Axel Linke

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi Transapical minimally invasive aortic valve implantation: multicenter experience
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 116:I240-5. 2007
  2. ncbi Successful treatment for intraoperatively evolving acute aortic dissection in a neonate
    Thomas Walther
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 76:1286-7. 2003
  3. doi Transapical aortic valve implantation: step by step
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 87:276-83. 2009
  4. ncbi Prospectively randomized evaluation of stented xenograft hemodynamic function in the aortic position
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Germany
    Circulation 110:II74-8. 2004
  5. ncbi Early results with stentless mitral valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Heart Valve Dis 13:766-770; discussion 770-1. 2004
  6. doi Transapical aortic valve implantation in patients requiring redo surgery
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strümpellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 36:231-4; discussion 234-5. 2009
  7. ncbi A novel adhesion barrier facilitates reoperations in complex congenital cardiac surgery
    Thomas Walther
    Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    J Thorac Cardiovasc Surg 129:359-63. 2005
  8. ncbi Beating heart off-pump myocardial revascularization in an infant
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Ann Thorac Surg 79:2151-3. 2005
  9. ncbi Surgical atrial septal defect closure after interventional occluder placement: incidence and outcome
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Thorac Cardiovasc Surg 134:731-7. 2007
  10. ncbi Valve-in-a-valve concept for transcatheter minimally invasive repeat xenograft implantation
    Thomas Walther
    Klinik fur Herzchirurgie, Leipzig, Germany
    J Am Coll Cardiol 50:56-60. 2007

Detail Information

Publications94

  1. ncbi Transapical minimally invasive aortic valve implantation: multicenter experience
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 116:I240-5. 2007
    ..To evaluate initial multicenter results with minimally invasive transapical aortic valve implantation (TAP-AVI) for high risk patients with aortic stenosis...
  2. ncbi Successful treatment for intraoperatively evolving acute aortic dissection in a neonate
    Thomas Walther
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 76:1286-7. 2003
    ..This required immediate ascending aorta and aortic arch reconstruction with coarctation of the aorta resection under hypothermic circulatory arrest. The surgical management of this rather unique situation is discussed here...
  3. doi Transapical aortic valve implantation: step by step
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 87:276-83. 2009
    ..Transapical aortic valve implantation is a new minimally invasive technique for beating heart, off-pump, aortic valve implantation in high-risk patients...
  4. ncbi Prospectively randomized evaluation of stented xenograft hemodynamic function in the aortic position
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Germany
    Circulation 110:II74-8. 2004
    ..Standard stented aortic xenograft valves have not yet been compared regarding their hemodynamic function using a stratified intraoperative randomization protocol...
  5. ncbi Early results with stentless mitral valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Heart Valve Dis 13:766-770; discussion 770-1. 2004
    ..Implantation of a chordally supported stentless mitral valve (SMV) may be the strategy of choice for patients with severe degenerative mitral valve disease. Herein, the early clinical results of this surgical technique were analyzed...
  6. doi Transapical aortic valve implantation in patients requiring redo surgery
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strümpellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 36:231-4; discussion 234-5. 2009
    ..To evaluate the results of minimally invasive transapical aortic valve implantation (TA-AVI) in patients requiring redo surgery...
  7. ncbi A novel adhesion barrier facilitates reoperations in complex congenital cardiac surgery
    Thomas Walther
    Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    J Thorac Cardiovasc Surg 129:359-63. 2005
    ..Reoperations are associated with an increased surgical risk due to adhesions. We prospectively evaluated a bioresorbable membrane after surgery for congenital heart defects over a 3.5-year period...
  8. ncbi Beating heart off-pump myocardial revascularization in an infant
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Ann Thorac Surg 79:2151-3. 2005
    ..Thus, closure of the left main stem and left internal mammary artery-left anterior descending coronary artery bypass grafting were performed successfully with the heart beating...
