Norbert Lubenow

Summary

Affiliation: University of Greifswald
Country: Germany

Publications

  1. ncbi request reprint Very low platelet counts in post-transfusion purpura falsely diagnosed as heparin-induced thrombocytopenia. Report of four cases and review of literature
    N Lubenow
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Thromb Res 100:115-25. 2000
  2. ncbi request reprint Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use
    Norbert Lubenow
    Institute of Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Ann Thorac Surg 75:577-9. 2003
  3. ncbi request reprint New developments in diagnosis and treatment of heparin-induced thrombocytopenia
    Norbert Lubenow
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat Greifswald, Germany
    Pathophysiol Haemost Thromb 33:407-12. 2003
  4. ncbi request reprint Should patients be informed about the risk of heparin-induced thrombocytopenia before prolonged low-molecular-weight heparin thromboprophylaxis post-trauma/orthopedic surgery?
    Norbert Lubenow
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Eur J Haematol 79:187-90. 2007
  5. ncbi request reprint [Hirudins in the treatment of heparin-induced thrombocytopenia and in thrombosis prophylaxis]
    N Lubenow
    Ernst Moritz Arndt Universitat, Institut für Immunologie und Transfusionsmedizin, Abt Transfusionsmedizin, Greifswald, Germany
    Hamostaseologie 22:44-54. 2002
  6. ncbi request reprint Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia
    David Juhl
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Eur J Haematol 76:420-6. 2006
  7. doi request reprint The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia
    Norbert Lubenow
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat, Greifswald
    Blood 115:1797-803. 2010
  8. ncbi request reprint Hirudin in heparin-induced thrombocytopenia
    Norbert Lubenow
    Ernst Moritz Arndt University, Greifswald, Germany
    Semin Thromb Hemost 28:431-8. 2002
  9. ncbi request reprint Results of a systematic evaluation of treatment outcomes for heparin-induced thrombocytopenia in patients receiving danaparoid, ancrod, and/or coumarin explain the rapid shift in clinical practice during the 1990s
    Norbert Lubenow
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Thromb Res 117:507-15. 2006
  10. ncbi request reprint Platelet receptor and clotting factor polymorphisms as genetic risk factors for thromboembolic complications in heparin-induced thrombocytopenia
    Lena E Carlsson
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Pharmacogenetics 13:253-8. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Very low platelet counts in post-transfusion purpura falsely diagnosed as heparin-induced thrombocytopenia. Report of four cases and review of literature
    N Lubenow
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Thromb Res 100:115-25. 2000
    ..If features consistent with PTP (such as a recent blood transfusion or a marked drop in platelet count to below 15 Gpt/L) are present, we recommend parallel testing for platelet alloantibodies to rule out PTP...
  2. ncbi request reprint Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use
    Norbert Lubenow
    Institute of Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Ann Thorac Surg 75:577-9. 2003
    ..Because of interference with the international normalized ratio (INR), switching from argatroban to oral anticoagulants is not straightforward...
  3. ncbi request reprint New developments in diagnosis and treatment of heparin-induced thrombocytopenia
    Norbert Lubenow
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat Greifswald, Germany
    Pathophysiol Haemost Thromb 33:407-12. 2003
    ..Short-term reexposure with heparin, for example during cardiopulmonary bypass, is possible in patients with history of HIT, provided HIT antiodies are no longer detectable. In children systematic data on treatment of HIT are lacking...
  4. ncbi request reprint Should patients be informed about the risk of heparin-induced thrombocytopenia before prolonged low-molecular-weight heparin thromboprophylaxis post-trauma/orthopedic surgery?
    Norbert Lubenow
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Eur J Haematol 79:187-90. 2007
    ..Paradoxically, refusal of thromboprophylaxis as a result of seeking informed consent could increase risk for thrombosis...
  5. ncbi request reprint [Hirudins in the treatment of heparin-induced thrombocytopenia and in thrombosis prophylaxis]
    N Lubenow
    Ernst Moritz Arndt Universitat, Institut für Immunologie und Transfusionsmedizin, Abt Transfusionsmedizin, Greifswald, Germany
    Hamostaseologie 22:44-54. 2002
    ..While lepirudin is used widely, besides danaparoid, for treatment of HIT, desirudin has not yet been widely accepted for thrombosis prophylaxis following knee or hip replacement surgery...
