Eicke Latz

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, et al. ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol. 2015;195:4446-55 pubmed publisher
    ..Our study therefore demonstrates an important role for ATF3 in modulating IFN responses in macrophages by controlling basal and inducible levels of IFNβ, as well as the expression of genes downstream of IFN signaling. ..
  2. Grebe A, Hoss F, Latz E. NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. Circ Res. 2018;122:1722-1740 pubmed publisher
  3. Zimmer S, Grebe A, Latz E. Danger signaling in atherosclerosis. Circ Res. 2015;116:323-40 pubmed publisher
    ..Excitingly, the concept that inflammation may be the core of cardiovascular disease is currently being clinically evaluated and will probably encourage further studies in this area. ..
  4. Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt S, Christ A, et al. The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. Immunity. 2018;48:911-922.e7 pubmed publisher
    ..These data are critical for an understanding of how UNC93B1 can regulate the function of a broad subset of TLRs. ..
  5. Mangan M, Latz E. TAK1ng control: TAK1 restrains NLRP3 activation. J Exp Med. 2018;215:1007-1008 pubmed publisher
    ..This has implications for therapeutically targeting TAK1, enhancing its potential function as an anticancer drug treatment. ..
  6. Bertheloot D, Naumovski A, Langhoff P, Horvath G, Jin T, Xiao T, et al. RAGE Enhances TLR Responses through Binding and Internalization of RNA. J Immunol. 2016;197:4118-4126 pubmed
    ..Gain- and loss-of-function studies demonstrate that RAGE increases the sensitivity of all ssRNA-sensing TLRs (TLR7, TLR8, TLR13), suggesting that RAGE is an integral part of the endosomal nucleic acid-sensing system. ..
  7. Hoss F, Budden C, Latz E. IRGB10 Exposes Bacteria's Intimate Secrets. Dev Cell. 2016;39:7-8 pubmed publisher
    ..In a recent issue of Cell, Man et al. (2016) show that the interferon-inducible protein IRGB10 liberates bacterial ligands for sensing by both the AIM2 and the non-canonical NLRP3 inflammasomes. ..
  8. Hoss F, Rodriguez Alcazar J, Latz E. Assembly and regulation of ASC specks. Cell Mol Life Sci. 2017;74:1211-1229 pubmed publisher
    ..Here, we review the role of ASC in inflammation, and focus on the structural mechanisms that lead to ASC speck formation, the regulation of ASC function during inflammasome assembly, and the importance of ASC specks in disease. ..
  9. Christ A, Günther P, Lauterbach M, Duewell P, Biswas D, Pelka K, et al. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell. 2018;172:162-175.e14 pubmed publisher
    ..Hence, NLRP3 mediates trained immunity following WD and could thereby mediate the potentially deleterious effects of trained immunity in inflammatory diseases. ..

More Information

Publications20

  1. von Kolontaj K, Horvath G, Latz E, Büscher M. Automated nanoscale flow cytometry for assessing protein-protein interactions. Cytometry A. 2016;89:835-43 pubmed publisher
    ..2016 International Society for Advancement of Cytometry. ..
  2. Labzin L, Lauterbach M, Latz E. Interferons and inflammasomes: Cooperation and counterregulation in disease. J Allergy Clin Immunol. 2016;138:37-46 pubmed publisher
  3. Horvath G, Langhoff P, Latz E. Toll-Like Receptor Interactions Measured by Microscopic and Flow Cytometric FRET. Methods Mol Biol. 2016;1390:41-64 pubmed publisher
    ..These techniques permit the dynamic visualization of early signaling events in living cells and can be utilized in pharmacological or genetic screens. ..
  4. Latz E, Xiao T, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013;13:397-411 pubmed publisher
    ..Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy. ..
  5. Labzin L, Heneka M, Latz E. Innate Immunity and Neurodegeneration. Annu Rev Med. 2017;: pubmed publisher
    ..Expected final online publication date for the Annual Review of Medicine Volume 69 is January 29, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
  6. Stutz A, Kolbe C, Stahl R, Horvath G, Franklin B, van Ray O, et al. NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 2017;214:1725-1736 pubmed publisher
    ..These results propose that the balance between kinases and phosphatases acting on the NLRP3 PYD is critical for NLRP3 activation. ..
  7. Próchnicki T, Latz E. Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control. Cell Metab. 2017;26:71-93 pubmed publisher
    ..Finally, we summarize the findings on metabolic control of pyrin and point to open questions to be addressed to broaden our understanding of metabolism-inflammasome interactions. ..
  8. Schmidt F, Latz E. CD14-New Tricks of an Old Acquaintance. Immunity. 2017;47:606-608 pubmed publisher
    ..Their findings reveal CD14 as a regulator of responses to infection and damage, relaying context-dependent signals that determine inflammatory cell fate decisions...
  9. Christ A, Bekkering S, Latz E, Riksen N. Long-term activation of the innate immune system in atherosclerosis. Semin Immunol. 2016;28:384-93 pubmed publisher
    ..According to this idea the epigenome of myeloid (progenitor) cells is presumably modified for prolonged periods of time, which, in turn, could evoke a condition of continuous immune cell over-activation. ..
  10. Zimmer S, Grebe A, Bakke S, Bode N, Halvorsen B, Ulas T, et al. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sci Transl Med. 2016;8:333ra50 pubmed publisher
    ..Because CD treatment in humans is safe and CD beneficially affects key mechanisms of atherogenesis, it may therefore be used clinically to prevent or treat human atherosclerosis. ..
  11. Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid Burgk J, Schmidt T, et al. Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. J Immunol. 2014;193:3257-61 pubmed publisher
    ..However, loss of AP function was not causal for altered TLR responses, suggesting AP-independent functions of YxxΦ in UNC93B1. ..