Silke Lassmann

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells
    Christiane D Fichter
    Institute of Pathology, University Medical Center, Freiburg, Germany
    BMC Cell Biol 12:13. 2011
  2. pmc Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes
    M Stumpf
    Department of Obstetrics and Gynecology, Albert Ludwigs University, Freiburg 79106, Germany
    Br J Cancer 101:1513-21. 2009
  3. doi request reprint A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University, Breisacherstr 115a, 79106, Freiburg, Germany
    J Mol Med (Berl) 87:211-24. 2009
  4. pmc STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation
    Silke Lassmann
    Institut für Parthologie, Universitatsklinikum Freiburg, Freiburg, Germany
    J Clin Pathol 60:173-9. 2007
  5. ncbi request reprint Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas
    Silke Lassmann
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr 115a, 79110, Freiburg, Germany
    J Mol Med (Berl) 85:293-304. 2007
  6. doi request reprint Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers
    Silke Lassmann
    Institute of Pathology, University Medical Center, Albert Ludwigs University, Breisacherstrasse 115a, Freiburg, Germany
    Mod Pathol 22:1385-97. 2009
  7. ncbi request reprint Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up
    Silke Lassmann
    Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104, Freiburg, Germany
    Int J Colorectal Dis 21:238-47. 2006
  8. ncbi request reprint Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
    Gastroenterology 133:1831-9. 2007
  9. ncbi request reprint Predictive pathology in routine diagnostics of solid tumors
    Silke Lassmann
    Institute of Pathology, University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Histol Histopathol 27:289-96. 2012
  10. ncbi request reprint Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
    Clin Cancer Res 13:4083-91. 2007

