Klaus Lieb

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint [Unresponsive patient. What should be done in stupor?]
    K Lieb
    Abtlg Psychiatrie und Psychotherapie, Univ Klinikum Freiburg
    MMW Fortschr Med 145:42-44. 2003
  2. ncbi request reprint Substance P and affective disorders: new treatment opportunities by neurokinin 1 receptor antagonists?
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg, Medical School, Germany
    Neuropsychobiology 45:2-6. 2002
  3. ncbi request reprint Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells
    Klaus Lieb
    Department of Psychiatry, University of Freiburg Medical School, D 79104, Freiburg, Germany
    Neurochem Int 42:131-7. 2003
  4. ncbi request reprint [Substance P-antagonists as a new class of antidepressant drugs]
    K Lieb
    Abteilung Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Germany
    Dtsch Med Wochenschr 127:2563-5. 2002
  5. ncbi request reprint No modulatory effect of neurokinin-1 receptor antagonists on serotonin uptake in human and rat brain synaptosomes
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Eur Neuropsychopharmacol 15:641-6. 2005
  6. ncbi request reprint Increased diurnal salivary cortisol in women with borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    J Psychiatr Res 38:559-65. 2004
  7. ncbi request reprint Effects of the neuropeptide substance P on sleep, mood, and neuroendocrine measures in healthy young men
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Neuropsychopharmacology 27:1041-9. 2002
  8. ncbi request reprint Borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Lancet 364:453-61. 2004
  9. ncbi request reprint [Management of acute suicidality]
    K Lieb
    Abteilung Psychiatrie und Psychotherapie, Universitatsklinik Freiburg
    MMW Fortschr Med 146:51-2. 2004
  10. ncbi request reprint [Substance P receptor antagonists--a new antidepressive and anxiolytic mechanism?]
    K Lieb
    Abt Psychiatrie und Psychotherapie, Universitatsklinik Freiburg
    Nervenarzt 71:758-61. 2000

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint [Unresponsive patient. What should be done in stupor?]
    K Lieb
    Abtlg Psychiatrie und Psychotherapie, Univ Klinikum Freiburg
    MMW Fortschr Med 145:42-44. 2003
  2. ncbi request reprint Substance P and affective disorders: new treatment opportunities by neurokinin 1 receptor antagonists?
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg, Medical School, Germany
    Neuropsychobiology 45:2-6. 2002
    ..It also reviews current treatment approaches with neurokinin 1 receptor antagonists which appear to be promising drugs for the future treatment of affective disorders...
  3. ncbi request reprint Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells
    Klaus Lieb
    Department of Psychiatry, University of Freiburg Medical School, D 79104, Freiburg, Germany
    Neurochem Int 42:131-7. 2003
    ....
  4. ncbi request reprint [Substance P-antagonists as a new class of antidepressant drugs]
    K Lieb
    Abteilung Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Germany
    Dtsch Med Wochenschr 127:2563-5. 2002
  5. ncbi request reprint No modulatory effect of neurokinin-1 receptor antagonists on serotonin uptake in human and rat brain synaptosomes
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Eur Neuropsychopharmacol 15:641-6. 2005
    ..These results show that in humans, as in rodents, inhibition of the 5-HT transporter is probably not the underlying mechanism of the assumed antidepressant activity of NK-1-RA...
  6. ncbi request reprint Increased diurnal salivary cortisol in women with borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    J Psychiatr Res 38:559-65. 2004
    ..Increased adrenal activity and lowered feedback sensitivity of the HPA-axis may characterise BPD. Further studies have to reveal reasons of heightened adrenal activity in these patients...
  7. ncbi request reprint Effects of the neuropeptide substance P on sleep, mood, and neuroendocrine measures in healthy young men
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Neuropsychopharmacology 27:1041-9. 2002
    ..These effects can be interpreted as evidence for a central arousing effect of SP. Further studies should focus on the effects of substance P in patients with depressive or other psychiatric disorders...
  8. ncbi request reprint Borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Lancet 364:453-61. 2004
    ..Current strategies are focusing on the neurobiological underpinnings of the disorder and the development and dissemination of better and more cost-effective treatments to clinicians...
