Research Topics
| Cornelia LiedtkeSummaryAffiliation: University Hospital Country: Germany Publications
| Collaborators
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Detail Information
Publications
Systematic analysis of in vitro chemosensitivity and mib-1 expression in molecular breast cancer subtypesCornelia Liedtke
Department of Gynecology and Obstetrics, University Hospital Muenster, Muenster, Germany
Eur J Cancer 48:2066-74. 2012..Molecular breast cancer subgroups show differences with regard to prognosis and response to chemotherapy. In vitro chemotherapy sensitivity and resistance assays (CSRAs) are a means to directly evaluate tumour cell response to a given drug...
Caveolin-1 expression in benign and malignant lesions of the breastCornelia Liedtke
Department of Obstetrics and Gynecology, University of Munster, Albert Schweitzer Str, 33, 48149 Munster, Germany
World J Surg Oncol 5:110. 2007..abstract:..
A clinically relevant gene signature in triple negative and basal-like breast cancerAchim Rody
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
Breast Cancer Res 13:R97. 2011..Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease...
Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progressionChristian Kersting
Institute of Pathology, University of Muenster, Muenster, Germany
Lab Invest 86:54-61. 2006..The observed association between intron 1 amplification and overexpression of EGFR provides further insight into regulation mechanisms of EGFR overexpression...
The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?Eberhard Korsching
Institute of Pathology, University of Munster, Germany
J Pathol 206:451-7. 2005..We therefore propose the alternative hypothesis that vimentin-expressing breast carcinomas may derive from breast progenitor cells with bilinear (glandular and myoepithelial) differentiation potential...
Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signaturesThomas Karn
Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
PLoS ONE 6:e28403. 2011..The identification of prognostic signatures from TNBC cohorts was limited in the past due to small sample sizes...
Prognostic evaluation of the B cell/IL-8 metagene in different intrinsic breast cancer subtypesLars C Hanker
Department of Gynecology and Obstetrics, University Medical Center Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
Breast Cancer Res Treat 137:407-16. 2013..This result underlines the importance of subtype-specific analyses and suggests a sequential multistep approach to developing and applying outcome predictors in the clinic...
T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancersAchim Rody
Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
Breast Cancer Res 11:R15. 2009..However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor...
Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinomaChristian Kersting
Institute of Pathology, University of Muenster, Muenster, Germany
Lab Invest 84:582-7. 2004..7% of cases. However, since about 75% of cases with EGFR protein overexpression lack either of these amplifications, other expression regulating mechanisms must be considered...
Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentationThomas Karn
Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
Eur J Cancer 48:12-23. 2012..Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer...
Personalized treatment of early-stage breast cancer: present concepts and future directionsNadia Harbeck
Breast Center, Department of Gynecology and Obstetrics, University Hospital Köln, Cologne, Germany
Cancer Treat Rev 36:584-94. 2010..It will also highlight how carefully molecular tests need to be methodologically and clinically validated before they can be applied for clinical decision making...
