Stefan Linder

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Expression of Reticulomyxa filosa alpha- and beta-tubulins in Escherichia coli yields soluble and partially correctly folded material
    S Linder
    Adolf Butenandt Institute Cell Biology, Munich, Germany
    Gene 212:87-94. 1998
  2. pmc Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages
    S Linder
    Max von Pettenkofer Institut für Medizinische Mikrobiologie, Pettenkoferstrasse 9a, Ludwig Maximilians Universitat, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 96:9648-53. 1999
  3. ncbi request reprint Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages
    S Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Pettenkoferstr 9, Germany
    J Cell Sci 113:4165-76. 2000
  4. ncbi request reprint Adhesion, cytoskeletal architecture and activation status of primary human macrophages on a diamond-like carbon coated surface
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Munchen, Germany
    Biomaterials 23:767-73. 2002
  5. ncbi request reprint Subconfluent endothelial cells form podosomes downstream of cytokine and RhoGTPase signaling
    Anna Eleonor Osiak
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    Exp Cell Res 307:342-53. 2005
  6. pmc Cytotoxic necrotizing factor 1 of Escherichia coli stimulates Rho/Rho-kinase-dependent myosin light-chain phosphorylation without inactivating myosin light-chain phosphatase in endothelial cells
    Markus Essler
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, LMU Munchen, 80336 Munich, Germany
    Infect Immun 71:5188-93. 2003
  7. ncbi request reprint PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation
    Alexandra Gringel
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Pettenkoferstr, Munchen, Germany
    J Cell Physiol 209:568-79. 2006
  8. pmc The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages
    Petra Kopp
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, 80336 Munich, Germany
    Mol Biol Cell 17:2811-23. 2006
  9. ncbi request reprint Podosomes at a glance
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    J Cell Sci 118:2079-82. 2005
  10. ncbi request reprint Macrophages of patients with X-linked thrombocytopenia display an attenuated Wiskott-Aldrich syndrome phenotype
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Dr von Haunersches Kinderspital, Klinikum Innenstadt, Lindwurmstr, Munchen, Germany
    Immunol Cell Biol 81:130-6. 2003

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Expression of Reticulomyxa filosa alpha- and beta-tubulins in Escherichia coli yields soluble and partially correctly folded material
    S Linder
    Adolf Butenandt Institute Cell Biology, Munich, Germany
    Gene 212:87-94. 1998
    ..The established expression system therefore seems well suited for further studies concerning the folding of tubulins...
  2. pmc Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages
    S Linder
    Max von Pettenkofer Institut für Medizinische Mikrobiologie, Pettenkoferstrasse 9a, Ludwig Maximilians Universitat, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 96:9648-53. 1999
    ..These findings indicate that WASp controls podosome assembly and, in cooperation with CDC42Hs, podosome disassembly in primary human macrophages...
  3. ncbi request reprint Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages
    S Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Pettenkoferstr 9, Germany
    J Cell Sci 113:4165-76. 2000
    ..In sum, our findings show that microtubules are essential for podosome formation in primary human macrophages and that WASp and CIP4 may be involved in this phenomenon...
  4. ncbi request reprint Adhesion, cytoskeletal architecture and activation status of primary human macrophages on a diamond-like carbon coated surface
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Munchen, Germany
    Biomaterials 23:767-73. 2002
    ..It is therefore unlikely that contact with a diamond-like carbon coated surface in the human body will elicit inflammatory signals by these cells...
  5. ncbi request reprint Subconfluent endothelial cells form podosomes downstream of cytokine and RhoGTPase signaling
    Anna Eleonor Osiak
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    Exp Cell Res 307:342-53. 2005
    ..We propose that HUVEC podosomes play an important role in endothelial cell migration and invasion...
  6. pmc Cytotoxic necrotizing factor 1 of Escherichia coli stimulates Rho/Rho-kinase-dependent myosin light-chain phosphorylation without inactivating myosin light-chain phosphatase in endothelial cells
    Markus Essler
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, LMU Munchen, 80336 Munich, Germany
    Infect Immun 71:5188-93. 2003
    ....
