Michael Landgrebe

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. pmc Methodological aspects of clinical trials in tinnitus: a proposal for an international standard
    Michael Landgrebe
    Department of Psychiatry and Psychotherapy, University of Regensburg, Germany
    J Psychosom Res 73:112-21. 2012
  2. pmc Linking the Tinnitus Questionnaire and the subjective Clinical Global Impression: which differences are clinically important?
    Ilya Adamchic
    Institute of Neuroscience and Medicine Neuromodulation, Research Center Julich, Leo Brand Straße, 52425, Julich, Germany
    Health Qual Life Outcomes 10:79. 2012
  3. doi request reprint Multisite rTMS for the treatment of chronic tinnitus: stimulation of the cortical tinnitus network--a pilot study
    Astrid Lehner
    Department of Psychiatry and Psychotherapy, University Regensburg, Universitaetsstraße 84, 93053, Regensburg, Germany
    Brain Topogr 26:501-10. 2013
  4. doi request reprint Neural correlates of tinnitus duration and distress: a positron emission tomography study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Germany
    Hum Brain Mapp 34:233-40. 2013
  5. doi request reprint Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study
    Elmar Frank
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053, Regensburg, Germany
    J Neurol 259:327-33. 2012
  6. doi request reprint Auditory cortex is implicated in tinnitus distress: a voxel-based morphometry study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany
    Brain Struct Funct 218:1061-70. 2013
  7. doi request reprint Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Otolaryngol Head Neck Surg 140:92-5. 2009
  8. doi request reprint Can repetitive transcranial magnetic stimulation prolong the antidepressant effects of sleep deprivation?
    Peter M Kreuzer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Germany
    Brain Stimul 5:141-7. 2012
  9. doi request reprint Transcranial magnetic stimulation for the treatment of tinnitus: 4-year follow-up in treatment responders--a retrospective analysis
    Julia Burger
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Brain Stimul 4:222-7. 2011
  10. doi request reprint Is motor cortex excitability associated with personality factors? A replication study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Universitätsstraße 84, Regensburg, Germany
    Int J Psychophysiol 83:323-7. 2012

Detail Information

Publications48

  1. pmc Methodological aspects of clinical trials in tinnitus: a proposal for an international standard
    Michael Landgrebe
    Department of Psychiatry and Psychotherapy, University of Regensburg, Germany
    J Psychosom Res 73:112-21. 2012
    ..We hope that the proposed methodological standard will stimulate scientific discussion and will help to improve the quality of trials in tinnitus...
  2. pmc Linking the Tinnitus Questionnaire and the subjective Clinical Global Impression: which differences are clinically important?
    Ilya Adamchic
    Institute of Neuroscience and Medicine Neuromodulation, Research Center Julich, Leo Brand Straße, 52425, Julich, Germany
    Health Qual Life Outcomes 10:79. 2012
    ..In this study we aimed to estimate the minimum change of the TQ score that could be considered clinically relevant...
  3. doi request reprint Multisite rTMS for the treatment of chronic tinnitus: stimulation of the cortical tinnitus network--a pilot study
    Astrid Lehner
    Department of Psychiatry and Psychotherapy, University Regensburg, Universitaetsstraße 84, 93053, Regensburg, Germany
    Brain Topogr 26:501-10. 2013
    ..Future studies should explore this new protocol with respect to clinical and neurobiological effects in more detail...
  4. doi request reprint Neural correlates of tinnitus duration and distress: a positron emission tomography study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Germany
    Hum Brain Mapp 34:233-40. 2013
    ..Earlier results of asymmetric activation of the auditory cortices in tinnitus were confirmed, i.e., left-sided overactivation was found independently from tinnitus laterality...
  5. doi request reprint Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study
    Elmar Frank
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053, Regensburg, Germany
    J Neurol 259:327-33. 2012
    ..Our open-label pilot study suggests some beneficial effect of bifrontal tDCS (anode right and cathode left) in the treatment of severe tinnitus, warranting further controlled studies...
  6. doi request reprint Auditory cortex is implicated in tinnitus distress: a voxel-based morphometry study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany
    Brain Struct Funct 218:1061-70. 2013
    ..The distress observed was dependent on grey matter alterations in the auditory cortex, which could reflect reverberations between perceptual and distress networks...
  7. doi request reprint Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Otolaryngol Head Neck Surg 140:92-5. 2009
    ..Here we investigated whether administration of the dopamine precursor levodopa before low-frequency rTMS enhances its efficacy in tinnitus treatment...
  8. doi request reprint Can repetitive transcranial magnetic stimulation prolong the antidepressant effects of sleep deprivation?