  9. ncbi request reprint [Management of acute suicidality]
    K Lieb
    Abteilung Psychiatrie und Psychotherapie, Universitatsklinik Freiburg
    MMW Fortschr Med 146:51-2. 2004
  10. ncbi request reprint [Substance P receptor antagonists--a new antidepressive and anxiolytic mechanism?]
    K Lieb
    Abt Psychiatrie und Psychotherapie, Universitatsklinik Freiburg
    Nervenarzt 71:758-61. 2000
    ..Although these findings are promising, further studies are necessary to prove the hypothesis that substance P receptor antagonists represent a new class of antidepressants or anxiolytics. Respective studies are currently underway...
  11. ncbi request reprint [Accelerating consult letter time in inpatient psychiatric and psychotherapeutic care]
    K Lieb
    Abteilung Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Hauptstrasse, Freiburg
    Nervenarzt 78:322-7. 2007
    ..In our own department, ward-specific consult letter efficiency has become an important quality indicator...
  12. ncbi request reprint [Acute treatment of psychiatric excitation. What to do when the patient is out of control?]
    K Lieb
    Abtlg Psychiatrie und Psychotherapie, Univ Klinikum Freiburg
    MMW Fortschr Med 145:49-51. 2003
  13. ncbi request reprint Valproic acid inhibits substance P-induced activation of protein kinase C epsilon and expression of the substance P receptor
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    J Neurochem 86:69-76. 2003
    ..Whether both mechanisms contribute to the mood-stabilizing properties of VPA has to be evaluated in further studies...
  14. doi request reprint Predictors of dropout from inpatient dialectical behavior therapy among women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Behav Ther Exp Psychiatry 39:497-503. 2008
    ..Experiential avoidance and anxiety may be associated with dropout in inpatient DBT. Low life-time suicidality and high anger could reflect a subtype at risk for discontinuation of inpatient treatment...
  15. ncbi request reprint Gender differences in axis I and axis II comorbidity in patients with borderline personality disorder
    Andre Tadic
    Department of Psychiatry, University of Mainz, Germany
    Psychopathology 42:257-63. 2009
    ..The purpose of this study was to investigate gender differences in axis I and axis II comorbidity and in diagnostic criteria in BPD patients...
  16. ncbi request reprint Shame and implicit self-concept in women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Am J Psychiatry 164:500-8. 2007
    ....
  17. ncbi request reprint The impact of posttraumatic stress disorder on dysfunctional implicit and explicit emotions among women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Nerv Ment Dis 195:537-9. 2007
    ..Self-reported guilt proneness and implicit anxiety may mediate the negative impact of comorbid PTSD on women with BPD...
  18. doi request reprint Time course of response to antidepressants: predictive value of early improvement and effect of additional psychotherapy
    Dietrich van Calker
    Department of Psychiatry and Psychotherapy, University Medical Centre Freiburg, Germany
    J Affect Disord 114:243-53. 2009
    ..We have analysed in more severely depressed inpatients treated with antidepressants i) the predictive value of early improvement for later response and ii) the impact of additional psychotherapy on the time course of response...
  19. ncbi request reprint Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroimmunol 174:39-51. 2006
    ....
  20. pmc Emotional modulation of motor response inhibition in women with borderline personality disorder: an fMRI study
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    J Psychiatry Neurosci 38:164-72. 2013
    ..Although both problems may be combined specifically in BPD, few studies to date have investigated the emotional modulation of impulsivity in BPD...
  21. ncbi request reprint Effects of substance P on memory and mood in healthy male subjects
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    Hum Psychopharmacol 22:567-73. 2007
    ..The results may be interpreted as evidence for an anxiogenic and memory-disturbing effect of SP. Further studies will focus on the effects of SP in patients with depression, anxiety and cognitive disorders...
  22. doi request reprint Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany
    World J Biol Psychiatry 11:45-58. 2010
    ....
  23. ncbi request reprint Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor
    Maike Hamke
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Brain Res 1102:135-44. 2006
    ..Further studies are needed to substantiate this link in vivo...
  24. doi request reprint Extraction of prefronto-amygdalar pathways by combining probability maps
    Tobias Bracht
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Psychiatry Res 174:217-22. 2009
    ..We believe that our approach provides a promising tool to assess the integrity of specific structural connections in patients with neuropsychiatric disorders...