Collaborators

Detail Information

Publications31

  1. pmc Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells
    Christiane D Fichter
    Institute of Pathology, University Medical Center, Freiburg, Germany
    BMC Cell Biol 12:13. 2011
    ..Here, we investigated the occurrence of multipolar mitoses, Aurora-A/-B gene copy numbers and expression/activation as well as p53 alterations in aneuploid ESCC and BAC cancer cell lines...
  2. pmc Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes
    M Stumpf
    Department of Obstetrics and Gynecology, Albert Ludwigs University, Freiburg 79106, Germany
    Br J Cancer 101:1513-21. 2009
    ..The aim of this study was to investigate the prognostic effect of tumour-infiltrating lymphocytes (TILs) in serous stage III ovarian carcinoma to determine TIL clonality and to correlate this to Her2/neu expression...
  3. doi request reprint A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University, Breisacherstr 115a, 79106, Freiburg, Germany
    J Mol Med (Berl) 87:211-24. 2009
    ..In summary, our approach represents a major step towards integration of microarrays into retrospective studies and enables further investigation of the relevance of microarray analysis for clinico-pathological diagnostics...
  4. pmc STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation
    Silke Lassmann
    Institut für Parthologie, Universitatsklinikum Freiburg, Freiburg, Germany
    J Clin Pathol 60:173-9. 2007
    ....
  5. ncbi request reprint Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas
    Silke Lassmann
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr 115a, 79110, Freiburg, Germany
    J Mol Med (Berl) 85:293-304. 2007
    ....
  6. doi request reprint Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers
    Silke Lassmann
    Institute of Pathology, University Medical Center, Albert Ludwigs University, Breisacherstrasse 115a, Freiburg, Germany
    Mod Pathol 22:1385-97. 2009
    ..Thus, sporadic colorectal cancers exhibit different mechanisms of aurora A regulation and this may impact the efficacy of aurora-targeted therapies...
  7. ncbi request reprint Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up
    Silke Lassmann
    Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104, Freiburg, Germany
    Int J Colorectal Dis 21:238-47. 2006
    ....
  8. ncbi request reprint Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
    Gastroenterology 133:1831-9. 2007
    ....
  9. ncbi request reprint Predictive pathology in routine diagnostics of solid tumors
    Silke Lassmann
    Institute of Pathology, University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Histol Histopathol 27:289-96. 2012
    ..This review will focus on the recent developments of molecular pathological techniques and the current tools and applications of predictive pathology in view of targeted therapies in solid cancers...
  10. ncbi request reprint Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
    Clin Cancer Res 13:4083-91. 2007
    ....
  11. doi request reprint Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition
    Corinna Herz
    Institute of Pathology, University Medical Center, Freiburg, Germany
    Mol Carcinog 51:696-710. 2012
    ..This appears to be largely independent of Aurora A expression alone. Although Aurora A inhibition causes apoptosis in both CIN- and MIN-type CRC cells, remaining PLK-1 activation by other factors may affect therapeutic Aurora inhibition...
  12. ncbi request reprint Centrosome-, chromosomal-passenger- and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancer
    Ulrike Gerlach
    Pathologisches Institut, Universitatsklinikum, Freiburg, Germany
    J Pathol 208:462-72. 2006
    ....
  13. ncbi request reprint Quantification of CK20 gene and protein expression in colorectal cancer by RT-PCR and immunohistochemistry reveals inter- and intratumour heterogeneity
    Silke Lassmann
    Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104 Freiburg, Germany
    J Pathol 198:198-206. 2002
    ..This suggests a promising supportive role for quantitative RT-PCR in molecular pathology...
  14. ncbi request reprint Numerical and structural centrosome aberrations are an early and stable event in the adenoma-carcinoma sequence of colorectal carcinomas
    Gian Kayser
    Institute of Pathology, University Hospital Freiburg, Germany
    Virchows Arch 447:61-5. 2005
    ..Here, we specifically address centrosome aberrations in the adenoma-carcinoma sequence of colorectal cancer by detailed evaluation of gamma-tubulin staining patterns...
  15. pmc Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells
    Carolin Manthey
    Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany
    BMC Cell Biol 11:2. 2010
    ..ID1 protein is localized at the centrosomes and forced (over-)expression of ID1 results in errors during centrosome duplication...
  16. doi request reprint Internuclear chromosome distribution of dysplastic megakaryocytes in myelodysplastic syndromes is dependent on the level of ploidy
    Claudia Münch
    Institute of Pathology, University Medical Center Freiburg, Germany
    Chromosoma 120:265-73. 2011
    ..In addition, centrosomal aberrations were not found in dysplastic MKs. Our results indicate that megakaryocytic multinucleation in MDS originates from dysregulated endomitosis, including restoration of karyokinesis...
  17. doi request reprint Microarray comparative genomic hybridization analysis of tubular breast carcinoma shows recurrent loss of the CDH13 locus on 16q
    Marc Oliver Riener
    Institute of Pathology, University Hospital Freiburg, Freiburg i Br, Germany
    Hum Pathol 39:1621-9. 2008
    ..The study provides the starting point for further delineating their detailed influence on the pathogenesis of tubular breast carcinoma...
