W Loscher

Summary

Affiliation: University of Veterinary Medicine
Country: Germany

Publications

  1. ncbi request reprint A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Neurosci 11:250-62. 1999
  2. ncbi request reprint Do cocarcinogenic effects of ELF electromagnetic fields require repeated long-term interaction with carcinogens? Characteristics of positive studies using the DMBA breast cancer model in rats
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Bioelectromagnetics 22:603-14. 2001
  3. ncbi request reprint Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    J Pharmacol Exp Ther 288:984-92. 1999
  4. ncbi request reprint Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsia 41:1499-506. 2000
  5. ncbi request reprint Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Prog Neurobiol 58:31-59. 1999
  6. ncbi request reprint Anticonvulsant efficacy of gabapentin and levetiracetam in phenytoin-resistant kindled rats
    W Loscher
    Department of Pharmacology, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Epilepsy Res 40:63-77. 2000
  7. ncbi request reprint Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsia 41:516-28. 2000
  8. ncbi request reprint Effect of depth electrode implantation with or without subsequent kindling on GABA turnover in various rat brain regions
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 37:95-108. 1999
  9. ncbi request reprint The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 38:231-48. 2000
  10. ncbi request reprint Anticonvulsant efficacy of L-deprenyl (selegiline) during chronic treatment in mice: continuous versus discontinuous administration
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neuropharmacology 37:1587-93. 1998

