Bettina Langhans

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint Intrahepatic IL-8 producing Foxp3⁺CD4⁺ regulatory T cells and fibrogenesis in chronic hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 59:229-35. 2013
  2. pmc Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42094. 2012
  3. doi request reprint Interferon-lambda serum levels in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 54:859-65. 2011
  4. doi request reprint Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Clin Sci (Lond) 119:97-109. 2010
  5. ncbi request reprint Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Vaccine 24:3066-75. 2006
  6. ncbi request reprint Comparative study of NK cell-mediated cytotoxicity using radioactive and flow cytometric cytotoxicity assays
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Germany
    J Immunol Methods 306:161-8. 2005
  7. ncbi request reprint Cytotoxic capacity of hepatitis C virus (HCV)--specific lymphocytes after in vitro immunization with HCV-derived lipopeptides
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Germany
    Cytometry A 65:59-68. 2005
  8. ncbi request reprint Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Hepatology 44:945-54. 2006
  9. doi request reprint Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2
    Martin Coenen
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:1375-82. 2011
  10. doi request reprint Regulation of NK cell trafficking by CD81
    Benjamin Kramer
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Immunol 39:3447-58. 2009

Collaborators

Detail Information

Publications15

  1. doi request reprint Intrahepatic IL-8 producing Foxp3⁺CD4⁺ regulatory T cells and fibrogenesis in chronic hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 59:229-35. 2013
    ..Regulatory CD4(+) T cells (Tregs) are considered to affect outcomes of HCV infection, because they increase in number during chronic hepatitis C and can suppress T-cell functions...
  2. pmc Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42094. 2012
    ..Our in vitro data suggest that--in addition to its immunostimulatory effects on TH1 cells--ribavirin can inhibit functions of HCV-specific Tregs and thus reverses Treg-mediated suppression of T effector cells in chronic hepatitis C...
  3. doi request reprint Interferon-lambda serum levels in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 54:859-65. 2011
    ..Thus far, studies have focused on types I and II interferon (IFN). We studied IFN-lambda1 (IL-29) and IFN-lambda2/3 (IL-28A/B) serum levels in patients with different outcomes of HCV infection...
  4. doi request reprint Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Clin Sci (Lond) 119:97-109. 2010
    ..Thus HCV core-specific Treg-cells may contribute to the immunoregulatory balance in chronic hepatitis C...
  5. ncbi request reprint Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Vaccine 24:3066-75. 2006
    ..In contrast, numbers of HLA-A2-pentamer-positive CD8+ T cells and granzyme B-secreting T cells remained unchanged. Thus, up-regulation of TLR2 during immunization with DC enhances functions of CD4+ T cells but not CD8+ T cells...
  6. ncbi request reprint Comparative study of NK cell-mediated cytotoxicity using radioactive and flow cytometric cytotoxicity assays
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Germany
    J Immunol Methods 306:161-8. 2005
    ..Thus, the particular choice of a cytotoxicity assay must be carefully adapted to the experimental situation under study...
  7. ncbi request reprint Cytotoxic capacity of hepatitis C virus (HCV)--specific lymphocytes after in vitro immunization with HCV-derived lipopeptides
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Germany
    Cytometry A 65:59-68. 2005
    ..We analyzed whether such T cells generated by in vitro immunization with HCV core-derived lipopeptides exert HCV-specific cytolytic activity...
  8. ncbi request reprint Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Hepatology 44:945-54. 2006
    ..In conclusion, migration of DC is markedly affected by interaction of HCV E2 with CD81. Failure of DC to recirculate to lymphoid tissue may be critically involved in impaired T cell priming during HCV infection...
  9. doi request reprint Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2
    Martin Coenen
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:1375-82. 2011
    ..Manipulating the TLR2 pathway may thus provide a new approach for antifibrotic therapies in HCV infection...
  10. doi request reprint Regulation of NK cell trafficking by CD81
    Benjamin Kramer
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Immunol 39:3447-58. 2009
    ..Thus, our data suggest that the tetraspanin CD81 is importantly involved in the regulation of NK cell recruitment...
  11. ncbi request reprint Hepatitis C virus-derived lipopeptides differentially induce epitope-specific immune responses in vitro
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 189:248-53. 2004
    ..IFN-gamma sfcs could only be induced with lipopeptide aa 20-44 but not by conventional antigens, which indicates that lipopeptides may alter T cell functions, depending on the epitope...
  12. ncbi request reprint The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells
    Daniela Schulte
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 200:1397-401. 2009
    ..038). Moreover, we found that the HLA-E(R) allelic variant confers protection against chronic infection with HCV genotypes 2 and 3. Taken together, our data indicate an important immunomodulating function of HLA-E in hepatitis C...
  13. ncbi request reprint Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC)
    Jacob Nattermann
    Department of General Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Hepatol 42:499-504. 2005
    ..Antibodies mediating ADCC are usually directed against viral envelope proteins. As cell surface expression of the HCV envelope E2 protein has been shown, the HCV E2 protein is an especially promising candidate target for ADCC...
  14. ncbi request reprint Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Vaccine 22:1441-7. 2004
    ..Thus, HCV lipopeptides are more immunogenic than unmodified peptides and can induce HCV-reactive B lymphocytes in antigen-naïve lymphocytes...
  15. pmc Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 8:e80848. 2013
    ..In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on the occurrence of alcohol induced liver cirrhosis and hepatocellular carcinoma (HCC)...