  25. ncbi request reprint Increased delta power and discrepancies in objective and subjective sleep measurements in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Haupt strasse 5, 79104 Freiburg, Germany
    J Psychiatr Res 39:489-98. 2005
    ..Earlier findings in sleep EEG abnormalities in BPD may have been confounded by concomitant depressive symptoms...
  26. doi request reprint Time course of anger and other emotions in women with borderline personality disorder: a preliminary study
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Behav Ther Exp Psychiatry 39:391-402. 2008
    ..The BPD group showed also stronger negative emotions over the whole experiment. The study is the first to demonstrate prolonged anger reactions in BPD patients in an experimental setting...
  27. ncbi request reprint Self-stigma in women with borderline personality disorder and women with social phobia
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    J Nerv Ment Dis 194:766-73. 2006
    ..This may reflect intense labeling processes as being mentally ill due to repeated hospitalizations, frequent interpersonal difficulties, and visible scars...
  28. doi request reprint Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:487-95. 2009
    ....
  29. doi request reprint Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2
    Antonio Carlos Pinheiro de Oliveira
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 56:844-55. 2008
    ....
  30. doi request reprint Borderline typical symptoms in adult patients with attention deficit/hyperactivity disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Atten Defic Hyperact Disord 1:11-8. 2009
    ..Females with ADHD and BPD share more clinical features than males. However, symptoms of self-destruction and affect dysregulation appear to be more severe in BPD patients...
  31. ncbi request reprint Sleep in adults with attention-deficit/hyperactivity disorder: a controlled polysomnographic study including spectral analysis of the sleep EEG
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Sleep 28:877-84. 2005
    ..We investigated objective and subjective sleep quality in adultADHD, including an electroencephalogram spectral power analysis...
  32. doi request reprint Effects of sleep deprivation on nocturnal cytokine concentrations in depressed patients and healthy control subjects
    Ulrich Voderholzer
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    J Neuropsychiatry Clin Neurosci 24:354-66. 2012
    ..The interaction between antidepressant effects of TSD and alterations of cytokines warrants further investigation...
  33. doi request reprint Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression
    Nadine Dreimüller
    Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, Germany
    Neuropharmacology 62:264-9. 2012
    ..This has to be confirmed in further investigations. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  34. doi request reprint Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD
    Alexandra Sebastian
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University Freiburg, Germany
    Psychiatry Res 202:132-41. 2012
    ....
  35. doi request reprint Small amygdala-high aggression? The role of the amygdala in modulating aggression in healthy subjects
    Swantje Matthies
    Department of Psychiatry and Psychotherapy, University Medical Centre Freiburg, Freiburg, Germany
    World J Biol Psychiatry 13:75-81. 2012
    ..In order to better understand the physiological role of the amygdala in modulating aggressive behaviour we investigated the relationship between amygdala volumes and lifetime aggression in healthy subjects...
  36. ncbi request reprint Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 93:549-59. 2005
    ..This study shows, for the first time, a central role of 5-HT7 receptor linked to p38 MAPK and PKC epsilon for the induction of cytokine synthesis in astrocytic cells...
  37. ncbi request reprint An intensive treatment program of interpersonal psychotherapy plus pharmacotherapy for depressed inpatients: acute and long-term results
    Elisabeth Schramm
    University Medical Center Freiburg, Department of Psychiatry, Hauptstrasse 5, 79104 Freiburg, Germany
    Am J Psychiatry 164:768-77. 2007
    ..The purpose of this article was to determine the relative efficacy of a psychotherapy program when combined with pharmacotherapy versus medication and clinical management in more severely depressed patients...
  38. ncbi request reprint Cognitive impairment in patients with chronic hepatitis treated with interferon alpha (IFNalpha): results from a prospective study
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, 79104 Freiburg, Germany
    Eur Psychiatry 21:204-10. 2006
    ..In addition to depression and anxiety, IFN-alpha associated cognitive impairment significantly affects patient's mental health and quality of life...
  39. pmc Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    BMC Psychiatry 11:16. 2011
    ..Peripheral blood markers and executive functions are particularly promising candidates as markers for the onset of action and thus the prediction of final treatment outcome in MDD...
  40. ncbi request reprint Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents...