    Peter M Kreuzer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Germany
    Brain Stimul 5:141-7. 2012
    ..In this study, we aimed to replicate these data coming from a small pilot study in a larger patient sample...
  9. doi request reprint Transcranial magnetic stimulation for the treatment of tinnitus: 4-year follow-up in treatment responders--a retrospective analysis
    Julia Burger
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Brain Stimul 4:222-7. 2011
    ..Even if most studies have shown beneficial effects, there is only limited knowledge about clinical predictors for treatment response and about the duration of treatment effects...
  10. doi request reprint Is motor cortex excitability associated with personality factors? A replication study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Universitätsstraße 84, Regensburg, Germany
    Int J Psychophysiol 83:323-7. 2012
    ..However, synopsis of literature indicates that association of personality and motor cortex excitability might be mediated rather by state than by trait factors...
  11. pmc Changes in motor cortex excitability associated with temporal repetitive transcranial magnetic stimulation in tinnitus: hints for cross-modal plasticity?
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany
    BMC Neurosci 15:71. 2014
    ..Variables of interest were resting motor threshold (RMT), short-interval intra-cortical inhibition (SICI), intracortical facilitation (ICF), and cortical silent period (CSP)...
  12. ncbi request reprint Antipsychotic treatment with quetiapine increases the cortical silent period
    Elmar Frank
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, D 93053 Regensburg, Germany
    Schizophr Res 156:128-32. 2014
    ..However all available data come from cross-sectional non-randomized studies. Thus it is not clear whether the observed difference is an effect of medication or reflects differences in disease severity or both...
  13. pmc State- and trait-related alterations of motor cortex excitability in tinnitus patients
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany
    PLoS ONE 9:e85015. 2014
    ..These findings are new and innovative as they enlarge the knowledge about basic physiologic and neuroplastic processes in tinnitus. ..
  14. pmc Mindfulness-and body-psychotherapy-based group treatment of chronic tinnitus: a randomized controlled pilot study
    Peter M Kreuzer
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse, Regensburg, Germany
    BMC Complement Altern Med 12:235. 2012
    ..Here we conducted a randomized, controlled clinical study to investigate the efficacy of a specific mindfulness- and body-psychotherapy based program in patients suffering from chronic tinnitus...
  15. doi request reprint Repetitive transcranial magnetic stimulation for tinnitus treatment: no enhancement by the dopamine and noradrenaline reuptake inhibitor bupropion
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Brain Stimul 4:65-70. 2011
    ..Recent preclinical data in healthy controls suggest that the effects of low-frequency rTMS can be enhanced by dopaminergic drugs...
  16. doi request reprint Cluster analysis for identifying sub-types of tinnitus: a positron emission tomography and voxel-based morphometry study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Germany
    Brain Res 1485:3-9. 2012
    ..However, it remains an open question to what extent the phenotypical and imaging levels may be interrelated. This article is part of a Special Issue entitled: Tinnitus Neuroscience...
  17. ncbi request reprint Allelic variation in the serotonin transporter promoter modulates cortical excitability
    Berthold Langguth
    Department of Psychiatry, University of Regensburg, Universitaetsstrasse 84, Regensburg D 93053, Germany
    Biol Psychiatry 66:283-6. 2009
    ..Transcranial magnetic stimulation (TMS) is a noninvasive procedure that may be used to study individual differences in motor cortex excitability. Such differences are assumed to reflect serotonergic and other inputs to the motor cortex...
  18. doi request reprint Repetitive transcranial magnetic stimulation for the treatment of chronic tinnitus after traumatic brain injury: a case study
    Peter Michael Kreuzer
    Department of Psychiatry and Psychotherapy, University of Regensburg, Germany
    J Head Trauma Rehabil 28:386-9. 2013
    ....
  19. ncbi request reprint Amygdalohippocampal neuroplastic changes following neuroleptic treatment with quetiapine in first-episode schizophrenia
    Timm B Poeppl
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Int J Neuropsychopharmacol 17:833-43. 2014
    ..These findings suggest that drug-induced neuroplastic changes in schizophrenia can occur quickly and are dependent on pharmacokinetics...
  20. doi request reprint Modulation of human motor cortex excitability by valproate
    Matthias Zunhammer
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, Germany
    Psychopharmacology (Berl) 215:277-80. 2011
    ..Valproate is widely used in the treatment of epilepsy, bipolar disorder, and chronic pain disorders, but its exact mechanisms of action is still incompletely understood...
