Research Topics
| Kari LaineSummaryAffiliation: University of Mainz Country: Germany Publications
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Publications
Automated determination of ziprasidone by HPLC with column switching and spectrophotometric detectionJulia Sachse
Department of Psychiatry, University of Mainz, Untere Zahlbacherstrasse 8, D-55131 Mainz, Germany
Ther Drug Monit 27:158-62. 2005..Forty to 130 ng/mL may be considered the recommended target plasma concentration range. HPLC with column switching and UV detection as described here is suitable for therapeutic drug monitoring of ziprasidone...- [Therapeutic drug monitoring of new antidepressives and antipsychotics]Sebastian Hartter
Neurochemisches Labor, Psychiatrische Klinik, Untere Zahlbacher Strasse 8, 55131 Mainz
Med Monatsschr Pharm 26:160-2. 2003 - The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19Sebastian Hartter
Department of Psychiatry, University of Mainz, Germany
Pharm Res 19:1034-7. 2002.... 
Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activitySebastian Hartter
Department of Psychiatry and Institute of Occupational, Social and Environmental Medicine University of Mainz, Mainz, Germany
Br J Clin Pharmacol 56:679-82. 2003..The aim of this study was to assess the influence of concomitant caffeine intake on the pharmacokinetics of oral melatonin, a probe drug for CYP1A2 activity...- How does the benzamide antipsychotic amisulpride get into the brain?--An in vitro approach comparing amisulpride with clozapineSebastian Hartter
Department of Psychiatry, University of Mainz, Mainz, Germany
Neuropsychopharmacology 28:1916-22. 2003..The permeation of AMS across the BBB was restricted partly due to an efflux transport. It is thus suggested that AMS reaches its target structures via transport across the blood-CSF barrier... - Increased bioavailability of oral melatonin after fluvoxamine coadministrationS Hartter
Department of Psychiatry, University of Mainz, Germany
Clin Pharmacol Ther 67:1-6. 2000..It has not been clear whether these effects might be attributed to an increased melatonin production or to an decreased elimination of melatonin. The latter hypothesis was tested by this study... - Fluvoxamine but not sertraline inhibits the metabolism of olanzapine: evidence from a therapeutic drug monitoring serviceH Weigmann
Department of Psychiatry, University of Mainz, Mainz, Germany
Ther Drug Monit 23:410-3. 2001..Combination therapy of olanzapine and fluvoxamine should be used cautiously, and therapeutic drug monitoring should be instituted to avoid olanzapine-induced adverse effects or intoxications... - Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxineM Grozinger
Department of Psychiatry, University of Mainz, Mainz, Germany
Pharmacopsychiatry 36:3-6. 2003..In an open pilot study, effects of melperone on the steady-state blood levels of venlafaxine, a recently introduced serotonin- and noradrenaline reuptake inhibiting antidepressant, were assessed... - Addition of low-dose fluvoxamine to low-dose clozapine monotherapy in schizophrenia: drug monitoring and tolerability data from a prospective clinical trialA Szegedi
Department of Psychiatry, University of Mainz, Germany
Pharmacopsychiatry 32:148-53. 1999..Further studies have to find out if the combined treatment could be advantageous to clozapine monotherapy... - Relationship between mirtazapine dose, plasma concentration, response, and side effects in clinical practiceK Grasmäder
Department of Psychiatry, University of Bonn, Germany
Pharmacopsychiatry 38:113-7. 2005..The aim of this study was to evaluate the benefit of mirtazapine plasma concentration monitoring in a typical clinical setting... - Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral applicationW Seiler
Department of Psychiatry, University of Mainz, Germany
Psychopharmacology (Berl) 116:457-63. 1994..2% after tablet administration respectively. All parameters studied exhibited large intersubject variation. The plasma concentrations of the presumed metabolite "reduced benperidol" were found to be very low... - Gender aspects in the clinical treatment of schizophrenic inpatients with amisulpride: a therapeutic drug monitoring studyM J Muller
Department of Psychiatry, University of Mainz, Mainz, Germany
Pharmacopsychiatry 39:41-6. 2006..However, to date no empirical evidence exists in support of this notion... - Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levelsR Schlosser
Department of Psychiatry, University of Mainz, Germany
Neuropsychobiology 46:33-40. 2002..However, the findings indicate also that treatment with amisulpride at clinically effective doses can be achieved at significantly lower prolactin levels during the long-term maintenance phase than during the prior acute phase... - Serum levels of sulpiride enantiomers after oral treatment with racemic sulpiride in psychiatric patients: a pilot studyM J Muller
Department of Psychiatry, University of Mainz, Germany
