Matthias Lohr

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint [Pancreatic Enzymes and intestinal Ischemia]
    J M Lohr
    II Medizinische Universitätsklinik, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg und Chirurgische Klinik, Universitat Freiburg
    Z Gastroenterol 40:147-8. 2002
  2. ncbi request reprint [Indications for pancreatic biopsy. Uncommon, but increasingly more important]
    J M Lohr
    II Medizinische Universitätsklinik Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Pathologe 26:67-72. 2005
  3. ncbi request reprint [Proteome analysis--basis for individualized pancreatic carcinoma therapy?]
    J M Lohr
    Klinische Kooperationseinheit für Molekulare Gastroenterologie dkfz E180, II Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg
    Internist (Berl) 47:S40-8. 2006
  4. ncbi request reprint Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century
    Matthias Lohr
    Molecular Gastroenterology, Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Cancer Chemother Pharmacol 49:S21-4. 2002
  5. pmc Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis
    Matthias Lohr
    Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Neoplasia 7:17-23. 2005
  6. pmc Genes and proteins differentially expressed during in vitro malignant transformation of bovine pancreatic duct cells
    R Jesnowski
    Clinical Cooperation Unit Molecular Gastroenterology E180, German Cancer Research Center Heidelberg and Department of Medicine II, Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany
    Neoplasia 9:136-46. 2007
  7. ncbi request reprint Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: low-dose ifosfamide and local tumor irradiation
    Eduard Ryschich
    Department of Surgery, University of Heidelberg, Germany
    Int J Cancer 113:649-53. 2005
  8. doi request reprint Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis
    Tomas Hucl
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University of Heidelberg, Mannheim D 68167, Germany
    Eur J Gastroenterol Hepatol 21:1032-5. 2009
  9. ncbi request reprint DNA microarray analysis of pancreatic malignancies
    Regine Brandt
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany
    Pancreatology 4:587-97. 2004
  10. ncbi request reprint Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma
    Jörg Ringel
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Heidelberg, Germany
    Cancer Res 66:9045-53. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint [Pancreatic Enzymes and intestinal Ischemia]
    J M Lohr
    II Medizinische Universitätsklinik, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg und Chirurgische Klinik, Universitat Freiburg
    Z Gastroenterol 40:147-8. 2002
  2. ncbi request reprint [Indications for pancreatic biopsy. Uncommon, but increasingly more important]
    J M Lohr
    II Medizinische Universitätsklinik Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Pathologe 26:67-72. 2005
    ..A new biopsy indication is the demonstration of certain markers or gene mutations that are needed for the initiation of special treatments, e.g. EGFR-Cetuximab...
  3. ncbi request reprint [Proteome analysis--basis for individualized pancreatic carcinoma therapy?]
    J M Lohr
    Klinische Kooperationseinheit für Molekulare Gastroenterologie dkfz E180, II Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg
    Internist (Berl) 47:S40-8. 2006
    ..First results, however, suggest some hope for the development of a new understanding of the molecular biology in pancreatic cancer yielding into very specific markers of disease or allowing a rational and individualized therapy...
  4. ncbi request reprint Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century
    Matthias Lohr
    Molecular Gastroenterology, Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Cancer Chemother Pharmacol 49:S21-4. 2002
    ..Angiographic experiments in the pig confirmed the feasibility of an intraarterial placement of the capsules into the pancreas. A clinical protocol was established and approved...
  5. pmc Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis
    Matthias Lohr
    Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Neoplasia 7:17-23. 2005
    ....
  6. pmc Genes and proteins differentially expressed during in vitro malignant transformation of bovine pancreatic duct cells
    R Jesnowski
    Clinical Cooperation Unit Molecular Gastroenterology E180, German Cancer Research Center Heidelberg and Department of Medicine II, Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany
    Neoplasia 9:136-46. 2007
    ..Thus, we were able to establish an in vitro model of pancreatic carcinogenesis, which enabled us to identify genes and proteins differentially expressed during the early steps of malignant transformation...
  7. ncbi request reprint Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: low-dose ifosfamide and local tumor irradiation
    Eduard Ryschich
    Department of Surgery, University of Heidelberg, Germany
    Int J Cancer 113:649-53. 2005
    ..There was no evidence of late activation of lymphocyte infiltration and PCNA-positive tumor cells...
  8. doi request reprint Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis
    Tomas Hucl
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University of Heidelberg, Mannheim D 68167, Germany
    Eur J Gastroenterol Hepatol 21:1032-5. 2009
    ..The ACE gene insertion/deletion (I/D) polymorphism in intron 16 accounts for nearly half the variation in serum ACE levels. This study determined the frequency of the I/D polymorphism in patients with acute and chronic pancreatitis...