  21. doi request reprint Transcranial magnetic stimulation for the treatment of depression: feasibility and results under naturalistic conditions: a retrospective analysis
    Elmar Frank
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, Regensburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:261-6. 2011
    ..0 ± 9.2 points. Fifty-three patients had an improvement of 50% or more. These results document that rTMS is feasible, safe and well tolerated under naturalistic conditions...
  22. pmc Association of tinnitus and electromagnetic hypersensitivity: hints for a shared pathophysiology?
    Michael Landgrebe
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Regensburg, Regensburg, Germany
    PLoS ONE 4:e5026. 2009
    ..The aim of the study was to elucidate the relationship between EMF-exposure, electromagnetic hypersensitivity and tinnitus using a case-control design...
  23. pmc Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus
    Astrid Lehner
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, Germany Interdisciplinary Tinnitus Center, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, Germany
    Neural Plast 2014:132058. 2014
    ..Baseline images correlated with change in tinnitus severity in the frontal cortex and the lingual gyrus, suggesting that GM at baseline might hold potential as a possible predictor for treatment outcome. ..
  24. doi request reprint Structural brain changes in tinnitus: grey matter decrease in auditory and non-auditory brain areas
    Michael Landgrebe
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany
    Neuroimage 46:213-8. 2009
    ..3.) Even groups with similar clinical characteristics might differ in the underlying neurobiological changes...
  25. doi request reprint Reduced intra-cortical inhibition after sleep deprivation: a transcranial magnetic stimulation study
    Peter Kreuzer
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany
    Neurosci Lett 493:63-6. 2011
    ..Whether this mechanism is also involved in mediating the antidepressant effect of sleep deprivation has to be addressed by further studies in depressive patients...
  26. doi request reprint Stable motor cortex excitability in red and green lighting conditions
    Berthold Langguth
    Department of Psychiatry, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany
    Neurosci Lett 460:32-5. 2009
    ..Our results suggest that motor cortex excitability as assessed by TMS is not sensitive to the modulatory effects of context-independent red and green light...
  27. pmc Trauma-associated tinnitus: audiological, demographic and clinical characteristics
    Peter M Kreuzer
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e45599. 2012
    ..Additionally, it remains a matter of debate whether the etiology of tinnitus constitutes a relevant criterion for defining tinnitus subtypes...
  28. pmc Relationship between Audiometric slope and tinnitus pitch in tinnitus patients: insights into the mechanisms of tinnitus generation
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e34878. 2012
    ..This study investigates the relationship between tinnitus pitch and audiometric slope in a large sample...
  29. pmc Predictors for rTMS response in chronic tinnitus
    Astrid Lehner
    Department of Psychiatry and Psychotherapy, University of Regensburg Regensburg, Germany
    Front Syst Neurosci 6:11. 2012
    ..Conclusions: The results from this large sample demonstrate that rTMS shows only small but clinically significant effects in the treatment of chronic tinnitus. There are no good demographic or clinical predictors for treatment outcome...
  30. ncbi request reprint Transcranial magnetic stimulation: a new diagnostic and therapeutic tool for tinnitus patients
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Int Tinnitus J 14:112-8. 2008
    ..g., hearing loss, tinnitus duration, age) and stimulation-related (e.g., stimulation site, stimulation protocols) factors seem to influence treatment outcome; however, their exact impact still remains to be clarified...
  31. pmc Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinnitus
    Michael Landgrebe
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Regensburg, Germany
    BMC Psychiatry 8:23. 2008
    ..However available studies have been mono-centric and are characterized by small sample sizes. Therefore, this multi-center trial will test the efficacy of rTMS treatment in a large sample of chronic tinnitus patients...
  32. doi request reprint Hypothermia associated with antipsychotic drug use: a clinical case series and review of current literature
    Peter Kreuzer
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Regensburg, Regensburg, Germany
    J Clin Pharmacol 52:1090-7. 2012
    ..These cases demonstrate the clinical relevance of hypothermia as an adverse reaction to antipsychotic treatment and the importance of careful monitoring of body temperature...
  33. pmc Temporomandibular joint disorder complaints in tinnitus: further hints for a putative tinnitus subtype
    Veronika Vielsmeier
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e38887. 2012
    ..Analyzing the Tinnitus Research Initiative Database we differentiated patients according to presence or absence of comorbid temporomandibular joint (TMJ) disorder complaints and compared the two groups with respect to etiologic factors...
  34. doi request reprint Controversy: Does repetitive transcranial magnetic stimulation/ transcranial direct current stimulation show efficacy in treating tinnitus patients?
    Berthold Langguth
    Department of Psychiatry, University of Regensburg, Germany
    Brain Stimul 1:192-205. 2008
    ..Therefore, targeted modulation of auditory cortex has been proposed as a new therapeutic approach for chronic tinnitus...
