H-M Lorenz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint [Rheumatoid arthritis: diagnostics and therapy 2012]
    H M Lorenz
    Sektion Rheumatologie, Medizinische Klinik V, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Orthopade 41:514-9. 2012
  2. ncbi request reprint [Tissue regeneration and immunosuppression by mesenchymal stem cells]
    H M Lorenz
    Medizinische Klinik V, Universitatsklinikum Heidelberg
    Dtsch Med Wochenschr 131:892-5. 2006
  3. doi request reprint Mycobacterium kansasii tenosynovitis in a rheumatoid arthritis patient with long-term therapeutic immunosuppression
    Hanns Martin Lorenz
    Department of Medicine, Division of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
    Arthritis Rheum 59:900-3. 2008
  4. doi request reprint [Biomarkers collections: the future or a waste of resources?]
    H M Lorenz
    Sektion Rheumatologie, Medizinische Klinik V, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Z Rheumatol 69:860-2. 2010
  5. pmc Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study
    Hanns Martin Lorenz
    Division of Rheumatology, University Hospital Heidelberg, INF410, 69120 Heidelberg, Germany
    Arthritis Res Ther 13:R36. 2011
  6. ncbi request reprint Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis
    M Schiller
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Cell Death Differ 15:183-91. 2008
  7. ncbi request reprint Hypothesis: human serum-borne albumin bound lipids promote cellular survival after apoptosis induction by a variety of stimuli
    Martin Schiller
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Apoptosis 13:319-28. 2008
  8. ncbi request reprint Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis
    Norbert Blank
    Department of Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    J Immunol 179:3613-21. 2007
  9. ncbi request reprint Apoptotic bodies derived from apoptotic lymphoblasts contain a distinct pattern of antigens
    M Schiller
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Autoimmunity 40:340-1. 2007
  10. ncbi request reprint Familial early onset sarcoidosis with bone cysts and erosions
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Skeletal Radiol 36:891-3. 2007