  7. ncbi request reprint PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation
    Alexandra Gringel
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Pettenkoferstr, Munchen, Germany
    J Cell Physiol 209:568-79. 2006
    ..In sum, we propose that PAK4 and alphaPIX can induce highly localized changes in actin dynamics and thereby regulate size and number of podosomes in primary human macrophages...
  8. pmc The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages
    Petra Kopp
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, 80336 Munich, Germany
    Mol Biol Cell 17:2811-23. 2006
    ..This is the first report to implicate a kinesin in podosome regulation and also the first to describe a function for KIF1C in human cells...
  9. ncbi request reprint Podosomes at a glance
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    J Cell Sci 118:2079-82. 2005
  10. ncbi request reprint Macrophages of patients with X-linked thrombocytopenia display an attenuated Wiskott-Aldrich syndrome phenotype
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Dr von Haunersches Kinderspital, Klinikum Innenstadt, Lindwurmstr, Munchen, Germany
    Immunol Cell Biol 81:130-6. 2003
    ..Further evaluation of this and other, as yet unrecognized, cellular defects may provide a more complete picture of the continuum of Wiskott-Aldrich syndrome and X-linked thrombocytopenia defects...
  11. ncbi request reprint The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia
    Katharina Hüfner
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstrasse 9, 80336 Munich, Germany
    FEBS Lett 514:168-74. 2002
    ....
  12. ncbi request reprint Yersinia enterocolitica invasin triggers phagocytosis via beta1 integrins, CDC42Hs and WASp in macrophages
    A Wiedemann
    , Pettenkoferstrasse 9a, , , Germany
    Cell Microbiol 3:693-702. 2001
    ..The contribution of Rac and Rho to phagocytic cup formation also suggests a complex interplay between different Rho GTPases during phagocytosis of pathogens...
  13. ncbi request reprint Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro
    Mihail Hristov
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Munchen, Germany
    Blood 104:2761-6. 2004
    ..Such a mechanism may facilitate the repair of injured endothelium and may represent a new signaling pathway between progenitor and damaged somatic cells...
  14. ncbi request reprint The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    Trends Cell Biol 17:107-17. 2007
    ..This review highlights important new developments in the field, discusses the common and divergent features of podosomes and invadopodia and summarizes current knowledge about matrix-degrading proteinases at these structures...
  15. ncbi request reprint Podosomes: adhesion hot-spots of invasive cells
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstrasse 9, 80336 Munich, Germany
    Trends Cell Biol 13:376-85. 2003
    ..Here, we summarize and discuss the known structural, regulatory and functional features of podosomes, our aim being to stimulate further research into these unique structures...
  16. doi request reprint Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling
    Christoph A Reichel
    Institute for Surgical review, University of Munich, Marchioninistr 27, D 81377 Munich, Germany
    J Leukoc Biol 83:864-74. 2008
    ....
  17. ncbi request reprint Expression of Reticulomyxa filosa tubulins in Pichia pastoris: regulation of tubulin pools
    S Linder
    Adolf Butenandt Institut für Zellbiologie, Munchen, Germany
    FEBS Lett 417:33-7. 1997
    ..filosa tubulin isoforms and on the level of the total tubulin pool. The P. pastoris/R. filosa system therefore seems to be an accessible system for the simultaneous study of the various mechanisms involved in tubulin regulation...
  18. ncbi request reprint Interleukin-6 induction by Helicobacter pylori in human macrophages is dependent on phagocytosis
    Stefan Odenbreit
    Max von Pettenkofer Institute for Hygiene und Medical Microbiology, Ludwig Maximilians University, Pettenkoferstrasse 9a, D 80336 Munich, Germany
    Helicobacter 11:196-207. 2006
    ..The aim of our study was to determine the mechanisms of IL-6 stimulation in phagocytes upon H. pylori infection...
