Daniel F Legler

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. ncbi request reprint Differential insertion of GPI-anchored GFPs into lipid rafts of live cells
    Daniel F Legler
    Department of Biology, Division of Immunology, University of Konstanz, Universitatsstrasse 10, Room P1105, Konstanz 78457, Germany
    FASEB J 19:73-5. 2005
  2. ncbi request reprint Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    Immunity 18:655-64. 2003
  3. ncbi request reprint The alpha v beta 3 integrin as a tumor homing ligand for lymphocytes
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Epalinges, Switzerland
    Eur J Immunol 34:1608-16. 2004
  4. doi request reprint Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells
    Petra Krause
    Biotechnology Institute Thurgau BITg, University of Konstanz, Kreuzlingen, Switzerland
    Blood 113:2451-60. 2009
  5. pmc Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition
    Jean Manuel Segura
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, CH 1066 Epalinges, Switzerland
    J Biol Chem 283:24254-63. 2008
  6. doi request reprint Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activation
    Markus Bruckner
    Biotechnology Institute Thurgau, University of Konstanz, Kreuzlingen, Switzerland
    Eur J Immunol 42:2949-58. 2012
  7. doi request reprint Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice
    Alexandre Johannsen
    Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland
    J Immunol 185:3445-55. 2010
  8. pmc A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins
    Eva Schlosser
    Division of Immunology, Department of Biology, Postbox M661, Universitatstrasse 10, University of Constance, Konstanz D 78457, Germany
    EMBO Rep 8:945-51. 2007
  9. doi request reprint Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration
    Karin Schaeuble
    Biotechnology Institute Thurgau, University of Konstanz, CH 8280 Kreuzlingen, Switzerland
    J Immunol 187:5645-52. 2011
  10. ncbi request reprint CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation
    Olivier Gaide
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 3:836-43. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Differential insertion of GPI-anchored GFPs into lipid rafts of live cells
    Daniel F Legler
    Department of Biology, Division of Immunology, University of Konstanz, Universitatsstrasse 10, Room P1105, Konstanz 78457, Germany
    FASEB J 19:73-5. 2005
    ..Thus, this study provides evidence that different GPI signal sequences lead to distinct membrane microdomain localization and that painted GFP-GPI(DAF) serves as an excellent fluorescent marker for lipid rafts in live cells...
  2. ncbi request reprint Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    Immunity 18:655-64. 2003
    ..We suggest that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways...
  3. ncbi request reprint The alpha v beta 3 integrin as a tumor homing ligand for lymphocytes
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Epalinges, Switzerland
    Eur J Immunol 34:1608-16. 2004
    ..These painted lymphocytes specifically bound to alpha v beta 3 in vitro and homed to vascularized, solid tumors in vivo. This novel strategy may provide a significant advance in anti-tumor treatment such as adoptive immune therapy...
  4. doi request reprint Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells
    Petra Krause
    Biotechnology Institute Thurgau BITg, University of Konstanz, Kreuzlingen, Switzerland
    Blood 113:2451-60. 2009
    ..This newly identified parameter will help to further optimize DC-based immunotherapy...
  5. pmc Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition
    Jean Manuel Segura
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, CH 1066 Epalinges, Switzerland
    J Biol Chem 283:24254-63. 2008
    ....
  6. doi request reprint Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activation
    Markus Bruckner
    Biotechnology Institute Thurgau, University of Konstanz, Kreuzlingen, Switzerland
    Eur J Immunol 42:2949-58. 2012
    ..In contrast, production of MMP9, CCL4, COX-2, and IL-23 is solely regulated by PGE(2) , but not by LXR activation, offering new perspectives for therapeutic interventions...
  7. doi request reprint Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice
    Alexandre Johannsen
    Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland
    J Immunol 185:3445-55. 2010
    ..These findings provide new opportunities for improving T cell cancer vaccines...
