Joachim Liepert

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi Reduction of excitability ("inhibition") in the ipsilateral primary motor cortex is mirrored by fMRI signal decreases
    Farsin Hamzei
    Neurologisches Universitätsklinikum, Hamburg Eppendorf Martinistrasse 52, 20246 Hamburg, Germany
    Neuroimage 17:490-6. 2002
  2. ncbi Lesion-induced and training-induced brain reorganization
    J Liepert
    Department of Neurology, University Hospital Eppendorf, D 20246 Hamburg, Germany
    Restor Neurol Neurosci 22:269-77. 2004
  3. ncbi Motor cortex excitability in stroke before and after constraint-induced movement therapy
    Joachim Liepert
    Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    Cogn Behav Neurol 19:41-7. 2006
  4. ncbi Motor cortex disinhibition in Alzheimer's disease
    J Liepert
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    Clin Neurophysiol 112:1436-41. 2001
  5. ncbi Motor excitability in myopathy
    Joachim Liepert
    Department of Neurology, University of Hamburg, University Hospital Eppendorf, Martini Strasse 52, D 20246 Hamburg, Germany
    Clin Neurophysiol 115:85-9. 2004
  6. ncbi Motor excitability in a patient with a somatosensory cortex lesion
    Joachim Liepert
    Department of Neurology, University of Hamburg, University Hospital Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Clin Neurophysiol 114:1003-8. 2003
  7. ncbi TMS in stroke
    Joachim Liepert
    Department of Neurology, University of Hamburg, D 20246 Hamburg, Germany
    Suppl Clin Neurophysiol 56:368-80. 2003
  8. ncbi The surround inhibition determines therapy-induced cortical reorganization
    Joachim Liepert
    Department of Neurology, University Medical Center Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Neuroimage 32:1216-20. 2006
  9. ncbi Exercise-induced changes of motor excitability with and without sensory block
    Joachim Liepert
    Department of Neurology, University Hospital Hamburg Eppendorf, Martinistr 52 D 20246 Hamburg, Germany
    Brain Res 1003:68-76. 2004
  10. ncbi Motor excitability and motor behaviour after modafinil ingestion--a double-blind placebo-controlled cross-over trial
    J Liepert
    Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    J Neural Transm 111:703-11. 2004

Detail Information

Publications49

  1. ncbi Reduction of excitability ("inhibition") in the ipsilateral primary motor cortex is mirrored by fMRI signal decreases
    Farsin Hamzei
    Neurologisches Universitätsklinikum, Hamburg Eppendorf Martinistrasse 52, 20246 Hamburg, Germany
    Neuroimage 17:490-6. 2002
    ..We suggest phasic low force pinch grip as a reproducible, easy model of focal inhibition. Decreased cortical excitability presents as decreased BOLD signal using fMRI...
  2. ncbi Lesion-induced and training-induced brain reorganization
    J Liepert
    Department of Neurology, University Hospital Eppendorf, D 20246 Hamburg, Germany
    Restor Neurol Neurosci 22:269-77. 2004
    ..We examined if distinct ischemic brain lesions are associated with a specific pattern of excitability changes. We also investigated the effects of a rehabilitative therapy on motor excitability...
  3. ncbi Motor cortex excitability in stroke before and after constraint-induced movement therapy
    Joachim Liepert
    Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    Cogn Behav Neurol 19:41-7. 2006
    ..To investigate motor cortex excitability in stroke patients and explore excitability changes induced by an intense physiotherapy...
  4. ncbi Motor cortex disinhibition in Alzheimer's disease
    J Liepert
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    Clin Neurophysiol 112:1436-41. 2001
    ..To explore subclinical disturbances in the motor cortex of patients with Alzheimer's disease (AD)...
  5. ncbi Motor excitability in myopathy
    Joachim Liepert
    Department of Neurology, University of Hamburg, University Hospital Eppendorf, Martini Strasse 52, D 20246 Hamburg, Germany
    Clin Neurophysiol 115:85-9. 2004
    ..To explore whether patients with myopathy present changes in motoneuronal excitability...
  6. ncbi Motor excitability in a patient with a somatosensory cortex lesion
    Joachim Liepert
    Department of Neurology, University of Hamburg, University Hospital Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Clin Neurophysiol 114:1003-8. 2003
    ..We report a patient with an ischemic lesion in right somatosensory cortex who developed dystonic posturing and pseudo-athetotic involuntary left-sided finger movements during voluntary muscle contractions...
  7. ncbi TMS in stroke
    Joachim Liepert
    Department of Neurology, University of Hamburg, D 20246 Hamburg, Germany
    Suppl Clin Neurophysiol 56:368-80. 2003
  8. ncbi The surround inhibition determines therapy-induced cortical reorganization
    Joachim Liepert
    Department of Neurology, University Medical Center Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Neuroimage 32:1216-20. 2006
    ..The correlations between motor functions and electrophysiological results indicate a functional relevance of the observed reorganization pattern...
