Research Topics
Genomes and Genes
| Julia KzhyshkowskaSummaryAffiliation: University of Heidelberg Country: Germany Publications
| Collaborators
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Detail Information
Publications
Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosisJulia Kzhyshkowska
Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Germany
J Immunol 180:3028-37. 2008..5 microg/ml in fetal circulation. We propose that stabilin-1-positive macrophages determine the difference in PL levels between maternal and fetal circulation...- Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARCJulia Kzhyshkowska
Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
J Immunol 176:5825-32. 2006..We propose that alternatively activated macrophages coordinate extracellular matrix remodeling, angiogenesis, and tumor progression via stabilin-1-mediated endocytosis of SPARC and thereby regulate its extracellular concentration... - Perspectives of mathematical modelling for understanding of intracellular signalling and vesicular trafficking in macrophagesJulia Kzhyshkowska
Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
Immunobiology 212:813-25. 2007..Identified critical elements of the system will facilitate the isolation of predictive/diagnostic markers as well as potential therapeutic targets... - Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathwayJulia Kzhyshkowska
Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Blood 107:3221-8. 2006..The 1C11 mAb detected SI-CLP in human bronchoalveolar lavage and peripheral-blood leukocytes (PBLs), and can be used to analyze the role of SI-CLP in human disorders... - Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDLJulia Kzhyshkowska
Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Immunobiology 210:161-73. 2005..Our data indicate that PI3K activity is required for the transfer of stabilin-1 and its ligand acLDL from early to late endosomal compartments... 
Cross-talk between endocytic clearance and secretion in macrophagesJulia Kzhyshkowska
Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Immunobiology 214:576-93. 2009..We propose novel level of regulation for the secretory repertoire of macrophages: cross-talk of uptake and release at the level of vesicular trafficking...- Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptorsJulia Kzhyshkowska
Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
J Leukoc Biol 76:1151-61. 2004.... 
Protein arginine methylation during lytic adenovirus infectionJulia Kzhyshkowska
Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Regensburg, Landshuterstr 22, D 93053 Regensburg, Germany
Biochem J 383:259-65. 2004..Our results suggest that protein arginine methylation is an important host-cell function required for efficient Ad replication...- Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7Julia Kzhyshkowska
Universitat Heidelberg, Uni Klinikum Mannheim, Dermatologie, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
Biochem J 371:385-93. 2003..We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation... - Stabilin-1, a homeostatic scavenger receptor with multiple functionsJulia Kzhyshkowska
Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
J Cell Mol Med 10:635-49. 2006..In summary, stabilin-1 is a homeostatic receptor which links signals from the extracellular environment to intracellular vesicular processes, creating a potential impact on the macrophage secretion profile... - A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1Jingjing Zhang
Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Mol Cell Biol 29:6097-105. 2009..Our data indicate that the novel GGA-binding site EDDADDD is essential for stabilin-1-mediated intracellular sorting but is not required for endocytosis... - Pro- and anti-inflammatory control of M-CSF-mediated macrophage differentiationAnna Popova
Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, and Center of Excellence in Dermatology, The State of Baden Württemberg, Mannheim, Germany
Immunobiology 216:164-72. 2011..Increased surface expression of CSF-1R in tolerogenic conditions guarantees response to minute amounts of exogenous M-CSF... - Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor IIAlexei Gratchev
Department of Dermatology, Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
J Immunol 180:6553-65. 2008.... - The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylationJochen Utikal
Department of Dermatology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
Int J Cancer 119:2287-93. 2006..In conclusion, we clearly demonstrate here that the expression of metastasis suppressor MIM is regulated by DNA methylation of a CpG island within its promoter region... - Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand bindingBerit Hansen
Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
Exp Cell Res 303:160-73. 2005..In conclusion, hepatic stabilins are both present in the early endocytic pathway, associating with clathrin/AP-2, but whereas stabilin-2 has a clear scavenging profile, stabilin-1 does not recognize these ligands... - Multifunctional receptor stabilin-1 in homeostasis and diseaseJulia Kzhyshkowska
Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
ScientificWorldJournal 10:2039-53. 2010.... - Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2Anna Popova
Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Center of Excellence in Dermatology, The State of Baden Württemberg, Mannheim, Germany
Immunobiology 217:321-8. 2012..In summary we established a new mechanism of IL17RB regulation-Smurf2 dependent degradation of its adaptor protein DAZAP2... - Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factorsKai Schledzewski
Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
J Clin Invest 121:703-14. 2011..These data lead us to conclude that stabilin-1 and -2 together guarantee proper hepatic clearance of potentially noxious agents in the blood and maintain tissue homeostasis not only in the liver but also distant organs... - Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologuesOliver Politz
Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
Biochem J 362:155-64. 2002.... - Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8AAstrid Schmieder
Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, and Center of Excellence in Dermatology, Mannheim, Germany
Int J Cancer 129:122-32. 2011..Furthermore, MS4A8A(+) TAM may serve as a novel cellular target for selective cancer therapy... - Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signalsAlexei Gratchev
Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
Immunobiology 211:473-86. 2006..Selective refractoriness of Mphi1 and Mphi2 to IFNgamma- and LPS-induced cytokine secretion may contribute to prevent autoimmunity... - Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathwayDiana Klein
Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Hepatology 47:1018-31. 2008..Wnt2 siRNA knock-down confirmed Wnt2 specificity of VEGFR-2 regulation in HSECs. CONCLUSION: Wnt2 is an autocrine growth and differentiation factor specific for HSECs that synergizes with the VEGF signaling pathway to exert its effects... - Human chitinases and chitinase-like proteins as indicators for inflammation and cancerJulia Kzhyshkowska
Department of Dermatology and Allergology, University Medical Centre Mannheim, Ruprecht Karls, University of Heidelberg, Mannheim D 68167, Germany
Biomark Insights 2:128-46. 2007..Human chitinases and chitinase-like proteins are found in tissues and circulation, and can be detected by non-invasive technologies... - Role of macrophage scavenger receptors in atherosclerosisJulia Kzhyshkowska
Department of Dermatology, Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Germany
Immunobiology 217:492-502. 2012..The activities of scavenger receptors that can contribute to each of these processes are a subject of current review... - Monocytes as a diagnostic marker of cardiovascular diseasesAlexei Gratchev
Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
Immunobiology 217:476-82. 2012.... - The neutrophil recombinatorial TCR-like immune receptor is expressed across the entire human life span but repertoire diversity declines in old ageTina Fuchs
Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, D 68167 Mannheim, Germany
Biochem Biophys Res Commun 419:309-15. 2012..The marked decline in TCRL(n) repertoire diversity in old age identifies a novel mechanism of immunosenescence in neutrophils... - Endogenous transforming growth factor-beta receptor-mediated Smad signaling complexes analyzed by mass spectrometryQilie Luo
Laboratory for Macromolecular Analysis and Proteomics, Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Cell Proteomics 5:1245-60. 2006..Although some of these have been reported in the literature, most have not been reported previously. This work expands the repertoire of proteins known to participate in the TGF-beta signal transduction processes...