Research Topics
Genomes and GenesSpecies | Silke LassmannSummaryAffiliation: University Hospital Country: Germany Publications
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Detail Information
Publications
Predictive pathology in routine diagnostics of solid tumorsSilke Lassmann
Institute of Pathology, University Medical Center, Albert Ludwigs University, Freiburg, Germany
Histol Histopathol 27:289-96. 2012..This review will focus on the recent developments of molecular pathological techniques and the current tools and applications of predictive pathology in view of targeted therapies in solid cancers...- Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomasSilke Lassmann
Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr 115a, 79110, Freiburg, Germany
J Mol Med (Berl) 85:293-304. 2007.... - Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapySilke Lassmann
Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
Clin Cancer Res 13:4083-91. 2007.... - Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-upSilke Lassmann
Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104, Freiburg, Germany
Int J Colorectal Dis 21:238-47. 2006.... - Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapySilke Lassmann
Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
Gastroenterology 133:1831-9. 2007.... 
A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimensSilke Lassmann
Institute of Pathology, University Hospital, Albert Ludwigs University, Breisacherstr 115a, 79106, Freiburg, Germany
J Mol Med (Berl) 87:211-24. 2009..In summary, our approach represents a major step towards integration of microarrays into retrospective studies and enables further investigation of the relevance of microarray analysis for clinico-pathological diagnostics...- Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancersSilke Lassmann
Institute of Pathology, University Medical Center, Albert Ludwigs University, Breisacherstrasse 115a, Freiburg, Germany
Mod Pathol 22:1385-97. 2009..Thus, sporadic colorectal cancers exhibit different mechanisms of aurora A regulation and this may impact the efficacy of aurora-targeted therapies... 
STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferationSilke Lassmann
Institut für Parthologie, Universitatsklinikum Freiburg, Freiburg, Germany
J Clin Pathol 60:173-9. 2007....- Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibitionCorinna Herz
Institute of Pathology, University Medical Center, Freiburg, Germany
Mol Carcinog 51:696-710. 2012..This appears to be largely independent of Aurora A expression alone. Although Aurora A inhibition causes apoptosis in both CIN- and MIN-type CRC cells, remaining PLK-1 activation by other factors may affect therapeutic Aurora inhibition... - Centrosome-, chromosomal-passenger- and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancerUlrike Gerlach
Pathologisches Institut, , Freiburg, Germany
J Pathol 208:462-72. 2006.... - Quantification of CK20 gene and protein expression in colorectal cancer by RT-PCR and immunohistochemistry reveals inter- and intratumour heterogeneitySilke Lassmann
Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104 Freiburg, Germany
J Pathol 198:198-206. 2002..This suggests a promising supportive role for quantitative RT-PCR in molecular pathology... - Numerical and structural centrosome aberrations are an early and stable event in the adenoma-carcinoma sequence of colorectal carcinomasGian Kayser
Institute of Pathology, University Hospital Freiburg, Germany
Virchows Arch 447:61-5. 2005.... - Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cellsChristiane D Fichter
Institute of Pathology, University Medical Center, Freiburg, Germany
BMC Cell Biol 12:13. 2011..Here, we investigated the occurrence of multipolar mitoses, Aurora-A/-B gene copy numbers and expression/activation as well as p53 alterations in aneuploid ESCC and BAC cancer cell lines... - Microarray comparative genomic hybridization analysis of tubular breast carcinoma shows recurrent loss of the CDH13 locus on 16qMarc Oliver Riener
Institute of Pathology, University Hospital Freiburg, Freiburg i Br, Germany
Hum Pathol 39:1621-9. 2008..The study provides the starting point for further delineating their detailed influence on the pathogenesis of tubular breast carcinoma... - Internuclear chromosome distribution of dysplastic megakaryocytes in myelodysplastic syndromes is dependent on the level of ploidyClaudia Münch
Institute of Pathology, University Medical Center Freiburg, Germany
Chromosoma 120:265-73. 2011..In addition, centrosomal aberrations were not found in dysplastic MKs. Our results indicate that megakaryocytic multinucleation in MDS originates from dysregulated endomitosis, including restoration of karyokinesis... - Application of BIOMED-2 primers in fixed and decalcified bone marrow biopsies: analysis of immunoglobulin H receptor rearrangements in B-cell non-Hodgkin's lymphomasSilke Lassmann
Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104 Freiburg
J Mol Diagn 7:582-91. 2005..In summary, this study provides an improved protocol for detection of clonality by IgH-specific BIOMED-2 primers in fixed, decalcified bone marrow biopsies... - Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancerKerstin Rönsch
Institute of Molecular Medicine and Cell Research, Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany
Epigenetics 6:610-22. 2011.... - The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemiaKonrad Aumann
Institute of Pathology, University Medical Center, 79106 Freiburg, Germany
Hum Pathol 42:719-26. 2011.... - Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissueSusanne Markert
Department of Obstetrics and Gynecology, University Medical Center, Hugstetter Strasse 55, Freiburg, Germany
Anticancer Res 28:3567-72. 2008..Materials and Methods: Using immunohistochemistry (IHC), alpha-FR protein expression was analyzed in specimens of 104 human ovarian carcinomas and 30 non-neoplastic ovaries... - Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cellsCarolin Manthey
Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany
BMC Cell Biol 11:2. 2010..ID1 protein is localized at the centrosomes and forced (over-)expression of ID1 results in errors during centrosome duplication... - Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissuesSandra Rauser
Institute of Pathology, GSF National Research Center for Environment and Health, Neuherberg, Germany
Clin Cancer Res 13:5115-23. 2007..We compared three HER2 laboratory methods, standard fluorescence in situ hybridization (FISH), image-based three-dimensional FISH in thick (16 microm) sections, and immunohistochemistry, to predict patient outcome... - Prognostic potential of the telomerase subunit human telomerase reverse transcriptase in tumor tissue and nontumorous mucosa from patients with colorectal carcinomaRalf Gertler
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
Cancer 95:2103-11. 2002..The objective of this study was to evaluate the use of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis for the quantification of hTERT in tumor and nontumorous tissue samples... - Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinomaRudolf Reiter
Department of Otolaryngology Head and Neck Surgery, Universitatsklinikum Ulm, Ulm, Germany
Clin Cancer Res 12:5136-41. 2006..In this study, we investigated the role of AURKA in head and neck squamous cell carcinoma (HNSCC)... - Telomere length and hTERT expression in patients with colorectal carcinomaRobert Rosenberg
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, , 81675 Munich, Germany
Recent Results Cancer Res 162:177-81. 2003..Telomere length and hTERT expression play an important role in ageing and carcinogenesis. Both parameters were identified as prognostic factors in patients with colorectal carcinoma... - Identification of gene signatures for invasive colorectal tumor cellsAnja H Wiese
Institut für allgemeine Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
Cancer Detect Prev 31:282-95. 2007..Gene signatures of sporadic colorectal carcinoma tissues and microdissected colorectal tumor cells were analyzed to identify stromal and tumor cell-specific markers, respectively... - DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomasClaudia Bredel
Department of General Neurosurgery, Neurocenter, University of Freiburg, D 79106 Freiburg, Germany
Int J Oncol 26:1187-92. 2005..The observed intratumor genetic heterogeneity for TIIalpha in PMNBGs may have an impact on the relevance of TIIalpha as a biological constituent of outcome in these neoplasms...