  35. doi request reprint rTMS over the cerebellum modulates temperature detection and pain thresholds through peripheral mechanisms
    Matthias Zunhammer
    Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Regensburg, Germany
    Brain Stimul 4:210-7.e1. 2011
    ..Even though evidence suggests an involvement of cerebellar structures in pain processing, the effect of rTMS over the cerebellum on pain perception has not yet been investigated...
  36. pmc Transcutaneous vagus nerve stimulation: retrospective assessment of cardiac safety in a pilot study
    Peter M Kreuzer
    Department of Psychiatry and Psychotherapy, University of Regensburg Regensburg, Germany
    Front Psychiatry 3:70. 2012
    ..In those subjects with no known pre-existing cardiac pathology, preliminary data do not indicate arrhythmic effects of tVNS...
  37. pmc The Tinnitus Research Initiative (TRI) database: a new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcome
    Michael Landgrebe
    Department of Psychiatry, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany
    BMC Med Inform Decis Mak 10:42. 2010
    ....
  38. doi request reprint Tinnitus and depression
    Berthold Langguth
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    World J Biol Psychiatry 12:489-500. 2011
    ..Depressive symptoms are common in individuals with tinnitus and may substantially aggravate their distress. The mechanisms, however, by which depression and tinnitus mutually interact are still not fully understood...
  39. pmc Neuroimaging and neuromodulation: complementary approaches for identifying the neuronal correlates of tinnitus
    Berthold Langguth
    Department of Psychiatry and Psychotherapy, University of Regensburg Regensburg, Germany
    Front Syst Neurosci 6:15. 2012
    ..Available data indicate the important value added by brain stimulation as a complementary approach to neuroimaging for identifying the neuronal correlates of the various clinical aspects of tinnitus...
  40. doi request reprint Tinnitus: the complexity of standardization
    Berthold Langguth
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Eval Health Prof 34:429-33. 2011
    ..They should also contain treatment recommendations that have shown clinically highly relevant effects in case series of specific tinnitus subgroups...
  41. pmc The revolving door phenomenon revisited: time to readmission in 17'415 patients with 37'697 hospitalisations at a German psychiatric hospital
    Ulrich Frick
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany Döpfer University of Applied Sciences, Department of Psychology, Cologne, Germany Research Institute on Public Health and Addiction, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e75612. 2013
    ....
  42. pmc Can Temporal Repetitive Transcranial Magnetic Stimulation be Enhanced by Targeting Affective Components of Tinnitus with Frontal rTMS? A Randomized Controlled Pilot Trial
    Peter Michael Kreuzer
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Front Syst Neurosci 5:88. 2011
    ..These results further support the involvement of the right DLPFC in the pathophysiology of tinnitus. The small effect size might be due to the study design comparing the protocol to an active control condition...
  43. ncbi request reprint Effects of colour exposure on auditory and somatosensory perception--hints for cross-modal plasticity
    Michael Landgrebe
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Regensburg, Germany
    Neuro Endocrinol Lett 29:518-21. 2008
    ..To get further insight into these complex synesthetic phenomena, the effect of colour stimulation on auditory and somatosensory perception was systematically investigated...
  44. pmc Paired associative stimulation of the auditory system: a proof-of-principle study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    PLoS ONE 6:e27088. 2011
    ..The objective was to investigate whether the auditory system can be modulated by PAS...
  45. doi request reprint Enhanced resting-state oscillations in schizophrenia are associated with decreased synchronization during inattentional blindness
    Simon Hanslmayr
    Department of Experimental Psychology, University of Regensburg, Regensburg, Germany
    Hum Brain Mapp 34:2266-75. 2013
    ..This finding has important implications for future studies examining abnormal brain oscillatory activity in schizophrenia, which usually treat resting-state activity as a baseline for task-related activity...
  46. ncbi request reprint Neuronal correlates of symptom formation in functional somatic syndromes: a fMRI study
    Michael Landgrebe
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Regensburg, Germany
    Neuroimage 41:1336-44. 2008
    ....
  47. pmc Phenotypic characteristics of hyperacusis in tinnitus
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    PLoS ONE 9:e86944. 2014
    ....
  48. doi request reprint Combined temporal and prefrontal transcranial magnetic stimulation for tinnitus treatment: a pilot study
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Otolaryngol Head Neck Surg 138:497-501. 2008
    ..Therefore, we have developed a new rTMS treatment strategy for tinnitus patients that consists of a combination of high-frequency prefrontal and low-frequency temporal rTMS...