Pharmacopsychiatry 34:27-32. 2001..66-0.97) in all patients. A slight negative correlation between CGI improvement and the ratio of L:D-SULP (p < 0.10) and a positive correlation between racemic SULP concentrations and side-effects at endpoint was found (p < 0.05)... - Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)U Schmitt
Department of Psychiatry, University of Mainz, Mainz, Germany
J Neural Transm 113:787-801. 2006..16 vs 2.98 micromol h l(-1) for brain tissue) while renal clearance was not affected. These results pointed to a pharmacokinetic drug interaction between CsA and amisulpride most likely caused by inhibition of P-gp... - [Standardized documentation procedure as a basis for improvement of process quality of treatment in psychiatric hospitals]K Mann
Psychiatrische Klinik der Universität Mainz
Nervenarzt 74:235-44. 2003..Moreover, in psychiatric care research, it is an adequate basis for evaluating the effectiveness and efficiency of treatment procedures... - Day- and night-time contents of monoamines and their metabolites in the medial preoptic area of the rat hypothalamusS Reuss
Department of Anatomy, Johannes Gutenberg University, Mainz, Germany
Neurosci Lett 266:29-32. 1999..Our results of sex-specific and day time-dependent variations in dopamine and norepinephrine concentrations indicate that the two monoamines are candidate neurotransmitters that may transmit diurnal information to the mPOA... - Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions?M J Muller
Department of Psychiatry, University of Mainz, Mainz, Germany
Pharmacopsychiatry 36:98-104. 2003..The results encourage further studies in order to optimize antidepressant pharmacotherapy when using TDM appropriately... - Pharmacokinetics of selective serotonin reuptake inhibitorsC Hiemke
Department of Psychiatry, University of Mainz, Germany
Pharmacol Ther 85:11-28. 2000.... - Effects of subchronic paroxetine administration on night-time endocrinological profiles in healthy male volunteersR Schlosser
Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131, Mainz, Germany
Psychoneuroendocrinology 25:377-88. 2000.... 
Duloxetine serum concentrations and clinical effects. Data from a therapeutic drug monitoring (TDM) surveyC Waldschmitt
Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
Pharmacopsychiatry 42:189-93. 2009..The aim of this study was to relate drug concentrations in serum and clinical effects in patients treated with the new antidepressant duloxetine...- [123I]IBZM SPECT in patients treated with typical and atypical neuroleptics: relationship to drug plasma levels and extrapyramidal side effectsR Schlosser
Department of Psychiatry, University of Mainz, Germany
Psychiatry Res 75:103-14. 1997..There was a negative continuous correlation between uptake of IBZM and extrapyramidal side effects, which is different from the threshold-based relationship between extrapyramidal side effects and IBZM uptake reported previously... - Amisulpride doses and plasma levels in different age groups of patients with schizophrenia or schizoaffective disorderMatthias J Muller
Department of Psychiatry, University of Mainz, Mainz, Germany
J Psychopharmacol 23:278-86. 2009.... - Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatographyH Weigmann
Department of Psychiatry, University of Mainz, Germany
J Chromatogr B Biomed Sci Appl 759:63-71. 2001..The limit of quantification was 10-20 ng/ml. Relative day to day standard variations ranged between 4.5 and 13.5%. The method is suitable for routine monitoring of olanzapine and clozapine including their demethylated metabolites... - Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatoninS Hartter
Department of Psychiatry, University of Mainz, Germany
J Clin Psychopharmacol 21:167-74. 2001..Because this inhibitory action is also found in vivo, fluvoxamine might be used as an enhancer of melatonin, which might offer new therapeutic possibilities of fluvoxamine... - Plasma levels of benperidol, prolactin, and homovanillic acid after intravenous versus two different kinds of oral application of the neuroleptic in schizophrenic patientsW Seiler
Department of Psychiatry, University of Mainz, Germany
Exp Clin Endocrinol 102:326-33. 1994.... - Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECTS Schlegel
Department of Psychiatry, University of Mainz, Germany
Psychopharmacology (Berl) 124:285-7. 1996..Prolactin levels were positively correlated with D2 receptor occupancy, reflecting at least in part a comparable dopamine receptor antagonism in different dopaminergic pathways... - Region specific distribution of levomepromazine in the human brainJ Kornhuber
Department of Psychiatry, University of Erlangen, Germany
J Neural Transm 113:387-97. 2006..The aim of this study was to examine concentrations of levomepromazine and its metabolite desmethyl-levomepromazine in different regions of human brain and in relationship to drug-free time... - CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxineM E E Shams