  9. ncbi Surgical atrial septal defect closure after interventional occluder placement: incidence and outcome
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Thorac Cardiovasc Surg 134:731-7. 2007
    ..Closure of ostium secundum atrial septal defects is generally performed by using an interventional approach. We evaluated the outcome of patients requiring secondary surgical therapy...
  10. ncbi Valve-in-a-valve concept for transcatheter minimally invasive repeat xenograft implantation
    Thomas Walther
    Klinik fur Herzchirurgie, Leipzig, Germany
    J Am Coll Cardiol 50:56-60. 2007
    ..This study sought to evaluate the feasibility of minimally invasive transapical repeat valve-in-a-valve (VinV) implantation...
  11. doi Transcatheter aortic valve implantation: time to expand?
    Thomas Walther
    Herzzentrum, Klinik für Herzchirurgie und Kardiologie, Universitat Leipzig, Leipzig, Germany
    Curr Opin Cardiol 23:111-6. 2008
    ..Transcatheter aortic valve implantation is a new, emerging technique that has been performed in elderly and higher-risk patients suffering severe, symptomatic aortic stenosis...
  12. ncbi Patient prosthesis mismatch affects short- and long-term outcomes after aortic valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 30:15-9. 2006
    ..The aim of this study was to evaluate the impact of patient prosthesis mismatch (PPM) and additional risk factors on outcome after aortic valve replacement (AVR)...
  13. ncbi Moderate versus deep hypothermia for arterial switch operation
    T Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Thorac Cardiovasc Surg 54:255-8. 2006
    ..We evaluated the impact of moderate versus deep intraoperative hypothermia on postoperative morbidity in patients receiving a standard arterial switch operation (ASO)...
  14. doi Transapical minimally invasive aortic valve implantation; the initial 50 patients
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Eur J Cardiothorac Surg 33:983-8. 2008
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  15. ncbi Reverse remodeling of cardiac collagen protein expression after surgical therapy for experimental aortic stenosis
    Thomas Walther
    University of Leipzig, Heart Center, Clinic for Heart Surgery, Leipzig, Germany
    J Heart Valve Dis 15:651-6. 2006
    ..Reversal of myocardial collagen gene expression was examined in parallel to left ventricular reverse remodeling after surgical correction of experimental aortic stenosis...
  16. ncbi Minimally invasive transapical beating heart aortic valve implantation--proof of concept
    Thomas Walther
    Department of Cardiac Surgery, Heartcenter, University Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 31:9-15. 2007
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  17. doi Human minimally invasive off-pump valve-in-a-valve implantation
    Thomas Walther
    Department of Cardiac Surgery, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 85:1072-3. 2008
    ..Hemodynamic function was excellent and the patient had a fast and uneventful recovery...
  18. ncbi Midterm results after stentless mitral valve replacement
    Thomas Walther
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Circulation 108:II85-9. 2003
    ..To analyze the midterm clinical results after stentless mitral valve (SMV) replacement...
  19. ncbi Stentless tricuspid valve replacement
    T Walther
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    Ann Thorac Surg 68:1858-9; discussion 1860. 1999
    ..Transvalvular hemodynamics are excellent, and right ventricular function can be preserved by suspending the valve at the papillary muscles...
  20. ncbi Quadrileaflet stentless mitral valve replacement
    T Walther
    Department of Cardiac Surgery, Leipzig University, Germany
    Thorac Cardiovasc Surg 47:357-60. 1999
    ..The study evaluates clinical results and hemodynamic parameters one year after implantation of a stentless quadrileaflet mitral valve (QMV)...
  21. ncbi Experimental evaluation and early clinical results of a new low-profile bileaflet aortic valve
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Artif Organs 26:416-9. 2002
    ..2 +/- 0.4 m/s) and low pressure gradients (20 +/- 6 mm Hg) postoperatively and at 6 months follow-up. In vitro testing and early clinical results are promising; however, long-term performance has to be proven...
