Affiliation: University of Erlangen-Nuremberg
- Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channelAndrias O O'Reilly
Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Bavaria, Germany
PLoS ONE 7:e41667. 2012..Therefore BPA block of the human heart sodium channel involves the local anesthetic receptor and both BPA and mexiletine may enter the closed-state pore via membrane-located side fenestrations...
- Sodium channelopathies and painAngelika Lampert
Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitatsstrasse 17, 91054, Erlangen, Germany
Pflugers Arch 460:249-63. 2010..We also recapitulate the role of Nav1.8 for peripheral pain processing and of additional sodium channelopathies which have been linked to disorders with pain as a significant component...
- Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivationMirjam Eberhardt
From the Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Universitatsstrasse 17, 91054 Erlangen, Germany
J Biol Chem 289:1971-80. 2014..7 mutation, A1632T. Therefore, persistent and resurgent currents are likely to determine whether a mutation in Nav1.7 leads to IEM or PEPD. ..
- Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neuronsAlexandra B Klinger
Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Universitätsstraße 17, 91054 Erlangen, Germany
Mol Pain 8:69. 2012..Here, we investigated if ATX-II induces resurgent currents in sensory neurons of the dorsal root ganglion (DRGs) and how this may translate into human sensations...
- The distinct effects of lipid emulsions used for "lipid resuscitation" on gating and bupivacaine-induced inhibition of the cardiac sodium channel Nav1.5Felix Nadrowitz
From the Departments of Anesthesiology and Intensive Care Medicine and Neurology, Hannover Medical School, Hannover, Germany and Institute for Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Germany
Anesth Analg 117:1101-8. 2013..5. In this study, we sought to determine whether lipid emulsions functionally interact with Nav1.5 or counteract inhibition by bupivacaine...
- Sensory renal innervation: a kidney-specific firing activity due to a unique expression pattern of voltage-gated sodium channels?Wolfgang Freisinger
Dept of Medicine 4, Univ of Erlangen Nürnberg, Loschgestraβe 8, 91054 Erlangen, Germany
Am J Physiol Renal Physiol 304:F491-7. 2013..Our findings support that this is due to an increased expression and activation of TTX-resistant Navs...