Stefan F Lichtenthaler

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10
    Regina Augustin
    Helmholtz Centre Munich, German Research Centre for Environmental Health GmbH and Technical University Munich, Institute of Developmental Genetics, Ingolstädter Landstraße, 1, 85764, Munich Neuherberg, Germany
    BMC Med Genet 13:35. 2012
  2. ncbi request reprint Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking
    Stefan F Lichtenthaler
    DZNE German Center for Neurodegenerative Diseases, 80336 Munich, Germany
    Curr Alzheimer Res 9:165-77. 2012
  3. doi request reprint α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential
    Stefan F Lichtenthaler
    DZNE German Center for Neurodegenerative Diseases, Munich, Germany
    J Neurochem 116:10-21. 2011
  4. pmc Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis
    Stefan F Lichtenthaler
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory of Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    EMBO Rep 8:537-41. 2007
  5. ncbi request reprint Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers
    Stefan F Lichtenthaler
    Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany
    Neurodegener Dis 3:262-9. 2006
  6. pmc Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
    Stefan F Lichtenthaler
    Adolf Butenandt Institut, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians Universitat, Munich, Germany
    J Clin Invest 113:1384-7. 2004
  7. doi request reprint A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein
    Susanne Schöbel
    Center for Integrated Protein Science and the Adolf Butenandt Institut, Ludwig Maximilians University, Munich, Germany
    J Biol Chem 283:14257-68. 2008
  8. ncbi request reprint Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein
    Stephanie Neumann
    Adolf Butenandt Institut, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    J Biol Chem 281:7583-94. 2006
  9. pmc Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase
    Sebastian Hogl
    German Center for Neurodegenerative Diseases, Munich, Germany
    PLoS ONE 6:e21337. 2011
  10. ncbi request reprint Expression cloning screen for modifiers of amyloid precursor protein shedding
    Susanne Schöbel
    Adolf Butenandt Institut, Ludwig Maximilians University, Schillerstr 44, 80336 Munich, Germany
    Int J Dev Neurosci 24:141-8. 2006