Detail Information

Publications28

  1. doi request reprint [Rheumatoid arthritis: diagnostics and therapy 2012]
    H M Lorenz
    Sektion Rheumatologie, Medizinische Klinik V, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Orthopade 41:514-9. 2012
    ....
  2. ncbi request reprint [Tissue regeneration and immunosuppression by mesenchymal stem cells]
    H M Lorenz
    Medizinische Klinik V, Universitatsklinikum Heidelberg
    Dtsch Med Wochenschr 131:892-5. 2006
  3. doi request reprint Mycobacterium kansasii tenosynovitis in a rheumatoid arthritis patient with long-term therapeutic immunosuppression
    Hanns Martin Lorenz
    Department of Medicine, Division of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
    Arthritis Rheum 59:900-3. 2008
  4. doi request reprint [Biomarkers collections: the future or a waste of resources?]
    H M Lorenz
    Sektion Rheumatologie, Medizinische Klinik V, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Z Rheumatol 69:860-2. 2010
    ..The present review compiles "PROs and CONs" in a subjective way in order to provoke a discussion on the meaningfulness of biomarkers, while at the same time supporting and encouraging further research in this field...
  5. pmc Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study
    Hanns Martin Lorenz
    Division of Rheumatology, University Hospital Heidelberg, INF410, 69120 Heidelberg, Germany
    Arthritis Res Ther 13:R36. 2011
    ....
  6. ncbi request reprint Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis
    M Schiller
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Cell Death Differ 15:183-91. 2008
    ..In autoimmune diseases, a defect in the clearance of ABs or AB formation may contribute to the development of autoimmunity...
  7. ncbi request reprint Hypothesis: human serum-borne albumin bound lipids promote cellular survival after apoptosis induction by a variety of stimuli
    Martin Schiller
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Apoptosis 13:319-28. 2008
    ..In conclusion human serum-enriched bioactive lipids promote survival of cultured cells overriding the pro-apoptotic effects of a variety of apoptosis inducing agents...
  8. ncbi request reprint Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis
    Norbert Blank
    Department of Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    J Immunol 179:3613-21. 2007
    ..Statins induce both lower levels of low-density lipoprotein cholesterol and inhibition of T cell activation, which might contribute to an inhibition of atherosclerosis...
  9. ncbi request reprint Apoptotic bodies derived from apoptotic lymphoblasts contain a distinct pattern of antigens
    M Schiller
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Autoimmunity 40:340-1. 2007
  10. ncbi request reprint Familial early onset sarcoidosis with bone cysts and erosions
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Skeletal Radiol 36:891-3. 2007
    ..This is the first report demonstrating bone cysts and erosions which could be a diagnostic feature in this rare disease and may help to differentiate other rheumatoid disorders...
  11. ncbi request reprint Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    Immunol Cell Biol 85:378-82. 2007
    ....
  12. ncbi request reprint Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytes
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Biochem Pharmacol 71:126-35. 2005
    ..However, inhibition of glucosphingolipid synthesis itself did not inhibit cellular activation. Our data show that glucosphingolipids - in contrast to cholesterol - are not essential for the stabilisation of MM...
  13. ncbi request reprint Multiple bone lesions of systemic multifocal fibrosclerosis
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany
    AJR Am J Roentgenol 185:668-70. 2005
  14. ncbi request reprint [New aspects of the pathogenesis of systemic lupus erythematosus]
    M Schiller
    Sektion Rheumatologie, Medizinische Klinik V, Universitat Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Deutschland
    Z Rheumatol 66:505-9. 2007
    ..These observations provide a link between dysregulation of apoptosis and phagocytosis and the type-I interferon signature observed in SLE patients...
  15. ncbi request reprint The role of DMARDs in systemic sclerosis therapy
    N Blank
    Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Rheumatology (Oxford) 45:iii42-4. 2006
    ..Current expert recommendations suggest a therapy with methotrexate for skin thickening or cyclophosphamide for acute alveolitis. However, more clinical trials with larger numbers of patients with recent onset SSc are needed...
  16. pmc Perspectives for TNF-alpha-targeting therapies
    Hanns Martin Lorenz
    Institute for Clinical Immunology and Rheumatology, Department of Medicine, University of Erlangen Nuremberg, Germany
    Arthritis Res 4:S17-24. 2002
    ..Combination partners other than methotrexate will be established as suitable cotreatment along with anti-TNF-alpha biologicals. Forthcoming new indications for TNF-alpha-targeted therapies are discussed...
  17. ncbi request reprint Dysregulation of apoptosis as mechanism supporting the induction of autoimmunity
    Hanns Martin Lorenz
    Department of Medicine V, Division of Rheumatology, University of Heidelberg, Hospitalstrasse 3, 69115 Heidelberg, Germany
    Curr Rheumatol Rep 6:249-51. 2004
  18. doi request reprint Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus
    Ram Kumar Chowdary Venigalla
    University of Heidelberg, Heidelberg, Germany
    Arthritis Rheum 58:2120-30. 2008
    ..To overcome this problem, we analyzed the phenotype and function of CD4+,CD25high,CD127(-/low) natural Treg (nTreg) cells isolated from the peripheral blood of patients with SLE...
  19. ncbi request reprint A fast, simple and sensitive method for the detection and quantification of detergent-resistant membranes
    Norbert Blank
    Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Glueckstrasse 4a, Germany
    J Immunol Methods 271:25-35. 2002
    ..The presence of protein in these fractions was confirmed by silver-stained polyacrylamide gels. We confirmed the presence of adaptor molecules (LAT) and Src kinases (Lck) in the DRM containing fractions 4 to 6...
  20. ncbi request reprint Hyporesponsiveness to gammac-chain cytokines in activated lymphocytes from patients with systemic lupus erythematosus leads to accelerated apoptosis
    Hanns Martin Lorenz
    Department of Medicine III, Institute for Clinical Immunology Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 32:1253-63. 2002
    ....
  21. doi request reprint Anti-HLA-DR-triggered monocytes mediate in vitro T cell anergy
    Martin A Kriegel
    Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
    Int Immunol 20:601-13. 2008
    ..In summary, anti-HLA-DR treatment can generate tolerogenic monocytes transmitting T cell anergy that may be exploited for future immunomodulatory strategies to treat immune-mediated disease states...
  22. ncbi request reprint T-cell-activation inhibitors in rheumatoid arthritis
    Hanns Martin Lorenz
    Department of Medicine III, Rheumatology Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    BioDrugs 17:263-70. 2003
    ....
  23. pmc Interleukin-4 supports interleukin-12-induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells
    Martin A Kriegel
    Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
    Immunology 119:43-53. 2006
    ..These findings should be of importance for the design of cytokine-targeted therapies of human Th-cell-driven diseases...
  24. ncbi request reprint Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion
    Rainer H Straub
    Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 48:1504-12. 2003
    ..Beyond local effects, anti-TNF treatment may modulate systemic antiinflammatory pathways such as the hypothalamic-pituitary-adrenal (HPA) axis. This longitudinal anti-TNF therapy study was designed to assess these effects in RA patients...
  25. doi request reprint Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 58:976-84. 2008
    ..We undertook this study to investigate the predictive value of hypothalamic-pituitary-adrenal (HPA) axis hormones for clinical improvement during anti-TNF therapy...
  26. pmc Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II
    Martin A Kriegel
    Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Germany
    J Exp Med 199:1285-91. 2004
    ..The defect was persistent and not due to responder cell resistance. These data provide novel insights into the pathogenesis of APS-II and possibly human autoimmunity in general...
  27. ncbi request reprint Abetimus (La Jolla pharmaceuticals)
    Hanns Martin Lorenz
    University of Erlangen Nuremberg, Department of Medicine III, Institute of Clnical Immunol Rheumatology, Germany
    Curr Opin Investig Drugs 3:234-9. 2002
    ..The patents also cover methods of synthesis and use [269583]. In November 2001, Morgan Keegan & Co estimated sales to be US $150 million in 2003, rising to US $600 million in 2005 [439326]...
  28. ncbi request reprint Extravasation into synovial tissue induces CCL20 mRNA expression in polymorphonuclear neutrophils of patients with rheumatoid arthritis
    Judith Schlenk
    Institute for Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    J Rheumatol 32:2291-8. 2005
    ..Examination of expression of the chemokine macrophage inflammatory protein-3a (CCL20/Mip-3alpha) in blood polymorphonuclear neutrophils (PMN) and synovial fluid (SF) PMN of patients with rheumatoid arthritis (RA)...