Affiliation: University of Erlangen-Nuremberg
- Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neuronsAlexandra B Klinger
Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Universitätsstraße 17, 91054 Erlangen, Germany
Mol Pain 8:69. 2012..Here, we investigated if ATX-II induces resurgent currents in sensory neurons of the dorsal root ganglion (DRGs) and how this may translate into human sensations...
- Sodium channelopathies and painAngelika Lampert
Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitatsstrasse 17, 91054, Erlangen, Germany
Pflugers Arch 460:249-63. 2010..We also recapitulate the role of Nav1.8 for peripheral pain processing and of additional sodium channelopathies which have been linked to disorders with pain as a significant component...
- Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channelAndrias O O'Reilly
Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Bavaria, Germany
PLoS ONE 7:e41667. 2012..Therefore BPA block of the human heart sodium channel involves the local anesthetic receptor and both BPA and mexiletine may enter the closed-state pore via membrane-located side fenestrations...
- Sensory renal innervation: a kidney-specific firing activity due to a unique expression pattern of voltage-gated sodium channels?Wolfgang Freisinger
Dept of Medicine 4, Univ of Erlangen Nürnberg, Loschgestraβe 8, 91054 Erlangen, Germany
Am J Physiol Renal Physiol 304:F491-7. 2013..Our findings support that this is due to an increased expression and activation of TTX-resistant Navs...