  22. ncbi Left ventricular reverse remodeling after surgical therapy for aortic stenosis: correlation to Renin-Angiotensin system gene expression
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Circulation 106:I23-6. 2002
    ..Surgical therapy for aortic stenosis leads to reverse remodeling, with normalization of left ventricular hypertrophy (LVH). The aim of this study was to examine Renin-Angiotensin system (RAS) gene expression in this setting...
  23. ncbi Early clinical results after stentless mitral valve implantation and comparison with conventional valve repair or replacement
    T Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 100:II78-83. 1999
    ..A new quadricusp stentless mitral bioprosthetic valve (QMV) is evaluated and compared with current standards...
  24. ncbi Closure of recurrent VSD due to dehiscence of calcified patch
    Thomas Walther
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 23:246-7. 2003
    ..We describe a novel technique for closure of such a defect placing a new patch over and around the calcified one in an 18-year-old patient who had undergone initial surgery 12 years ago...
  25. ncbi Hemodynamic evaluation of stentless mitral valve replacement
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Germany
    Artif Organs 26:847-50. 2002
    ..TEE and TTE are extremely useful to assist SMV implantation as well as for regular follow-up evaluation. The hemodynamic function after SMV implantation with preservation of the annulo-ventricular continuity is promising...
  26. ncbi Regression of left ventricular hypertrophy after surgical therapy for aortic stenosis is associated with changes in extracellular matrix gene expression
    T Walther
    Department of Cardiac Surgery, Heartcenter, University Leipzig, Leipzig, Germany
    Circulation 104:I54-8. 2001
    ..The aim of this study was to examine whether there is an association between LVH regression and extracellular matrix (ECM) gene expression...
  27. ncbi Prospectively randomized evaluation of stentless versus conventional biological aortic valves: impact on early regression of left ventricular hypertrophy
    T Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 100:II6-10. 1999
    ..The aim of this prospectively randomized study was to evaluate left ventricular hypertrophy and its regression after stentless versus conventional biological aortic valve replacement...
  28. ncbi Experimental aortic stenosis and corresponding left ventricular hypertrophy in sheep
    T Walther
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    J Invest Surg 13:327-31. 2000
    ..Echocardiography is an easy tool for follow-up evaluations. Due to low complication rates, the sheep model is well suited for further research in LVH...
  29. ncbi Combined stentless mitral valve implantation and radiofrequency ablation
    T Walther
    Department of Heart Surgery, Heartcenter, University of Leipzig, Germany
    Ann Thorac Surg 70:1080-2. 2000
    ..The aim of this study was to evaluate the results of combined stentless mitral valve (SMV) replacement and intraoperative radiofrequency ablation for chronic atrial fibrillation (IRAAF) to restore physiologic hemodynamic function...
  30. ncbi Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Heart Fail 3:486-94. 2010
    ....
  31. doi Valve-in-valve implantation of Medtronic CoreValve prosthesis in patients with failing bioprosthetic aortic valves
    Axel Linke
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Cardiovasc Interv 5:689-97. 2012
    ..Transcatheter aortic valve implantation (TAVI) using the Medtronic CoreValve (MCV) system might represent an alternative to conventional redo surgery in older high-risk patients with a failing aortic valve bioprosthesis...
  32. doi Transapical aortic valve implantation at 3 years
    Thomas Walther
    Department of Cardiac Surgery, University Leipzig, Heart Center, Leipzig, Germany
    J Thorac Cardiovasc Surg 143:326-31. 2012
    ..Our objective was to analyze the results of transapical aortic valve implantation in high-risk patients with aortic stenosis at up to 3 years after the procedure...
