H Kurzen

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration
    Zbigniew Mikulski
    Institute for Anatomy and Cell Biology, University of Giessen Lung Center, Justus Liebig University Giessen, Aulweg 123, Giessen, Germany
    Respir Res 11:133. 2010
  2. pmc Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases
    Martin Deichmann
    Department of Dermatology, Heidelberg University Clinics, Vossbstrasse 2, 69115 Heidelberg, Germany
    BMC Cancer 5:58. 2005
  3. ncbi [The extraneuronal cholinergic system of the skin. Basic facts and clinical relevance]
    H Kurzen
    Klinik fur Dermatologie, Venerologie und Allergologie des Universitätsklinikums Mannheim
    Hautarzt 55:453-9. 2004
  4. ncbi Functional characterization of the epidermal cholinergic system in vitro
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Invest Dermatol 126:2458-72. 2006
  5. ncbi Desmoglein antibodies and pemphigus vulgaris: a tale of treason and a fight for life
    Hjalmar Kurzen
    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Exp Dermatol 15:1016. 2006
  6. ncbi The non-neuronal cholinergic system of human skin
    H Kurzen
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 39:125-35. 2007
  7. ncbi Novel aspects in cutaneous biology of acetylcholine synthesis and acetylcholine receptors
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Exp Dermatol 13:27-30. 2004
  8. ncbi [Benign cellular fibrous histiocytoma with erosion of the phalanx]
    H Kurzen
    Hautklinik der Universität Heidelberg
    Hautarzt 54:453-6. 2003
  9. ncbi Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogene
    K Schledzewski
    Department of Dermatology, Venerology, and Allergy, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Germany
    J Pathol 209:67-77. 2006
  10. ncbi [Defect reduction by serial tightening of loop sutures]
    Wolfgang Koenen
    Klinik fur Dermatologie, Venerologie und Allergologie, Klinikum Mannheim gGmbH Universitätsklinikum, Medizinische Fakultät Mannheim der Ruprecht Karls Universität Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 5:330-1. 2007

