M Loeffler

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. doi request reprint A biomathematical model of human thrombopoiesis under chemotherapy
    Markus Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
    J Theor Biol 264:287-300. 2010
  2. doi request reprint Classifying prostate cancer malignancy by quantitative histomorphometry
    Markus Loeffler
    Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany
    J Urol 187:1867-75. 2012
  3. ncbi request reprint Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin's disease. International Database on Hodgkin's Disease Overview Study Group
    M Loeffler
    Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany
    J Clin Oncol 16:818-29. 1998
  4. ncbi request reprint Model based development of the BEACOPP regimen for advanced stage Hodgkin's disease. German Hodgkin's Lymphoma Study Group
    M Loeffler
    Institute for Medical Informatics, Statistics und Epidemiology IMISE, University of Leipzig, Germany
    Ann Oncol 9:S73-8. 1998
  5. ncbi request reprint Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models--a conceptual approach
    Markus Loeffler
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Cells Tissues Organs 171:8-26. 2002
  6. doi request reprint Impact of first- and second-line treatment for Hodgkin's lymphoma on the incidence of AML/MDS and NHL--experience of the German Hodgkin's Lymphoma Study Group analyzed by a parametric model of carcinogenesis
    M Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Ann Oncol 22:681-8. 2011
  7. ncbi request reprint Acute hematologic toxicity and practicability of dose-intensified BEACOPP chemotherapy for advanced stage Hodgkin's disease. German Hodgkin's Lymphoma Study Group (GHSG)
    C Engel
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany
    Ann Oncol 11:1105-14. 2000
  8. doi request reprint Comparison and modelling of pegylated or unpegylated G-CSF schedules in CHOP-14 regimen of elderly patients with aggressive B-cell lymphoma
    S Zeynalova
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Haertelstraße 16 18, 04107, Leipzig, Germany
    Ann Hematol 92:1641-52. 2013
  9. ncbi request reprint Low acute hematological toxicity during chemotherapy predicts reduced disease control in advanced Hodgkin's disease
    O Brosteanu
    Coordinating Center for Clinical Trials, University of Leipzig, Prager Str 34, 04317, Leipzig, Germany
    Ann Hematol 83:176-82. 2004
  10. ncbi request reprint Prognostic factors for hematotoxicity of chemotherapy in aggressive non-Hodgkin's lymphoma
    M Ziepert
    Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Ann Oncol 19:752-62. 2008

Detail Information

Publications47

  1. doi request reprint A biomathematical model of human thrombopoiesis under chemotherapy
    Markus Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
    J Theor Biol 264:287-300. 2010
    ..We conclude that our proposed model proved validity for both, different chemotherapeutic regimens and thrombopheresis as well. It is useful to assess the thrombocytopenic risk in the planning phase of a clinical trial...
  2. doi request reprint Classifying prostate cancer malignancy by quantitative histomorphometry
    Markus Loeffler
    Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany
    J Urol 187:1867-75. 2012
    ..Thus, we investigated whether digital image based automated quantitative histomorphometry could be used to achieve a more standardized, reproducible classification outcome...
  3. ncbi request reprint Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin's disease. International Database on Hodgkin's Disease Overview Study Group
    M Loeffler
    Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany
    J Clin Oncol 16:818-29. 1998
    ..To perform a meta-analysis of all randomized trials that compared chemotherapy (CT) alone versus combined modality treatment (CT + radiotherapy [RT]) for which individual patient data could be made available...
  4. ncbi request reprint Model based development of the BEACOPP regimen for advanced stage Hodgkin's disease. German Hodgkin's Lymphoma Study Group
    M Loeffler
    Institute for Medical Informatics, Statistics und Epidemiology IMISE, University of Leipzig, Germany
    Ann Oncol 9:S73-8. 1998
    ..The dose level found feasible for a large multicentre setting turned out to be in the required magnitude. The HD9 trial of the GHSG was then initiated to examine whether the predicted dose response curve really exists...
  5. ncbi request reprint Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models--a conceptual approach
    Markus Loeffler
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Cells Tissues Organs 171:8-26. 2002
    ..We provide some general ideas on how to proceed with such theories and illustrate this with worked models for tissue stem cells of the hematopoietic system and the intestinal epithelium...