  41. doi request reprint Neurochemical alterations in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    World J Biol Psychiatry 11:372-81. 2010
    ..Borderline personality disorder (BPD) is associated with structural and functional brain changes. Recent models and findings refer to alterations of glutamate and total N-acetylaspartate (tNAA) in this condition...
  42. doi request reprint Association analysis of SCN9A gene variants with borderline personality disorder
    Andre Tadic
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    J Psychiatr Res 43:155-63. 2008
    ....
  43. ncbi request reprint Clonidine in acute aversive inner tension and self-injurious behavior in female patients with borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    J Clin Psychiatry 65:1414-9. 2004
    ....
  44. doi request reprint Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    Psychiatry Res 181:151-4. 2010
    ..Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD...
  45. doi request reprint Group therapy module to enhance self-esteem in patients with borderline personality disorder: a pilot study
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical Centre, Germany
    Int J Group Psychother 60:373-87. 2010
    ..Results showed a greater improvement in self-esteem in the intervention group. The findings suggest that the therapy module is an effective adjunctive treatment in increasing self-esteem in BPD...
  46. doi request reprint Attention-deficit hyperactivity disorder as a potentially aggravating factor in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Br J Psychiatry 192:118-23. 2008
    ..Clinical experience suggests that people with borderline personality disorder often meet criteria for attention-deficit hyperactivity disorder (ADHD). However, empirical data are sparse...
  47. ncbi request reprint Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells
    Bernd L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, D 79104 Freiburg, Germany
    J Neuroimmunol 132:18-24. 2002
    ..The data suggest that parthenolide might have a potential in the treatment of CNS diseases where NO is part of the pathophysiology...
  48. doi request reprint The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 35:415-20. 2011
    ..If replicated, this combined marker could be considered useful for prospective confirmatory trials in patients with MDD...
  49. pmc Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    PLoS ONE 7:e46004. 2012
    ..As a growing body of evidence suggests that brain plasticity is disturbed in affective disorders, we examined the short-term and remote effects of early life stress on different forms of brain plasticity...
  50. ncbi request reprint Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder
    Petra Ludäscher
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Psychiatry Res 149:291-6. 2007
    ..Measuring electric pain thresholds is a valid and reasonable method for larger studies...
  51. doi request reprint Emotional reactions to standardized stimuli in women with borderline personality disorder: stronger negative affect, but no differences in reactivity
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Nerv Ment Dis 197:808-15. 2009
    ..Extreme negative affectivity may be a more appropriate description of BPD-related emotional problems than emotional hyperreactivity...
  52. doi request reprint Impulsivity in borderline personality disorder: impairment in self-report measures, but not behavioral inhibition
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Psychopathology 43:180-8. 2010
    ..However, previous clinical and experimental studies investigating impulsivity in BPD rendered mixed results. In this study, impulsivity was assessed by self-report scales and behavioral inhibition tasks to compare different data levels...
  53. pmc Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with major depressive disorder--the EMC trial
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Trials 11:21. 2010
    ..Even more important, non-improvement (HAMD decrease <20%) after 14 days of treatment was found to be highly predictive for a poor final treatment outcome...
  54. pmc Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder
    NICOLAS RUSCH
    Rüsch, Zahn, Ebert, Tebartz van Elst Department of Psychiatry and Psychotherapy, University of Freiburg, and the South German Brain Imaging Center, Freiburg, Germany
    J Psychiatry Neurosci 32:417-22. 2007
    ..Recent models suggest impaired structural and functional connectivity in this condition. To investigate this, we studied the thickness of the corpus callosum, the largest connecting fibre bundle in the human brain...
  55. doi request reprint Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Atten Defic Hyperact Disord 2:203-12. 2010
    ..The trial is funded by the German Federal Ministry of Research and Education (01GV0606) and is part of the German network for the treatment of ADHD in children and adults (ADHD-NET)...
  56. doi request reprint Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    J Neural Transm 116:1185-8. 2009
    ..Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients...
  57. ncbi request reprint Impulsivity in borderline personality disorder: a matter of disturbed impulse control or a facet of emotional dysregulation?
    Alexandra Sebastian
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    Curr Psychiatry Rep 15:339. 2013
    ..In sum, although basic mechanisms of impulse control seem not to be disturbed in BPD, clinically well observed impulsive behaviors may be explained by comorbid ADHD or may be the consequence of dysregulation of BPD salient emotions...
