H Lang

..To describe a large single-center experience with hepatic resection for metastatic leiomyosarcoma...

..In these cases mesohepatectomy reduces the risk for postoperative liver insufficiency but still allows oncologic tumor resection...

..We evaluated the impact of computer-assisted risk analysis on operation planning for major hepatectomies, in particular on extent of resection or need for vascular reconstruction...

..Based on the patient history of a 62-year-old man with a centrally located hepatocellular carcinoma we describe the potential influence of three-dimensional computed tomography (3D CT) on operation planning in extended left hepatectomy...

..Mesohepatectomy should be considered in selected cases of central liver tumors in which extended resection would be associated with a high risk of liver insufficiency...

..The increasing experience with living donor transplantation and recent advances in neoadjuvant tumor therapy may lead to renewed discussion of liver transplantation in hilar cholangiocarcinoma...

..Hepatocellular carcinoma (HCC) arising in normal liver parenchyma is rare and the outcome after hepatectomy is not well documented...

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..Tumor resection is the treatment of choice, but so far the value of hepatic resection has not been well defined. We report results with an aggressive surgical approach for the treatment of this tumor entity...

..Left hepatic trisectionectomy is the most extended hepatic resection. To date, few data are available on longterm outcomes after this operation...

..Due to the problems of prematurity, any surgery during pregnancy should be carried out only in perinatal clinics outfitted with neonatologic intensive care units...

..To evaluate the role of extended hepatectomy in locally advanced intrahepatic cholangiocarcinoma (ICC)...

..In addition to the donor's risk, to the prognosis of the recipient and to economical aspects the desire of the donor to offer the chance of transplantation despite a probably poor prognosis has to be considered and respected...

..For small, functionally irresectable hepatocellular carcinoma in cirrhosis liver transplantation is the treatment of choice today...

..Up till now in more than 1000 living-related liver donations only three deaths occured due to thromboembolic and septic complications (< 0,3 %) (until 12/1998)...

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..The purpose of our study was to systematically describe this complex anatomy in clinically applicable fashion...

..CONCLUSION: Both dominance definitions provide independent mappings of the liver and offer helpful insight into venous dominance relationship...

..While 3-D CT volumetry based on the 'largest' (venous) CT phase is associated with considerable overestimation, 3-D volumetry based on the 'smallest' (native) CT phase accurately matches the intraoperative findings...

..The present study describes our institutional experience with patients who underwent transplantation for ICC as well as those with ICC who underwent transplantation with the incorrect diagnosis of hepatocellular carcinoma (HCC)...

..A virtual simulation of the liver transsection on 3D-model additionally increased the safety of the operation, consequently decreasing the risk for the donor...

..The aim of this study was to analyze vascular and biliary variants at the hilar and sectorial level in right graft adult living donor liver transplantation...

..This comprehensive data acquisition supports preoperative evaluation and provides a high degree of safety for donors and improved outcomes for recipients...

..The purpose of this study was to provide a systematic classification of its branching patterns to enhance clinical decision-making...

..The purpose of this study was to determine the impact of our classification on right graft adult live donor liver transplantation (ALDLT) outcomes...

..The purpose of this study was to investigate the effect of liver compliance on computed tomography (CT) volumetry and to determine its association with postoperative small-for-size syndrome (SFSS)...

..The purpose of this study was to review the long-term outcomes after OLT during a 2-year period of 45 rescue offers organs within Eurotransplant...

..This study was designed to delineate 'territorial belonging' of the middle hepatic vein (MHV) and to identify hepatic venous anatomy at high risk of outflow congestion...

..This work provides an overview of the current status of surgical therapy for the most frequent, benign liver tumours, as well as for hepatocellular and cholangiocellular carcinoma...

..The aim of our prospective study was to assess the results of major hepatic resections for primary liver tumours in patients 75 years of age or older...

..The purpose of this study was to evaluate our experience with orthotopic liver transplantation (OLT) using grafts from septuagenarians...

..The purpose of this study was to review our institutional experience with re-liver transplantation (OLT) after split and full-size OLT...

