J Lotsch

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint The negative mucosal potential: separating central and peripheral effects of NSAIDs in man
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Eur J Clin Pharmacol 52:359-64. 1997
  2. ncbi request reprint Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Anesthesiology 87:1348-58. 1997
  3. pmc Effects of azapropazone on pain-related brain activity in human subjects
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Br J Clin Pharmacol 40:545-52. 1995
  4. ncbi request reprint Trigeminal chemosensitivity: Differences in relation to the time of the day
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Chem Senses 23:755-9. 1998
  5. ncbi request reprint Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Clin Pharmacol Ther 63:629-39. 1998
  6. ncbi request reprint Factors affecting pain intensity in a pain model based upon tonic intranasal stimulation in humans
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Inflamm Res 47:446-50. 1998
  7. ncbi request reprint Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Anesthesiology 90:1026-38. 1999
  8. ncbi request reprint Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency
    R Oelkers
    Department of Experimental and Clinical Pharmacology, University of Erlangen Nurnberg, Germany
    Brain 122:1147-55. 1999
  9. ncbi request reprint Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia
    H Guhring
    Institut für Experimentelle Pharmakologie and Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
    Inflamm Res 50:83-8. 2001

Collaborators

Detail Information

Publications9

  1. ncbi request reprint The negative mucosal potential: separating central and peripheral effects of NSAIDs in man
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Eur J Clin Pharmacol 52:359-64. 1997
    ..For this purpose, experimental conditions were created in which NSAIDs had previously been observed to produce effects on phasic and tonic pain by either central or peripheral mechanisms...
  2. ncbi request reprint Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Anesthesiology 87:1348-58. 1997
    ..The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine...
  3. pmc Effects of azapropazone on pain-related brain activity in human subjects
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Br J Clin Pharmacol 40:545-52. 1995
    ..4. Analgesic properties of azapropazone were demonstrated in man. The topographical pattern of the changes in the CSSERPs and the effects on EEG background activity suggest a central component of the analgesic action of azapropazone...
  4. ncbi request reprint Trigeminal chemosensitivity: Differences in relation to the time of the day
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Chem Senses 23:755-9. 1998
    ..Day-night differences were found with N 1 P2 amplitudes, P2 latencies and pain ratings. It is concluded that the time of the day must not be ignored when human chemosensitivity is investigated at suprathreshold levels...
  5. ncbi request reprint Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Clin Pharmacol Ther 63:629-39. 1998
    ..Research is needed to establish whether morphine-6-beta-glucuronide qualifies as an analgesic; this study provides the pharmacokinetic bases for such studies...
  6. ncbi request reprint Factors affecting pain intensity in a pain model based upon tonic intranasal stimulation in humans
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Inflamm Res 47:446-50. 1998
    ..The aim of the present study was to investigate the influence of flow, humidity and temperature of the air-stream on the intensity of the evoked pain sensations...
  7. ncbi request reprint Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers
    J Lotsch
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Anesthesiology 90:1026-38. 1999
    ..Under the conditions of long-term oral morphine administration, the accumulation of M6G may contribute to the analgesic effects, but it may also cause respiratory depression...
  8. ncbi request reprint Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency
    R Oelkers
    Department of Experimental and Clinical Pharmacology, University of Erlangen Nurnberg, Germany
    Brain 122:1147-55. 1999
    ..These results reflect an interictally persisting dysfunction of precortical visual processing which might be relevant in the pathophysiology of migraine...
  9. ncbi request reprint Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia
    H Guhring
    Institut für Experimentelle Pharmakologie and Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
    Inflamm Res 50:83-8. 2001
    ..To assess the involvement of spinal inducible nitric oxide synthase (iNOS) in inflammation and nociception...