  58. doi request reprint Psychological therapies for people with borderline personality disorder
    Jutta M Stoffers
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    Cochrane Database Syst Rev 8:CD005652. 2012
    ..In recent years, several disorder-specific interventions have been developed. This is an update of a review published in the Cochrane Database of Systematic Reviews in 2006...
  59. ncbi request reprint Increased nocturnal interleukin-6 excretion in patients with primary insomnia: a pilot study
    Ivonne Burgos
    Department of Psychiatry and Psychotherapy, University Hospital of Leipzig, Leipzig, Germany
    Brain Behav Immun 20:246-53. 2006
    ..This might also implicate a higher risk for inflammatory and cardiovascular diseases in patients with chronic insomnia...
  60. ncbi request reprint Transient total sleep loss in cerebral Whipple's disease: a longitudinal study
    Ulrich Voderholzer
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Sleep Res 11:321-9. 2002
    ..The extent of sleep disruption in this case of organic insomnia was similar to cases of familial fatal insomnia, but was at least partially reversible with treatment...
  61. doi request reprint Comparison of different strategies to decrease negative affect and increase positive affect in women with borderline personality disorder
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Behav Res Ther 49:68-73. 2011
    ..In this study we compared the effect of different emotion regulation strategies on positive and negative emotions in patients with borderline personality disorder...
  62. ncbi request reprint Effectiveness of inpatient dialectical behavioral therapy for borderline personality disorder: a controlled trial
    Martin Bohus
    Department of Psychiatry and Psychotherapy with Polyclinic, Albert Ludwig University of Freiburg, Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Behav Res Ther 42:487-99. 2004
    ..Within a relatively short time frame, improvement was found across a broad range of psychopathological features. Stability of the recovery after one month following discharge, however, was not evaluated and requires further study...
  63. doi request reprint Reliability of three alternate forms of the trail making tests a and B
    Stefanie Wagner
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    Arch Clin Neuropsychol 26:314-21. 2011
    ..76 and 0.89 and between 0.86 and 0.94, respectively. Because of their identical difficulty and high reliability, the herein described versions of the TMT A and B are suitable for sequential testing of executive functioning...
  64. ncbi request reprint Measuring shame and guilt by self-report questionnaires: a validation study
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Psychiatry Res 150:313-25. 2007
    ..The discriminant validity of the TOSCA-3 to distinguish between shame- and guilt-proneness may be diminished in clinical samples. The measure of state shame (ESS) showed a large overlap with state anxiety...
  65. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of personality disorders
    Sabine C Herpertz
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    World J Biol Psychiatry 8:212-44. 2007
    ....
  66. ncbi request reprint Substance P and Substance P receptor antagonists in the pathogenesis and treatment of affective disorders
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    World J Biol Psychiatry 4:56-63. 2003
    ..Key words: substance P, neurokinin1-receptor, affective disorders, depression, review...
  67. ncbi request reprint Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices
    Jens M Langosch
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstr 5, D 79104 Freiburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:315-9. 2005
    ..In conclusion, SP has excitatory effects in the hippocampus and is able to facilitate LTP via activation of the NK-1 receptor...
  68. doi request reprint Dopamine D2/D3 receptor availability and venturesomeness
    Nina Bernow
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    Psychiatry Res 193:80-4. 2011
    ..Our results suggest the involvement of extrastriatal dopaminergic neurotransmission in venturesomeness, a component of impulsivity...
  69. ncbi request reprint Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    CNS Drugs 19:275-93. 2005
    ..These compounds may be more efficacious in antagonising the effects of SP than compounds that only block the NK1R...
  70. ncbi request reprint Self-stigma, empowerment, and perceived legitimacy of discrimination among women with mental illness
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    Psychiatr Serv 57:399-402. 2006
    ..The authors hypothesized that a high level of perceived discrimination, little sense of identification with the group of people with mental illness, and a high level of perceived legitimacy of discrimination lead to self-stigma...
  71. ncbi request reprint Synergistic inhibitory effect of ascorbic acid and acetylsalicylic acid on prostaglandin E2 release in primary rat microglia
    Bernd L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Germany
    J Neurochem 86:173-8. 2003
    ..Our results show that ascorbic acid and acetylsalicylic acid act synergistically in inhibiting PGE2 synthesis, which may help to explain a possible protective effect of ascorbic acid in various brain diseases...