  6. doi request reprint Impact of first- and second-line treatment for Hodgkin's lymphoma on the incidence of AML/MDS and NHL--experience of the German Hodgkin's Lymphoma Study Group analyzed by a parametric model of carcinogenesis
    M Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Ann Oncol 22:681-8. 2011
    ..Using a parametric carcinogenesis model, we disentangle the superimposing effects of primary and relapse therapies of Hodgkin's disease on secondary neoplasias...
  7. ncbi request reprint Acute hematologic toxicity and practicability of dose-intensified BEACOPP chemotherapy for advanced stage Hodgkin's disease. German Hodgkin's Lymphoma Study Group (GHSG)
    C Engel
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany
    Ann Oncol 11:1105-14. 2000
    ..To enable more extensive testing of BEACOPP we characterized its practicability regarding schedule adherence, acute hematotoxicity and need for supportive treatment...
  8. doi request reprint Comparison and modelling of pegylated or unpegylated G-CSF schedules in CHOP-14 regimen of elderly patients with aggressive B-cell lymphoma
    S Zeynalova
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Haertelstraße 16 18, 04107, Leipzig, Germany
    Ann Hematol 92:1641-52. 2013
    ..Our model correctly predicts time courses of leukocytes. Further model predictions are presented, which can be tested in subsequent clinical trials...
  9. ncbi request reprint Low acute hematological toxicity during chemotherapy predicts reduced disease control in advanced Hodgkin's disease
    O Brosteanu
    Coordinating Center for Clinical Trials, University of Leipzig, Prager Str 34, 04317, Leipzig, Germany
    Ann Hematol 83:176-82. 2004
    ..Hematotoxicity is an independent prognostic factor for treatment outcome. This observation suggests a strategy of individualized dosing adapted to hematotoxicity...
  10. ncbi request reprint Prognostic factors for hematotoxicity of chemotherapy in aggressive non-Hodgkin's lymphoma
    M Ziepert
    Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Ann Oncol 19:752-62. 2008
    ..Little is known on the heterogeneity of hematotoxicity in patients receiving multicycle chemotherapy...
  11. ncbi request reprint Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
    V Boehme
    Department of Haematology, General Hospital St Georg, Hamburg, and Institute of Medical Informatics, Statistics and Epidemiology, University Leipzig, Germany
    Ann Oncol 18:149-57. 2007
    ....
  12. ncbi request reprint Modelling of chemotherapy: the effective dose approach
    D Hasenclever
    University of Leipzig, IMISE, Germany
    Ann Hematol 80:B89-94. 2001
    ..The model is applied to explain why treatment differences in aggressive NHL appear to differ by risk groups in aggressive NHL. A respective meta-subgroup analysis to confirm this interaction hypothesis is proposed...
  13. doi request reprint Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats
    M Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany
    Cell Prolif 42:823-37. 2009
    ..This comparison was performed using rat experiments and biomathematical modelling of granulopoiesis...
  14. ncbi request reprint A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Germany
    Exp Hematol 30:853-61. 2002
    ..To solve this problem, we propose a new, comprehensive model concept...
  15. ncbi request reprint Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
    A Wunderlich
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Ann Oncol 14:881-93. 2003
    ..To enable more extensive testing of these schemes we here characterise their practicability regarding schedule adherence, acute haematotoxicity and need for supportive treatment...
  16. doi request reprint A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaenia
    M Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Cell Prolif 42:813-22. 2009
    ..In this study, we have aimed to construct a pharmacokinetic model of G-CSF derivatives filgrastim and pegfilgrastim in mice...
  17. ncbi request reprint Treatment of anaemia in myelodysplastic syndromes with prolonged administration of recombinant human granulocyte colony-stimulating factor and erythropoietin
    L Mantovani
    Department of Haematology and Oncology, St Georg Hospital, Leipzig, Germany
    Br J Haematol 109:367-75. 2000
    ..Our results suggest that a prolonged combination treatment with rhG-CSF and rhEPO is highly effective in achieving a stable and long-lasting erythroid response in many patients with MDS and low blast count...