  19. pmc Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex
    S Linder
    , , 80336 Munich, Germany
    Infect Immun 69:1739-46. 2001
    ..Our findings should enhance the understanding of the infection process of B. burgdorferi and contribute to devising new strategies for countering Lyme disease...
  20. ncbi request reprint Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells
    Markus Essler
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Universitat Munchen, Pettenkoferstr 9, 80336, Munchen, Germany
    Cell Signal 14:607-13. 2002
    ..These findings indicate that S1P is able to induce dynamic cycles of MLC phosphatase deactivation and activation. This novel feature of S1P could contribute to its chemotactic and angiogenic activity...
  21. ncbi request reprint Post-translational and cell type-specific regulation of CXCR4 expression by cytokines
    Hilke Bruhl
    Medical Policlinic, University of Munich, Munich, Germany
    Eur J Immunol 33:3028-37. 2003
    ..Internalization of CXCR4 by cytokines in a cell type-specific manner is a novel and functionally important mechanism of chemokine receptor regulation...
  22. ncbi request reprint Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell
    S Stender
    Max von Pettenkofer Institut, Munich, Germany
    Mol Microbiol 36:1206-21. 2000
    ..In conclusion, as a result of SopE2 all S. typhimurium strains tested have the capacity to activate Cdc42 signalling inside host cells which is important to ensure efficient entry...
  23. ncbi request reprint Prevalence of Rho-inactivating epidermal cell differentiation inhibitor toxins in clinical Staphylococcus aureus isolates
    A Czech
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Munich, Germany
    J Infect Dis 184:785-8. 2001
    ..Given that toxins acting on Rho GTPases are considered to be important for bacterial virulence, the EDIN toxins of S. aureus should receive more attention in future studies...
  24. doi request reprint Assembly and biological role of podosomes and invadopodia
    Mario Gimona
    Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, 66030 Santa Maria Imbaro Chieti, Italy
    Curr Opin Cell Biol 20:235-41. 2008
    ..The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair...
  25. ncbi request reprint Yersinia protein kinase YopO is activated by a novel G-actin binding process
    Claudia Trasak
    Institut fur Medizinische Mikrobiologie, Virologie, und Hygiene, Universitätsklinikum Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 282:2268-77. 2007
    ..Thus, YopO kinase is activated by a novel G-actin binding process, and this appears to be crucial for its anti-host cell functions...
  26. pmc Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells
    Andreas Schröder
    Institut fur Medizinische Mikrobiologie, Virologie und Hygiene, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    Mol Biol Cell 17:5198-210. 2006
    ..aureus FnBPA produces attachment sites that promote bacterial movements but subvert actin- and Rab5 reorganization during invasion. This may constitute a novel strategy of S. aureus to postpone invasion until its toxins become effective...
  27. ncbi request reprint Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology
    Sonja Majstoravich
    Department of Biochemistry HB7200, Dartmouth Medical School, Hanover, NH 03755 3844, USA
    Blood 104:1396-403. 2004
    ..These results suggest that WASp is either not involved in or is redundant in the rapid dynamics of lymphocyte microvilli...
  28. doi request reprint Viva adhesion! A Mediterranean meeting on cell-matrix contacts and tissue invasion
    Roberto Buccione
    Eur J Cell Biol 87:457-8. 2008
  29. ncbi request reprint Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption
    Meenakshi A Chellaiah
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Biol Chem 282:10104-16. 2007
    ..Our findings suggest that both tyrosine kinase(s) and the tyrosine phosphatase PTP-PEST coordinate the formation of the sealing ring and thus the bone-resorbing function of osteoclasts...
  30. ncbi request reprint The Kindlins: subcellular localization and expression during murine development
    Siegfried Ussar
    Max Planck Institute of Biochemistry, Department of Molecular Medicine, D 82152 Martinsried, Germany
    Exp Cell Res 312:3142-51. 2006
    ....