Christian la Fougere

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi Where in-vivo imaging meets cytoarchitectonics: the relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET
    Christian la Fougere
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 56:951-60. 2011
  2. ncbi The value of the dopamine D2/3 receptor ligand 18F-desmethoxyfallypride for the differentiation of idiopathic and nonidiopathic parkinsonian syndromes
    Christian la Fougere
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    J Nucl Med 51:581-7. 2010
  3. doi Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    Neuroimage 49:1406-15. 2010
  4. doi PET and SPECT in epilepsy: a critical review
    C la Fougere
    Department of Nuclear Medicine, Ludwig Maximilian University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    Epilepsy Behav 15:50-5. 2009
  5. ncbi Restaging of patients with lymphoma. Comparison of low dose CT (20 mAs) with contrast enhanced diagnostic CT in combined [18F]-FDG PET/CT
    C la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University, Munich, Germany
    Nuklearmedizin 47:37-42. 2008
  6. ncbi Value of PET/CT versus PET and CT performed as separate investigations in patients with Hodgkin's disease and non-Hodgkin's lymphoma
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Munich, Germany
    Eur J Nucl Med Mol Imaging 33:1417-25. 2006
  7. ncbi Value of 99mTc-TRODAT-1 SPECT to predict clinical response to methylphenidate treatment in adults with attention deficit hyperactivity disorder
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    Nucl Med Commun 27:733-7. 2006
  8. doi Re-irradiation in recurrent malignant glioma: prognostic value of [18F]FET-PET
    Maximilian Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University Munich, Marchioninistr 15, 81377, Munich, Germany
    J Neurooncol 110:389-95. 2012
  9. doi Functional disturbance of the locomotor network in progressive supranuclear palsy
    Andreas Zwergal
    Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany
    Neurology 80:634-41. 2013
  10. ncbi Effects of acute detoxification of the herbal blend 'Spice Gold' on dopamine D2/3 receptor availability: a [18F]fallypride PET study
    Axel Rominger
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany Electronic address
    Eur Neuropsychopharmacol 23:1606-10. 2013

Detail Information

Publications46

  1. doi Where in-vivo imaging meets cytoarchitectonics: the relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET
    Christian la Fougere
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 56:951-60. 2011
    ....
  2. ncbi The value of the dopamine D2/3 receptor ligand 18F-desmethoxyfallypride for the differentiation of idiopathic and nonidiopathic parkinsonian syndromes
    Christian la Fougere
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    J Nucl Med 51:581-7. 2010
    ..On the basis of the superior sensitivity of PET, we hypothesized that (18)F-DMFP should have properties for the differential diagnosis of these syndromes superior to what has been reported for the more conventional SPECT procedures...
  3. doi Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    Neuroimage 49:1406-15. 2010
    ..TQD (15 mg/kg) evoked a 45% global increase in [(18)F]-FDG uptake, suggesting perturbation of brain energy metabolism due to P-gp blockade...
  4. doi PET and SPECT in epilepsy: a critical review
    C la Fougere
    Department of Nuclear Medicine, Ludwig Maximilian University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    Epilepsy Behav 15:50-5. 2009
    ..Currently some of these radioligands are also used to investigate new treatment approaches...
  5. ncbi Restaging of patients with lymphoma. Comparison of low dose CT (20 mAs) with contrast enhanced diagnostic CT in combined [18F]-FDG PET/CT
    C la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University, Munich, Germany
    Nuklearmedizin 47:37-42. 2008
    ..Assessment of the clinical benefit of i.v. contrast enhanced diagnostic CT (CE-CT) compared to low dose CT with 20 mAs (LD-CT) without contrast medium in combined [(18)F]-FDG PET/CT examinations in restaging of patients with lymphoma...
  6. ncbi Value of PET/CT versus PET and CT performed as separate investigations in patients with Hodgkin's disease and non-Hodgkin's lymphoma
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Munich, Germany
    Eur J Nucl Med Mol Imaging 33:1417-25. 2006
    ..The aim of this study was to assess the clinical benefit of combined [(18)F]FDG PET/CT in patients with malignant lymphoma as compared to separately performed PET and CT...
  7. ncbi Value of 99mTc-TRODAT-1 SPECT to predict clinical response to methylphenidate treatment in adults with attention deficit hyperactivity disorder
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    Nucl Med Commun 27:733-7. 2006
    ..In a previous study, binding of Tc-TRODAT-1 to the dopamine transporter (DAT) was found to be higher in patients with attention deficit hyperactivity disorder (ADHD) as compared to healthy controls...