  33. doi Minimally invasive off-pump valve-in-a-valve implantation: the atrial transcatheter approach for re-operative mitral valve replacement
    Jörg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Struempellstrasse 39, 04289 Leipzig, Germany
    Eur Heart J 29:2382-7. 2008
    ..This study was designed to evaluate the feasibility and haemodynamic performance of transcatheter valve-in-a-valve (VinV) implantation for failed mitral xenografts using a minimally invasive, transatrial, off-pump approach...
  34. ncbi Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure
    Rainer Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:401-6. 2005
    ..Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I)...
  35. doi Maximal exercise, limb ischemia, and endothelial progenitor cells
    Marcus Sandri
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 18:55-64. 2011
    ..The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers...
  36. ncbi Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle
    Axel Linke
    Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:1763-70. 2005
    ..Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF...
  37. ncbi Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:393-400. 2005
    ..INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF...
  38. doi Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study
    Marcus Sandri
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Germany
    Eur Heart J 33:1758-68. 2012
    ..We therefore assessed DD in a cohort of referent controls (RCs) and HFREF patients and studied the response of DD to endurance exercise in two age groups (≤55 years and ≥65 years)...
  39. doi Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease
    Ephraim B Beck
    Heart Center, Department of Cardiology, University of Leipzig, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:412-8. 2012
    ..The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in patients with CAD...
  40. ncbi Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 13:826-31. 2006
    ....
  41. ncbi Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial
    Sandra Erbs
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:336-44. 2003
    ..This analysis was conducted, to evaluate the effects of ET on left ventricular function and haemodynamics in patients with advanced CHF (NYHA class III) fulfilling the inclusion criteria of the COPERNICUS trial...
  42. doi Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size
    Robert Höllriegel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Int J Cardiol 167:975-80. 2013
    ....
  43. doi The utility of trans-catheter aortic valve replacement after commercialization: does the European experience provide a glimpse into the future use of this technology in the United States?
    Axel Linke
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Catheter Cardiovasc Interv 75:511-8. 2010
    ..Despite of the progress in this field, we are still lacking an optimal transcatheter heart valve. Once it is available, we can take the plunge to compare transcatheter valve implantation with convention surgery in severe aortic stenosis!..
  44. doi Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair
    Yasuharu Matsumoto
    Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur Heart J 30:346-55. 2009
    ..This study investigated whether degenerative AV stenosis (AS) is associated with the presence of valvular endothelial senescence and a reduction in the number and function of endothelial progenitor cells (EPCs)...
  45. doi Transapical aortic valve implantation: analysis of risk factors and learning experience in 299 patients
    Jörg Kempfert
    Department of Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Circulation 124:S124-9. 2011
    ..Transapical aortic valve implantation has evolved to a reproducible therapeutic option for high-risk patients. The aim of the present study was to evaluate our learning experience over 4 years and to analyze outcome-related risk factors...
  46. ncbi Transapical off-pump valve-in-valve implantation in patients with degenerated aortic xenografts
    Jörg Kempfert
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 89:1934-41. 2010
    ..We evaluated the off-pump beating heart concept of transapical aortic valve implantation using the valve-in-valve (VinV) concept...
  47. ncbi Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Department of Internal Medicine and Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    J Am Coll Cardiol 42:861-8. 2003
    ..The aim of this study was to assess the effects of regular physical exercise on local inflammatory parameters in the skeletal muscle of patients with chronic heart failure (CHF)...
  48. ncbi Improved mitral valve performance after transapical aortic valve implantation
    Martin Haensig
    Department of Cardiac Surgery, Heart Center of the University of Leipzig, Leipzig, Germany Electronic address
    Ann Thorac Surg 97:1247-53; discussion 1253-4. 2014
    ..Our aim was to study the impact of MR on outcome and the effect of TA-AVI on MR using the Edwards SAPIEN prosthesis (Edwards Lifesciences, Irvine, CA)...
  49. ncbi Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
    ..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium...
  50. ncbi Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
    ..The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases...
