Julia Kzhyshkowska

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Cross-talk between endocytic clearance and secretion in macrophages
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Immunobiology 214:576-93. 2009
  2. ncbi request reprint Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis
    Julia Kzhyshkowska
    Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Germany
    J Immunol 180:3028-37. 2008
  3. ncbi request reprint Perspectives of mathematical modelling for understanding of intracellular signalling and vesicular trafficking in macrophages
    Julia Kzhyshkowska
    Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Immunobiology 212:813-25. 2007
  4. ncbi request reprint Stabilin-1, a homeostatic scavenger receptor with multiple functions
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Cell Mol Med 10:635-49. 2006
  5. ncbi request reprint Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Immunol 176:5825-32. 2006
  6. ncbi request reprint Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway
    Julia Kzhyshkowska
    Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Blood 107:3221-8. 2006
  7. ncbi request reprint Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Leukoc Biol 76:1151-61. 2004
  8. ncbi request reprint Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Immunobiology 210:161-73. 2005
  9. pmc Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7
    Julia Kzhyshkowska
    Universitat Heidelberg, Uni Klinikum Mannheim, Dermatologie, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Biochem J 371:385-93. 2003
  10. pmc Protein arginine methylation during lytic adenovirus infection
    Julia Kzhyshkowska
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Regensburg, Landshuterstr 22, D 93053 Regensburg, Germany
    Biochem J 383:259-65. 2004