  9. ncbi Exercise-induced changes of motor excitability with and without sensory block
    Joachim Liepert
    Department of Neurology, University Hospital Hamburg Eppendorf, Martinistr 52 D 20246 Hamburg, Germany
    Brain Res 1003:68-76. 2004
    ..An impairment of cutaneous afferents decreased the cortical representation of the target muscle. The decrease of motor excitability induced by the sensory deficit could only partially be reversed by the motor exercise...
  10. ncbi Motor excitability and motor behaviour after modafinil ingestion--a double-blind placebo-controlled cross-over trial
    J Liepert
    Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    J Neural Transm 111:703-11. 2004
    ..Thus, this study does not demonstrate significant differences between a single dose of modafinil and placebo in healthy subjects...
  11. ncbi Motor cortex excitability after cerebellar infarction
    J Liepert
    Department of Neurology, University Hospital Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Stroke 35:2484-8. 2004
    ..We investigated if the location of a cerebellar infarction was crucial for changes of motor cortex excitability and if the electrophysiological findings were correlated with motor performance...
  12. ncbi Motor cortex excitability and fatigue in multiple sclerosis: a transcranial magnetic stimulation study
    J Liepert
    Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    Mult Scler 11:316-21. 2005
    ..We conclude that MS patients with fatigue have an impairment of inhibitory circuits in their primary motor cortex. The results also indicate that fatigue severity is associated with an exercise-induced reduction of membrane excitability...
  13. ncbi Transcranial magnetic stimulation in neurorehabilitation
    J Liepert
    Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    Acta Neurochir Suppl 93:71-4. 2005
    ..Some evidence is emerging that the application of low frequency repetitive TMS over the non-lesioned hemisphere improves neglect phenomena by down-regulation of the excitability of the non-lesioned hemisphere...
  14. ncbi Motor strokes: the lesion location determines motor excitability changes
    Joachim Liepert
    Department of Neurology, University Medical Center Eppendorf, Hamburg, Germany
    Stroke 36:2648-53. 2005
    ..The purpose of this research was to investigate the impact of lesion location on motor excitability and motor performance...
  15. ncbi Motor cortex plasticity during forced-use therapy in stroke patients: a preliminary study
    J Liepert
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    J Neurol 248:315-21. 2001
    ..Due to the small number of patients and the lack of a control group, these results are preliminary observations and require replication in a larger sample...
  16. ncbi Disinhibition of somatosensory and motor cortex in mitochondriopathy without myoclonus
    J Liepert
    Department of Neurology, Friedrich Schiller University of Jena, Jena, Germany
    Clin Neurophysiol 112:917-22. 2001
    ..To test electrophysiologically, if patients with mitochondriopathy but without evidence of myocloni have subclinical signs of disinhibition in motor and somatosensory cortices...
  17. ncbi Motor cortex disinhibition of the unaffected hemisphere after acute stroke
    J Liepert
    Neurologische Klinik der Friedrich Schiller Universität, Philosophenweg 3, D 07743 Jena, Germany
    Muscle Nerve 23:1761-3. 2000
    ..In the patient group, intracortical inhibition was reduced. We suggest that this disinhibition is due to an impairment of transcallosal fibers and may affect recovery...
  18. ncbi Inhibition of ipsilateral motor cortex during phasic generation of low force
    J Liepert
    Department of Neurology, Friedrich Schiller University Jena, Jena, Germany
    Clin Neurophysiol 112:114-21. 2001
    ..To study the effect of different types of unilateral pinch grips on excitability of the ipsilateral motor cortex...
  19. ncbi Orally administered atropine enhances motor cortex excitability: a transcranial magnetic stimulation study in human subjects
    J Liepert
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    Neurosci Lett 300:149-52. 2001
    ..Thus, an antagonist of pre- and postsynaptic muscarinic receptors increased excitability in the human motor cortex in a dose-dependent manner, indicating an influence of the cholinergic system on motor cortex excitation...
  20. ncbi Modulation of intracortical facilitatory circuits of the human primary motor cortex by digital nerve stimulation
    Simone Zittel
    Department of Neurology, University Medical Center Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Exp Brain Res 176:425-31. 2007
    ..They further support the hypothesis that intracortical facilitation (ICF) and short-interval intracortical facilitation (SICF) are evoked through different mechanisms...
  21. ncbi Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer's cramp
    Tobias Bäumer
    Department of Neurology, University of Hamburg, Hamburg, Germany
    Mov Disord 22:81-90. 2007
    ....