  18. ncbi request reprint Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer
    Sabine Jägle
    Institute of Molecular Medicine and Cell Research, Faculty of Biology, Institute of Pathology, University Medical Center, Department of Hematology and Oncology, University Medical Center, Freiburg Institute for Advanced Studies, and BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University Freiburg, D 79117 Freiburg, Germany
    Proc Natl Acad Sci U S A 111:4886-91. 2014
    ..In summary, our results uncover enhancer decommissioning as a mechanism for transcriptional silencing of the EPHB3 tumor suppressor and argue for an antitumorigenic function of Notch signaling in advanced colorectal cancer. ..
  19. doi request reprint ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes
    Annette M May
    Department of Pathology, University Medical Center, Breisacher Str 115a, 79106, Freiburg, Germany
    Histochem Cell Biol 141:431-40. 2014
    ..Importantly, the distinct ID2/3 expression patterns in AL indicate a specific deregulation of ID2/3 in the various types of AL and may support subtyping of AL. ..
  20. ncbi request reprint Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissues
    Sandra Rauser
    Institute of Pathology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Clin Cancer Res 13:5115-23. 2007
    ..We compared three HER2 laboratory methods, standard fluorescence in situ hybridization (FISH), image-based three-dimensional FISH in thick (16 microm) sections, and immunohistochemistry, to predict patient outcome...
  21. pmc Application of BIOMED-2 primers in fixed and decalcified bone marrow biopsies: analysis of immunoglobulin H receptor rearrangements in B-cell non-Hodgkin's lymphomas
    Silke Lassmann
    Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104 Freiburg
    J Mol Diagn 7:582-91. 2005
    ..In summary, this study provides an improved protocol for detection of clonality by IgH-specific BIOMED-2 primers in fixed, decalcified bone marrow biopsies...
  22. ncbi request reprint Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer
    Kerstin Rönsch
    Institute of Molecular Medicine and Cell Research, Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany
    Epigenetics 6:610-22. 2011
    ....
  23. doi request reprint The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia
    Konrad Aumann
    Institute of Pathology, University Medical Center, 79106 Freiburg, Germany
    Hum Pathol 42:719-26. 2011
    ....
  24. ncbi request reprint Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue
    Susanne Markert
    Department of Obstetrics and Gynecology, University Medical Center, Hugstetter Strasse 55, Freiburg, Germany
    Anticancer Res 28:3567-72. 2008
    ..Materials and Methods: Using immunohistochemistry (IHC), alpha-FR protein expression was analyzed in specimens of 104 human ovarian carcinomas and 30 non-neoplastic ovaries...
  25. doi request reprint EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer
    Christiane Daniela Fichter
    Department of Pathology, University Medical Center, Freiburg, Germany Faculty of Biology, University of Freiburg, Freiburg, Germany
    Int J Cancer . 2014
    ..g., with HER3. Such RTK dimerization patterns affect responses to EGFR and HER2 targeting inhibitors in ESCC and EAC cells in vitro and hence may influence future prediction for particularly HER2-targeting inhibitors in EACs...
  26. ncbi request reprint Epigenetics in esophageal cancers
    Theresa D Ahrens
    Department of Pathology, University Medical Center, Freiburg, Germany
    Cell Tissue Res 356:643-55. 2014
    ..This review provides a critical update on this increasing knowledge of epigenetic alteration in esophageal cancers by specifically focusing on the translational aspects of epigenetic analyses from human tissue specimens. ..
  27. ncbi request reprint Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma
    Rudolf Reiter
    Department of Otolaryngology Head and Neck Surgery, Universitatsklinikum Ulm, Ulm, Germany
    Clin Cancer Res 12:5136-41. 2006
    ..In this study, we investigated the role of AURKA in head and neck squamous cell carcinoma (HNSCC)...
  28. ncbi request reprint Telomere length and hTERT expression in patients with colorectal carcinoma
    Robert Rosenberg
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    Recent Results Cancer Res 162:177-81. 2003
    ..Telomere length and hTERT expression play an important role in ageing and carcinogenesis. Both parameters were identified as prognostic factors in patients with colorectal carcinoma...
  29. ncbi request reprint Prognostic potential of the telomerase subunit human telomerase reverse transcriptase in tumor tissue and nontumorous mucosa from patients with colorectal carcinoma
    Ralf Gertler
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Cancer 95:2103-11. 2002
    ..The objective of this study was to evaluate the use of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis for the quantification of hTERT in tumor and nontumorous tissue samples...
  30. ncbi request reprint Identification of gene signatures for invasive colorectal tumor cells
    Anja H Wiese
    Institut für allgemeine Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Cancer Detect Prev 31:282-95. 2007
    ..Gene signatures of sporadic colorectal carcinoma tissues and microdissected colorectal tumor cells were analyzed to identify stromal and tumor cell-specific markers, respectively...
  31. ncbi request reprint DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas
    Claudia Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, D 79106 Freiburg, Germany
    Int J Oncol 26:1187-92. 2005
    ..The observed intratumor genetic heterogeneity for TIIalpha in PMNBGs may have an impact on the relevance of TIIalpha as a biological constituent of outcome in these neoplasms...