Collaborators

Detail Information

Publications33

  1. pmc Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration
    Zbigniew Mikulski
    Institute for Anatomy and Cell Biology, University of Giessen Lung Center, Justus Liebig University Giessen, Aulweg 123, Giessen, Germany
    Respir Res 11:133. 2010
    ..In the present study, we determine the nAChR inventory of rat alveolar macrophages (AM), and investigate the cellular events evoked by stimulation with nicotine...
  2. pmc Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases
    Martin Deichmann
    Department of Dermatology, Heidelberg University Clinics, Vossbstrasse 2, 69115 Heidelberg, Germany
    BMC Cancer 5:58. 2005
    ....
  3. ncbi [The extraneuronal cholinergic system of the skin. Basic facts and clinical relevance]
    H Kurzen
    Klinik fur Dermatologie, Venerologie und Allergologie des Universitätsklinikums Mannheim
    Hautarzt 55:453-9. 2004
    ..Hence diseases like acne vulgaris, vitiligo, psoriasis, pemphigus vulgaris and atopic dermatitis may be influenced. The exploration of the extraneuronal cholinergic system of the skin has only just begun...
  4. ncbi Functional characterization of the epidermal cholinergic system in vitro
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Invest Dermatol 126:2458-72. 2006
    ..In summary, we show that epidermal AChR are crucially involved in the regulation of epidermal homeostasis...
  5. ncbi Desmoglein antibodies and pemphigus vulgaris: a tale of treason and a fight for life
    Hjalmar Kurzen
    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Exp Dermatol 15:1016. 2006
  6. ncbi The non-neuronal cholinergic system of human skin
    H Kurzen
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 39:125-35. 2007
    ..The pathophysiological consequences of this complex cholinergic "concert" are only beginning to be understood. The present review aims at providing insight into basic mechanisms of this highly complex system...
  7. ncbi Novel aspects in cutaneous biology of acetylcholine synthesis and acetylcholine receptors
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Exp Dermatol 13:27-30. 2004
    ..However, recently, the presence of both different nACh-R and mACh-R in myoepithelial and acinar cells of eccrine sweat glands has been documented, indicating a more complex regulation of sweat production and expulsion...
  8. ncbi [Benign cellular fibrous histiocytoma with erosion of the phalanx]
    H Kurzen
    Hautklinik der Universität Heidelberg
    Hautarzt 54:453-6. 2003
    ..The diagnosis was benign cellular fibrous histiocytoma (BZFH). BZFH belong to the group of BFH with a high recurrence rate especially after incomplete removal. Damage to the underlying bone has not been reported so far...
  9. ncbi Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogene
    K Schledzewski
    Department of Dermatology, Venerology, and Allergy, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Germany
    J Pathol 209:67-77. 2006
    ..This improved approach will help to clarify the prognostic significance of lymphangiogenesis in malignant tumours...
  10. ncbi [Defect reduction by serial tightening of loop sutures]
    Wolfgang Koenen
    Klinik fur Dermatologie, Venerologie und Allergologie, Klinikum Mannheim gGmbH Universitätsklinikum, Medizinische Fakultät Mannheim der Ruprecht Karls Universität Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 5:330-1. 2007
  11. ncbi [Persistent facial erythema and edema]
    Jochen Utikal
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Mannheim, Fakultät für Klinische Medizin Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
    J Dtsch Dermatol Ges 3:467-9. 2005
  12. ncbi Infiltrating basal cell carcinoma of the neck 34 years after irradiation of an haemangioma in early childhood. A case-report
    Georg Eggers
    Department of Oral and Cranio Maxillofacial Surgery, Heidelberg University, Germany
    J Craniomaxillofac Surg 33:197-200. 2005
    ..Thirty years ago the patient had undergone radiotherapy for an infantile haemangioma of the skin of the neck. The effects of this treatment when given in childhood in the aetiology of a basal cell carcinoma are discussed...
  13. doi [Red and purple maculas and plaques at the lateral aspects of the thighs]
    Georg Haus
    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 6:149-50. 2008
  14. ncbi Unusual spindle cell squamous carcinoma in a renal transplant patient
    Hjalmar Kurzen
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Acta Derm Venereol 84:61-4. 2004
    ....
  15. ncbi Expression of desmosomal proteins in squamous cell carcinomas of the skin
    Hjalmar Kurzen
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    J Cutan Pathol 30:621-30. 2003
    ..Desmosomal proteins are well established markers of epithelial differentiation. Down-regulation of desmosomal proteins has been suggested to be a sign of reduced adhesiveness in metastasizing cells...
  16. ncbi Inhibition of angiogenesis by non-toxic doses of temozolomide
    Hjalmar Kurzen
    Department of Dermatology, University of Heidelberg, Germany
    Anticancer Drugs 14:515-22. 2003
    ..Therefore, the antitumor activity of TMZ may, at least in part, be due to its antiangiogenic properties. The precise mechanism of its antiangiogenic action remains to be elucidated...
  17. ncbi Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas)
    Martin Deichmann
    Department of Dermatology, Heidelberg University Clinics, Heidelberg, Germany
    J Cutan Pathol 30:363-8. 2003
    ....
  18. ncbi Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Heidelberg, Germany
    J Invest Dermatol 123:937-49. 2004
    ..Taken together, our data result in a complete molecular map of the extraneuronal cholinergic system of the skin that may be translated into distinct functional reaction patterns...