  8. doi Re-irradiation in recurrent malignant glioma: prognostic value of [18F]FET-PET
    Maximilian Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University Munich, Marchioninistr 15, 81377, Munich, Germany
    J Neurooncol 110:389-95. 2012
    ..Thus, [(18)F]FET-PET kinetics may provide valuable additional prognostic information for treatment decisions...
  9. doi Functional disturbance of the locomotor network in progressive supranuclear palsy
    Andreas Zwergal
    Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany
    Neurology 80:634-41. 2013
    ....
  10. ncbi Effects of acute detoxification of the herbal blend 'Spice Gold' on dopamine D2/3 receptor availability: a [18F]fallypride PET study
    Axel Rominger
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany Electronic address
    Eur Neuropsychopharmacol 23:1606-10. 2013
    ....
  11. ncbi Dynamic 18F-FET PET in newly diagnosed astrocytic low-grade glioma identifies high-risk patients
    Nathalie L Jansen
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    J Nucl Med 55:198-203. 2014
    ....
  12. ncbi Hepatic yttrium-90 radioembolization of chemotherapy-refractory colorectal cancer liver metastases
    Tobias F Jakobs
    Department of Radiology, Ludwig Maximilians University of Munich, Munich, Germany
    J Vasc Interv Radiol 19:1187-95. 2008
    ..To present data for radioembolization with yttrium-90 ((90)Y) resin microspheres in patients with colorectal cancer liver metastases in whom currently available therapies had failed...
  13. doi [18F]Fallypride PET measurement of striatal and extrastriatal dopamine D 2/3 receptor availability in recently abstinent alcoholics
    Axel Rominger
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    Addict Biol 17:490-503. 2012
    ..Receptor availability was unaltered by acute withdrawal, but increased in the subgroup of patients with long-term follow-up, suggesting reversibility of receptor changes...
  14. ncbi D2 receptor occupancy during high- and low-dose therapy with the atypical antipsychotic amisulpride: a 123I-iodobenzamide SPECT study
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximillians University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany
    J Nucl Med 46:1028-33. 2005
    ..The aim of this study was to assess striatal dopamine D(2) receptor availability by means of (123)I-iodobenzamide (IBZM) SPECT in patients treated with high and low doses of this atypical antipsychotic drug...
  15. doi In vivo imaging of macrophage activity in the coronary arteries using 68Ga-DOTATATE PET/CT: correlation with coronary calcium burden and risk factors
    Axel Rominger
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    J Nucl Med 51:193-7. 2010
    ....
  16. pmc Prediction of oligodendroglial histology and LOH 1p/19q using dynamic [(18)F]FET-PET imaging in intracranial WHO grade II and III gliomas
    Nathalie L Jansen
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    Neuro Oncol 14:1473-80. 2012
    ..Histological examination is still required for an accurate diagnosis...
  17. ncbi Compensation for cranial spill-in into the cerebellum improves quantitation of striatal dopamine D₂/₃ receptors in rats with prolonged [¹⁸F]-DMFP infusions
    Erik Mille
    Department of Nuclear Medicine, University Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
    Synapse 66:705-13. 2012
    ..Based on this phenomenon, we developed an analytic method compensating for the effects of progressive cranial labeling on the estimation of specific binding in striatum...
  18. ncbi Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy
    Hero Bartmann
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Epilepsia 51:1780-90. 2010
    ..The preclinical study is intended for eventual translation to clinical research of patients with pharmacoresistant seizure disorders...
  19. ncbi Effects of a 6-month cognitive intervention program on brain metabolism in amnestic mild cognitive impairment and mild Alzheimer's disease
    Stefan Forster
    Department of Nuclear Medicine, Ludwig Maximilian University, Munich, Germany
    J Alzheimers Dis 25:695-706. 2011
    ..A six-month cognitive intervention imparted cognitive benefits in patients with aMCI, which were concurrent with an attenuated decline of glucose metabolism in cortical regions affected by neurodegenerative AD...
  20. ncbi Re-irradiation and bevacizumab in recurrent high-grade glioma: an effective treatment option
    Maya Flieger
    Department of Radiation Oncology, University of Munich, Marchioninistr 15, 81377, Munich, Germany
    J Neurooncol 117:337-45. 2014
    ..Re-irradiation with bevacizumab remains a feasible and highly effective treatment schedule. Studies on further salvage strategies and timing of sequential treatment options versus observation are warranted. ..
