Volkmar Lessmann

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi Neurotrophin secretion: current facts and future prospects
    Volkmar Lessmann
    Department of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz 55128, Germany
    Prog Neurobiol 69:341-74. 2003
  2. ncbi Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128 Mainz, Germany
    Life Sci 82:1281-7. 2008
  3. ncbi Cellular mechanisms of subplate-driven and cholinergic input-dependent network activity in the neonatal rat somatosensory cortex
    Ileana L Hanganu
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, 55128 Mainz, Germany
    Cereb Cortex 19:89-105. 2009
  4. ncbi Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Neurochem 102:501-7. 2007
  5. ncbi Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128 Mainz, Germany
    Neuropharmacology 51:907-13. 2006
  6. ncbi Mechanisms of C-reactive protein-induced blood-brain barrier disruption
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Stroke 40:1458-66. 2009
  7. ncbi The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors
    Anne M Martin
    Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration and Institute of Physiology, Johannes Gutenberg University Mainz, D 55099 Mainz, Germany
    J Biol Chem 283:12004-13. 2008
  8. ncbi Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor
    Matthias Hartmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany
    J Cell Sci 117:5803-14. 2004
  9. ncbi Activity-dependent regulation of neuronal apoptosis in neonatal mouse cerebral cortex
    Nicolas Heck
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D 55128 Mainz, Germany
    Cereb Cortex 18:1335-49. 2008
  10. ncbi Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
    Laurent R Gauthier
    Unité Mixte de Recherche 146, Centre National de la Recherche Scientifique, Institut Curie, Building 110, Centre Universitaire, 91405 Orsay Cedex, France
    Cell 118:127-38. 2004

Collaborators

Detail Information

Publications17

  1. ncbi Neurotrophin secretion: current facts and future prospects
    Volkmar Lessmann
    Department of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz 55128, Germany
    Prog Neurobiol 69:341-74. 2003
    ....
  2. ncbi Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128 Mainz, Germany
    Life Sci 82:1281-7. 2008
    ..This oxidative stress then activates the MLC kinase. Fluvastatin preserves barrier function in a NO-dependent way and reduces glutamate-induced oxidative stress...
  3. ncbi Cellular mechanisms of subplate-driven and cholinergic input-dependent network activity in the neonatal rat somatosensory cortex
    Ileana L Hanganu
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, 55128 Mainz, Germany
    Cereb Cortex 19:89-105. 2009
    ....
  4. ncbi Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Neurochem 102:501-7. 2007
    ..Furthermore, ML-7 and apocynin blocked hypoxia-dependent phosphorylation of MLC. Our data demonstrate that hypoxia causes a breakdown of the BBB in vitro and in vivo involving ROS and the contractile machinery...
  5. ncbi Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128 Mainz, Germany
    Neuropharmacology 51:907-13. 2006
    ..In conclusion, our data demonstrate a BBB stabilizing effect of fluvastatin that correlates with the NO-dependent dephosphorylation of endothelial MLC via the MLC phosphatase...
  6. ncbi Mechanisms of C-reactive protein-induced blood-brain barrier disruption
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Stroke 40:1458-66. 2009
    ..The aim of this study was to examine whether CRP directly affects blood-brain barrier stability and to analyze the underlying signaling pathways...
  7. ncbi The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors
    Anne M Martin
    Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration and Institute of Physiology, Johannes Gutenberg University Mainz, D 55099 Mainz, Germany
    J Biol Chem 283:12004-13. 2008
    ..These results provide new insights into the mechanism of a tPA-induced, LRP1-mediated gating mechanism for NMDA receptors...
  8. ncbi Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor
    Matthias Hartmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany
    J Cell Sci 117:5803-14. 2004
    ..We thus propose a novel signalling pathway initiated by neurotrophin-independent extracellular or intramembrane interaction of TrkB.T1 with the p75NTR receptor, which modulates dendritic growth via p75NTR signalling cascades...
  9. ncbi Activity-dependent regulation of neuronal apoptosis in neonatal mouse cerebral cortex
    Nicolas Heck
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D 55128 Mainz, Germany
    Cereb Cortex 18:1335-49. 2008
    ..Our results demonstrate that synchronized spontaneous network bursts activating ionotropic glutamate receptors promote neuronal survival in the neonatal mouse cerebral cortex...
  10. ncbi Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
    Laurent R Gauthier
    Unité Mixte de Recherche 146, Centre National de la Recherche Scientifique, Institut Curie, Building 110, Centre Universitaire, 91405 Orsay Cedex, France
    Cell 118:127-38. 2004
    ..Our findings indicate that a key role of huntingtin is to promote BDNF transport and suggest that loss of this function might contribute to pathogenesis...
  11. ncbi Backpropagating action potentials trigger dendritic release of BDNF during spontaneous network activity
    Nicola Kuczewski
    Institut de Neurobiologie de la Mediterranee, Inserm Unité 901 and Université de La Méditerranée, 13273 Marseille Cedex 09, France
    J Neurosci 28:7013-23. 2008
    ..Therefore, together, our results support the hypothesis that BDNF might act as a target-derived messenger of activity-dependent synaptic plasticity and development...
  12. ncbi Impaired GABAergic inhibition in the visual cortex of brain-derived neurotrophic factor heterozygous knockout mice
    Ismail Abidin
    Department of Neurophysiology, MA 4 149, Ruhr University Bochum, D 44780 Bochum, Germany
    J Physiol 586:1885-901. 2008
    ....
  13. ncbi Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening
    Richard Kolarow
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, 55128 Mainz, Germany
    J Neurosci 27:10350-64. 2007
    ....
  14. ncbi Differential vesicular targeting and time course of synaptic secretion of the mammalian neurotrophins
    Tanja Brigadski
    Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, 55128 Mainz, Germany
    J Neurosci 25:7601-14. 2005
    ....
  15. ncbi Reduced presynaptic efficiency of excitatory synaptic transmission impairs LTP in the visual cortex of BDNF-heterozygous mice
    Ismail Abidin
    Department of Neurophysiology, MA 4 149, Faculty of Medicine, Ruhr University Bochum, D 44780 Bochum, Germany
    Eur J Neurosci 24:3519-31. 2006
    ....
  16. ncbi Presynaptic plasticity in an immature neocortical network requires NMDA receptor activation and BDNF release
    Corinna Walz
    Institut für Neuro und Sinnesphysiologie, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    J Neurophysiol 96:3512-6. 2006
    ..These results indicate that BDNF might play an important role as a plasticity-related messenger molecule in neocortical neurons...
  17. ncbi N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons
    Kay Jüngling
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Neurosci 26:6968-78. 2006
    ..This indicates a retrograde control of short-term plasticity by N-cadherin. In summary, our results revealed an unexpected involvement of a synaptic adhesion molecule in the regulation of short-term plasticity at glutamatergic synapses...