  51. pmc Exercise training prevents TNF-α induced loss of force in the diaphragm of mice
    Norman Mangner
    Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e52274. 2013
    ..Inflammatory cytokines like tumor necrosis factor alpha (TNF-α) are elevated in congestive heart failure and are known to induce the production of reactive oxygen species as well as to deteriorate respiratory muscle function...
  52. doi Comparison of aortic root measurements in patients undergoing transapical aortic valve implantation (TA-AVI) using three-dimensional rotational angiography (3D-RA) and multislice computed tomography (MSCT): differences and variability
    Lukas H J Lehmkuhl
    Department of Diagnostic and Interventional Radiology, University of Leipzig Heart Center, Strümpellstraße 39, 04289, Leipzig, Germany
    Int J Cardiovasc Imaging 29:417-24. 2013
    ..Due to a lower interobserver variability in sizing the aortic annulus MSCT remains more suitable for aortic root assessment prior to TA-AVI...
  53. pmc Regular exercise or changing diet does not influence aortic valve disease progression in LDLR deficient mice
    Florian Schlotter
    University of Leipzig Heart Center Leipzig, Department of Internal Medicine Cardiology, Leipzig, Germany
    PLoS ONE 7:e37298. 2012
    ..We aimed to investigate the impact of exercise training on the progression of CAVD in LDLR(-/-) mice in the setting of secondary prevention..
  54. ncbi Latest advances in transcatheter aortic valve implantation
    Jörg Kempfert
    Heart Center, University of Leipzig, Clinic for Cardiac Surgery, Leipzig, Germany
    Surg Technol Int 19:147-54. 2010
    ..Nevertheless, TAVI has already evolved into a routine procedure in selected specialized centers providing a safe and reproducible treatment option for high-risk elderly patients suffering from severe symptomatic aortic stenosis...
  55. doi Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training
    Volker Adams
    Department of Cardiology, University of Leipzig, Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:293-9. 2008
    ..Exercise training (ET) exhibits great potential to attenuate the development of muscle atrophy and cardiac remodeling. The aim of this study was to investigate the impact of ET on myocardial expression of Murf-1 and MAFbx...
  56. ncbi Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease
    Volker Adams
    University Leipzig, Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Circulation 111:555-62. 2005
    ..The aim of the present study was to analyze the impact of ET on sources of ROS generation in the left internal mammary artery of patients with symptomatic coronary artery disease...
  57. ncbi Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
    P Christian Schulze
    Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:33-40. 2003
    ..This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF...
  58. doi Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure
    Karsten Lenk
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:404-11. 2012
    ..In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome...
  59. doi A second prosthesis as a procedural rescue option in trans-apical aortic valve implantation
    Jörg Kempfert
    Department of Cardiac Surgery, Heartcenter University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 40:56-60. 2011
    ..Results of this 'bailout' maneuver have not been reported yet...
  60. doi Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model
    Karsten Lenk
    Clinic of Cardiology, University Leipzig Heart Center Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur J Heart Fail 11:342-8. 2009
    ..This study aimed to investigate the expression of myostatin in CHF, the influence of exercise training on myostatin levels, and regulation of myostatin by tumour necrosis factor-alpha (TNF-alpha)...
  61. doi High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Int J Cardiol 146:56-63. 2011
    ..Therefore, we aimed to evaluate the pleiotropic effects of rosuvastatin on vascular and tissue regeneration, its impact on endothelial function and hemodynamics in CHF...
  62. ncbi Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial
    Rainer Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Circulation 109:1371-8. 2004
    ....
  63. doi New anatomically oriented transapical aortic valve implantation
    Volkmar Falk
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 87:925-6. 2009
    ..Here we report implantation of this new valve in a patient. The valve demonstrated excellent function with a low transvalvular gradient...
  64. ncbi Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Am Heart J 146:280-5. 2003
    ..It remains unclear, however, whether the degree of endothelial dysfunction caused by oxidative stress differs between CAD and CHF because of ischemic (ICM) or dilated cardiomyopathy (DCM)...