  21. ncbi Quantitative assessment of cardiac allograft vasculopathy by real-time myocardial contrast echocardiography: a comparison with conventional echocardiographic analyses and [Tc99m]-sestamibi SPECT
    Marcus Hacker
    Department of Cardiology, Medizinische Poliklinik, Innenstadt, University of Munich, Ziemssenstrasse 1, 80336 Munchen, Germany
    Eur J Echocardiogr 9:494-500. 2008
    ..To evaluate the additional benefit of visual and quantitative perfusion measurements compared with conventional real-time myocardial contrast echocardiography (MCE) in the detection of CAV...
  22. ncbi Surrogate markers for cerebral blood flow correlate with [¹⁸F]-fallypride binding potential at dopamine D(2/3) receptors in human striatum
    Paul Cumming
    Department of Nuclear Medicine, Ludwig Maximilian University, Munich, Germany
    Synapse 67:199-203. 2013
    ....
  23. ncbi [18F]fluoroethyltyrosine-positron emission tomography-based therapy monitoring after stereotactic iodine-125 brachytherapy in patients with recurrent high-grade glioma
    Nathalie L Jansen
    Department of Nuclear Medicine, Ludwig Maximilians University Munich, Munich, Germany
    Mol Imaging 12:137-47. 2013
    ..Six months after SBT (or later), however, increased SUVmax/BG and BTV values are associated with a worse prognosis. Multivariate analysis stresses the prognostic importance of dynamic studies...
  24. doi Impulsivity is related to striatal dopamine transporter availability in healthy males
    Anna Costa
    Department of Psychiatry, Ludwig Maximilians Universitat, Munich, Germany
    Psychiatry Res 211:251-6. 2013
    ..These results suggest that individual differences in the dopamine system may be a neural correlate of trait impulsivity in healthy individuals...
  25. doi Real versus imagined locomotion: a [18F]-FDG PET-fMRI comparison
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    Neuroimage 50:1589-98. 2010
    ..Real steady-state locomotion seems to use a direct pathway via the primary motor cortex, whereas imagined modulatory locomotion an indirect pathway via a supplementary motor cortex and basal ganglia loop...
  26. ncbi F-18-fluoro-2-deoxyglucose positron emission tomography/computed tomography in the follow-up of breast cancer with elevated levels of tumor markers
    Alexander Robert Haug
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    J Comput Assist Tomogr 31:629-34. 2007
    ..The value of combined positron emission tomography (PET)/computed tomography (CT) in the follow-up of patients with breast cancer with elevated tumor markers but without proven metastases or local recurrence was assessed...
  27. ncbi Erroneous cardiac ECG-gated PET list-mode trigger events can be retrospectively identified and replaced by an offline reprocessing approach: first results in rodents
    Guido Böning
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Munich, Germany
    Phys Med Biol 58:7937-59. 2013
    ..Furthermore, we aim to transfer the proposed QC methods and the fully reprocessing approach to human myocardial PET/CT. ..
  28. doi MRI-suspected low-grade glioma: is there a need to perform dynamic FET PET?
    Nathalie L Jansen
    Department of Nuclear Medicine, Ludwig Maximilians University Munich, Marchioninistr 15, 81377 Munich, Germany
    Eur J Nucl Med Mol Imaging 39:1021-9. 2012
    ..Since differentiation between low-grade glioma (LGG) and high-grade glioma (HGG) remains challenging according to MRI criteria alone, we investigated the discriminative value of additional dynamic FET PET in patients with MRI-suspected LGG...
  29. doi Irradiation and bevacizumab in high-grade glioma retreatment settings
    Maximilian Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 82:67-76. 2012
    ..To study the feasibility of reirradiation combined with bevacizumab treatment, the toxicity and treatment outcomes of this approach were analyzed retrospectively...
  30. ncbi Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke
    Gassan Massaweh
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Nucl Med Biol 36:721-7. 2009
    ..18)F-Labeled flumazenil ([(18)F]FZ) provides a potentially useful tracer to investigate those disorders by means of positron emission tomography (PET)...
  31. ncbi Clinical validation of the gated blood pool SPECT QBS processing software in congestive heart failure patients: correlation with MUGA, first-pass RNV and 2D-echocardiography
    Marcus Hacker
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    Int J Cardiovasc Imaging 22:407-16. 2006
    ..Aim of the study was to evaluate a commercially available automated GBPS processing software for EF measurements and wall motion analysis in heart failure patients...
  32. ncbi Functional representation of olfactory impairment in early Alzheimer's disease
    Stefan Forster
    Department of Nuclear Medicine, Ludwig Maximilian University, Munich, Germany
    J Alzheimers Dis 22:581-91. 2010
    ....
  33. doi 3D-OSEM and FP-CIT SPECT quantification: benefit for studies with a high radius of rotation?