  22. doi Citalopram improves dexterity in chronic stroke patients
    Simone Zittel
    Department of Neurology, University Medical Center Eppendorf, Hamburg, Germany
    Neurorehabil Neural Repair 22:311-4. 2008
    ..A majority of stroke patients have persisting motor deficits despite ongoing physiotherapy. Therefore, additional treatment options are desirable...
  23. ncbi Motor cortex excitability after thalamic infarction
    J Liepert
    Department of Neurology, University Hospital Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Clin Neurophysiol 116:1621-7. 2005
    ..We examined 8 patients with hemihypesthesia due to an ischemic thalamic lesion to explore the effects of a central sensory dysfunction on motor cortex excitability...
  24. ncbi Improvement of dexterity by single session low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in acute stroke: a double-blind placebo-controlled crossover trial
    Joachim Liepert
    Department of Neurology, University Hospital, Freiburg, Germany
    Restor Neurol Neurosci 25:461-5. 2007
    ..We investigated if inhibitory 1~Hz repetitive transcranial magnetic stimulation (rTMS) over the contralesional M1 improved motor performance of the affected hand in acute stroke...
  25. ncbi Rapid functional plasticity in the primary somatomotor cortex and perceptual changes after nerve block
    Thomas Weiss
    Department of Biological and Clinical Psychology, Friedrich Schiller University Jena, Am Steiger 3 Haus 1, D 07743 Jena, Germany
    Eur J Neurosci 20:3413-23. 2004
    ....
  26. ncbi Reboxetine improves motor function in chronic stroke. A pilot study
    Simone Zittel
    Department of Neurology, University Medical Center Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Neurol 254:197-201. 2007
    ..TMS results and dexterity measurements remained unchanged. We conclude that reboxetine improved simple hand functions in chronic stroke patients. Reboxetine should be considered as an additional tool in neurorehabilitation...
  27. ncbi Pre-movement motor excitability is reduced ipsilateral to low force pinch grips
    A C Weiss
    Department of Neurology, University of Hamburg, Federal Republic of Germany
    J Neural Transm 110:201-8. 2003
    ..TMS delayed reaction time if applied close to the go-signal. We conclude that the motor cortex ipsilateral to low force movements is inhibited prior to and during movement...
  28. ncbi Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans
    Tobias Bäumer
    Department of Neurology, University of Hamburg, Hamburg, Germany
    Neuroimage 20:550-60. 2003
    ....
  29. ncbi Treatment-induced cortical reorganization after stroke in humans
    J Liepert
    Department of Neurology, Friedrich Schiller University of Jena, Germany
    Stroke 31:1210-6. 2000
    ..The aim of the present study was to evaluate reorganization in the motor cortex of stroke patients that was induced with an efficacious rehabilitation treatment...
  30. ncbi Motor plasticity induced by synchronized thumb and foot movements
    J Liepert
    Neurologische Universitatsklinik, Friedrich Schiller University, Jena, Germany
    Exp Brain Res 125:435-9. 1999
    ..We conclude that a short-lasting training of synchronous movements induces modulations of motor output maps which probably occur due to interactions between hand and foot representation areas in the motor cortex...
  31. ncbi Motor cortex disinhibition in acute stroke
    J Liepert
    Department of Neurology, Friedrich Schiller University, D 07743, Jena, Germany
    Clin Neurophysiol 111:671-6. 2000
    ..To test whether a disinhibition occurs in the human motor cortex after stroke...
  32. ncbi Two different reorganization patterns after rehabilitative therapy: an exploratory study with fMRI and TMS
    Farsin Hamzei
    Department of Neurology, University Medical Center Hamburg Eppendorf, Germany
    Neuroimage 31:710-20. 2006
    ....
  33. ncbi Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis
    Miriam Sach
    Department of Neurology, NeuroImage Nord, University Hosptial Hamburg, Eppendorf, Germany
    Brain 127:340-50. 2004
    ....
  34. ncbi No effect of a levodopa single dose on motor performance and motor excitability in chronic stroke. A double-blind placebo-controlled cross-over pilot study
    C Restemeyer
    Department of Neurology, University Medical Center Eppendorf, Hamburg, Germany
    Restor Neurol Neurosci 25:143-50. 2007
    ..Drugs that modulate neuronal transmission can influence motor recovery after stroke. Here, we tested if a single dose of levodopa could improve motor functions and change motor excitability in a group of chronic stroke patients...
  35. ncbi Modulation of motor cortex excitability induced by pinch grip repetition
    A Gorsler
    Department of Neurology, University Hospital, Hamburg Eppendorf, Germany
    J Neural Transm 111:1005-16. 2004
    ..These changes are distinct and independent of each other. Motor training has an interhemispheric effect on intracortical excitability...
