Falko Lange

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. pmc Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach
    Falko Lange
    Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany
    Mol Cancer 10:13. 2011
  2. pmc Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach
    Falko Lange
    Department of Systems Biology and Bioinformatics, University of Rostock, 18057 Rostock, Germany
    World J Gastroenterol 18:6226-34. 2012
  3. pmc Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells
    Katja Rateitschak
    Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany
    PLoS Comput Biol 8:e1002815. 2012
  4. doi Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity
    Katja Rateitschak
    Systems Biology and Bioinformatics Group, University of Rostock, 18051 Rostock, Germany
    Cell Signal 22:97-105. 2010
  5. doi Systems biology of JAK-STAT signalling in human malignancies
    Julio Vera
    Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany
    Prog Biophys Mol Biol 106:426-34. 2011

Detail Information

Publications5

  1. pmc Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach
    Falko Lange
    Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany
    Mol Cancer 10:13. 2011
    ..To elucidate the molecular action of IFNγ, we have established a mathematical model of STAT1 activation and combined experimental studies with computer simulations...
  2. pmc Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach
    Falko Lange
    Department of Systems Biology and Bioinformatics, University of Rostock, 18057 Rostock, Germany
    World J Gastroenterol 18:6226-34. 2012
    ..To gain insights into the molecular action of erlotinib in pancreatic cancer (PC) cells...
  3. pmc Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells
    Katja Rateitschak
    Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany
    PLoS Comput Biol 8:e1002815. 2012
    ..This provides the basis for a prediction of therapeutic targets that are valid for both cell types...
  4. doi Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity
    Katja Rateitschak
    Systems Biology and Bioinformatics Group, University of Rostock, 18051 Rostock, Germany
    Cell Signal 22:97-105. 2010
    ..We believe that further investigations into mathematical modelling of the STAT1 pathway will improve the understanding of the antifibrotic interferon action...
  5. doi Systems biology of JAK-STAT signalling in human malignancies
    Julio Vera
    Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany
    Prog Biophys Mol Biol 106:426-34. 2011
    ..We describe the modelling workflow that realises a systems biology approach and give an example for interferon-γ signalling in pancreatic stellate cells...