Collaborators

Detail Information

Publications53

  1. ncbi request reprint A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Neurosci 11:250-62. 1999
    ..e. LU 97175, LU 115455 and LU 136541, exerted potent anticonvulsant effects without inducing motor impairment in the rotarod test. This combination of actions is thought to be a prerequisite for selective anticonvulsant drug action...
  2. ncbi request reprint Do cocarcinogenic effects of ELF electromagnetic fields require repeated long-term interaction with carcinogens? Characteristics of positive studies using the DMBA breast cancer model in rats
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Bioelectromagnetics 22:603-14. 2001
    ....
  3. ncbi request reprint Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    J Pharmacol Exp Ther 288:984-92. 1999
    ..The data thus suggest that selective MAO-A inhibitors such as esuprone may be an interesting new approach for the treatment of epilepsy...
  4. ncbi request reprint Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsia 41:1499-506. 2000
    ..To study whether the efficacy of the drug changes during chronic treatment, we evaluated the anticonvulsant activity of LEV during prolonged daily administration in amygdala-kindled rats...
  5. ncbi request reprint Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Prog Neurobiol 58:31-59. 1999
    ..By the experimental observations summarized in this review, most clinical effects of valproate can be explained, although much remains to be learned at a number of different levels of valproate's mechanisms of action...
  6. ncbi request reprint Anticonvulsant efficacy of gabapentin and levetiracetam in phenytoin-resistant kindled rats
    W Loscher
    Department of Pharmacology, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Epilepsy Res 40:63-77. 2000
    ..The data of this study substantiate that phenytoin nonresponders are a unique model for the search of new AEDs with improved efficacy in refractory partial epilepsy...
  7. ncbi request reprint Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsia 41:516-28. 2000
    ..To evaluate the possible effect of the season, experiments in group 1 were started in autumn, and experiments in group 2 in spring...
  8. ncbi request reprint Effect of depth electrode implantation with or without subsequent kindling on GABA turnover in various rat brain regions
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 37:95-108. 1999
    ..Furthermore, the data substantiate that the choice of adequate controls is critical in neurochemical and functional studies on the kindling phenomenon...
  9. ncbi request reprint The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 38:231-48. 2000
    ..Furthermore, the present data add to the accumulating evidence that endogenous circannual rhythms should be considered during animal experiments under controlled laboratory conditions...
  10. ncbi request reprint Anticonvulsant efficacy of L-deprenyl (selegiline) during chronic treatment in mice: continuous versus discontinuous administration
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neuropharmacology 37:1587-93. 1998
    ..In view of the short half-life of L-deprenyl, these reversible effects can only be maintained during chronic treatment when the drug is given continuously such as via implanted minipumps...
  11. ncbi request reprint Kindling alters the anticonvulsant efficacy of phenytoin in Wistar rats
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Epilepsy Res 39:211-20. 2000
    ..The present results substantiate that kindled subgroups of Wistar rats with different response to phenytoin are a valuable source for studying the mechanisms underlying the development of pharmaco-resistant limbic seizures...
  12. ncbi request reprint N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy
    C Brandt
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuroscience 118:727-40. 2003
    ..E. is an effective means to reduce the damage produced by a sustained S.E. in several brain regions, including the hippocampus, but show that this partial neuroprotection of the limbic system does not prevent the development of epilepsy...
  13. ncbi request reprint Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage
    C Brandt
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Epilepsy Res 62:135-56. 2004
    ..The data demonstrate that extended kindling does not cause any hippocampal damage resembling hippocampal sclerosis, but that SRS develop in the absence of such damage...
  14. ncbi request reprint Altered spontaneous discharge rate and pattern of basal ganglia output neurons in the circling (ci2) rat mutant
    M Fedrowitz
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Neuroscience 118:867-78. 2003
    ..The data substantiate previous findings of altered basal ganglia function in ci2 rats. The abnormal basal ganglia output activity, i.e. of the SNr, is likely to contribute to the complex behavioral disturbances seen in ci2 rats...
  15. ncbi request reprint Bilateral microinjections of vigabatrin in the central piriform cortex retard amygdala kindling in rats
    K Schwabe
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Neuroscience 129:425-9. 2004
    ....
  16. ncbi request reprint Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of experimental and environmental factors
    U Ebert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 33:199-215. 1999
    ..The data suggest that the difference between phenytoin responders and non-responders is not due to experimental factors, but may rather be genetically determined...
  17. ncbi request reprint Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus
    C Freichel
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Neuroscience 141:2177-94. 2006
    ..The data substantiate the particular susceptibility of the central PC to seizure-induced plasticity and indicate that this brain region provides an interesting tool to study the regulation of GAD isoenzymes...
  18. ncbi request reprint Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Pharmacol 369:335-8. 1999
    ..The GABApotentiating activity of gabapentin could explain the antidystonic effects of low doses, while the loss of efficacy at higher doses may be due to other mechanisms of gabapentin...
  19. ncbi request reprint Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures
    H A Volk
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Neuroscience 123:751-9. 2004
    ....
  20. ncbi request reprint Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats
    P Wlaz
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neuropharmacology 38:243-51. 1999
    ..25-5 mg/kg or CGP 40116 1.25 mg/kg combined with eliprodil 10 mg/kg. These data suggest that combination therapy with antagonists at the polyamine and glycine sites might potentially treat therapy-resistant complex partial seizures...
  21. pmc Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 113:1349-57. 1994
    ....
  22. ncbi request reprint Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of genetic factors
    U Ebert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 33:217-26. 1999
    ..The low reproductive success of the kindled and phenytoin-treated rats made it impossible to achieve a strain of phenytoin non-responders...
  23. ncbi request reprint Frontal versus transcorneal stimulation to induce maximal electroshock seizures or kindling in mice and rats
    P Wlaz
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 30:219-29. 1998
    ..Nevertheless, this type of stimulation cannot be used to produce minimal electroshock seizures and seems not to be useful to produce kindling in rats and mice...
  24. pmc Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 112:97-106. 1994
    ....
  25. ncbi request reprint Anticonvulsant effects by combined treatment with a glycineB receptor antagonist and a polyamine site antagonist in amygdala-kindled rats
    U Ebert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Pharmacol 322:179-84. 1997
    ....
  26. doi request reprint Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice
    C J Muller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, D 30559 Hannover, Germany
    Genes Brain Behav 8:481-92. 2009
    ..As the described differences have a genetic basis, they offer a unique opportunity to identify the genes and pathways involved and contribute to a better understanding of the underlying molecular mechanisms of seizure susceptibility...
  27. ncbi request reprint Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Brain Res 821:277-85. 1999
