Christian Kupatt

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Munich, Germany
    J Leukoc Biol 72:455-61. 2002
  2. ncbi request reprint Endothelial nitric oxide synthase overexpression provides a functionally relevant angiogenic switch in hibernating pig myocardium
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    J Am Coll Cardiol 49:1575-84. 2007
  3. pmc VEGF-B: a more balanced approach toward cardiac neovascularization?
    Christian Kupatt
    Medizinische Klinik I Klinikum Großhadern, Munich, Germany
    EMBO Mol Med 6:297-8. 2014
  4. pmc Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury
    Anne Karin Hesse
    Institute for Surgical Research, University of Munich, Marchioninistr, 15, 81366 Munich, Germany
    Respir Res 5:11. 2004
  5. ncbi request reprint Cotransfection of vascular endothelial growth factor-A and platelet-derived growth factor-B via recombinant adeno-associated virus resolves chronic ischemic malperfusion role of vessel maturation
    Christian Kupatt
    Medizinische Klinik I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, 81377 Munich, Germany
    J Am Coll Cardiol 56:414-22. 2010
  6. ncbi request reprint The vascular compartments of neovascularization: spotlight on the microcirculation
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Curr Pharm Biotechnol 8:27-33. 2007
  7. ncbi request reprint Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of phosphatidylinositol 3-kinase/AKT kinase
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Munich, Germany
    Circulation 112:I117-22. 2005
  8. ncbi request reprint Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model
    Christian Kupatt
    Internal Medicine 1, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Cardiovasc Res 61:530-7. 2004
  9. ncbi request reprint Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation
    Christian Kupatt
    Department of Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Arterioscler Thromb Vasc Biol 24:1435-41. 2004
  10. doi request reprint Partial inferior sternotomy and deep hypothermic circulatory arrest for rescue of a failed TAVI case: what does constitute 'inoperable'?
    Rene Schramm
    Clinic of Cardiac Surgery, Ludwig Maximilian University Munich, Campus Grosshadern, Munich, Germany
    Thorac Cardiovasc Surg 61:431-4. 2013

