M F Langhorst
Affiliation: University of Konstanz
- Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cellsSvenja Kunerth
University Hospital Hamburg-Eppendorf, Center for Experimental Medicine, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, Martinistr. 52, 20246 Hamburg, Germany
J Cell Sci 117:2141-9. 2004..Taken together, our results show that, under physiological conditions in human T cells, RyRs play crucial roles in the local amplification and the spatiotemporal development of subcellular Ca(2+) pacemaker signals...
- Reggies/flotillins regulate cytoskeletal remodeling during neuronal differentiation via CAP/ponsin and Rho GTPasesMatthias F Langhorst
Department of Biology, University of Konstanz, Developmental Neurobiology Group, Universitatsstrasse 10, D 78457 Konstanz, Germany
Eur J Cell Biol 87:921-31. 2008..Thus, the reggies/flotillins are crucial for coordinated assembly of signaling complexes regulating cytoskeletal remodeling...
- Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2Matthias F Langhorst
Department of Biology, University of Konstanz, Universitatsstrasse 10, D 78457 Konstanz, Germany
Eur J Cell Biol 87:211-26. 2008..Thus, regulated vesicular cycling might be a general feature of SPFH protein-dependent trafficking...
- Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cellsMatthias F Langhorst
Developmental Neurobiology Group, Department of Biology, University of Konstanz, Konstanz, Germany
FASEB J 20:711-3. 2006..Thus, the preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation...
- Accumulation of FlAsH/Lumio Green in active mitochondria can be reversed by beta-mercaptoethanol for specific staining of tetracysteine-tagged proteinsMatthias F Langhorst
Developmental Neurobiology Group, Department of Biology, University of Konstanz, Universitaetsstr 10, 78457, Konstanz, Germany
Histochem Cell Biol 125:743-7. 2006..Furthermore, we show that staining efficiency was greatly enhanced by introducing a second tetracysteine sequence in tandem...
- Scaffolding microdomains and beyond: the function of reggie/flotillin proteinsM F Langhorst
Developmental Neurobiology Group, Department of Biology, University of Konstanz, Universitatstrasse 10, 78457, Konstanz, Germany
Cell Mol Life Sci 62:2228-40. 2005..Since, under certain circumstances, reggie-2/flotillin-1 translocates to the nucleus, reggie/ flotillin microdomains are not only stable scaffolds but also dynamic units with their own regulatory functions...
- Activation of T cell calcium influx by the second messenger ADP-riboseAndreas Gasser
University Medical Center Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction
J Biol Chem 281:2489-96. 2006..Moreover, gene silencing of TRPM2 abolished the ADPR- and ConA-mediated inward current. Thus, ADPR is a novel second messenger significantly involved in ConA-mediated cell death in T cells...
- PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transductionClaudia A O Stuermer
Department of Biology University of Konstanz, 78457 Konstanz, Germany
FASEB J 18:1731-3. 2004....
- Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actinMatthias F Langhorst
Department of Biology, University of Konstanz, Universitaetsstrasse 10, D 78457 Konstanz, Germany
FEBS Lett 581:4697-703. 2007....
- Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytesMatthias F Langhorst
Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, University Hospital Hamburg-Eppendorf, Center of Experimental Medicine, Martinistr. 52, D-20246, Germany
Cell Signal 16:1283-9. 2004..These data indicate that in T cells (i) ryanodine receptor are the major intracellular Ca2+ release channels involved in NAADP induced Ca2+ signals, and that (ii) such Ca2+ release events are largely amplified by Ca2+ entry...