M Lommatzsch

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. ncbi request reprint The impact of age, weight and gender on BDNF levels in human platelets and plasma
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Neurobiol Aging 26:115-23. 2005
  2. pmc Against all odds: anti-IgE for intrinsic asthma?
    Marek Lommatzsch
    Department of Pneumology and Critical Care Medicine, University of Rostock, Rostock, Germany
    Thorax 69:94-6. 2014
  3. pmc Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD
    Paul Stoll
    Department of Pneumology and Critical Care Medicine, University of Rostock, Ernst Heydemann Str, 6, 18057 Rostock, Germany
    Respir Res 15:48. 2014
  4. ncbi request reprint Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Rostock, Germany
    Respir Res 14:114. 2013
  5. pmc Stage-dependent association of BDNF and TGF-β1 with lung function in stable COPD
    Paul Stoll
    Department of Pneumology and Critical Care Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057, Rostock, Germany
    Respir Res 13:116. 2012
  6. doi request reprint Airway hyperresponsiveness: new insights into the pathogenesis
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Rostock, Germany
    Semin Respir Crit Care Med 33:579-87. 2012
  7. ncbi request reprint Platelet and plasma BDNF in lower respiratory tract infections of the adult
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, 18057 Rostock, Germany
    Respir Med 101:1493-9. 2007
  8. ncbi request reprint Airway dendritic cell phenotypes in inflammatory diseases of the human lung
    M Lommatzsch
    Abteilung fur Pneumologie, Klinik und Poliklinik für Innere Medizin, Universitat Rostock, Ernst Heydemann Str 6, 18057, Rostock, Germany
    Eur Respir J 30:878-86. 2007
  9. pmc Adverse effects of salmeterol in asthma: a neuronal perspective
    M Lommatzsch
    Abteilung fur Pneumologie, Klinik und Poliklinik für Innere Medizin, Universitat Rostock, D 18057 Rostock, Germany
    Thorax 64:763-9. 2009
  10. doi request reprint Acute effects of tobacco smoke on human airway dendritic cells in vivo
    M Lommatzsch
    Dept of Pneumology, University of Rostock, Rostock, Germany
    Eur Respir J 35:1130-6. 2010

Detail Information

Publications36

  1. ncbi request reprint The impact of age, weight and gender on BDNF levels in human platelets and plasma
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Neurobiol Aging 26:115-23. 2005
    ..In addition, platelet BDNF levels changed during the menstrual cycle. In conclusion, we demonstrate that parameters such as age or gender have a specific impact on stored and circulating BDNF levels in peripheral blood...
  2. pmc Against all odds: anti-IgE for intrinsic asthma?
    Marek Lommatzsch
    Department of Pneumology and Critical Care Medicine, University of Rostock, Rostock, Germany
    Thorax 69:94-6. 2014
    ..In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment. ..
  3. pmc Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD
    Paul Stoll
    Department of Pneumology and Critical Care Medicine, University of Rostock, Ernst Heydemann Str, 6, 18057 Rostock, Germany
    Respir Res 15:48. 2014
    ..Myeloid dendritic cells (DCs) are increased in the airway wall of patients with chronic obstructive pulmonary disease (COPD), and postulated to play a crucial role in COPD. However, DC phenotypes in COPD are poorly understood...
  4. ncbi request reprint Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Rostock, Germany
    Respir Res 14:114. 2013
    ..Effects of inhaled corticosteroids (ICS) on airway DCs in smokers are unknown...
  5. pmc Stage-dependent association of BDNF and TGF-β1 with lung function in stable COPD
    Paul Stoll
    Department of Pneumology and Critical Care Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057, Rostock, Germany
    Respir Res 13:116. 2012
    ..In patients with asthma, it was previously shown that elevated serum BDNF concentrations correlate with disease severity, whereas TGF-β1 concentrations were normal...
  6. doi request reprint Airway hyperresponsiveness: new insights into the pathogenesis
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Rostock, Germany
    Semin Respir Crit Care Med 33:579-87. 2012
    ..New therapeutic strategies are, therefore, needed to modulate structural and functional changes in the airways, especially in patients with treatment-resistant severe asthma...
  7. ncbi request reprint Platelet and plasma BDNF in lower respiratory tract infections of the adult
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, 18057 Rostock, Germany
    Respir Med 101:1493-9. 2007
    ..In conclusion, these data suggest that lower respiratory tract infections might be associated with an augmented release of BDNF by platelets and mononuclear cells...