Collaborators

Detail Information

Publications40

  1. pmc Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10
    Regina Augustin
    Helmholtz Centre Munich, German Research Centre for Environmental Health GmbH and Technical University Munich, Institute of Developmental Genetics, Ingolstädter Landstraße, 1, 85764, Munich Neuherberg, Germany
    BMC Med Genet 13:35. 2012
    ..To predict miRNAs regulating ADAM10 expression concerning AD, we developed a computational approach...
  2. ncbi request reprint Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking
    Stefan F Lichtenthaler
    DZNE German Center for Neurodegenerative Diseases, 80336 Munich, Germany
    Curr Alzheimer Res 9:165-77. 2012
    ..This review highlights the role of signaling pathways and protein trafficking in the control of APP α-secretase cleavage...
  3. doi request reprint α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential
    Stefan F Lichtenthaler
    DZNE German Center for Neurodegenerative Diseases, Munich, Germany
    J Neurochem 116:10-21. 2011
    ..This review focuses on the recent progress made in unraveling the molecular identity, regulation and therapeutic potential of α-secretase in Alzheimer's disease...
  4. pmc Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis
    Stefan F Lichtenthaler
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory of Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    EMBO Rep 8:537-41. 2007
  5. ncbi request reprint Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers
    Stefan F Lichtenthaler
    Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany
    Neurodegener Dis 3:262-9. 2006
    ..Moreover, it highlights the particular importance of endocytic APP trafficking as a prime modulator of APP shedding...
  6. pmc Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
    Stefan F Lichtenthaler
    Adolf Butenandt Institut, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians Universitat, Munich, Germany
    J Clin Invest 113:1384-7. 2004
    ..alpha-Secretase cleaves within the A beta peptide domain and thus precludes A beta peptide generation. Now, new results demonstrate that activation of alpha-secretase indeed reduces A beta peptide generation and toxicity in vivo...
  7. doi request reprint A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein
    Susanne Schöbel
    Center for Integrated Protein Science and the Adolf Butenandt Institut, Ludwig Maximilians University, Munich, Germany
    J Biol Chem 283:14257-68. 2008
    ....
  8. ncbi request reprint Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein
    Stephanie Neumann
    Adolf Butenandt Institut, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    J Biol Chem 281:7583-94. 2006
    ..In summary, our study provides a novel mechanism for APP shedding, in which APLP1 affects the endocytosis of APP and makes more APP available for alpha-secretase cleavage...
  9. pmc Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase
    Sebastian Hogl
    German Center for Neurodegenerative Diseases, Munich, Germany
    PLoS ONE 6:e21337. 2011
    ..Determination of the APLP2 cleavage sites enables functional studies of the different APLP2 ectodomain fragments and the production of cleavage-site specific antibodies for APLP2, which may be used for biomarker development...
  10. ncbi request reprint Expression cloning screen for modifiers of amyloid precursor protein shedding
    Susanne Schöbel
    Adolf Butenandt Institut, Ludwig Maximilians University, Schillerstr 44, 80336 Munich, Germany
    Int J Dev Neurosci 24:141-8. 2006
    ..In summary, this study shows that expression cloning is a suitable way to identify proteins controlling ectodomain shedding of membrane proteins...
  11. doi request reprint Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling
    Daniel Fleck
    Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 33:7856-69. 2013
    ..Our data suggest that NRG1 type III-dependent myelination is not only controlled by membrane-retained NRG1 type III, but also in a paracrine manner via proteolytic liberation of the EGF-like domain...
  12. pmc Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
    Peer Hendrik Kuhn
    DZNE German Center for Neurodegenerative Diseases, Munich, Germany
    EMBO J 31:3157-68. 2012
    ..SPECS is also suitable for quantitative secretome analyses of primary cells and may be used for the discovery of biomarkers secreted from tumour or stem cells...
  13. pmc Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region
    Sven Lammich
    German Center for Neurodegenerative Diseases DZNE and Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 285:15753-60. 2010
    ..Thus, we provide evidence that the 5'-UTR of ADAM10 may have an important role for post-transcriptional regulation of ADAM10 expression and consequently Abeta production...
  14. pmc The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein
    Sylvia Ullrich
    German Center for Neurodegenerative Diseases Munich DZNE and Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Biol Chem 285:20664-74. 2010
    ....
  15. ncbi request reprint Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase
    Peer Hendrik Kuhn
    Adolf Butenandt Institut, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    J Biol Chem 282:11982-95. 2007
    ..This study reveals a similar proteolytic processing of IL-1R2 and APP and may provide an explanation for the increased IL-1R2 secretion observed in AD...
  16. doi request reprint Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments
    Richard M Page
    Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 32:18204-14. 2012
    ..In view of the absence of a neurological phenotype in PAFAH1B2 knock-out mice, targeted downregulation of PAFAH1B2 may be a promising new strategy for lowering Aβ...
  17. pmc ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons
    Peer Hendrik Kuhn
    Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Munich, Germany
    EMBO J 29:3020-32. 2010
    ..We conclude that ADAM10 is the physiologically relevant, constitutive alpha-secretase of APP...
  18. pmc Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex
    Ulf Dettmer
    German Center for Neurodegenerative Diseases DZNE and the Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, D 80336 Munich, Germany
    J Biol Chem 285:26174-81. 2010
    ..We conclude that TMEM147 is a novel core component of the Nicalin-NOMO complex, further emphasizing its similarity with gamma-secretase...
  19. doi request reprint Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase
    Benedikt Kretner
    Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Munich, Germany
    J Neurochem 125:144-56. 2013
    ..We suggest that L383 and the flanking glycine residues form a spatial arrangement in PS1 that is critical for docking and/or cleavage of different γ-secretase substrates...
  20. ncbi request reprint Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme
    Gil G Westmeyer
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstrasse 44, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 279:53205-12. 2004