  8. pmc A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins
    Eva Schlosser
    Division of Immunology, Department of Biology, Postbox M661, Universitatstrasse 10, University of Constance, Konstanz D 78457, Germany
    EMBO Rep 8:945-51. 2007
    ....
  9. doi request reprint Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration
    Karin Schaeuble
    Biotechnology Institute Thurgau, University of Konstanz, CH 8280 Kreuzlingen, Switzerland
    J Immunol 187:5645-52. 2011
    ..Collectively, we characterize a cross-talk between the TCR and CCR7 and provide mechanistic evidence that the activation status of T cells controls lymphocyte motility and sets a threshold for their migratory response...
  10. ncbi request reprint CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation
    Olivier Gaide
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 3:836-43. 2002
    ..Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation...
  11. ncbi request reprint The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation
    Marie Agnès Doucey
    Institute for Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    J Biol Chem 278:26983-91. 2003
    ..The T cell receptor, by association with Pyk2, becomes part of this adhesion-induced activation cluster, which greatly increases its signaling...
  12. ncbi request reprint Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells
    Matthias F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Konstanz, Germany
    FASEB J 20:711-3. 2006
    ..Thus, the preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation...
  13. doi request reprint Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis
    Carolina Otero
    Department of Biology, Division of Immunology, University of Konstanz, Konstanz, Germany
    J Cell Sci 121:2759-67. 2008
    ..Finally, G-protein coupling was critical for [Ca2+](i) mobilization, Erk1/2 phosphorylation and chemotaxis, but not for CCR7 trafficking...
  14. ncbi request reprint PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction
    Claudia A O Stuermer
    Department of Biology University of Konstanz, 78457 Konstanz, Germany
    FASEB J 18:1731-3. 2004
    ....
  15. doi request reprint V domain of RAGE interacts with AGEs on prostate carcinoma cells
    Edith Uetz von Allmen
    Biotechnology Institute Thurgau, University of Konstanz, Kreuzlingen, Switzerland
    Prostate 68:748-58. 2008
    ..However, the mechanism of RAGE/sRAGE-induced cancer cell activation and ligand usage remain largely unknown...
  16. ncbi request reprint Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO
    Petra Krause
    Biotechnology Institute Thurgau BITg, University of Konstanz, Unterseestrasse 47, CH 8280, Kreuzlingen, Switzerland
    J Leukoc Biol 82:1106-14. 2007
    ..As PGE(2) is critical for DC migration and enhances the capability of MoDCs to induce T cell proliferation, we highly recommend supplementing DC maturation stimuli with PGE(2) for use in clinical trials...
  17. ncbi request reprint Soluble major histocompatibility complex-peptide octamers with impaired CD8 binding selectively induce Fas-dependent apoptosis
    Philippe Guillaume
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    J Biol Chem 278:4500-9. 2003
    ..Remarkably, however, this octamer efficiently activates CTLs for Fas (CD95)-dependent apoptosis...
  18. ncbi request reprint Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation
    Carolina Otero
    Biotechnology Institute Thurgau, University of Konstanz, Konstanzerstrasse 19, CH 8274 Tägerwilen, Switzerland
    J Immunol 177:2314-23. 2006
    ..In contrast, internalized CCL19 was sorted to lysosomes for degradation, showing opposite fate for endocytosed CCR7 and its ligand...
  19. ncbi request reprint Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts
    Ueli Nachbur
    Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstr 31, 3010 Bern, Switzerland
    Blood 107:2790-6. 2006
    ..We conclude that Fas ligand clustering in lipid rafts represents an important control mechanism in the regulation of T cell-mediated cytotoxicity...
  20. ncbi request reprint Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors
    Daniel F Legler
    Biotechnology Institute Thurgau, Tägerwilen, Switzerland
    J Immunol 176:966-73. 2006
    ..Our results provide clear evidence that PGE2 is a general and mandatory factor for the development of a migratory phenotype of human MoDCs as well as for peripheral blood myeloid DCs...