some of these patients ultrastructural connective tissue changes can be detected. An overview of connective tissue disorders associated with dissections of the carotid or vertebral arteries is presented...
  84. ncbi request reprint Spastin related hereditary spastic paraplegia with dysplastic corpus callosum
    Burkhard Alber
    Department of Neurology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neurol Sci 236:9-12. 2005
    ..We conclude that apparently pure HSP may present with MRI features of dysplastic CC. This finding extended the spastin-related phenotype which is distinct from previous reports of thin CC in HSP...
  85. doi request reprint Levodopa-induced striatal activation in Parkinson's disease: a functional MRI study
    Eduard Kraft
    Department of Neurology, University of Ulm, Ulm, Germany
    Parkinsonism Relat Disord 15:558-63. 2009
    ..To assess the effect of a single levodopa dose (200 mg levodopa, 50 mg carbidopa=sdLD) on cortical and subcortical motor-circuit activation during bimanual grip force in patients with Parkinson's disease (PD)...
  86. ncbi request reprint Frequency of a tau genotype in amyotrophic lateral sclerosis
    Christoph Munch
    Department of Neurology, Jewish Hospital, Heinz Galinski Strasse 1, 13347 Berlin, Germany
    J Neurol Sci 236:13-6. 2005
    ..There was no association of the A0/A0 genotype with the age and site of disease onset or the presence of dementia. The studied tau genotype may contribute to the multifactorial genetic background of ALS...
  87. ncbi request reprint Chemical hypoxia facilitates alternative splicing of EAAT2 in presymptomatic APP23 transgenic mice
    Christoph Munch
    Department of Neurology, Jewish Hospital Berlin, Heinz Galinski Str 1, 13347 Berlin, Germany
    Neurochem Res 33:1005-10. 2008
    ..Our results demonstrate that hypoxia facilitates alternative splicing of EAAT2 in the APP23 model. This may be a molecular mechanism linking vascular factors to early pathophysiology of Alzheimer's disease...
  88. ncbi request reprint Chromosomal translocation t(18;21)(q23;q22.1) indicates novel susceptibility loci for frontotemporal dementia with ALS
    Johannes Prudlo
    Department of Neurology, University Hospital, Homburg Saar, Germany
    Ann Neurol 55:134-8. 2004
    ..1. The breakpoints are assigned to sequences flanked by the markers ATA1H06, D18S462, D21S1915, and D21S1898. These critical regions may contain susceptibility loci for FTD associated with ALS...
  89. ncbi request reprint MR-pathologic comparison of the upper spinal cord in different motor neuron diseases
    Anne Dorte Sperfeld
    Department of Neurology, University of Ulm, Ulm, Germany
    Eur Neurol 53:74-7. 2005
    ..At the thoracic level, KD patients had significant upper cord atrophy as compared with controls and LMND. Marked atrophy of the upper spinal cord seems to be a feature of the KD-associated central-peripheral distal axonopathy...
  90. ncbi request reprint Emotional responding in amyotrophic lateral sclerosis
    Dorothee Lule
    University of Ulm, Dept of Neurology, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Neurol 252:1517-24. 2005
    ..These findings contradict assumptions of a generally negative impact of the disease on the emotional disposition and may indicate compensatory cognitive or neuroplastic changes...
  91. ncbi request reprint Amyotrophic lateral sclerosis: disease stage related changes of tau protein and S100 beta in cerebrospinal fluid and creatine kinase in serum
    Sigurd D Sussmuth
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neurosci Lett 353:57-60. 2003
    ..Elevation of the CSF/serum albumin quotient occurred in 20% of the cases most likely representing a non-specific finding in ALS...
  92. ncbi request reprint Longitudinal effects of noninvasive positive-pressure ventilation in patients with amyotrophic lateral sclerosis
    Miriam Butz
    Department of Neurology, University of Ulm, Ulm, Germany
    Am J Phys Med Rehabil 82:597-604. 2003
    ..To evaluate the duration of benefit on symptoms, quality of life, and survival derived from the use of noninvasive positive-pressure ventilation by patients with amyotrophic lateral sclerosis...
  93. ncbi request reprint Hereditary motor neuropathies and motor neuron diseases: which is which
    Clemens O Hanemann
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:186-9. 2002
    ....
  94. ncbi request reprint Measures of quality of life: pro
    Albert C Ludolph
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:S19. 2002
  95. ncbi request reprint Tau isoforms expression in transgenic mouse model of amyotrophic lateral sclerosis
    Ewa Usarek
    Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02 097 Warsaw, Poland
    Neurochem Res 31:597-602. 2006
    ..The decrease in 2N expression resulted in lower levels of total tau mRNA and tau protein. No changes in tau expression were observed in spinal cord of studied animals...
  96. ncbi request reprint Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    Heiko G Niessen
    Department of Neurology II, Otto von Guericke University Magdeburg, Leipziger Str 44, Magdeburg, Germany
    Eur J Neurosci 25:1669-77. 2007
    ..Overall, high-resolution (1)H-MRS allows a sensitive spatial and temporal metabolite profiling in the presymptomatic phase of ALS even before significant neuronal cell loss occurs...
  97. ncbi request reprint Age-related changes in tau expression in transgenic mouse model of amyotrophic lateral sclerosis
    Anna Baranczyk-Kuzma
    Department of Biochemistry, Medical University of Warsaw, Banacha 1, Warsaw 02 097, Poland
    Neurochem Res 32:415-21. 2007
    ..It can be concluded that the SOD1 G93A mutation causes early alterations of tau expression in cns, which are not exclusively restricted to the upper and lower motor neuron...
  98. ncbi request reprint In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient
    Heiko G Niessen
    Department of Neurology II, Otto von Guericke University Magdeburg, Leipziger Str 44, Magdeburg, Germany
    Exp Neurol 201:293-300. 2006
    ..While both T2 and ADC might prove useful as progression markers and enable the longitudinal non-invasive evaluation of ALS in G93A-SOD1 mice, the potential is limited by age-dependent effects in case of ADC mapping...
  99. pmc Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit
    Rohini Kuner
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 102:5826-31. 2005
    ....
  100. ncbi request reprint Age-dependent changes in MRI of motor brain stem nuclei in a mouse model of ALS
    Frank Angenstein
    Leibniz Institute for Neurobiology, Special Lab Non Invasive Brain Imaging, Brenneckestr 6, 39118 Magdeburg, Germany
    Neuroreport 15:2271-4. 2004
    ..Here, we demonstrate that in G93A-SOD1 mice the MRI signal intensities of nucleus V, VII, XII, and nucleus ambiguus show a time-dependent increase starting around day 90, parallel to first behavioral signs of a motoneuron disorder...
  101. ncbi request reprint Seroprevalence of Borna disease virus antibodies is not increased in patients with amyotrophic lateral sclerosis
    Johannes Prudlo
    J Neurol 249:1462-3. 2002