  18. pmc A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt
    Peter Buske
    Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany
    PLoS Comput Biol 7:e1001045. 2011
    ..We predict that the tissue should be able to fully recover after complete elimination of cellular subpopulations including subpopulations deemed to be functional stem cells. This challenges current views of tissue stem cell organisation...
  19. doi request reprint Genetic regulation of serum phytosterol levels and risk of coronary artery disease
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
    Circ Cardiovasc Genet 3:331-9. 2010
    ..Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD)...
  20. doi request reprint Mathematical modeling of genesis and treatment of chronic myeloid leukemia
    Matthias Horn
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Cells Tissues Organs 188:236-47. 2008
    ....
  21. pmc Noise-driven stem cell and progenitor population dynamics
    Martin Hoffmann
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany
    PLoS ONE 3:e2922. 2008
    ..Herein, stochastic fluctuations are either suppressed or can trigger the transition, but they do not actually determine the attractor states...
  22. pmc Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Blood 112:4874-83. 2008
    ..The model provides comprehensive systemic and quantitative insights into the clonal heterogeneity among HSCs with potential applications in predicting the behavior of malignant and/or genetically modified cells...
  23. pmc Stem cell proliferation and quiescence--two sides of the same coin
    Ingmar Glauche
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    PLoS Comput Biol 5:e1000447. 2009
    ..Furthermore, we suggest an experimental strategy which is suited to demonstrate that the repopulation ability among the population of label retaining cells changes during the course of dilution...
  24. doi request reprint Efficacy of annual colonoscopic surveillance in individuals with hereditary nonpolyposis colorectal cancer
    Christoph Engel
    Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Clin Gastroenterol Hepatol 8:174-82. 2010
    ..Individuals with hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome) have a high risk for developing colorectal cancer (CRC). We evaluated the efficacy of annual surveillance colonoscopies to detect adenomas and CRCs...
  25. doi request reprint Standard International prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era
    Marita Ziepert
    Dipl Math, Institute for Medical Informatics, Statistics, and Epidemiology, Universitat Leipzig, Härtelstrasse 16 18, D 04107 Leipzig, Germany
    J Clin Oncol 28:2373-80. 2010
    ..To investigate whether the IPI has maintained its power for risk stratification when rituximab is combined with CHOP, we analyzed the prognostic relevance of IPI in three prospective clinical trials...
  26. ncbi request reprint Epidemiology of sepsis in Germany: results from a national prospective multicenter study
    Christoph Engel
    Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107, Leipzig, Germany
    Intensive Care Med 33:606-18. 2007
    ..To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size...
  27. pmc Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion
    Joerg Galle
    Interdisciplinary Center for Bioinformatics, Research Laboratories, University of Leipzig, Leipzig, Germany
    Am J Pathol 169:1802-11. 2006
    ..Our combined experimental-theoretical analysis provides novel insight to how variations of individual cell properties can be linked to individual patterns of tumor cell invasion...
  28. pmc Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro
    Jörg Galle
    Interdisciplinary Centre for Bioinformatics, Leipzig, Germany
    Biophys J 88:62-75. 2005
    ..We compare our simulation results with experimental findings on a number of epithelial and tumor cell populations and suggest in vitro experiments to test our model predictions...
  29. ncbi request reprint Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Blood 105:609-16. 2005
    ..We conclude that hematopoietic stem cell organization should be understood as a flexible, self-organized rather than a fixed, preprogrammed process...
  30. ncbi request reprint Conceptual models to understand tissue stem cell organization
    Markus Loeffler
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany
    Curr Opin Hematol 11:81-7. 2004
    ..Specifically, they contribute to an understanding of latent mechanisms and crucial parameters of biologic processes. The following review gives an overview of recent developments in the field of hematopoietic tissue stem cell modeling...
  31. ncbi request reprint Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer
    Christoph Engel
    Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Int J Cancer 118:115-22. 2006
    ..A cost analysis reveals that about 25% of the costs can be saved using this strategy...
  32. ncbi request reprint Model-based design of chemotherapeutic regimens that account for heterogeneity in leucopoenia
    Markus Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Br J Haematol 132:723-35. 2006
    ....