Department of Psychiatry, University of Mainz, Mainz, Germany
J Clin Pharm Ther 31:493-502. 2006..CONCLUSION: The O-demethylation phenotype of V depends strongly on the CYP2D6 genotype. A PM phenotype of CYP2D6 increases the risk of side effects... - Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association studyC Fehr
Department of Psychiatry, University of Mainz, Germany
Psychiatr Genet 10:59-65. 2000..0178). The potential mechanisms of the observed gender difference in allele frequencies, including transmission ratio distortion, are discussed... - The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsyC Fehr
Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55101, Mainz, Germany
Psychiatry Res 97:1-10. 2000.... - Anxiolytic-like effects of acute and chronic GABA transporter inhibition in ratsU Schmitt
Department of Psychiatry, University of Mainz, Mainz, Federal Republic of Germany
J Neural Transm 109:871-80. 2002..It is concluded that anxiolytic effects of acute GABA-uptake inhibition by tiagabine persist under chronic treatment and are sensitive to concomitant use of benzodiazepine receptor ligands... - Determination of benperidol and its reduced metabolite in human plasma by high-performance liquid chromatography and electrochemical detectionS Suss
Department of Psychiatry, University of Mainz, Germany
J Chromatogr 565:363-73. 1991..In plasma samples collected from a schizophrenic patient treated with a single oral dose of 6 mg of benperidol, plasma levels of benperidol and of the metabolite could be measured from 20 min to at least 12 h after administration... - Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-mazeU Schmitt
Department of Psychiatry, University of Mainz, Germany
Behav Pharmacol 10:131-7. 1999..SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might be a pharmacological strategy to treat not only epilepsy, but also anxiety disorders... - Appropriateness of therapeutic drug monitoring for antidepressants in routine psychiatric inpatient careKlaus Mann
Department of Psychiatry, University of Mainz, Mainz, Germany
Ther Drug Monit 28:83-8. 2006.... - Citalopram counteracts depressive-like symptoms evoked by chronic social stress in ratsRafal Rygula
Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
Behav Pharmacol 17:19-29. 2006..These observations provide evidence for the predictive validity of the chronic social stress paradigm as a model of depressive symptoms in rats... - Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in miceUlrich Schmitt
Department of Psychiatry, Johannes Gutenberg University, 55101 Mainz, Germany
Behav Brain Res 175:278-84. 2006..Nevertheless, it could be concluded that both, ADAM10 and ADAM10-dn mice are suitable control mice for the assessment of alpha-secretase-related effects in animal models of Alzheimer's disease... - Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detectionJulia Sachse
Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 830:342-8. 2006..The method was thus suitable for routine therapeutic drug monitoring and may be extended to other drugs... - Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophreniaMatthias J Muller
Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
J Psychiatr Res 41:673-9. 2007..Although our results were mainly explorative, TDM of amisulpride seems very useful for clinical decision making... - The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophreniaGerhard Grunder
Department of Psychiatry, University of Mainz, Mainz, Germany
Neuropsychopharmacology 31:1027-35. 2006..Extrastriatal binding of clozapine may be more relevant to its antipsychotic actions than striatal. However, further studies with an intraindividual comparison of untreated vs treated state are desirable to confirm this finding... - Nocturnal hormone profiles in patients with schizophrenia treated with olanzapineKlaus Mann
Department of Psychiatry, University of Mainz, Untere Zahibacher Strasse 8, Mainz D 55101, Germany
Psychoneuroendocrinology 31:256-64. 2006.... - Appropriateness of plasma level determinations for lithium and valproate in routine care of psychiatric inpatients with affective disordersKlaus Mann
J Clin Psychopharmacol 26:671-3. 2006 - Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET studyGerhard Grunder
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
Am J Psychiatry 165:988-95. 2008.... - Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises?Christoph Hiemke
Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
Eur Arch Psychiatry Clin Neurosci 258:21-7. 2008..Moreover, many drug interactions have been detected by using TDM. In conclusion, TDM is a reliable tool to optimise psychopharmacotherapy. When used adequately it is helpful for many psychiatric patients and in many situations... - Clinical utility of drug measurement and pharmacokinetics: therapeutic drug monitoring in psychiatryChristoph Hiemke
Department of Psychiatry, University of Mainz, Mainz, Germany
