M Linnebank

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a potential pitfall in diagnosis: a first family outside Europe
    Alexander Semmler
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Clin Chem Lab Med 44:1088-9. 2006
  2. ncbi request reprint Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, 53125 Bonn, Germany
    Neurobiol Dis 23:725-30. 2006
  3. ncbi request reprint Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Eur J Neurol 12:614-8. 2005
  4. ncbi request reprint The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Int J Mol Med 16:759-61. 2005
  5. ncbi request reprint The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype
    Michael Linnebank
    University Hospital Muenster, Dept Pediatrics, Muenster, Germany
    Hum Mutat 24:352-3. 2004
  6. ncbi request reprint Methionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases
    M Linnebank
    Children s Hospital, University of Munster, Munster, Germany
    J Inherit Metab Dis 28:1167-8. 2005
  7. pmc The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
    M Linnebank
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, Bonn D 53125, Germany
    Br J Cancer 90:1969-71. 2004
  8. ncbi request reprint Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Neurology 66:442-3. 2006
  9. ncbi request reprint Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis
    M Linnebank
    Klinik und Poliklinik fuer Neurologie, Universitaetsklinikum Bonn, Germany
    Neurology 61:1819-20. 2003
  10. ncbi request reprint Isolated thrombosis due to the cystathionine beta-synthase mutation c.833T>C (1278T)
    M Linnebank
    Klinik und Poliklinik für Kinderheilkunde, Universitaetsklinikum Münster, Germany
    J Inherit Metab Dis 26:509-11. 2003

Detail Information

Publications40

  1. ncbi request reprint Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a potential pitfall in diagnosis: a first family outside Europe
    Alexander Semmler
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Clin Chem Lab Med 44:1088-9. 2006
    ..Benign autosomal-dominant hyper-ACE-emia should be considered for differential diagnosis of elevated ACE levels worldwide...
  2. ncbi request reprint Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, 53125 Bonn, Germany
    Neurobiol Dis 23:725-30. 2006
    ..The Cu(2+) chelating action of HCys and impairement of COX activity represent novel mechanisms of HCys neurotoxicity, which might be preventable by supplementation of Cu(2+)...
  3. ncbi request reprint Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Eur J Neurol 12:614-8. 2005
    ..677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies...
  4. ncbi request reprint The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Int J Mol Med 16:759-61. 2005
    ..Separate analysis of female and male subjects revealed that the influence of the MTR genotype on male subjects became relevant at a younger age as opposed to female subjects suggesting a gender-dependent effect...
  5. ncbi request reprint The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype
    Michael Linnebank
    University Hospital Muenster, Dept Pediatrics, Muenster, Germany
    Hum Mutat 24:352-3. 2004
    ..862G>C (p.Ala288Pro) and c.1135C>T (p.Arg379Trp). In summary, the data of this study suggest that the CBS c.1224-2A>C allele confers vitamin B6 nonresponsiveness and that this mutant allele came from a common ancestor...
  6. ncbi request reprint Methionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases
    M Linnebank
    Children s Hospital, University of Munster, Munster, Germany
    J Inherit Metab Dis 28:1167-8. 2005
    ..Thus, MAT I/III deficiency is important in the differential diagnoses of hyperhomocysteinaemia, which may lead to clinical complications of MAT I/III deficiency...
  7. pmc The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
    M Linnebank
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, Bonn D 53125, Germany
    Br J Cancer 90:1969-71. 2004
    ..26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis...
  8. ncbi request reprint Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Neurology 66:442-3. 2006
    ..002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy...
  9. ncbi request reprint Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis
    M Linnebank
    Klinik und Poliklinik fuer Neurologie, Universitaetsklinikum Bonn, Germany
    Neurology 61:1819-20. 2003
  10. ncbi request reprint Isolated thrombosis due to the cystathionine beta-synthase mutation c.833T>C (1278T)
    M Linnebank
    Klinik und Poliklinik für Kinderheilkunde, Universitaetsklinikum Münster, Germany
    J Inherit Metab Dis 26:509-11. 2003
    ..Thus, not only C-terminal mutations but also the most common mutation in classical homocystinuria, CBS 1278T, can lead to isolated thrombophilic events. These data support the hypothesis that homocystinuria is an underdiagnosed disease...
  11. ncbi request reprint The cystathionine beta-synthase variant c.844_845ins68 protects against CNS demyelination in X-linked adrenoleukodystrophy
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Hum Mutat 27:1063-4. 2006
    ..Since methionine metabolism can easily be influenced by vitamin and amino acid substitution, this observation could be a basis of novel treatment strategies in this yet untreatable disease. (c) 2006 Wiley-Liss, Inc...