    Walter Koch
    Department of Nuclear Medicine, University of Munich, Germany
    Nucl Med Commun 34:971-7. 2013
    ..The aim of this study was to systematically evaluate the potential benefits of 3D-OSEM in comparison with 2D-OSEM under critical imaging conditions, for example, scans with a high radius of rotation...
  34. doi PET/CT in malignant melanoma: contrast-enhanced CT versus plain low-dose CT
    Thomas Pfluger
    Department of Nuclear Medicine, LMU, Munich, Germany
    Eur J Nucl Med Mol Imaging 38:822-31. 2011
    ....
  35. ncbi The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder
    Klaus Henning Krause
    Friedrich Baur Institute, Ludwig Maximilians University, Ziemssenstr 1a, D 80336 Munich, Germany
    Neurosci Biobehav Rev 27:605-13. 2003
    ..DAT seem to be elevated in non-smoking ADHD patients suffering from the purely inattentive subtype of ADHD as well as in those with the combined or purely hyperactive/impulsive subtype...
  36. ncbi Effects of peripheral vascular intervention on ischemia-modified albumin
    Marcus Hacker
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    Coron Artery Dis 18:375-9. 2007
    ....
  37. doi Bilateral temporal lobe epilepsy confirmed with intracranial EEG in chorea-acanthocytosis
    Benedikt Bader
    Neurologische Klinik und Poliklinik, Ludwig Maximilians Universitat, Marchioninistr 15, 81377 Munchen, Germany
    Seizure 20:340-2. 2011
    ....
  38. doi FET-PET for malignant glioma treatment planning
    Maximilian Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University Munich, Munchen, Germany
    Radiother Oncol 99:44-8. 2011
    ....
  39. ncbi Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients
    Sabina Eigenbrod
    Center for Neuropathology and Prion Research, University of Munich Medical Center Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    Acta Neurochir (Wien) 156:1427-40. 2014
    ..We developed and validated prospectively (6/10-12/11) a protocol allowing for both reliable determination of multiple biomarkers and representative histological diagnoses from small-sized biopsies...
  40. ncbi Radioembolization in patients with hepatic metastases from breast cancer
    Tobias F Jakobs
    Department of Radiology, Ludwig Maximilians University of Munich, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    J Vasc Interv Radiol 19:683-90. 2008
    ....
  41. ncbi Increase of striatal dopamine transmission in first episode drug-naive schizophrenic patients as demonstrated by [(123)I]IBZM SPECT
    Gisela Johanna Elisabeth Schmitt
    Department of Psychiatry, Medical Center of the University of Munich, Munich, Germany
    Psychiatry Res 173:183-9. 2009
    ..The data obtained show a significant difference between acute psychotic patients, patients with predominant negative syndrome, and healthy controls, according to the concept of a "hyperdopaminergic state" in psychotic exacerbation...
  42. doi Radius dependence of FP-CIT quantification: a Monte Carlo-based simulation study
    Walter Koch
    Department of Nuclear Medicine, University of Munich, Marchioninistr 15, 81377, Munich, Germany
    Ann Nucl Med 28:103-11. 2014
    ..This study systematically evaluates the potential influence of radius of rotation on apparent tracer binding and describes methods for correction...
  43. doi Myocardial perfusion imaging is feasible for infarct size quantification in mice using a clinical single-photon emission computed tomography system equipped with pinhole collimators
    Tim Wollenweber
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    Mol Imaging Biol 12:427-34. 2010
    ..The aim of this study is to evaluate a non-invasive method for measuring myocardial perfusion defect size in mice using a clinical single-photon emission computed tomography system equipped with pinhole collimators (pinhole SPECT)...
  44. pmc Molecular imaging of gliomas with PET: opportunities and limitations
    Christian la Fougere
    Department of Nuclear Medicine, University of Munich Campus Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Neuro Oncol 13:806-19. 2011
    ....
  45. pmc Determination of split renal function using dynamic CT-angiography: preliminary results
    Andreas Helck
    Institute for Clinical Radiology, University Hospital Grosshadern LMU, Munich, Germany
    PLoS ONE 9:e91774. 2014
    ..To determine the feasibility of a dynamic CT angiography-protocol with regard to simultaneous assessment of renal anatomy and function...
  46. doi Ictal SPECT in Sturge-Weber syndrome
    Ozgur Bilgin
    University of Munich, Klinikum Grosshadern Department of Neurology, Germany
    Epilepsy Res 78:240-3. 2008
    ..Right orbito-frontal resection and disconnection from corpus callosum resulted in seizure freedom...