..Poor information is available about the real "gain" in patients' outcome when extending the listing criteria from Milan to UCSF...

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..Herein we have reported successful "preemptive" living donor liver transplantation for presumed recurrence of FL-HCC after an extended right hepatectomy with resection and synthetic graft replacement of the inferior vena cava...

..To study the disease course of patients with hepatocellular carcinoma (HCC) showing complete tumor necrosis in their liver explants after undergoing bridging treatments followed by liver transplantation (LTx)...

..This report provided encouraging information on the potential of yttrium-90 microspheres as a bridging option before OLT for multifocal HCC...

..To determine the prognostic relevance of cyclo-oxygenase-2 (COX-2) expression in hepatocellular carcinoma (HCC) and its relationship to important clinicopathological parameters...

..We report herein the case of a patient with a recurrent giant biloma following deceased donor split LT, which despite its volume was treated conservatively...

..Intrahepatic lymphatic invasion may not be an absolute adverse prognostic factor in cases of HCC with no hilar lymph node involvement at the time of OLT...

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..The purpose of this study was to evaluate the outcome of patients with HCC and ALD in the absence of viral hepatitic infections...

..CONCLUSIONS: We propose a new classification based on both anatomical and physiological hepatic venous configurations. Our model also provides a new nomenclature that can be universally applied to preoperative planning in LDLT...

..The development of navigation techniques to ensure the accurate application of the preoperative planned resection line is under investigation but not available yet...

..Intrahepatic cholangiocarcinoma (ICC) is a rare primary liver malignancy. Until now, outcomes and prognostic factors after liver resection for these tumors have not been well-documented...

..Furthermore, in view of the fact that the results are not yet optimal, additive and adjuvant treatment modalities are needed...

..Today, this should be questioned critically...

..The indication for an ex situ liver resection resulting in autotransplantation of the remnant liver exists only in rare cases for oncological reasons...

..The administration of corticoids has to be considered if a sufficient circulation can not be regained...

..The present study reports a German survey addressing outcomes in nonselected historical series of liver transplantation (OLT) for hilar cholangiocarcinoma (HL)...

..The purpose of this study was to systematically review tumor characteristics leading to recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT)...

..Laparoscopy has been suggested as an appropriate staging modality in a variety of upper gastrointestinal malignancies...

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..Intraoperative complications are also discussed...

..Operative planning and anesthesiological management are discussed...

..The aim of our present study was to examine the effects of terlipressin and Gelatinepolysuccinat on renal function and hemodynamics in a time period of six days...

..Finally, we discuss future upcoming therapeutic options based on targeting these signaling pathways...

..It is our hope that all these findings will translate into enhanced donor and recipient safety...

..We have recently shown that TT genotypes of the single-nucleotide polymorphism T393C in the gene GNAS1 predict the clinical outcome of patients with various carcinomas...

..Considering the scarcity of available organs, liver resection remains the best alternative option. TACE remains a potential therapy in patients within the Milan criteria, where it may be more beneficial than resection...

..The purpose of this study was to describe and validate our modus 3-D CT volumetry...

..These issues become much more relevant with increased adult-to-adult living donor liver transplantation, where the scheduled operation allows a precise preoperative management in an Intensive Care Unit (ICU)...

..Hepatocellular carcinoma occurring in noncirrhotic livers is rare. The purpose of this article was to evaluate the outcomes and prognostic factors after hepatectomy in this setting...

..The aim of the study was to determine the prognostic relevance of AKT and extracellular regulated kinases (ERK1/2), which are implied in the regulation of cell proliferation and apoptosis, in hepatocellular carcinoma (HCC)...

..The purpose of our study was to evaluate the outcome of major hepatic resections in the elderly population...

..Iatrogenic esophageal perforations are still a life-threatening clinical entity...

..The incidence of proximal gastric third carcinoma (PGC) has been rising in recent years. Classification and surgical therapy remain controversial...

..Our aim is to describe the feasibility of duct-to-duct anastomoses independent of the presence of one or multiple graft bile ducts...