Collaborators

Detail Information

Publications31

  1. doi request reprint Cross-talk between endocytic clearance and secretion in macrophages
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Immunobiology 214:576-93. 2009
    ..We propose novel level of regulation for the secretory repertoire of macrophages: cross-talk of uptake and release at the level of vesicular trafficking...
  2. ncbi request reprint Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis
    Julia Kzhyshkowska
    Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Germany
    J Immunol 180:3028-37. 2008
    ..5 microg/ml in fetal circulation. We propose that stabilin-1-positive macrophages determine the difference in PL levels between maternal and fetal circulation...
  3. ncbi request reprint Perspectives of mathematical modelling for understanding of intracellular signalling and vesicular trafficking in macrophages
    Julia Kzhyshkowska
    Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Immunobiology 212:813-25. 2007
    ..Identified critical elements of the system will facilitate the isolation of predictive/diagnostic markers as well as potential therapeutic targets...
  4. ncbi request reprint Stabilin-1, a homeostatic scavenger receptor with multiple functions
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Cell Mol Med 10:635-49. 2006
    ..In summary, stabilin-1 is a homeostatic receptor which links signals from the extracellular environment to intracellular vesicular processes, creating a potential impact on the macrophage secretion profile...
  5. ncbi request reprint Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Immunol 176:5825-32. 2006
    ..We propose that alternatively activated macrophages coordinate extracellular matrix remodeling, angiogenesis, and tumor progression via stabilin-1-mediated endocytosis of SPARC and thereby regulate its extracellular concentration...
  6. ncbi request reprint Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway
    Julia Kzhyshkowska
    Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Blood 107:3221-8. 2006
    ..The 1C11 mAb detected SI-CLP in human bronchoalveolar lavage and peripheral-blood leukocytes (PBLs), and can be used to analyze the role of SI-CLP in human disorders...
  7. ncbi request reprint Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Leukoc Biol 76:1151-61. 2004
    ....
  8. ncbi request reprint Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Immunobiology 210:161-73. 2005
    ..Our data indicate that PI3K activity is required for the transfer of stabilin-1 and its ligand acLDL from early to late endosomal compartments...
  9. pmc Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7
    Julia Kzhyshkowska
    Universitat Heidelberg, Uni Klinikum Mannheim, Dermatologie, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Biochem J 371:385-93. 2003
    ..We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation...
  10. pmc Protein arginine methylation during lytic adenovirus infection
    Julia Kzhyshkowska
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Regensburg, Landshuterstr 22, D 93053 Regensburg, Germany
    Biochem J 383:259-65. 2004
    ..Our results suggest that protein arginine methylation is an important host-cell function required for efficient Ad replication...
  11. pmc A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1
    Jingjing Zhang
    Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Mol Cell Biol 29:6097-105. 2009
    ..Our data indicate that the novel GGA-binding site EDDADDD is essential for stabilin-1-mediated intracellular sorting but is not required for endocytosis...
  12. doi request reprint Pro- and anti-inflammatory control of M-CSF-mediated macrophage differentiation
    Anna Popova
    Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, and Center of Excellence in Dermatology, The State of Baden Württemberg, Mannheim, Germany
    Immunobiology 216:164-72. 2011
    ..Increased surface expression of CSF-1R in tolerogenic conditions guarantees response to minute amounts of exogenous M-CSF...
  13. ncbi request reprint Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II
    Alexei Gratchev
    Department of Dermatology, Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    J Immunol 180:6553-65. 2008
    ....
  14. ncbi request reprint The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation
    Jochen Utikal
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Int J Cancer 119:2287-93. 2006
    ..In conclusion, we clearly demonstrate here that the expression of metastasis suppressor MIM is regulated by DNA methylation of a CpG island within its promoter region...
  15. ncbi request reprint Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding
    Berit Hansen
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    Exp Cell Res 303:160-73. 2005
    ..In conclusion, hepatic stabilins are both present in the early endocytic pathway, associating with clathrin/AP-2, but whereas stabilin-2 has a clear scavenging profile, stabilin-1 does not recognize these ligands...
  16. ncbi request reprint Novel monocyte biomarkers of atherogenic conditions
    Alexei Gratchev
    Institute of Transfusion Medicine and Immunology, Klinikum Mannheim gGmbH Universitätsklinikum Ruprecht Karls Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Curr Pharm Des 19:5859-64. 2013
    ..Functions of all three proteins suggest that they are not only diagnostic markers, but also involved in atherogenesis and can be used as targets for novel therapeutic approaches. ..
  17. pmc Expression of stabilin-1 in M2 macrophages in human granulomatous disease and melanocytic lesions
    Kathrin Schönhaar
    Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Center of Excellence in Dermatoloy T Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Clin Exp Pathol 7:1625-34. 2014
    ..Stabilin-1 positive vessels were found in all analysed non-Langerhans cell histiocytoses and melanocytic lesions. No stabilin-1 positive vessels were present in any other granulomatous diseases. ..
  18. doi request reprint A second combinatorial immune receptor in monocytes/macrophages is based on the TCRγδ
    Tina Fuchs
    Institute for Clinical Chemistry, University of Heidelberg, Medical Faculty Mannheim, D 68167 Mannheim, Germany
    Immunobiology 218:960-8. 2013
    ....
  19. doi request reprint Multifunctional receptor stabilin-1 in homeostasis and disease
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    ScientificWorldJournal 10:2039-53. 2010
    ....
  20. doi request reprint Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2
    Anna Popova
    Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Center of Excellence in Dermatology, The State of Baden Württemberg, Mannheim, Germany
    Immunobiology 217:321-8. 2012
    ..In summary we established a new mechanism of IL17RB regulation-Smurf2 dependent degradation of its adaptor protein DAZAP2...
  21. pmc Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues
    Oliver Politz
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Biochem J 362:155-64. 2002
    ....
  22. pmc Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors
    Kai Schledzewski
    Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Clin Invest 121:703-14. 2011
    ..These data lead us to conclude that stabilin-1 and -2 together guarantee proper hepatic clearance of potentially noxious agents in the blood and maintain tissue homeostasis not only in the liver but also distant organs...
  23. doi request reprint Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A
    Astrid Schmieder
    Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, and Center of Excellence in Dermatology, Mannheim, Germany
    Int J Cancer 129:122-32. 2011
    ..Furthermore, MS4A8A(+) TAM may serve as a novel cellular target for selective cancer therapy...
  24. ncbi request reprint Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals
    Alexei Gratchev
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Immunobiology 211:473-86. 2006
    ..Selective refractoriness of Mphi1 and Mphi2 to IFNgamma- and LPS-induced cytokine secretion may contribute to prevent autoimmunity...
  25. doi request reprint Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway
    Diana Klein
    Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Hepatology 47:1018-31. 2008
    ..Inhibition of Wnt signaling down-regulated VEGFR-2 messenger RNA and protein. Wnt2 siRNA knock-down confirmed Wnt2 specificity of VEGFR-2 regulation in HSECs...
  26. pmc Human chitinases and chitinase-like proteins as indicators for inflammation and cancer
    Julia Kzhyshkowska
    Department of Dermatology and Allergology, University Medical Centre Mannheim, Ruprecht Karls, University of Heidelberg, Mannheim D 68167, Germany
    Biomark Insights 2:128-46. 2007
    ..Human chitinases and chitinase-like proteins are found in tissues and circulation, and can be detected by non-invasive technologies...
  27. doi request reprint Role of macrophage scavenger receptors in atherosclerosis
    Julia Kzhyshkowska
    Department of Dermatology, Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Germany
    Immunobiology 217:492-502. 2012
    ..The activities of scavenger receptors that can contribute to each of these processes are a subject of current review...
  28. doi request reprint Monocytes as a diagnostic marker of cardiovascular diseases
    Alexei Gratchev
    Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Immunobiology 217:476-82. 2012
    ....
  29. doi request reprint The neutrophil recombinatorial TCR-like immune receptor is expressed across the entire human life span but repertoire diversity declines in old age
    Tina Fuchs
    Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, D 68167 Mannheim, Germany
    Biochem Biophys Res Commun 419:309-15. 2012
    ..The marked decline in TCRL(n) repertoire diversity in old age identifies a novel mechanism of immunosenescence in neutrophils...
  30. ncbi request reprint Endogenous transforming growth factor-beta receptor-mediated Smad signaling complexes analyzed by mass spectrometry
    Qilie Luo
    Laboratory for Macromolecular Analysis and Proteomics, Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Proteomics 5:1245-60. 2006
    ..Although some of these have been reported in the literature, most have not been reported previously. This work expands the repertoire of proteins known to participate in the TGF-beta signal transduction processes...