M F Langhorst

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. ncbi Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells
    Svenja Kunerth
    University Hospital Hamburg-Eppendorf, Center for Experimental Medicine, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, Martinistr. 52, 20246 Hamburg, Germany
    J Cell Sci 117:2141-9. 2004
  2. ncbi Reggies/flotillins regulate cytoskeletal remodeling during neuronal differentiation via CAP/ponsin and Rho GTPases
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Developmental Neurobiology Group, Universitatsstrasse 10, D 78457 Konstanz, Germany
    Eur J Cell Biol 87:921-31. 2008
  3. ncbi Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Universitatsstrasse 10, D 78457 Konstanz, Germany
    Eur J Cell Biol 87:211-26. 2008
  4. ncbi Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells
    Matthias F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Konstanz, Germany
    FASEB J 20:711-3. 2006
  5. ncbi Accumulation of FlAsH/Lumio Green in active mitochondria can be reversed by beta-mercaptoethanol for specific staining of tetracysteine-tagged proteins
    Matthias F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Universitaetsstr 10, 78457, Konstanz, Germany
    Histochem Cell Biol 125:743-7. 2006
  6. ncbi Scaffolding microdomains and beyond: the function of reggie/flotillin proteins
    M F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Universitatstrasse 10, 78457, Konstanz, Germany
    Cell Mol Life Sci 62:2228-40. 2005
  7. ncbi Activation of T cell calcium influx by the second messenger ADP-ribose
    Andreas Gasser
    University Medical Center Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction
    J Biol Chem 281:2489-96. 2006
  8. ncbi PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction
    Claudia A O Stuermer
    Department of Biology University of Konstanz, 78457 Konstanz, Germany
    FASEB J 18:1731-3. 2004
  9. ncbi Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Universitaetsstrasse 10, D 78457 Konstanz, Germany
    FEBS Lett 581:4697-703. 2007
  10. ncbi Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytes
    Matthias F Langhorst
    Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, University Hospital Hamburg-Eppendorf, Center of Experimental Medicine, Martinistr. 52, D-20246, Germany
    Cell Signal 16:1283-9. 2004

Collaborators

  • Helmut Plattner
  • A Reuter
  • Daniel F Legler
  • A H Guse
  • C A Stuermer
  • Andreas Gasser
  • Svenja Kunerth
  • Günter Glassmeier
  • Ralf Fliegert
  • Inka Heiner
  • Karin Weber
  • Norman Oppenheimer
  • Dörte Hein
  • Jurgen R Schwarz
  • Sylvia Krüger
  • Stephan Meinke
  • Steven J Mills
  • Xianfeng Gu
  • Nadine Schwarzmann
  • Zhenjun Yang
  • Barry V L Potter
  • Li-He Zhang
  • Liangren Zhang
  • Lijun Huang

Detail Information

Publications10

  1. ncbi Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells
    Svenja Kunerth
    University Hospital Hamburg-Eppendorf, Center for Experimental Medicine, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, Martinistr. 52, 20246 Hamburg, Germany
    J Cell Sci 117:2141-9. 2004
    ..Taken together, our results show that, under physiological conditions in human T cells, RyRs play crucial roles in the local amplification and the spatiotemporal development of subcellular Ca(2+) pacemaker signals...
  2. ncbi Reggies/flotillins regulate cytoskeletal remodeling during neuronal differentiation via CAP/ponsin and Rho GTPases
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Developmental Neurobiology Group, Universitatsstrasse 10, D 78457 Konstanz, Germany
    Eur J Cell Biol 87:921-31. 2008
    ..Thus, the reggies/flotillins are crucial for coordinated assembly of signaling complexes regulating cytoskeletal remodeling...
  3. ncbi Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Universitatsstrasse 10, D 78457 Konstanz, Germany
    Eur J Cell Biol 87:211-26. 2008
    ..Thus, regulated vesicular cycling might be a general feature of SPFH protein-dependent trafficking...
  4. ncbi Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells
    Matthias F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Konstanz, Germany
    FASEB J 20:711-3. 2006
    ..Thus, the preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation...
  5. ncbi Accumulation of FlAsH/Lumio Green in active mitochondria can be reversed by beta-mercaptoethanol for specific staining of tetracysteine-tagged proteins
    Matthias F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Universitaetsstr 10, 78457, Konstanz, Germany
    Histochem Cell Biol 125:743-7. 2006
    ..Furthermore, we show that staining efficiency was greatly enhanced by introducing a second tetracysteine sequence in tandem...
  6. ncbi Scaffolding microdomains and beyond: the function of reggie/flotillin proteins
    M F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Universitatstrasse 10, 78457, Konstanz, Germany
    Cell Mol Life Sci 62:2228-40. 2005
    ..Since, under certain circumstances, reggie-2/flotillin-1 translocates to the nucleus, reggie/ flotillin microdomains are not only stable scaffolds but also dynamic units with their own regulatory functions...
  7. ncbi Activation of T cell calcium influx by the second messenger ADP-ribose
    Andreas Gasser
    University Medical Center Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction
    J Biol Chem 281:2489-96. 2006
    ..Moreover, gene silencing of TRPM2 abolished the ADPR- and ConA-mediated inward current. Thus, ADPR is a novel second messenger significantly involved in ConA-mediated cell death in T cells...
  8. ncbi PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction
    Claudia A O Stuermer
    Department of Biology University of Konstanz, 78457 Konstanz, Germany
    FASEB J 18:1731-3. 2004
    ....
  9. ncbi Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Universitaetsstrasse 10, D 78457 Konstanz, Germany
    FEBS Lett 581:4697-703. 2007
    ....
  10. ncbi Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytes
    Matthias F Langhorst
    Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, University Hospital Hamburg-Eppendorf, Center of Experimental Medicine, Martinistr. 52, D-20246, Germany
    Cell Signal 16:1283-9. 2004
    ..These data indicate that in T cells (i) ryanodine receptor are the major intracellular Ca2+ release channels involved in NAADP induced Ca2+ signals, and that (ii) such Ca2+ release events are largely amplified by Ca2+ entry...