  19. ncbi Functional significance of non-neuronal acetylcholine in skin epithelia
    Anisa Hana
    Department of Dermatology, Venereology and Allergology, Medical Faculty of Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Life Sci 80:2214-20. 2007
    ..Altogether we provide first hints for a causative role of the non-neuronal cholinergic system in the pathogenesis of HS by promoting infundibular epithelial hyperplasia and thus follicular plugging...
  20. ncbi Expression of MUC 1 and Ep-CAM in Merkel cell carcinomas: implications for immunotherapy
    Hjalmar Kurzen
    Department of Dermatology, University of Heidelberg, Vossstrasse 2, 69115 Heidelberg, Germany
    Arch Dermatol Res 295:146-54. 2003
    ..This opens the door for treatments based on monoclonal antibodies or vaccination strategies against these antigens, already established for other tumor entities...
  21. doi A case of cutaneous Rosai-Dorfman disease refractory to imatinib therapy
    Carl Gebhardt
    Department of Dermatology, Venereology, and Allergology, Universitätsklinikum Leipzig Anstalt öffentlichen Rechts, Philipp Rosenthal Strasse 23 25, 04103 Leipzig, Germany
    Arch Dermatol 145:571-4. 2009
    ..Rosai-Dorfman disease is a non-Langerhans cell histiocytosis that recently has been treated successfully with imatinib mesylate in a patient with a systemic variant of the disease...
  22. ncbi Significance of autoimmunity to non-desmoglein targets in pemphigus
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Heidelberg, Germany
    Autoimmunity 39:549-56. 2006
    ..The field is open for controlled clinical trials and further basic research to unfold the true story of the pemphigus enigma and provide the basis for a better treatment of pemphigus patients...
  23. ncbi The chemoresistance gene ABCG2 (MXR/BCRP1/ABCP1) is not expressed in melanomas but in single neuroendocrine carcinomas of the skin
    Martin Deichmann
    Department of Dermatology, Heidelberg University Clinics, Heidelberg, Germany
    J Cutan Pathol 32:467-73. 2005
    ..Besides melanoma, we addressed the neuroendocrine carcinoma of the skin (Merkel cell carcinoma), another cutaneous cancer supposed to originate from neuroectoderm and usually chemoresistant...
  24. pmc MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome
    J C Hassel
    Skin Cancer Unit, German Cancer Research Center, University Hospital Mannheim, Mannheim, Germany
    Br J Cancer 103:820-6. 2010
    ..For melanoma, data are limited and controversial...
  25. ncbi Forms of epithelial differentiation of draining sinus in acne inversa (hidradenitis suppurativa)
    H Kurzen
    Division of Cell Biology, German Cancer Research Centre, Heidelberg, Germany
    Br J Dermatol 141:231-9. 1999
    ..The three phenotypes are characterized as pathological stratified squamous epithelia reflecting the dynamic process of inflammation, proliferation and stratification taking place in acne inversa...
  26. ncbi Tightening of endothelial cell contacts: a physiologic response to cocultures with smooth-muscle-like 10T1/2 cells
    Hjalmar Kurzen
    German Cancer Research Center, Division of Cell Biology A0100, University of Heidelberg, 69120 Heidelberg, Germany
    J Invest Dermatol 119:143-53. 2002
    ..In conclusion, mural cells such as smooth muscle cells and pericytes may be important for stabilizing endothelial cell-to-cell contacts and may influence vessel-type specific differences of the endothelial phenotype...
  27. doi Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
    ..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland...
  28. ncbi Compositionally different desmosomes in the various compartments of the human hair follicle
    H Kurzen
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Differentiation 63:295-304. 1998
    ..The differential molecular composition of desmosomes is discussed in relation to possible functional differences between the individual cell types...
  29. ncbi Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma
    H Kurzen
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Am J Dermatopathol 23:501-9. 2001
    ..This indicates a differentiation toward the outer root sheath epithelium or the companion layer and not toward the inner root sheath, matrix, or cortex...
  30. ncbi Imatinib as a treatment option for systemic non-Langerhans cell histiocytoses
    Jochen Utikal
    Department of Dermatology, Venereology, and Allergology, Central Laboratory, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Germany
    Arch Dermatol 143:736-40. 2007
    ..Systemic non-Langerhans cell histiocytoses are disorders characterized by the accumulation of histiocytes that do not meet the criteria for Langerhans cells in various organs. So far, no causative treatment is known...
  31. ncbi Decline in angiogenic factors, such as interleukin-8, indicates response to chemotherapy of metastatic melanoma
    Sabine Brennecke
    Department of Dermatology, University of Heidelberg, Germany
    Melanoma Res 15:515-22. 2005
    ..The distinct variability of serum levels indicates that processes other than tumour angiogenesis also influence the serum concentration of the examined angiogenic factors...
  32. ncbi High-grade trichoblastic carcinoma arising in trichoblastoma: a rare adnexal neoplasm often showing metastatic spread
    Tilman Schulz
    Institute of Pathology, Ansbach, Germany
    Am J Dermatopathol 27:9-16. 2005
    ..Our cases emphasize that high-grade trichoblastic carcinoma develops via malignant transformation of trichoblastoma, and is very rare...
  33. ncbi Cutaneous necrosis after subcutaneous injection of polyethylene-glycol-modified interferon alpha
    Hjalmar Kurzen
    Acta Derm Venereol 82:310-2. 2002