  12. ncbi request reprint Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevance
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Stroke 37:2840-2. 2006
    ..Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT...
  13. ncbi request reprint Acute methotrexate-induced encephalopathy--causal relation to homozygous allelic state for MTR c.2756A>G (D919G)?
    M Linnebank
    Dept of Neurology, University Hospital of Bonn, Germany
    J Chemother 19:455-7. 2007
    ..This finding encourages further studies to determine to what extent the individual conditions of folate and methionine metabolism influence the effects or side-effects of MTX treatment...
  14. ncbi request reprint MTX-induced white matter changes are associated with polymorphisms of methionine metabolism
    M Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neurology 64:912-3. 2005
    ..7 (p = 0.001). The authors conclude that methionine metabolism influences MTX neurotoxicity...
  15. ncbi request reprint The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis
    H G Koch
    Department of Paediatrics, University Hospital, Munster, Germany
    Eur J Pediatr 158:S113-6. 1999
    ..3 micromol/l and the CT genotype of the MTHFR C677T variant are significant risk factors for venous vascular occlusion in children...
  16. ncbi request reprint Neuropsychological outcome after chemotherapy for primary CNS lymphoma: a prospective study
    K Fliessbach
    Department of Neurology, University Hospital Bonn, Germany
    Neurology 64:1184-8. 2005
    ..The impact of high-dose methotrexate (MTX)-based chemotherapy alone on cognition and quality of life (QOL) is controversial...
  17. ncbi request reprint High prevalence of the I278T mutation of the human cystathionine beta-synthase detected by a novel screening application
    M Linnebank
    Klinik und Poliklinik für Kinderheilkunde, Westfällische Wilhelms Universität Münster, Germany
    Thromb Haemost 85:986-8. 2001
    ..800. Our data indicate that homocystinuria due to cystathionine beta-synthase deficiency is a frequently unrecognized disorder resulting in a high risk of thromboembolic events...
  18. pmc Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma
    M Linnebank
    Department Neurology, University Hospital Bonn, Bonn, Germany
    Br J Cancer 107:1840-3. 2012
    ..Here, we investigated whether such variants are associated with MTX efficacy in terms of overall survival in MTX-treated PCNSL patients...
  19. ncbi request reprint A common haplotype for the 677T thermolabile variant of the 5,10-methylenetetrahydrofolate reductase gene in thrombophilic patients and controls
    M Linnebank
    Universitaetsklinikum Muenster, Klinik und Poliklinik fuer Kinderheilkunde, Muenster, Germany
    Hum Mutat 20:478. 2002
    ..The results of this study demonstrate that the 677T alleles are associated with a common haplotype most likely due to a founder effect and that the 677T haplotype was the same in the healthy and the thrombophilic German subjects...
  20. doi request reprint The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study
    L Klotz
    Department of Neurology, University Bonn, Bonn, Germany
    Neurosci Lett 468:183-5. 2010
    ..If confirmed in an independent study sample, the underlying mechanisms should be investigated, which may lead to novel insights in biochemical factors influencing the aetiology and pathophysiology of MS...
  21. ncbi request reprint FDG-PET in immunocompetent patients with primary central nervous system lymphoma: correlation with MRI and clinical follow-up
    H Palmedo
    Department of Nuclear Medicine, University Hospital of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Eur J Nucl Med Mol Imaging 33:164-8. 2006
    ..The role of FDG-PET in primary central nervous system lymphoma (PCNSL) is unclear. It was the aim of this study to investigate the role of FDG-PET in detecting PCNSL and in predicting response to chemotherapy...
  22. doi request reprint Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms
    Alexander Semmler
    Department of Neurology, University of Bonn, Bonn, Germany
    Cerebrovasc Dis 26:425-9. 2008
    ..We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms...
  23. ncbi request reprint The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme
    Alexander Semmler
    Department of Neurology, University Hospital Bonn, Sigmund Freud Strasse, 25, 53105 Bonn, Germany
    Cancer Epidemiol Biomarkers Prev 15:2314-6. 2006
    ..72/0.26/0.02 and controls AA/AG/GG: 0.57/0.38/0.05, degrees of freedom = 2; chi(2) = 17.86 (Pearson); P < 0.001]. No association between glioblastoma multiforme and the two other polymorphisms was observed...
  24. ncbi request reprint Structure of the human argininosuccinate synthetase gene and an improved system for molecular diagnostics in patients with classical and mild citrullinemia
    J Haberle
    Klinik und Poliklinik für Kinderheilkunde, Universitatsklinikum Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
    Hum Genet 110:327-33. 2002
    ....
  25. ncbi request reprint Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
    H Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Neurology 63:2255-60. 2004
    ..Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke...