  6. ncbi request reprint Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia
    David Juhl
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Eur J Haematol 76:420-6. 2006
    ..While antigen assays are very sensitive and recognize immunoglobulin (Ig)G, IgA, and IgM antibodies, the role of IgM and IgA HIT-antibodies is debated. Platelet activation assays recognize IgG and are more specific for clinical HIT...
  7. doi request reprint The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia
    Norbert Lubenow
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat, Greifswald
    Blood 115:1797-803. 2010
    ..In major trauma certoparin may be safer than UFH because it induces HIT-antibody seroconversion, and the corresponding risk of HIT, less frequently...
  8. ncbi request reprint Hirudin in heparin-induced thrombocytopenia
    Norbert Lubenow
    Ernst Moritz Arndt University, Greifswald, Germany
    Semin Thromb Hemost 28:431-8. 2002
    ..The choice between the available drugs for HIT, namely lepirudin, danaparoid, and argatroban, has to be made according to the clinical presentation of the patient...
  9. ncbi request reprint Results of a systematic evaluation of treatment outcomes for heparin-induced thrombocytopenia in patients receiving danaparoid, ancrod, and/or coumarin explain the rapid shift in clinical practice during the 1990s
    Norbert Lubenow
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Thromb Res 117:507-15. 2006
    ..During the 1990s, danaparoid+/-coumarin began to replace ancrod (+/-coumarin), or coumarin alone, for treating HIT, despite danaparoid not being approved for treatment of HIT...
  10. ncbi request reprint Platelet receptor and clotting factor polymorphisms as genetic risk factors for thromboembolic complications in heparin-induced thrombocytopenia
    Lena E Carlsson
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Pharmacogenetics 13:253-8. 2003
    ..However, this would need to be assessed in further larger studies. Most likely, the high levels of thrombin generation during acute HIT are so procoagulant that less pronounced risk factors such as polymorphisms are overshadowed...
  11. ncbi request reprint [Current recommendations for diagnosis and therapy of heparin-induced thrombocytopenia]
    P Hinz
    Abteilung für Unfall und Wiederherstellungschirurgie, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Unfallchirurg 105:845-50. 2002
    ..Because of earlier discharge of patients to rehabilitation or outpatient care, the problem of HIT-diagnosis and therapy gains increasing relevance in these sectors...
  12. ncbi request reprint Heparin-induced thrombocytopenia: temporal pattern of thrombocytopenia in relation to initial use or reexposure to heparin
    Norbert Lubenow
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Chest 122:37-42. 2002
    ..We therefore analyzed the temporal pattern of thrombocytopenia in patients with laboratory-confirmed HIT to assess whether patients with previous heparin exposure have an increased risk of early onset of HIT...
  13. ncbi request reprint Antibodies against lepirudin are polyspecific and recognize epitopes on bivalirudin
    Petra Eichler
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Sauerbruchstr Diagnostikzentrum, 17487 Greifswald, Germany
    Blood 103:613-6. 2004
    ..Yet, as lepirudin and antilepirudin antibodies have recently been implicated in severe anaphylactic reactions, caution is warranted when using bivalirudin in patients previously treated with lepirudin...
  14. ncbi request reprint Heparin-induced thrombocytopenia in children: 12 new cases and review of the literature
    Anne F Klenner
    Ernst Moritz Arndt Universitat Greifswald, Institut für Immunologie und Transfusionsmedizin, Sauerbruchstr Diagnostikzentrum, 17487 Greifswald, Germany
    Thromb Haemost 91:719-24. 2004
    ..Most data are available for lepirudin and danaparoid. Substitution of unfractionated heparin by low-molecular-weight heparins for regular anticoagulation may reduce the incidence of HIT...
  15. ncbi request reprint Recombinant hirudin in clinical practice: focus on lepirudin
    A Greinacher
    Institute for Immunology and Transfusion Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Circulation 103:1479-84. 2001
    ..An overview of usage of lepirudin in acute coronary syndromes is given, as well as a summary of rare indications for lepirudin, such as extracorporeal circulation, for which comprehensive data are lacking...