  36. ncbi Fatigue suppresses ipsilateral intracortical facilitation
    T Baumer
    Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Exp Brain Res 146:467-73. 2002
    ..These results indicate interhemispheric interactions between the two motor cortices that are still effective after cessation of movements...
  37. ncbi Interhemispheric effects of high and low frequency rTMS in healthy humans
    A Gorsler
    Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Neurophysiol 114:1800-7. 2003
    ..We investigated whether repetitive transcranial magnetic stimulation (rTMS) applied to the right motor cortex modified the excitability of the unstimulated left motor cortex...
  38. ncbi Individual factors in constraint-induced movement therapy after stroke
    Michel Rijntjes
    Department of Neurology, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Neurorehabil Neural Repair 19:238-49. 2005
    ..It is worthwhile to investigate the influence of individual factors for two reasons: to find out whether they influence outcome and to see whether they support the theory underlying CIMT...
  39. ncbi Chronic dose effects of reboxetine on motor skill acquisition and cortical excitability
    R Lange
    Department of Neurology, University Freiburg, Freiburg, Germany
    J Neural Transm 114:1085-9. 2007
    ..In this study, we tested if a chronic dose application of RBX improved motor skill acquisition and modulated cortical excitability...
  40. ncbi Motor cortex plasticity during constraint-induced movement therapy in stroke patients
    J Liepert
    Department of Neurology, Friedrich Schiller University of Jena, Germany
    Neurosci Lett 250:5-8. 1998
    ..The data therefore demonstrate a CNS correlate of therapy-induced recovery of function after nervous system damage in humans...
  41. ncbi Riluzole suppresses motor cortex facilitation in correlation to its plasma level. A study using transcranial magnetic stimulation
    P Schwenkreis
    Department of Neurology, Buerkle de la Camp Platz 1, Ruhr University Bochum, BG Kliniken Bergmannsheil, 44789 Bochum, Germany
    Exp Brain Res 135:293-9. 2000
    ..The most probable mechanism involves an effect on glutamatergic synaptic transmission...
  42. pmc Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFE
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Lancet Neurol 7:875-84. 2008
    ..The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial...
  43. ncbi The influence of lorazepam on somatosensory-evoked fast frequency (600 Hz) activity in MEG
    J Haueisen
    Department of Neurology, Biomagnetisches Zentrum, Friedrich Schiller Universitat Jena, Philosophenweg 3, 07740, Jena, Germany
    Brain Res 874:10-4. 2000
    ..The source strengths of both N20m and 600-Hz bursts were significantly increased. Our results provide evidence for two components of the 600-Hz activity with a different generator structure...
  44. ncbi Prediction of short-term and long-term outcomes after cardiac arrest: a prospective multivariate approach combining biochemical, clinical, electrophysiological, and neuropsychological investigations
    Jörn Prohl
    Department of Biological Psychology and Neuropsychology, University of Hamburg, Germany
    Crit Care Med 35:1230-7. 2007
    ..To determine the prognostic accuracy of biochemical, clinical, electrophysiological, and neuropsychological investigations in predicting outcomes after cardiac arrest...
  45. ncbi Mapping plastic brain changes after acute lesions
    J Liepert
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    Curr Opin Neurol 12:709-13. 1999
    ..Recent research focused not only on lesion-induced plasticity, but also on therapy-induced reorganization of the brain. Data from animal experiments has expanded our knowledge of mechanisms that underlie plastic changes...
  46. ncbi Plasticity of cortical hand muscle representation in patients with hemifacial spasm
    J Liepert
    Department of Neurology, Friedrich Schiller University Jena, Germany
    Neurosci Lett 272:33-6. 1999
    ..The results indicate activity dependent interactions between hand and face representations in the adult human motor cortex...
  47. ncbi Abnormal motor cortex organization contralateral to early upper limb amputation in humans
    C Dettmers
    Neurologie, Friedrich Schiller Universitat, Jena, Germany
    Neurosci Lett 263:41-4. 1999
    ..In addition to previous functional studies, these new structural data suggest that maturation of the central sulcus develops in response to daily practice of the contralateral hand, possibly until adolescence...
  48. ncbi Structural and functional cortical abnormalities after upper limb amputation during childhood
    F Hamzei
    Department of Neurology, Friedrich-Schiller-University, Jena, Germany
    Neuroreport 12:957-62. 2001
    ..Therefore, arm amputation in childhood affects functional organization as well as anatomical structure in both hemispheres...
  49. pmc Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]
    Francisco Martinez-Torres
    Department of Neurology, University of Heidelberg, Germany
    BMC Neurol 8:40. 2008
    ..But currently there is no available evidence to support the routine use of adjuvant corticosteroid treatment in HSVE. A randomized multicenter trial is the only useful instrument to address this question...