    ..Dimerization of BACE might, thus, facilitate binding and cleavage of physiological substrates...
  21. doi request reprint Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains
    Sebastian Hogl
    German Center for Neurodegenerative Diseases DZNE, Munich, Germany
    Proteomics 13:1519-27. 2013
    ....
  22. doi request reprint Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33
    Bastian Dislich
    German Center for Neurodegenerative Diseases, Munich, 80336 Munich, Germany
    Biochem J 433:75-83. 2011
    ....
  23. doi request reprint Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing
    Stefan F Lichtenthaler
    DZNE German Center for Neurodegenerative Diseases, Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Munich, Germany
    J Neurochem 117:779-96. 2011
    ..Focusing on APP as the best-studied RIP substrate, this review describes the function and mechanism of the APP RIP proteases with the goal to elucidate cellular mechanisms and common principles of the RIP process in general...
  24. ncbi request reprint The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
    Stefan F Lichtenthaler
    Massachusetts General Hospital Harvard Medical School, Department of Molecular Biology, Boston, Massachusetts 02114, USA
    J Biol Chem 278:48713-9. 2003
    ..The cleavage occurred at a Leu-Ser peptide bond as identified by mass spectrometry using a synthetic peptide. We conclude that PSGL-1 is an additional substrate for BACE1...
  25. pmc Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3)
    Matthias Voss
    Adolf Butenandt Institute for Biochemistry, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Biol Chem 287:43401-9. 2012
    ..Thus, human SPPL3 is the first GxGD-type aspartyl protease shown to be capable of acting like a sheddase, similar to members of the rhomboid family, which belong to the class of intramembrane-cleaving serine proteases...
  26. doi request reprint The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO
    Anne Kathrin Müller-Rischart
    Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
    Mol Cell 49:908-21. 2013
    ....
  27. doi request reprint Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms
    Stefan Mitterreiter
    German Center for Neurodegenerative Diseases Munich and Adolf Butenandt Institute, Biochemistry, University of Munich, 80336 Munich, Germany
    J Neurosci 30:8974-83. 2010
    ..In addition to Alzheimer's disease, compounds with dual properties may also be useful for drug development targeting other membrane proteins...
  28. pmc Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region
    Sven Lammich
    Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Adolf Butenandt Institute, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    EMBO Rep 5:620-5. 2004
    ..Our data therefore demonstrate translational repression as a new mechanism controlling BACE1 expression...
  29. pmc Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM
    Matthias Hachmeister
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 8:e71836. 2013
    ....
  30. pmc Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth
    Bettina Schmid
    German Center for Neurodegenerative Diseases, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 110:4986-91. 2013
    ..Strikingly, Filamin C is similarly increased in the frontal cortex of FTLD-TDP patients, suggesting aberrant expression in smooth muscle cells and TDP-43 loss-of-function as one underlying disease mechanism...
  31. pmc iRHOM2 takes control of rheumatoid arthritis
    Stefan F Lichtenthaler
    German Center for Neurodegenerative Diseases DZNE, Munich, Germany
    J Clin Invest 123:560-2. 2013
    ..In this issue of the JCI, Issuree et al. report that iRHOM2 is a TACE activator in immune cells. Loss of iRHOM2 largely protects mice from inflammatory arthritis, making iRHOM2 a potential drug target for this condition...
  32. ncbi request reprint Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
    Steffen Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Prog Neurobiol 79:95-111. 2006
    ....
  33. ncbi request reprint GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing
    Christine A F von Arnim
    Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:9913-22. 2006
    ..GGA1 may act as a specific spatial switch influencing APP trafficking and processing, so that APP-GGA1 interactions may have pathophysiological relevance in AD...
  34. ncbi request reprint No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 12:110-20. 2003
    ..These data implicate that expression of beta-CTF per se is not neurotoxic, and that other mechanisms are responsible for the neurotoxic events in Alzheimer's disease brain...
  35. ncbi request reprint gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta
    Heike S Grimm
    Center for Molecular Biology Heidelberg ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    J Biol Chem 278:13077-85. 2003
    ....
  36. doi request reprint The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding
    Andreas Heiseke
    Institute of Virology, Technical University of Munich, Trogerstr 30, 81675 Munich, Germany
    Traffic 9:1116-29. 2008
    ..Using deletion mutants, we demonstrate that production of PrP fragment N1 is not influenced by SNX33. Our data provide new insights into the cellular mechanisms of PrP(c) shedding and show how this can affect cellular PrP(Sc) conversion...
  37. ncbi request reprint The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted
    Beate Grziwa
    Center for Molecular Biology Heidelberg, University of Heidelberg, INF 282, D 69120 Heidelberg, Germany
    J Biol Chem 278:6803-8. 2003
    ..Moreover, the center of the TMD is positioned at the gamma-cleavage site at residue 42. Our data are consistent with a model in which gamma-secretase is a membrane protein that cleaves at the center of the membrane...
  38. pmc The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain
    Stefan F Lichtenthaler
    Massachusetts General Hospital Harvard Medical School, Wellman Building, 50 Blossom Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 99:1365-70. 2002
    ..One cleavage site was located around the middle of the TMD, regardless of its actual length. An additional cleavage occurred within the N-terminal half of their TMD and thus at the opposite side of the Notch cleavage site...
  39. ncbi request reprint SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production
    Elena Friedmann
    Institute of Biochemistry, Swiss Federal Institute of Technology ETH, ETH Hoenggerberg, 8092 Zurich, Switzerland
    Nat Cell Biol 8:843-8. 2006
    ..Our study reveals a critical function for SPPL2a and SPPL2b in the regulation of innate and adaptive immunity...
  40. ncbi request reprint Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8
    Silvia Naus
    Entwicklungsbiologie und Molekulare Pathologie, W7, Universitat Bielefeld, D 33615 Bielefeld, Germany
    Biol Chem 387:337-46. 2006
    ..Taken together, the results allowed us to identify novel candidate substrates that could be cleaved by ADAM8 in vivo under pathologic conditions...