  72. ncbi request reprint Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs
    M Hull
    Department of Psychiatry, Neurochemistry Research, University of Freiburg, Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Curr Med Chem 9:83-8. 2002
    ..Inhibitors of p38MAPK and PPAR gamma agonists may be suitable agents to suppress inflammatory activation in AD...
  73. ncbi request reprint Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E(2) synthesis in rat microglial cells
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Neuropharmacology 39:2205-13. 2000
    ..Furthermore, these results may help explain the clinical experience of an adjuvant analgesic effect of caffeine and paracetamol when combined with acetylsalicylic acid...
  74. ncbi request reprint The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Neuropharmacology 38:1325-33. 1999
    ....
  75. ncbi request reprint The neuropeptide substance P activates p38 mitogen-activated protein kinase resulting in IL-6 expression independently from NF-kappa B
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Immunol 165:5606-11. 2000
    ..Drugs targeting this MAPK may therefore interfere with SP-correlated neuropsychiatric disorders and may represent a therapeutic approach in these disorders...
  76. ncbi request reprint Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder
    L T van Elst
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University, Freiburg, Germany
    J Neuropsychiatry Clin Neurosci 13:511-4. 2001
    ..01) compared with control subjects...
  77. ncbi request reprint Anti-inflammatory drugs: a hope for Alzheimer's disease?
    M Hull
    Department of Psychiatry, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Expert Opin Investig Drugs 9:671-83. 2000
    ....
  78. ncbi request reprint Pain perception during self-reported distress and calmness in patients with borderline personality disorder and self-mutilating behavior
    M Bohus
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104, Freiburg, Germany
    Psychiatry Res 95:251-60. 2000
    ..This may reflect a state-independent increased pain threshold which is further elevated during stress. Interpretation of these findings is limited by their reliance upon self-reports...
  79. ncbi request reprint Inhibition of substance P-induced cytokine synthesis by St. John's wort extracts
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Germany
    Pharmacopsychiatry 34:S26-8. 2001
    ..John's wort, but also lend support to the hypothesis that the antidepressant effect of St. John's wort is, at least in part, a result of its inhibitory effects on SP-induced protein synthesis...
  80. ncbi request reprint Evidence of disturbed amygdalar energy metabolism in patients with borderline personality disorder
    L Tebartz van Elst
    South German Brain Imaging Center, and Department of Psychiatry and Psychotherapy, Medical School, Albert Ludwigs University Freiburg, Hauptstrasse 5, 79104 Freiburg, Germany
    Neurosci Lett 417:36-41. 2007
    ..This pilot study of simultaneous amygdalar morphometry and spectroscopy in BPD reveals a possible link between amygdalar volume loss, psychopathology and neurochemical abnormalities in terms of creatine signals...
  81. ncbi request reprint Subtype differentiation of patients with borderline personality disorder using a circumplex model of interpersonal behavior
    Florian Leihener
    1 Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    J Nerv Ment Dis 191:248-54. 2003
    ..Implications of these findings for future research and management of BPD are discussed...
  82. ncbi request reprint Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study
    Ludger Tebartz van Elst
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    Biol Psychiatry 54:163-71. 2003
    ..We measured limbic and prefrontal brain volumes to test the hypothesis that frontolimbic brain pathology might be associated with borderline personality disorder...
  83. ncbi request reprint Effects of substance P and selected other neuropeptides on the synthesis of interleukin-1 beta and interleukin-6 in human monocytes: a re-examination
    K Lieb
    Abteilung Psychiatrie und Psychotherapie, , Germany
    J Neuroimmunol 67:77-81. 1996
    ....
  84. ncbi request reprint Naloxone in the treatment of acute dissociative states in female patients with borderline personality disorder
    A Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    Pharmacopsychiatry 37:196-9. 2004
    ..Acute dissociative states are common in patients with borderline personality disorder (BPD). However, there are no established pharmacotherapeutic treatment options for this severe clinical condition...
  85. ncbi request reprint Positron emission tomography in female patients with borderline personality disorder
    F D Juengling
    Department of Nuclear Medicine, PET Group, University of Freiburg Medical School, Hugstetterstr 55, D 79106, Freiburg, Germany
    J Psychiatr Res 37:109-15. 2003
    ..Dysfunction in this network of brain regions, which has been implicated in the regulation of emotion, may underlie symptoms of BPD...