  16. ncbi request reprint Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3
    N Lubenow
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    J Thromb Haemost 3:2428-36. 2005
    ..To assess efficacy and safety of lepirudin in patients with heparin-induced thrombocytopenia (HIT) in a prospective study (HAT-3) as well as in a combined analysis of all HAT study data...
  17. ncbi request reprint The new ID-heparin/PF4 antibody test for rapid detection of heparin-induced antibodies in comparison with functional and antigenic assays
    Petra Eichler
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Br J Haematol 116:887-91. 2002
    ..Evaluation of the test in a prospective setting as well as interlaboratory variation should be assessed as a next step...
  18. doi request reprint [Thrombosis prophylaxis in trauma surgery units in Germany: a survey]
    P Hinz
    Unfall und Wiederherstellungschirurgie, Klinikum der Ernst Moritz Arndt Universität, Greifswald, Deutschland
    Unfallchirurg 112:1029-33. 2009
    ..A questionnaire study was conducted to ask trauma surgery centers about thrombosis prophylaxis methods and strategies for the diagnosis and therapy of heparin-induced thrombocytopenia (HIT)...
  19. ncbi request reprint Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes
    A Greinacher
    Institut für Immunologie und Transfusionsmedizin Ernst Moritz Arndt Universität Greifswald, Greifswald, Germany
    J Thromb Haemost 5:1666-73. 2007
    ..However, the relative utility of functional (platelet activation) vs. antigen [enzyme-immunoassay (EIA)] assays, and the significance of assay discrepancies remain unresolved...
  20. ncbi request reprint Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range
    A Greinacher
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Blood 96:846-51. 2000
    ..02). In conclusion, this meta-analysis provides further evidence that lepirudin is an effective and acceptably safe treatment for patients with HIT...
  21. ncbi request reprint Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia
    A Greinacher
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat, Klinikum Sauerbruchstrasse, 17489 Greifswald, Germany
    Circulation 108:2062-5. 2003
    ..Because 3 cases of fatal anaphylaxis possibly associated with use of lepirudin have been reported, we initiated an investigation of putative lepirudin-associated anaphylaxis...
  22. ncbi request reprint Drug-induced and drug-dependent immune thrombocytopenias
    A Greinacher
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Rev Clin Exp Hematol 5:166-200; discussion 311-2. 2001
    ..Clinically, these patients present with very low platelet counts and acute, sometimes severe, hemorrhage. Treatment is restricted to withdrawal of the drug and symptomatic treatment of bleeding...
  23. ncbi request reprint Glucosamine sulfate does not crossreact with the antibodies of patients with heparin-induced thrombocytopenia
    G Weimann
    , Ernst-Moritz-Arndt-University Greifswald, Sauerbruchstr/Diagnostikzentrum, 17487 Greifswald, Germany
    Eur J Haematol 66:195-9. 2001
    ..CONCLUSIONS: In contrast to sulfated glycosaminoglycans, there is no evidence for an immunological crossreactivity of HIT antibodies between heparin and glucosamine sulfate...
  24. doi request reprint Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests
    A Greinacher
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat, Greifswald, Germany
    J Thromb Haemost 8:2025-31. 2010
    ..Platelet factor 4 (PF4)/heparin enzyme-immunoassays (EIA) are a widely available surrogate for platelet-activating antibodies...
  25. ncbi request reprint Profiling of alterations in platelet proteins during storage of platelet concentrates
    Thomas Thiele
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Transfusion 47:1221-33. 2007
    ..In contrast, proteomic technologies provide a comprehensive overview of the PLT proteome. High interassay variability, however, limits meaningful assessment of samples taken from the same product over time or before and after processing...
  26. ncbi request reprint Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies
    Norbert Lubenow
    Dept of Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Blood 104:3072-7. 2004
    ..Dose reductions in renal impairment are important. Keeping the aPTT in the range corresponding to 600 to 700 microg/L lepirudin during treatment may minimize bleeding complications...