  9. ncbi request reprint DNA microarray analysis of pancreatic malignancies
    Regine Brandt
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany
    Pancreatology 4:587-97. 2004
    ..In addition, the applied techniques are discussed in the context of pancreatic malignancies...
  10. ncbi request reprint Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma
    Jörg Ringel
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Heidelberg, Germany
    Cancer Res 66:9045-53. 2006
    ..In conclusion, our findings provide evidence of aberrant expression of the proteolytically active ADAM17/TACE in advanced precursor lesions (PanIN-3) and PDAC while identifying its critical involvement in the invasion process...
  11. doi request reprint Inhibition of ankyrin-B expression reduces growth and invasion of human pancreatic ductal adenocarcinoma
    Ying Chen
    Clinical Cooperation Unit Molecular Gastroenterology G350, DKFZ, Heidelberg, Germany
    Pancreatology 10:586-96. 2010
    ..Ankyrin-B (ANK2) was identified as being overexpressed in PDAC in a previous study by our group. ANK2 overexpression has been described in several tumors; however, the function of ANK2 in pancreatic carcinoma has not been elucidated...
  12. ncbi request reprint The gut origin of bacterial pancreatic infection during acute experimental pancreatitis in rats
    Stephan Samel
    Department of Surgery, University Hospital Mannheim, Germany
    Pancreatology 2:449-55. 2002
    ..A novel animal model was used to assess minimal transit time of bacterial translocation (BT) across the gut mucosa in vivo using green fluorescent protein-transfected Escherichia coli and intravital video microscopy...
  13. ncbi request reprint Poorly differentiated small cell carcinoma of the pancreas. A case report and review of the literature
    Simone Berkel
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Heidelberg, Germany
    Pancreatology 4:521-6. 2004
    ..Thus, 5-fluorouracil on a weekly basis was started. The patient died 8 months after diagnosis and had not been hospitalised in the meantime...
  14. pmc The MUC gene family: their role in diagnosis and early detection of pancreatic cancer
    Jörg Ringel
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Mol Cancer 2:9. 2003
    ..Furthermore, the potential use of MUCs in the diagnosis and differentiation of intraductal papillary-mucinous neoplasm's (IPMNs) will be discussed...
  15. doi request reprint Doxorubicin and mitoxantrone drug eluting beads for the treatment of experimental peritoneal carcinomatosis in colorectal cancer
    Michael Keese
    Department of Surgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Cancer 124:2701-8. 2009
    ..No animal survived 3 injections of free doxorubicin. We conclude that bead encapsulation of chemotherapeutic drugs may show the advantage of less toxicity in peritoneal spread of colorectal cancer...
  16. ncbi request reprint Proteome analysis of isolated myenteric plexus reveals significant changes in protein expression during postnatal development
    Cornelia Irene Hagl
    University of Heidelberg, Clinical Faculty Mannheim, Department of Paediatric Surgery, Mannheim, Germany
    Auton Neurosci 122:1-8. 2005
    ....
  17. ncbi request reprint Is it possible to survive pancreatic cancer?
    Matthias Lohr
    University of Heidelberg, Heidelberg, Germany
    Nat Clin Pract Gastroenterol Hepatol 3:236-7. 2006
  18. ncbi request reprint Acute recurrent pancreatitis curtaining an intraductal papillary mucinous tumor of the pancreas
    Jurgen Retter
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg
    J Gastrointestin Liver Dis 16:445-7. 2007
    ..The usual clinical presentation is recurrent episodes of pancreatitis due to hypersecretion of mucin and temporary obstruction of the main pancreatic duct...
  19. ncbi request reprint HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma
    Tomas Hucl
    Department of Medicine II, University of Heidelberg, Mannheim, Germany
    Genet Med 9:479-83. 2007
    ..C282Y and p.H63D may increase susceptibility to chronic liver and pancreatic disease. This study determines the frequencies of p.C282Y and p.H63D alterations in patients with chronic pancreatitis and pancreatic adenocarcinoma...
  20. ncbi request reprint Proteomics in pancreatic disease
    Matthias Lohr
    Molecular Gastroenterology, Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Pancreatology 4:67-75. 2004
    ..Finally, potential applications of proteomics for the pancreas, in concert with other techniques, are cited...
  21. ncbi request reprint Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine
    Ralf Jesnowski
    Clinical Cooperation Unit Molecular Gastroenterology, DKFZ, Heidelberg, Germany
    Lab Invest 85:1276-91. 2005
    ..Cultivation of activated PSC on a reconstituted basement membrane plus treatment with NAC was able to deactivate the cells, thus pointing to the possibility of an antifibrosis therapy in chronic pancreatitis...