  65. doi Transapical aortic valve implantation: therapy of choice for patients with aortic stenosis and porcelain aorta?
    Jörg Kempfert
    Clinic for Cardiac Surgery, University of Leipzig, Heart Center, Leipzig, Germany
    Ann Thorac Surg 90:1457-61. 2010
    ..Minimally invasive off-pump transapical aortic valve implantation may be an optimal strategy to treat elderly patients with porcelain aorta requiring aortic valve replacement...
  66. doi Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice
    Yasuharu Matsumoto
    Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Circulation 121:759-67. 2010
    ..Regular exercise training (ET) slows the progression of atherosclerotic lesions, reduces oxidative stress, and increases nitric oxide bioavailability, all of which may be expected to improve degenerative aortic valve disease...
  67. doi Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners
    Volker Adams
    Department of Cardiology, University Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:602-7. 2008
    ..The aim of this study was to investigate the influence of a marathon race on the amount of circulating progenitor cells immediately after the race in advanced-aged runners...
  68. ncbi Exercise and the coronary circulation-alterations and adaptations in coronary artery disease
    Axel Linke
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Prog Cardiovasc Dis 48:270-84. 2006
    ....
  69. doi The Leipzig prospective vascular ultrasound registry in radial artery catheterization: impact of sheath size on vascular complications
    Madlen Uhlemann
    Department of Internal Medicine Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    JACC Cardiovasc Interv 5:36-43. 2012
    ....
  70. doi Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease
    Claudia Walther
    Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:107-12. 2008
    ..We investigated the impact of 2 years regular ET versus percutaneous intervention (PCI) on chronic inflammation and cardiovascular events...
  71. doi How to improve endothelial repair mechanisms: the lifestyle approach
    Sven Mobius-Winkler
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum GmbH, Strümpellstr 39, 04289 Leipzig, Germany
    Expert Rev Cardiovasc Ther 8:573-80. 2010
    ..This review focuses on lifestyle interventions to correct endothelial dysfunction in different cardiovascular diseases...
  72. ncbi Transapical aortic valve implantation in 100 consecutive patients: comparison to propensity-matched conventional aortic valve replacement
    Thomas Walther
    Department of Cardiac Surgery, Heartcenter, University Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, Leipzig 04289, Germany
    Eur Heart J 31:1398-403. 2010
    ..To evaluate the outcome of transapical aortic valve implantation (TA-AVI) in comparison to conventional surgery...
  73. ncbi Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions
    Holger Thiele
    University of Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Int J Cardiol 135:287-95. 2009
    ..Cardiac magnetic resonance imaging (CMRI) is an excellent tool for serial assessment of underlying structural changes in perfusion, left ventricular function, and infarct size...
  74. ncbi Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure
    P Christian Schulze
    University of Leipzig, Heart Center, Department of Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 11:155-61. 2004
    ..The aim of this study was to investigate morphological, functional and electromyographical parameters of the skeletal muscle in CHF...
  75. ncbi Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression
    Nicolle Krankel
    Department of Cardiology, Heart Center, University of Leipzig, D 04289 Leipzig, Germany
    Mol Genet Metab 80:262-71. 2003
    ..The upregulation of PP2A, an important regulator in intracellular signaling and apoptosis, may be due to an increase of inflammatory cytokines...
  76. ncbi Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction
    Sandra Erbs
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 23:1814-9. 2003
    ..Therefore, we aimed to determine the effects of these polymorphisms on endothelial function and endothelial response to physical exercise in patients with coronary artery disease (CAD)...
  77. ncbi Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells
    Nicolle Krankel
    Department of Internal Medicine Cardiology, Heart Center Leipzig, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 25:698-703. 2005
    ..Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function...
  78. ncbi Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
    ..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs...