Eur J Clin Pharmacol 64:159-66. 2008..This would merely increase the amount of work and costs, as high-throughput methods are now available in many laboratories. Any progress in TDM has direct benefits for the treatment of many individual patients... - Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in miceKatrin M Kirschbaum
Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, Mainz, Germany
Behav Brain Res 188:298-303. 2008..P-gp-dependent brain distribution kinetics and behavioral effects of risperidone give evidence that the expression of P-gp has an impact on psychotropic drug actions when treating patients with drugs that are substrates of P-gp... - Effects of fluoxetine on behavioral deficits evoked by chronic social stress in ratsRafal Rygula
Clinical Neurobiology Laboratory, German Primate Center, , Germany
Behav Brain Res 174:188-92. 2006..The stress-induced effects on locomotor activity and rearing behavior were counteracted by fluoxetine treatment... - Clinical improvement in a case of frontotemporal dementia under aripiprazole treatment corresponds to partial recovery of disturbed frontal glucose metabolismAndreas Fellgiebel
Department of Psychiatry, University Hospital of Mainz, Mainz, Germany
World J Biol Psychiatry 8:123-6. 2007.... - [Individualized treatment with tricyclic antidepressives. The pharmacogenetics of depression]Christoph Hiemke
, , Untere Zahlbacher Str. 8, 55131 Mainz
Pharm Unserer Zeit 37:234-40. 2008 - Therapeutic drug monitoring-based clozapine dosing recommendationsGerald Zernig
Ther Drug Monit 29:130-1. 2007 - Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepamRafal Rygula
Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
Behav Pharmacol 19:183-96. 2008.... - Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detectionKatrin M Kirschbaum
Department of Psychiatry, University of Mainz, Mainz, Germany
Clin Chem 51:1718-21. 2005 - [Important to atypical antipsychotics: pharmacokinetics, interaction potential and therapeutic drug monitoring]Sebastian Hartter
I Gutenberg Universität Mainz, Psychiatrische Klinik und Poliklinik, Untere Zahlbacher Str 8, 55131 Mainz
Pharm Unserer Zeit 31:546-57. 2002 - Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallyprideGerhard Grunder
Department of Psychiatry, University of Mainz, Mainz, Germany
J Nucl Med 44:109-16. 2003..18)F-Desmethoxyfallypride ((18)F-DMFP) is a benzamide tracer with the advantage of an (18)F label. We optimized the synthesis and evaluated (18)F-DMFP in PET studies on healthy human volunteers... - Tiagabine, a gamma-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-mazeUlrich Schmitt
Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Germany
Behav Brain Res 133:391-4. 2002..Retrieval was impaired in rats treated only at the probe trial with tiagabine. These results further elucidate the role of GABA in learning and memory... - Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical settingKatja Grasmäder
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Eur J Clin Pharmacol 60:329-36. 2004..Side effects and treatment response were analysed in an exploratory approach in poor and ultra-rapid metabolisers... - Therapeutic monitoring of new antipsychotic drugsChristoph Hiemke
Department of Psychiatry, University of Mainz, D 55101 Mainz, Germany
Ther Drug Monit 26:156-60. 2004..The few reported investigations, however, need to be confirmed and extended... - Assessment of storage and transport stability of new antidepressant and antipsychotic drugs for a nationwide TDM serviceSandra Heller
Ther Drug Monit 26:459-61. 2004 - Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substratesAmal Abou El Ela
Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Mainz, Germany
J Pharm Pharmacol 56:967-75. 2004..The findings are explained on the basis of the limited contribution of P-gp-mediated transport to the elimination of fluphenazine and to a direct effect with respect to its distribution into the brain... - Elevated quetiapine serum concentrations in a patient treated concomitantly with doxepin, lorazepam, and pantoprazoleSebastian Hartter
J Clin Psychopharmacol 24:568-71. 2004 - New dopamine D2 receptor polymorphisms in rats and association with apomorphine-induced stereotypiesSabine Germeyer
Department of Psychiatry of the University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
Brain Res 926:1-9. 2002..These findings indicate that in Wistar rats at least part of an individual apomorphine stimulated behavioural phenotype might be due to an individual dopamine receptor D2 genotype... - High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophreniaIngo Vernaleken
Department of Psychiatry, University of Mainz, Mainz, Germany
Int J Neuropsychopharmacol 7:421-30. 2004..However, our data show high striatal D2-like receptor occupancies under rising plasma concentrations. Using the full range of recommended amisulpride dosage, striatal occupancies up to 90% can be measured... - Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholismNorbert Dahmen