    ....
  28. ncbi request reprint Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus?
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Pharmacol 332:133-41. 1997
    ....
  29. ncbi request reprint The novel competitive N-methyl-D-aspartate (NMDA) antagonist CGP 37849 preferentially induces phencyclidine-like behavioral effects in kindled rats: attenuation by manipulation of dopamine, alpha-1 and serotonin1A receptors
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, F R G
    J Pharmacol Exp Ther 257:1146-53. 1991
    ..abstract truncated at 250 words)..
  30. ncbi request reprint Subconvulsive dose of pentylenetetrazole increases the firing rate of substantia nigra pars reticulata neurons in dystonic but not in nondystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Synapse 33:259-67. 1999
    ....
  31. pmc Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover F R G
    Br J Pharmacol 97:843-52. 1989
    ....
  32. ncbi request reprint Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Eur J Pharmacol 397:343-50. 2000
    ..Tentatively, activity-dependent GABA-mediated excitation caused by chronic treatment with phenobarbital may be important for the prodystonic effects under pathological conditions in dt(sz) hamsters...
  33. ncbi request reprint Strong olfactory stimulation reduces seizure susceptibility in amygdala-kindled rats
    U Ebert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neurosci Lett 287:199-202. 2000
    ..Thus, olfactory stimulation could contribute to anticonvulsant therapy...
  34. doi request reprint Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain
    Jens P Bankstahl
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Neuropharmacology 54:1006-16. 2008
    ..The finding that MK-801 counteracts both Pgp overexpression and neuronal damage when administered after SE may offer a clinically useful therapeutic option in patients with refractory SE...
  35. ncbi request reprint The central piriform cortex: anatomical connections and anticonvulsant effect of GABA elevation in the kindling model
    K Schwabe
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Neuroscience 126:727-41. 2004
    ..These differences in anatomical connectivity between PC subregions may be involved in the differences in seizure susceptibility observed in the present and previous studies...
  36. ncbi request reprint Spontaneous paroxysmal circling behavior in the ci2 rat mutant: epilepsy with rotational seizures or hyperkinetic movement disorder?
    S Lindemann
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Büntewag 17, Hannover, 30559, Germany
    Exp Neurol 172:437-45. 2001
    ..The data indicate that spontaneous paroxysmal circling behavior in the ci2 rat is not a consequence of epilepsy but reflects a hyperkinetic movement disorder with abnormal lateralization of brain function...
  37. ncbi request reprint Pathology of idiopathic dystonia: findings from genetic animal models
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Prog Neurobiol 54:633-77. 1998
    ..In addition to increasing our understanding of the pathophysiology of idiopathic dystonia, animal models may help to improve therapeutic strategies for this movement disorder...
  38. ncbi request reprint The electrical activity is impaired in the red nucleus of dt(sz) mutant hamsters with paroxysmal dystonia: an EEG power spectrum analysis of depth electrode recordings
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Brain Res 760:102-8. 1997
    ..Although the observed changes of neural activity in the RN are probably based on a primary dysfunction in related structures, the present data demonstrate its importance in the expression of dystonic movements...
  39. ncbi request reprint In vivo extracellular electrophysiology of pallidal neurons in dystonic and nondystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    J Neurosci Res 57:894-905. 1999
    ..In view of recent findings, we assume that GABAergic dysfunctions in dystonic hamsters are of regionally different extent...
  40. ncbi request reprint Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis
    H Potschka
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Neurosci 16:2157-65. 2002
    ....
  41. ncbi request reprint A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions
    A Lessenich
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neuroscience 107:615-28. 2001
    ..Apart from the use of ci3 rats for studying the functional lateralization of brain functions, the ci3 mutant may serve as a new model for movement disorders with abnormal lateralization...
  42. ncbi request reprint Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats
    M Gernert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559, Hannover, Germany
    Eur J Pharmacol 432:35-41. 2001
    ..The data indicate that, in contrast to flurothyl seizures, in kindled rats the anterior pars reticulata of the substantia nigra is not a site at which muscimol causes robust anticonvulsant effects...
  43. ncbi request reprint Critical re-evaluation of previous preclinical strategies for the discovery and the development of new antiepileptic drugs
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Buenteweg 17, Hannover, Germany
    Epilepsy Res 50:17-20. 2002
    ..Overall, it was felt that the current preclinical strategies for the discovery and development of new AEDs have to be redefined in order to identify agents that are clearly superior to current medications...
  44. ncbi request reprint Piracetam and levetiracetam, two pyrrolidone derivatives, exert antidystonic activity in a hamster model of paroxysmal dystonia
    W Loscher
    Department of Pharmacology, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Eur J Pharmacol 391:251-4. 2000
    ..The antidystonic activity of piracetam and levetiracetam was not associated with any behavioral side effects. The data indicate that piracetam and levetiracetam are interesting novel treatments for idiopathic dystonia...
  45. pmc Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 131:921-6. 2000
    ..Peripheral side effects may limit the clinical use of NO synthase inhibitors, but more selective inhibitors of the neuronal NO synthase should be considered as interesting candidates for the treatment of paroxysmal dystonia...
  46. ncbi request reprint Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy
    M Glien
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
    Epilepsy Res 46:111-9. 2001
    ..The present study demonstrates that systemic treatment of lithium-pretreated rats with several low doses of pilocarpine efficiently produces SE and chronic epilepsy with much lower mortality rates than single-dose pilocarpine...
  47. ncbi request reprint Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia
    W Loscher
    Department of Pharmacology, School of Veterinary Medicine, Hannover, Federal Republic of Germany
    Naunyn Schmiedebergs Arch Pharmacol 341:483-93. 1990
    ..5-HT2 antagonists, such as ketanserin or ritanserin, are capable of counteracting the fatality of this syndrome...
  48. ncbi request reprint Alterations in dopamine D3 receptors in the circling (ci3) rat mutant
    M Schirmer
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Bunteweg 17, D 30559 Hannover, Germany
    Neuroscience 144:1462-9. 2007
    ....
  49. ncbi request reprint In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, FRG
    Neurosci Lett 160:177-80. 1993
    ....
  50. ncbi request reprint Auditory and vestibular defects in the circling (ci2) rat mutant
    A Kaiser
    Department of Zoology, School of Veterinary Medicine, 30559 Hannover, Germany
    Eur J Neurosci 14:1129-42. 2001
    ....
  51. ncbi request reprint Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain
    H Potschka
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, 30559 Hannover, Germany
    Neuroreport 12:2387-9. 2001
    ..The data indicate that MRP critically participates in the regulation of extracellular brain concentrations of the major antiepileptic drug phenytoin...
  52. ncbi request reprint P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain
    H Potschka
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
    Neuroreport 12:3557-60. 2001
    ..The data indicate that both PGP and MRP participate in the regulation of extracellular brain concentrations of the major AED carbamazepine...
  53. ncbi request reprint In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats
    H Potschka
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsia 42:1231-40. 2001
    ....