  8. ncbi request reprint Airway dendritic cell phenotypes in inflammatory diseases of the human lung
    M Lommatzsch
    Abteilung fur Pneumologie, Klinik und Poliklinik für Innere Medizin, Universitat Rostock, Ernst Heydemann Str 6, 18057, Rostock, Germany
    Eur Respir J 30:878-86. 2007
    ..These data suggest that inflammatory diseases of the human lung are associated with a differential phenotype and recruitment of airway dendritic cells...
  9. pmc Adverse effects of salmeterol in asthma: a neuronal perspective
    M Lommatzsch
    Abteilung fur Pneumologie, Klinik und Poliklinik für Innere Medizin, Universitat Rostock, D 18057 Rostock, Germany
    Thorax 64:763-9. 2009
    ..The neurotrophin brain-derived neurotrophic factor (BDNF) has recently been identified as a mediator of airway hyper-responsiveness in asthma...
  10. doi request reprint Acute effects of tobacco smoke on human airway dendritic cells in vivo
    M Lommatzsch
    Dept of Pneumology, University of Rostock, Rostock, Germany
    Eur Respir J 35:1130-6. 2010
    ..Acute tobacco smoke inhalation results in an immediate and selective recruitment of mDCs into human airways, which might reflect the very early reaction of the adaptive immune system to smoke exposure...
  11. ncbi request reprint The course of allergen-induced leukocyte infiltration in human and experimental asthma
    Marek Lommatzsch
    Department of Pneumology, Clinic of Internal Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    J Allergy Clin Immunol 118:91-7. 2006
    ....
  12. ncbi request reprint Maternal serum concentrations of BDNF and depression in the perinatal period
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    Psychoneuroendocrinology 31:388-94. 2006
    ..This phenomenon might reflect an increased risk for the development of mood disorders in the perinatal period. However, the individual serum concentration of BDNF alone did not predict maternal depression in our study...
  13. ncbi request reprint Brain-derived neurotrophic factor in platelets and airflow limitation in asthma
    Marek Lommatzsch
    Department of Pneumology and Institute of Clinical Chemistry and Pathobiochemistry, University of Rostock, Rostock, Germany
    Am J Respir Crit Care Med 171:115-20. 2005
    ..In addition, we provide evidence that corticosteroids suppress BDNF production by activated immune cells...
  14. ncbi request reprint Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, 18057 Rostock, Germany
    Int J Dev Neurosci 23:495-500. 2005
    ..In conclusion, we show that neurotrophins display a very differential and dynamic profile in internal organs after birth...
  15. doi request reprint Granzyme K: a novel mediator in acute airway inflammation
    K Bratke
    University Medical Clinics Rostock, Department of Pneumology, Rostock, Germany
    Thorax 63:1006-11. 2008
    ..Therefore, the release and expression of GrK in allergic asthma, chronic obstructive pulmonary disease (COPD) and bronchopneumonia were investigated...
  16. ncbi request reprint Vitamin D binding protein and vitamin D in human allergen-induced endobronchial inflammation
    K Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Clin Exp Immunol 177:366-72. 2014
    ..In conclusion, we report a significant increase in VDBP and 25(OH)D(3) in human BALF 24 h after allergen challenge, suggesting a role for these factors in the asthmatic late-phase reaction...
  17. ncbi request reprint Functional expression of granzyme B in human plasmacytoid dendritic cells: a role in allergic inflammation
    K Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Clin Exp Allergy 40:1015-24. 2010
    ..Plasmacytoid dendritic cells (pDCs) are involved in a variety of immune functions. However, the expression of cytotoxic granule proteins like granzymes and perforin in human pDCs is still poorly understood...
  18. doi request reprint Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus
    K Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Allergy 66:386-95. 2011
    ..Therefore, we investigated the impact of Th1- and Th2-like conditions during the development of pDCs on their antigen expression and function...
  19. doi request reprint [Hypertrophic pulmonary osteoarthropathy as a cue for NSCLC: four cases in the light of the current literature]
    M Lommatzsch
    Abteilung fur Pneumologie, Universitat Rostock
    Pneumologie 66:67-73. 2012
    ..In addition to the case reports, the current literature on hypertrophic pulmonary osteoarthropathy is reviewed in this article, with special reference to pathogenetic concepts und to therapeutic options...
  20. ncbi request reprint Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment
    K Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Clin Exp Allergy 43:312-21. 2013
    ..Plasmacytoid dendritic cells (pDCs) infiltrate sites of acute Th2-dominant inflammation, but their role in allergic asthma remains unclear...