..The aim of this study was to compare outcomes in patients with synchronous and metachronous colorectal liver metastases, with special emphasis on prognostic determinants...

..We hereby report the first case of successful treatment of hepatorenal syndrome with terlipressin and hydroxyethyl starch, which appears to be a safe and effective treatment...

..The reconstructed common outflow is anastomosed to a triangular opening of the IVC. Such enhanced outflow provides optimal venous drainage, especially during the early phase of growth of the graft...

..The purpose of this study was to correlate pathologic findings with outcomes after liver transplantation for hepatocellular carcinoma and to evaluate associations between various tumor characteristics and patient outcomes...

..The aim of this study was to evaluate survival and prognostic factors associated with a liberal exclusionary policy...

..The aim of this study was to compare the efficacy of IORT to surgery alone in patients with unresectable hilar cholangiocarcinoma...

..3%) of patients. However, multifocal tumors could not be successfully under-staged through this treatment and, furthermore, vital tumor was always observed in pathology; the usefulness of TACE in multifocal disease has to be re-estimated...

..In diffuse disease, the use of extended resections or liver transplantation can provide good longterm results...

..In conclusion, all efforts should be made in order to develop an effective screening protocol for the evaluation of donors with the aim of saving time and resources for a liver transplantation program...

..In conclusion, LDLT is a promising treatment option for patients with HCC. Even longer follow-up and bigger patients' series are needed to fully assess the benefits of LDLT for HCC patients exceeding the Milan criteria...

..The purpose of this study was to evaluate the outcome of patients with these tumors in our series and in literature reports, and to compare their prognosis to that of HCC diagnosed preoperatively...

..As prevention of cell dissemination is barely obtainable, alternative concepts have to be discussed...

..We herein present two cases of pancreatic metastases of renal cell carcinoma which occurred 17 and 19 years after the primary diagnosis...

..Given the ever-present diagnostic dilemma associated with enlarged hilar LN, especially in hepatitis C-positive patients, hilar LN sampling during LT for HCC could better define patients at risk...

..To prospectively evaluate the feasibility of postoperative contrast enhanced Multi-detector-CT cholangiography (ceMDCT-CA) in living liver donors and transplant recipients...

..The risk-benefit ratio in these instances should be evaluated on a case-by-case basis...

..The benefit of surgical therapy in this clinical entity is not well documented. The purpose of this study was to evaluate the outcome of such patients both in our own experience as well as in the published literature...

..CONCLUSIONS: Surgery for metastatic carcinoid tumors may be curative or palliative, with a potential for cure in some cases and prolongation of survival and amelioration of symptoms in the majority of patients...

..Small pulmonary nodules in high-risk HCC patients (low tumor grading, exceeding Milan criteria) may be characterized as nodules at risk, and evaluated very closely prior to listing and during the pre- and post-transplant periods...

..When considering a radical resection, intraoperative cholangioscopy is strongly recommended to confirm any localized papillomatosis and rule out any diffuse papillomatosis of the entire biliary tract...

..To present an institutional experience with the use of right liver grafts in adult patients and to assess the practicability and efficacy of this procedure by analyzing the results...

..The impact of venous outflow impairment and its consequences for liver regeneration and function are still a matter of debate...

..The purpose of this study was to evaluate the results after LT for HCC patients with very low alpha fetoprotein (AFP) values both in our series and in literature reports...

..This study aimed to prove the clinical validation of the recently developed bile leakage test, "white test" (WT), in major liver resection...

..If venous outflow cannot be interventionally restored and liver function deteriorates or cirrhosis develops during this time course, liver transplantation is the therapy of choice...

..Overall patient survival was 84.4%. LTx with such "rescue organs" constitutes an additional transplant option and a safe mechanism to "rescue" organs within Eurotransplant...

..In comparison, lack of metallothionein expression seems to be associated with cholangiocarcinoma with a papillary phenotype, which is generally recognized to have a better prognosis...

..However, it is frequently difficult to establish preoperatively whether the thrombus is associated with tumor invasion or with stagnant flow. The purpose of this study was to further address this controversial issue...

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