R Kuppers

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Mechanisms of chromosomal translocations in B cell lymphomas
    R Kuppers
    Institute of Cancer Genetics, Columbia University, New York, NY 10032, USA
    Oncogene 20:5580-94. 2001
  2. ncbi request reprint The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease
    R Kuppers
    Institute for Genetics, University of Cologne, Germany
    Annu Rev Immunol 16:471-93. 1998
  3. ncbi request reprint Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions
    R Kuppers
    Institute for Genetics and the Department of Internal Medicine I, University of Cologne, Cologne, Germany
    Blood 97:818-21. 2001
  4. pmc Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL
    R Kuppers
    Institute for Genetics, University of Cologne, Germany
    Mol Med 7:285-92. 2001
  5. ncbi request reprint Identifying the precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease: role of the germinal center in B-cell lymphomagenesis
    R Kuppers
    Institute for Genetics, University of Cologne, Germany
    J Acquir Immune Defic Syndr 21:S74-9. 1999
  6. ncbi request reprint Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes
    M MUSCHEN
    Institute for Genetics, Department of Immunology, Universitat zu Koln, Germany
    Lab Invest 81:289-95. 2001
  7. ncbi request reprint EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency
    J Kurth
    Institute for Genetics and Department of Internal Medicine I, University of Cologne, Germany
    Immunity 13:485-95. 2000
  8. ncbi request reprint Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells
    M MUSCHEN
    Institute for Genetics, Department of Immunology, University of Cologne, Koln, Germany
    Cancer Res 60:5640-3. 2000
  9. pmc Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease
    T Goossens
    Institute for Genetics, University of Cologne, 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 95:2463-8. 1998
  10. pmc Rare occurrence of classical Hodgkin's disease as a T cell lymphoma
    M MUSCHEN
    Institute for Genetics, Department of Immunology, Universitat zu Koln, Germany
    J Exp Med 191:387-94. 2000

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Mechanisms of chromosomal translocations in B cell lymphomas
    R Kuppers
    Institute of Cancer Genetics, Columbia University, New York, NY 10032, USA
    Oncogene 20:5580-94. 2001
    ....
  2. ncbi request reprint The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease
    R Kuppers
    Institute for Genetics, University of Cologne, Germany
    Annu Rev Immunol 16:471-93. 1998
    ..One candidate for the latter is EBV infection...
  3. ncbi request reprint Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions
    R Kuppers
    Institute for Genetics and the Department of Internal Medicine I, University of Cologne, Cologne, Germany
    Blood 97:818-21. 2001
    ..In none of the 6 cases was evidence for additional IgH (or TCRbeta) alleles obtained, strongly arguing against a role of cell fusion in HRS cell generation...
  4. pmc Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL
    R Kuppers
    Institute for Genetics, University of Cologne, Germany
    Mol Med 7:285-92. 2001
    ..Such composite lymphomas represent interesting models to study the pathogenesis of B-cell lymphomas and the relationship between HD and B-cell NHL...
  5. ncbi request reprint Identifying the precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease: role of the germinal center in B-cell lymphomagenesis
    R Kuppers
    Institute for Genetics, University of Cologne, Germany
    J Acquir Immune Defic Syndr 21:S74-9. 1999
    ..It is likely that chromosomal translocations resulting from mistakes in class switch recombination or somatic hypermutation (and potentially V gene editing) play an important role in the pathogenesis of GC B-cell-derived lymphomas...
  6. ncbi request reprint Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes
    M MUSCHEN
    Institute for Genetics, Department of Immunology, Universitat zu Koln, Germany
    Lab Invest 81:289-95. 2001
    ..Thus, the rare occurrence of H/RS cells with unmutated V genes is expected if the H/RS cells are derived from the pool of pre-apoptotic germinal center B cells...
  7. ncbi request reprint EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency
    J Kurth
    Institute for Genetics and Department of Internal Medicine I, University of Cologne, Germany
    Immunity 13:485-95. 2000
    ....
  8. ncbi request reprint Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells
    M MUSCHEN
    Institute for Genetics, Department of Immunology, University of Cologne, Koln, Germany
    Cancer Res 60:5640-3. 2000
    ..In conclusion, somatic mutations of the CD95 gene occur in a fraction of cHD cases and may favor the escape of the precursor of the H/RS clone from apoptosis...
  9. pmc Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease
    T Goossens
    Institute for Genetics, University of Cologne, 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 95:2463-8. 1998
    ....
  10. pmc Rare occurrence of classical Hodgkin's disease as a T cell lymphoma
    M MUSCHEN
    Institute for Genetics, Department of Immunology, Universitat zu Koln, Germany
    J Exp Med 191:387-94. 2000
    ..In a third case, however, H/RS cells were derived from a T cell, demonstrating that cHD can also occur as a T cell lymphoma...
  11. ncbi request reprint Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal
    A Roers
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 28:2424-31. 1998
    ..These data suggest that the HRS cells attract CD4+ T cells nonspecifically...
  12. ncbi request reprint Biology of Hodgkin's lymphoma
    R Kuppers
    Institute for Genetics, Department of Internal Medicine I, University of Cologne, Germany
    Ann Oncol 13:11-8. 2002
    ....
  13. pmc Single-cell PCR analysis of T helper cells in human lymph node germinal centers
    A Roers
    Institute for Genetics, University of Cologne, Cologne University of Frankfurt, Frankfurt, Germany
    Am J Pathol 156:1067-71. 2000
    ..The detection of clonal expansions accounting for more than half of the sampled B cells in addition to ongoing somatic hypermutation of Ig V region genes suggested that GC3 was a fully developed GC...
  14. pmc Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
    R Kuppers
    Institute for Genetics, University of Cologne, Germany
    EMBO J 12:4955-67. 1993
    ..A polyclonal population of activated B cells expressing unmutated antibodies in the dark zone of the other germinal centre may represent the initial founder cells...
  15. ncbi request reprint Phenotypic and molecular characterization of human peripheral blood B-cell subsets with special reference to N-region addition and J kappa-usage in V kappa J kappa-joints and kappa/lambda-ratios in naive versus memory B-cell subsets to identify traces of
    U Klein
    Institute for Genetics, University of Cologne, Germany
    Curr Top Microbiol Immunol 246:141-6; discussion 147. 1999
    ....
  16. pmc Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma
    B Jungnickel
    Institute for Genetics, University of Cologne, 50931 Cologne, Germany
    J Exp Med 191:395-402. 2000
    ....
  17. ncbi request reprint Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
    L Pasqualucci
    Institute for Cancer Genetics and the Department of Pathology, Columbia University, New York, New York 10032, USA
    Nature 412:341-6. 2001
    ..By mutating multiple genes, and possibly by favouring chromosomal translocations, aberrant hypermutation may represent the major contributor to lymphomagenesis...
  18. ncbi request reprint Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene
    R Kuppers
    Institute for Genetics, Department of Internal Medicine I, LFI E4 R706, University of Cologne, Joseph Stelzmannstrasse 9, D 50931 Cologne, Germany
    Leukemia 16:937-9. 2002
    ....
  19. ncbi request reprint Genetic evidence for latent Septata intestinalis infection in human immunodeficiency virus-infected patients with intestinal microsporidiosis
    C Franzen
    Department of Internal Medicine I, University of Cologne, Germany
    J Infect Dis 173:1038-40. 1996
    ..intestinalis. Thus, S. intestinalis seems to occur more frequently in the form of latent infections and the true prevalence of the parasites may be much higher than previously reported...
  20. ncbi request reprint Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes
    M Fischer
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 28:2971-7. 1998
    ....