  26. doi request reprint Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease
    Julius Popp
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Alzheimers Dis 18:819-28. 2009
    ..The results suggest that alteration of the homocysteine metabolism is related to increased accumulation of phosphorylated tau and may contribute to the neurofibrillary pathology in normal aging and in AD...
  27. doi request reprint Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigation
    Alexander Semmler
    Department of Neurology, University Hospital of Bonn, Germany
    J Neurosurg 108:999-1004. 2008
    ..The authors investigated the association of 7 functional polymorphisms of methionine metabolism with meningioma formation...
  28. pmc The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiforme
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 10:548-52. 2008
    ..89, p = 0.015). These data suggest the MTHFR c.677C>T variant is a risk factor for survival in GBM patients...
  29. ncbi request reprint Common genetic coagulation variants are not associated with ischemic stroke in a case-control study
    Susanna Moskau
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurol Res 32:519-22. 2010
    ..Abnormalities in the coagulation pathway are often included in the diagnostic work-up of stroke patients, especially in young adults with cryptogenic stroke...
  30. ncbi request reprint Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease
    Aleksandar Rakovic
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Mov Disord 24:429-33. 2009
    ..7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD...
  31. doi request reprint Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population
    Delia Kurzwelly
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    J Neurooncol 100:187-92. 2010
    ..Our results suggest the hypothesis that folate and methionine metabolism is relevant to susceptibility to PCNSL...
  32. ncbi request reprint Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients
    Delia Kurzwelly
    Clinical Neurooncology Unit, Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurooncol 90:53-5. 2008
    ..No significant difference between these two groups was found using Pearson's chi(2) test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL...
  33. pmc Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 11:2-8. 2009
    ..73; p < 0.001), in addition to male gender (chi(2) = 11.95; p = 0.001). These data strengthen the hypothesis that MTX effects are influenced by methionine metabolism, which may offer new strategies to improve MTX-based therapies...
  34. doi request reprint Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma
    Annika Juergens
    Department of Neurology, Knappschaftskrankenhaus, University of Bochum, Bochum, Germany
    Ann Neurol 67:182-9. 2010
    ..To evaluate long-term progression-free survival and overall survival, quality of life, and cognitive function in primary central nervous system lymphoma after systemic and intraventricular chemotherapy without radiotherapy...
  35. ncbi request reprint Identification and functional analysis of two novel mutations in the CBS gene in Polish patients with homocystinuria
    Marek Orendáè
    Institute of Inherited Metabolic Diseases, Charles University First Faculty of Medicine, Prague, Czech Republic
    Hum Mutat 23:631. 2004
    ..442G>A) and two novel mutations (c.429C>G and c.1039+1G>T). The pathogenicity of the novel mutations was demonstrated by expression in E.coli. This is the first published communication on mutations leading to CBS deficiency in Poland...
  36. ncbi request reprint Lack of genetic dispositions to hyperhomocysteinemia in Alzheimer disease
    Michael Linnebank
    Am J Med Genet A 131:101-2. 2004
  37. pmc Diversity of cystathionine beta-synthase haplotypes bearing the most common homocystinuria mutation c.833T>C: a possible role for gene conversion
    Petr Vyletal
    Center for Applied Genomics, Institute of Inherited Metabolic Disorders, Charles University 1st Faculty of Medicine, Prague, Czech Republic
    Hum Mutat 28:255-64. 2007
    ..833C; -] chromosomes may have originated by recurrent gene conversion employing the common nonpathogenic c.[833C; 844_845ins68] chromosomes as templates...
  38. ncbi request reprint Cardiomyopathy in congenital disorders of glycosylation
    Josef Gehrmann
    Department of Pediatric Cardiology, Westfalische Wilhelms Universitat Munster Westf, Munster, Germany
    Cardiol Young 13:345-51. 2003
    ..Cardiac involvement contributes significantly to morbidity and mortality, and probably to sudden cardiac death in this disorder...
  39. ncbi request reprint Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene
    Michael Linnebank
    Universitatsklinikum Munster, Klinik und Poliklinik fuer Kinderheilkunde, 48149 Munster, Germany
    Hum Genet 111:350-9. 2002
    ..1153C-->T (4). This study introduces a system for mutation analysis in the ASL gene, thereby elucidating the genetic background of ASL deficiency, which was found to be associated with considerable allelic heterogeneity...
  40. doi request reprint Global DNA methylation is influenced by smoking behaviour
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Eur Neuropsychopharmacol 18:295-8. 2008
    ..68, p=0.02) and completely vanished if the offspring smoked or had ever smoked. These findings suggest an association between smoking behaviour and global DNA methylation, which may be of importance for a wide range of diseases...