  21. pmc Regulation of brain-derived neurotrophic factor (BDNF) during sleep apnoea treatment
    R Staats
    Department of Pneumology, University of Rostock, Germany
    Thorax 60:688-92. 2005
    ..Brain-derived neurotrophic factor (BDNF) is a key mediator of memory and cognition, but its regulation in OSAS and during CPAP treatment is unknown...
  22. ncbi request reprint Neurotrophins in allergic airway dysfunction: what the mouse model is teaching us
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, 18055 Rostock, Germany marek lommatzschmed uni rostock de
    Ann N Y Acad Sci 992:241-9. 2003
    ..Thus, our experiments suggest that NGF and BDNF have a profound, but differential impact on allergic airway dysfunction...
  23. pmc Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge
    Kai Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Thorax 62:168-75. 2007
    ..Dendritic cells control pulmonary immune reactions. Characteristics of dendritic cells in human bronchoalveolar lavage fluid (BALF) after allergen challenge are unknown...
  24. ncbi request reprint Safety of segmental allergen challenge in human allergic asthma
    Peter Julius
    Department of Pneumology, University of Rostock, Rostock, Germany
    J Allergy Clin Immunol 121:712-7. 2008
    ..Segmental allergen challenge is widely used to study mechanisms of human allergic asthma. Despite the relatively large dissemination, limited information is available about the safety of this method...
  25. doi request reprint Function-associated surface molecules on airway dendritic cells in cigarette smokers
    Kai Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Am J Respir Cell Mol Biol 38:655-60. 2008
    ..We provide the first evidence that a reduced CCR7 expression on airway mDCs is associated with airflow limitation in smokers...
  26. ncbi request reprint A role for the neurotrophin receptor TrkB on maturing dendritic cells
    Kai Bratke
    Department of Pneumology, University of Rostock, Germany
    J Neuroimmunol 189:88-94. 2007
    ..Neurotrophins are involved in neuroimmune interactions. However, the expression and role of neurotrophin receptors on dendritic cells have not been systematically studied...
  27. doi request reprint Extracellular adenosine triphosphate and chronic obstructive pulmonary disease
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Rostock, Germany
    Am J Respir Crit Care Med 181:928-34. 2010
    ..Extracellular ATP promotes inflammation, but its role in chronic obstructive pulmonary disease (COPD) is unknown...
  28. pmc Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation
    Armin Braun
    Department of Immunology and Allergology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Strasse 1, Hannover D 30625, Germany
    Br J Pharmacol 141:431-40. 2004
    ..Our data indicate that development of allergen-induced neuronal hyper-reactivity in mice is partially mediated by BDNF. British Journal of Pharmacology (2004) 141, 431-440. doi:10.1038/sj.bjp.0705638..
  29. pmc The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma
    Christina Nassenstein
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    J Exp Med 198:455-67. 2003
    ..Our findings suggest that neurotrophin-mediated activation of bronchial eosinophils might play a role in the regulation of eosinophilic inflammation in allergic asthma...
  30. ncbi request reprint Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes
    Olaf Schulte-Herbrüggen
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    J Neuroimmunol 160:204-9. 2005
    ..None of the cytokines induced BDNF secretion in T- or B-cells. Thus, our data provide evidence that IL-6 and TNF-alpha represent a specific link between monocyte infiltration and neuronal changes in inflammatory diseases...
  31. ncbi request reprint Maternal nerve growth factor serum levels in the perinatal period
    Olaf Schulte-Herbrüggen
    Department of Psychiatry, University Medicine Berlin, Germany
    J Reprod Immunol 74:170-3. 2007
    ..32, p<0.05). In conclusion, NGF is not altered during normal pregnancy on a systemic level. In addition, NGF displays a different regulation compared with BDNF during the menstrual cycle...
  32. ncbi request reprint Postnatal dexamethasone for lung disease of prematurity
    Marek Lommatzsch
    N Engl J Med 350:2715-8; author reply 2715-8. 2004
  33. ncbi request reprint A role for brain-derived neurotrophic factor in B cell development
    Berit Schuhmann
    Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, Philipps Universitat, Baldingerstrasse, 35033 Marburg, Germany
    J Neuroimmunol 163:15-23. 2005
    ..In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow...
  34. ncbi request reprint Mice running late: T-cell kinetics in models of asthma
    Marek Lommatzsch
    Am J Respir Crit Care Med 175:522b-523. 2007
  35. ncbi request reprint The neural underpinnings of asthma
    Marek Lommatzsch
    J Allergy Clin Immunol 119:254-5; author reply 255. 2007
  36. ncbi request reprint Letter regarding article by Ejiri et al, "possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease"
    Marek Lommatzsch
    Circulation 113:e724; author reply e724-5. 2006