Karsten Lenk

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
  2. pmc Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial
    Madlen Uhlemann
    Sports Medicine, University Wuppertal, Wuppertal, Germany
    Trials 13:167. 2012
  3. pmc Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model
    Karsten Lenk
    Heart Center Leipzig, Clinic of Cardiology, University Leipzig, Strumpellstrasse 39, 04289, Leipzig, Germany
    J Cachexia Sarcopenia Muscle 4:63-9. 2013
  4. ncbi Complete occlusion of the aortic isthmus
    Karsten Lenk
    Department of Cardiology, Heart Centre, University of Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur Heart J 29:30. 2008
  5. doi Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model
    Karsten Lenk
    Clinic of Cardiology, University Leipzig Heart Center Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur J Heart Fail 11:342-8. 2009
  6. ncbi Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
  7. doi Maximal exercise, limb ischemia, and endothelial progenitor cells
    Marcus Sandri
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 18:55-64. 2011
  8. doi Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure
    Karsten Lenk
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:404-11. 2012
  9. ncbi Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
  10. doi Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease
    Karsten Lenk
    University Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    J Appl Physiol (1985) 111:321-8. 2011

Collaborators

Detail Information

Publications14

  1. ncbi Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
    ..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs...
  2. pmc Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial
    Madlen Uhlemann
    Sports Medicine, University Wuppertal, Wuppertal, Germany
    Trials 13:167. 2012
    ..Until now, data demonstrating the positive effect of ET on the collateral blood flow and the functional capacity of the coronary collateral circulation are still lacking...
  3. pmc Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model
    Karsten Lenk
    Heart Center Leipzig, Clinic of Cardiology, University Leipzig, Strumpellstrasse 39, 04289, Leipzig, Germany
    J Cachexia Sarcopenia Muscle 4:63-9. 2013
    ..It has been further demonstrated that the expression of myostatin, a negative regulator of skeletal muscle mass, is increased in CHF. The aim of the study was to investigate the influence of ghrelin or its analogues on myostatin in CHF...
  4. ncbi Complete occlusion of the aortic isthmus
    Karsten Lenk
    Department of Cardiology, Heart Centre, University of Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur Heart J 29:30. 2008
  5. doi Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model
    Karsten Lenk
    Clinic of Cardiology, University Leipzig Heart Center Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur J Heart Fail 11:342-8. 2009
    ..This study aimed to investigate the expression of myostatin in CHF, the influence of exercise training on myostatin levels, and regulation of myostatin by tumour necrosis factor-alpha (TNF-alpha)...
  6. ncbi Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
    ..The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases...
  7. doi Maximal exercise, limb ischemia, and endothelial progenitor cells
    Marcus Sandri
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 18:55-64. 2011
    ..The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers...
  8. doi Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure
    Karsten Lenk
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:404-11. 2012
    ..In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome...
  9. ncbi Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
    ..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium...
  10. doi Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease
    Karsten Lenk
    University Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    J Appl Physiol (1985) 111:321-8. 2011
    ..This review will discuss the role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease...
  11. doi Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions
    Holger Thiele
    University of Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Int J Cardiol 135:287-95. 2009
    ..Cardiac magnetic resonance imaging (CMRI) is an excellent tool for serial assessment of underlying structural changes in perfusion, left ventricular function, and infarct size...
  12. ncbi Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells
    Nicolle Krankel
    Department of Internal Medicine Cardiology, Heart Center Leipzig, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 25:698-703. 2005
    ..Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function...
  13. ncbi Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia
    Karsten Lenk
    Department of Cardiology, University of Leipzig Heart Center, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur Heart J 26:1903-9. 2005
    ..It remains unclear, however, whether an intra-arterial application of autologous CPCs in patients with infrapopliteal PAOD and CLI is safe, feasible, and of potentially beneficial effects...
  14. ncbi Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction
    Sandra Erbs
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 23:1814-9. 2003
    ..Therefore, we aimed to determine the effects of these polymorphisms on endothelial function and endothelial response to physical exercise in patients with coronary artery disease (CAD)...