  86. doi request reprint Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    Br J Psychiatry 196:4-12. 2010
    ..Many patients with borderline personality disorder receive pharmacological treatment, but there is uncertainty about the usefulness of such therapies...
  87. ncbi request reprint 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 91:263-73. 2004
    ....
  88. ncbi request reprint Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    Neuroimage 35:738-47. 2007
    ....
  89. ncbi request reprint Neurotransmitter changes by interferon-alpha and therapeutic implications
    M Schaefer
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S203-6. 2003
    ..We review recent research about IFN-associated neurotransmitter changes in the central nervous system and discuss treatment strategies...
  90. doi request reprint The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD)
    S Wagner
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany
    Acta Psychiatr Scand 122:110-7. 2010
    ....
  91. ncbi request reprint Deep brain stimulation for treatment of refractory depression
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Lancet 366:1420-2. 2005
  92. doi request reprint The 5-HTTLPR polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with Borderline Personality Disorder
    Stefanie Wagner
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    J Psychiatr Res 43:1067-72. 2009
    ..On the other hand, serious life events (SLE) are of major importance in the development of BPD. However, the inter-relations between SLEs, impulsivity, and 5-HTTLPR are not understood...
  93. ncbi request reprint Interferon alpha (IFNalpha) and psychiatric syndromes: a review
    Martin Schaefer
    Department of Psychiatry, Charite, Humboldt University, Humboldt, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 26:731-46. 2002
    ..Future research should improve our understanding of the role of IFNalpha for the etiopathology of psychiatric syndromes and has an impact on treatment of IFNalpha-induced psychiatric syndromes...
  94. ncbi request reprint A voxel-based morphometric MRI study in female patients with borderline personality disorder
    N Rusch
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    Neuroimage 20:385-92. 2003
    ..Our findings support the hypothesis that temporolimbic abnormalities play a role in the pathophysiology of BPD. Prefrontal structural alterations in BPD were not observed in this study...
  95. doi request reprint Modulatory role of the brain-derived neurotrophic factor Val66Met polymorphism on the effects of serious life events on impulsive aggression in borderline personality disorder
    S Wagner
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Genes Brain Behav 9:97-102. 2010
    ..The interrelations between serious life events, impulsive aggression and the BDNF Val(66)Met polymorphism as well as their implication for BPD are far from understood and require further investigations...
  96. ncbi request reprint Borna disease virus--does it infect humans and cause psychiatric disorders?
    K Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Clin Virol 21:119-27. 2001
    ..We conclude that there is presently no strong experimental evidence supporting the notion that BDV is a human pathogen. The possibility remains, however, that an antigenically related agent is associated with human psychiatric disorders...
  97. ncbi request reprint No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress
    Nicolas Rohleder
    Department of Psychology, Dresden University of Technology, Zellescher Weg 17, D 01069 Dresden, Germany
    Life Sci 78:3082-9. 2006
    ..Further studies have to reveal the mechanisms involved in the stress-induced up regulation of IL-1ra...
  98. ncbi request reprint State affective instability in borderline personality disorder assessed by ambulatory monitoring
    Ulrich W Ebner-Priemer
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Germany
    Psychol Med 37:961-70. 2007
    ..Furthermore, the pattern of instability that characterizes BPD has not yet been identified...
  99. ncbi request reprint [University privatization as a prospect or nightmare]
    Josef Aldenhoff
    Klinik fur Psychiatrie und Psychotherapie, Zentrum für Integrative Psychiatrie, ZIP gGmbH, Niemannsweg, Kiel
    Nervenarzt 77:1393-8. 2006
  100. ncbi request reprint Neural correlates of antinociception in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 63:659-67. 2006
    ..We predicted that heat stimuli in patients with BPD would activate brain areas concerned with cognitive and emotional evaluation of pain...
  101. ncbi request reprint Substance P in serum and cerebrospinal fluid of depressed patients: no effect of antidepressant treatment
    Michael Deuschle
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Psychiatry Res 136:1-6. 2005
    ..Serum SP concentrations were not related to treatment response or the class of antidepressant administered. Our data do not support the hypothesis that changes in SP levels in serum or CSF are related to antidepressant response...