  79. doi Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance
    Axel Linke
    Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Atherosclerosis 205:207-13. 2009
    ..Adipose tissue is an important site of niacin action. Here we sought to determine potential pleiotropic effects of ER niacin on adipose tissue biology in patients with impaired glucose tolerance (IGT)...
  80. ncbi Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotion
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Am Heart J 145:E3. 2003
    ..The aim of this consecutive study was to assess whether a home-based exercise program with reduced average training duration can sustain previously achieved effects on coronary endothelial function...
  81. ncbi Effects of exercise training on mortality in patients with coronary heart disease
    Sandra Erbs
    Department of Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Coron Artery Dis 17:219-25. 2006
    ....
  82. ncbi Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility
    Volker Adams
    University Leipzig Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Cardiovasc Res 73:120-9. 2007
    ..However, it is unknown whether the E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process and whether their expression is regulated by TNF-alpha...
  83. ncbi Effects of exercise training upon endothelial function in patients with cardiovascular disease
    Axel Linke
    University of Leipzig, Heart Center, Department of Cardiology, Leipzig, Germany
    Front Biosci 13:424-32. 2008
    ..Given the prognostic value of endothelial function further studies are necessary to elucidate whether the ET-induced correction of vasomotion is the key mechanism responsible for the decline in mortality in patients with CVD...
  84. ncbi Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure
    Rainer Hambrecht
    University of Leipzig Heart Center, Department of Cardiology, Leipzig, Germany
    J Am Coll Cardiol 39:1175-81. 2002
    ..We sought to assess the role of insulin-like growth factor-I (IGF-I) in muscle wasting in chronic heart failure (CHF), serum concentrations and local muscular IGF-I expression were determined in patients with severe CHF...
  85. ncbi Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infa
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Circulation 116:366-74. 2007
    ....
  86. ncbi Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imaging
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 28:1433-9. 2007
    ..Delayed enhancement magnetic resonance imaging (DE-MRI) has excellent spatial resolution to uncover these relations...
  87. ncbi Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase
    Volker Adams
    Clinic of Cardiology, Leipzig Heart Center, University Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:273-7. 2003
    ..The aim of this study was to assess whether NF-kappaB is activated in skeletal muscle of patients with CHF and linked to the expression of iNOS...
  88. doi Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 55:2201-9. 2010
    ....
  89. doi Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Circulation 118:49-57. 2008
    ..Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus...
  90. doi Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice
    Volker Adams
    Heart Center Leipzig, University Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    J Mol Biol 384:48-59. 2008
    ..However, the casual relationships between MuRF1 and TNF-alpha and their relative contributions to muscle function impairment are not known...
  91. ncbi Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study
    Volker Adams
    University Leipzig Heart Center Leipzig, Clinic of Cardiology, Germany
    Cardiovasc Res 54:95-104. 2002
    ..In vitro studies, using different cell types, suggest that inflammatory cytokines are potential triggers to induce iNOS expression...
  92. doi Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene
    Andreas Oberbach
    Department of Medicine, Faculty of Medicine, University of Leipzig, Philipp Rosenthal Str 27, D 04103 Leipzig, Germany
    Eur J Endocrinol 159:129-36. 2008
    ..However, there are heterogeneous data on whether circulating IL-6 is altered by exercise training. We therefore hypothesize that genetic factors modify the individual changes in IL-6 levels after long-term training...
  93. doi Anesthesia management for transapical transcatheter aortic valve implantation: a case series
    Jens Fassl
    Department of Anesthesiology and Intensive Care II, University of Leipzig, Heart Center, Leipzig, Germany
    J Cardiothorac Vasc Anesth 23:286-91. 2009
    ..The purpose of this study was to review the management of anesthesia for transapical transcatheter aortic valve implantation...
  94. ncbi [Exercise training in the treatment of coronary artery disease and obesity]
    Axel Linke
    Universität Leipzig Herzzentrum, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Herz 31:224-33. 2006
    ..Most importantly, patients should enjoy the proposed kind of physical exercise...