Department of Psychiatry, University of Mainz, Germany
Psychiatr Genet 15:13-6. 2005..This effect was largely due to the association with early-onset alcoholism (77.8%), whereas no difference was noted between late-onset patients and controls. Our results suggest a role for tyrosine hydroxylase in early-onset alcoholism... - The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathologyIon Anghelescu
Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
Addict Behav 30:1135-43. 2005.... - Fluvoxamine augmentation of olanzapine in chronic schizophrenia: pharmacokinetic interactions and clinical effectsChristoph Hiemke
Department of Psychiatry, University of Mainz, Germany
J Clin Psychopharmacol 22:502-6. 2002.... - Hormonal influences on cardiovascular norepinephrine transporter responses in healthy womenIryna Moldovanova
Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
Hypertension 51:1203-9. 2008..The phenomenon may be explained by an effect of female sex hormones on norepinephrine transporter function, on compensatory cardiovascular responses, or both... - The chronic psychosocial stress paradigm in male tree shrews: evaluation of a novel animal model for depressive disordersMarja Van Kampen
Division of Neurobiology, German Primate Center, Kellnerweg 4, , Germany
Stress 5:37-46. 2002.... - Schizophrenic patients who smoke have a faster finger tapping rate than non-smokersHenry Silver
Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat, Israel
Eur Neuropsychopharmacol 12:141-4. 2002..Nicotine can improve central processing in medicated schizophrenia patients and this may constitute part of the incentive for smoking... - Free-choice ethanol consumption under the influence of GABAergic drugs in ratsUlrich Schmitt
Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse, Germany
Alcohol Clin Exp Res 26:457-62. 2002.... - The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressantsPierre Baumann
Department of Psychiatry, University of Lausanne, Prilly Lausanne, Switzerland
Dialogues Clin Neurosci 7:231-47. 2005..These consensus guidelines should be helpful for optimizing TDM of antidepressants... - Automated determination of amisulpride by liquid chromatography with column switching and spectrophotometric detectionJulia Sachse
Department of Psychiatry, University of Mainz, Untere Zahlbacher Str. 8, D-55131, Mainz, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 784:405-10. 2003..1%. The performance of daily calibration standards revealed an imprecision always below 15% and maximum inaccuracy of 7.7%. The method can be applied to therapeutic drug monitoring as well as pharmacokinetic studies of amisulpride... - Therapeutic drug monitoring of the antidepressant mirtazapine and its N-demethylated metabolite in human serumMohamed Shams
Department of Psychiatry, University of Mainz, Mainz, Germany
Ther Drug Monit 26:78-84. 2004..05) lower N-desmethylmirtazapine/mirtazapine ratios were found under concomitant medications of the antidepressant sertraline and the antipsychotic amisulpride... - Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the ratNashat Abumaria
Laboratory of Clinical Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
Eur Neuropsychopharmacol 17:417-29. 2007..These findings demonstrate that in the dorsal raphe nucleus of chronically stressed rats, citalopram normalizes TPH expression and blocks stress effects on distinct genes related to neurotransmitter release and neuroplasticity... - Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatmentBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Neuropsychopharmacology 32:1490-503. 2007..These pronounced changes in gliogenesis after chronic stress exposure may relate to the abnormalities of glial cell numbers reported in the frontolimbic areas of depressed patients... - A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse modelRolf Postina
Institute of Biochemistry, University of Mainz, Mainz, Germany
J Clin Invest 113:1456-64. 2004.... - Clinical relevance of TDM of SSRIsMarkus J Schwarz
Ther Drug Monit 28:716-7; author reply 717. 2006 - Population pharmacokinetic analysis of mirtazapineKatja Grasmäder
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53121 Bonn, Germany
Eur J Clin Pharmacol 60:473-80. 2004..While controlled clinical studies have evaluated the effect of individual covariates on the pharmacokinetics of mirtazapine, our analysis aims to identify covariates within a naturalistic clinical setting... - What the clinician still has to be reminded ofGerald Zernig
Ther Drug Monit 26:582. 2004 - Measurement of duloxetine in blood using high-performance liquid chromatography with spectrophotometric detection and column switchingChristine Waldschmitt
Department of Psychiatry, University of Mainz, Mainz, Germany
Ther Drug Monit 29:767-72. 2007..HPLC with column switching and ultraviolet detection as described here is suitable for pharmacokinetic studies and therapeutic drug monitoring of duloxetine...