  33. ncbi request reprint Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, D 04107 Leipzig, Haertelstrasse 16 18, Germany
    Nat Med 12:1181-4. 2006
    ..Moreover, we predict that the therapeutic benefit of imatinib can, under certain circumstances, be accelerated by combination with proliferation-stimulating treatment strategies...
  34. ncbi request reprint A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy
    Christoph Engel
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Blood 104:2323-31. 2004
    ..It is demonstrated that the model can be used to design and to select new drug schedules for subsequent clinical trial testing...
  35. ncbi request reprint Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications
    Ingmar Glauche
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Stem Cells 25:1791-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  36. ncbi request reprint Immunogenetic markers and seropositivity predict radiological progression in early rheumatoid arthritis independent of disease activity
    S Kaltenhäuser
    Department of Medicine IV, University of Leipzig, Germany
    J Rheumatol 28:735-44. 2001
    ....
  37. ncbi request reprint Cell migration and organization in the intestinal crypt using a lattice-free model
    F A Meineke
    Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany
    Cell Prolif 34:253-66. 2001
    ....
  38. ncbi request reprint Modelling human granulopoiesis under poly-chemotherapy with G-CSF support
    M Scholz
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    J Math Biol 50:397-439. 2005
    ..Conversely, our model can be used in a planning phase of a clinical trial to estimate the haematotoxicity of regimens based on new combinations of drugs already considered and with or without growth factor support...
  39. ncbi request reprint Development and implementation of an analysis tool for array-based comparative genomic hybridization
    M Kreuz
    University of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology, IMISE, Haertelstr 16 18, 04107 Leipzig, and Department of Internal Medicine III, University Hospital of Ulm, Germany
    Methods Inf Med 46:608-13. 2007
    ..Multi-step analysis of high-dimensional data requires an integrated suite of bioinformatic tools. In this paper we detail an analysis pipeline for array CGH data...
  40. ncbi request reprint AdaptFlow: protocol-based medical treatment using adaptive workflows
    U Greiner
    Department of Computer Science, University of Leipzig, Germany
    Methods Inf Med 44:80-8. 2005
    ....
  41. ncbi request reprint Large histological serial sections for computational tissue volume reconstruction
    U D Braumann
    University of Leipzig, Translational Centre for Regenerative Medicine, Department of Obstetrics and Gynecology, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Methods Inf Med 46:614-22. 2007
    ..A proof of principle study was conducted for microscopic tissue volume reconstructions using a new image processing chain operating on alternately stained large histological serial sections...
  42. ncbi request reprint Five theses concerning the clinical consequences of pathology and prognostic factors
    D Hasenclever
    University of Leipzig, IMISE, Germany
    Ann Hematol 80:B58-60. 2001
    ..In this conceptual and methodological paper we defend five theses concerning the clinical consequences of pathological and biological differences from a somewhat unorthodox biometrical point of view...
  43. ncbi request reprint Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration
    I Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Blood 91:3222-9. 1998
    ..The results illustrate that the cytokine network has nonlinear dynamic properties in vivo with dose-response characteristics of one cytokine being continuously modified by other cytokines...
  44. ncbi request reprint Standardized terminology for clinical trial protocols based on top-level ontological categories
    B Heller
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany
    Stud Health Technol Inform 101:46-60. 2004
    ..The concepts and relations described in the data dictionary are represented in natural language, semi-formally or formally according to their use...
  45. pmc Individual fates of mesenchymal stem cells in vitro
    Axel Krinner
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Haertelstr, 16 18, 04107 Leipzig, Germany
    BMC Syst Biol 4:73. 2010
    ..Here, we study MSC plasticity on the level of individual cells applying a multi-scale computer model that is based on the concept of noise-driven stem cell differentiation...
  46. ncbi request reprint A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa
    D Barthel
    University of Leipzig, Institute of Medical Informatics, Statistics and Epidemiology, Liebigstrasse 27, Leipzig D 04103, Germany
    Cell Prolif 35:48-59. 2002
    ..The results show a strong circadian rhythm in the migration velocity and the related parameters...
  47. ncbi request reprint Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals
    Anke Tonjes
    University of Leipzig, IIIrd Medical Department, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes Care 29:2489-97. 2006
    ..The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic meta-analysis of all available published evidence...