Research Topics

Genomes and Genes

Thomas Laux


Affiliation: University of Freiburg
Country: Germany


  1. Biedermann S, Laux T. Plant Development: Adding HAM to Stem Cell Control. Curr Biol. 2018;28:R1261-R1263 pubmed publisher
    ..The stem cell niche of the shoot meristem is stably maintained despite a rapidly changing cellular context. Recent papers reveal a mechanism controlling the spatial patterning of the stem cell niche that prevents its self-termination. ..
  2. Robert H, Park C, Gutièrrez C, Wójcikowska B, Pencík A, Novak O, et al. Maternal auxin supply contributes to early embryo patterning in Arabidopsis. Nat Plants. 2018;4:548-553 pubmed publisher
    ..We show that auxin response increases in ovules after fertilization, due to upregulated auxin biosynthesis in the integuments, and this maternally produced auxin is required for correct embryo development. ..
  3. Pi L, Aichinger E, van der Graaff E, Llavata Peris C, Weijers D, Hennig L, et al. Organizer-Derived WOX5 Signal Maintains Root Columella Stem Cells through Chromatin-Mediated Repression of CDF4 Expression. Dev Cell. 2015;33:576-88 pubmed publisher
    ..Our results show that chromatin-mediated repression of differentiation programs is a common strategy in plant and animal stem cell niches. ..
  4. Holt A, van Haperen J, Groot E, Laux T. Signaling in shoot and flower meristems of Arabidopsis thaliana. Curr Opin Plant Biol. 2014;17:96-102 pubmed publisher
    ..In recent years, progress has been made in the identification of signaling pathways and their integration into mechanistic networks. ..
  5. Dolzblasz A, Nardmann J, Clerici E, Causier B, van der Graaff E, Chen J, et al. Stem Cell Regulation by Arabidopsis WOX Genes. Mol Plant. 2016;9:1028-39 pubmed publisher
    ..Yet undiscovered functional domains in addition to the homeodomain and the WUS-box are necessary for this function. ..
  6. Groot E, Laux T. Ageing: How Do Long-Lived Plants Escape Mutational Meltdown?. Curr Biol. 2016;26:R530-R532 pubmed publisher
    ..A recent study shows that massive tree stature requires surprisingly few stem cell divisions, and that the mutational load is not proportional to stature, but to branching order. ..
  7. Tucker M, Roodbarkelari F, Truernit E, Adamski N, Hinze A, Lohmüller B, et al. Accession-specific modifiers act with ZWILLE/ARGONAUTE10 to maintain shoot meristem stem cells during embryogenesis in Arabidopsis. BMC Genomics. 2013;14:809 pubmed publisher
    ..Reduced SQN expression levels in Col-0 correlate with transposon insertions adjoining the transcriptional start site, which may contribute to stem cell maintenance in other ZLL-independent accessions. ..
  8. Roodbarkelari F, Du F, Truernit E, Laux T. ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response. BMC Biol. 2015;13:74 pubmed publisher
    ..Our results indicate that maintenance of shoot meristem stem cells by AGO10 involves negative regulation of auxin signaling and, via REV-mediated downregulation of ARF2 expression, auxin response. ..
  9. Zhang Z, Tucker E, Hermann M, Laux T. A Molecular Framework for the Embryonic Initiation of Shoot Meristem Stem Cells. Dev Cell. 2017;40:264-277.e4 pubmed publisher
    ..Our findings link transcriptional regulation of early embryo patterning to hormonal control of stem cell initiation and suggest that similar strategies have evolved in plant and animal stem cell formation. ..