Detail Information

Publications47

  1. ncbi request reprint Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Munich, Germany
    J Leukoc Biol 72:455-61. 2002
    ..23+/-4/field), an effect sensitive to Tirofiban inhibition (23+/-4 leukocytes/field, 22+/-3 platelets/field). We conclude that platelets contribute postischemic leukocyte adhesion in the heart via P-selectin and GPIIb/IIIa...
  2. ncbi request reprint Endothelial nitric oxide synthase overexpression provides a functionally relevant angiogenic switch in hibernating pig myocardium
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    J Am Coll Cardiol 49:1575-84. 2007
    ..We investigated whether retroinfusion of liposomal endothelial nitric oxide synthase (eNOS) S1177D complementary deoxyribonucleic acid (cDNA) would affect neovascularization and function of the ischemic myocardium...
  3. pmc VEGF-B: a more balanced approach toward cardiac neovascularization?
    Christian Kupatt
    Medizinische Klinik I Klinikum Großhadern, Munich, Germany
    EMBO Mol Med 6:297-8. 2014
    ....
  4. pmc Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury
    Anne Karin Hesse
    Institute for Surgical Research, University of Munich, Marchioninistr, 15, 81366 Munich, Germany
    Respir Res 5:11. 2004
    ..In the present study, we used a murine hyperoxic model to evaluate the effects of iNOS deficiency on the inflammatory response...
  5. ncbi request reprint Cotransfection of vascular endothelial growth factor-A and platelet-derived growth factor-B via recombinant adeno-associated virus resolves chronic ischemic malperfusion role of vessel maturation
    Christian Kupatt
    Medizinische Klinik I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, 81377 Munich, Germany
    J Am Coll Cardiol 56:414-22. 2010
    ....
  6. ncbi request reprint The vascular compartments of neovascularization: spotlight on the microcirculation
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Curr Pharm Biotechnol 8:27-33. 2007
    ..Potential signal cascades will be discussed...
  7. ncbi request reprint Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of phosphatidylinositol 3-kinase/AKT kinase
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Munich, Germany
    Circulation 112:I117-22. 2005
    ..Here, we assessed the potential of eEPCs to limit organ dysfunction after ischemia and reperfusion in a preclinical pig model...
  8. ncbi request reprint Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model
    Christian Kupatt
    Internal Medicine 1, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Cardiovasc Res 61:530-7. 2004
    ..We tested the efficacy of both agents applied regionally into the myocardium immediately before reperfusion...
  9. ncbi request reprint Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation
    Christian Kupatt
    Department of Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Arterioscler Thromb Vasc Biol 24:1435-41. 2004
    ..Here, we examined whether overexpression of Hsp90 in a pig model of cardiac infarct could preserve the myocardium from the deleterious effects of ischemia-reperfusion...
  10. doi request reprint Partial inferior sternotomy and deep hypothermic circulatory arrest for rescue of a failed TAVI case: what does constitute 'inoperable'?
    Rene Schramm
    Clinic of Cardiac Surgery, Ludwig Maximilian University Munich, Campus Grosshadern, Munich, Germany
    Thorac Cardiovasc Surg 61:431-4. 2013
    ..A conventional 27-mm aortic valve bioprosthesis was successfully implanted during deep hypothermic circulatory arrest. The patient recovered normally exhibiting no neurological or cardiocirculatory complications. ..
  11. ncbi request reprint Liposomal Hsp90 cDNA induces neovascularization via nitric oxide in chronic ischemia
    Achim Pfosser
    Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Marchioninistr 15, 81377 Munich, Germany
    Cardiovasc Res 65:728-36. 2005
    ..Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model...
  12. ncbi request reprint Transcutaneous aortic valve replacement with the Edwards SAPIEN XT and Medtronic CoreValve prosthesis under fluoroscopic guidance and local anaesthesia only
    Martin Greif
    Medizinische Klinik und Poliklinik I, Klinikum Grosshadern, University Hospital of Munich, Munich, Germany
    Heart 100:691-5. 2014
    ..To assess the feasibility of transcatheter aortic valve implantation (TAVI; Medtronic CoreValve and Edwards SAPIEN XT) under local anaesthesia with only mild analgesic medication and fluoroscopic guidance...
  13. ncbi request reprint Percutaneous approach to a stent-based ventricle to coronary vein bypass (venous VPASS): comparison to catheter-based selective pressure-regulated retro-infusion of the coronary vein
    Philip Raake
    Department of Internal Medicine I, Grosshadern University Hospital, Marchioninistr 15, D 81377 Munich, Germany
    Eur Heart J 26:1228-34. 2005
    ..In this study, the efficacy of venous VPASS was compared with catheter-based selective pressure-regulated retro-infusion of arterial blood during acute ischaemia...
  14. ncbi request reprint Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins: comparison with surgical and percutaneous intramyocardial gene delivery
    Philip Raake
    Internal Medicine I, Grosshadern University Hospital, Munich, Germany
    J Am Coll Cardiol 44:1124-9. 2004
    ..We sought to study adenoviral gene delivery using percutaneous selective pressure-regulated retroinfusion and to compare it directly with surgical and percutaneous intramyocardial delivery (PIMD) for the first time...
  15. ncbi request reprint Angiogenetic potential of Ad2/Hif-1α/VP16 after regional application in a preclinical pig model of chronic ischemia
    Rabea Hinkel
    Internal Medicine I, University Clinic Grosshadern, Marchioninistr 15, D 81371 Munich, Germany
    Curr Vasc Pharmacol 11:29-37. 2013
    ..Utilizing an adenoviral vector system, we investigated the efficacy of selective pressure-regulated venous retroinfusion of an enhanced Hif-1α mutant (Hif-1α/VP16) in a randomized investigator-blinded study...
  16. pmc Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection
    Rabea Hinkel
    Medizinische Klinik I, University Clinic Grosshadern, Munich, Germany
    Circulation 117:2232-40. 2008
    ..Here, we investigated the role of thymosin beta4 (Tbeta4) as a mediator of eEPC-mediated cardioprotection...
  17. pmc Thymosin beta4: a key factor for protective effects of eEPCs in acute and chronic ischemia
    Rabea Hinkel
    Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Ann N Y Acad Sci 1194:105-11. 2010
    ..Therapeutic neovascularization was absent when thymosin beta4 shRNA was introduced into eEPCs before application. In conclusion, eEPCs are capable of acute and chronic ischemia protection in a thymosin beta4 dependent manner...
  18. ncbi request reprint Embryonic endothelial progenitor cells expressing a broad range of proangiogenic and remodeling factors enhance vascularization and tissue recovery in acute and chronic ischemia
    Christian Kupatt
    GSF Research Center for Environment and Health, Institute for Clinical Molecular Biology and Tumor Genetics, Munich, Germany
    FASEB J 19:1576-8. 2005
    ..Our findings show that eEPCs induce blood vessel growth and cardioprotection in severe ischemic conditions providing a readily available source to study the mechanisms of neovascularization and tissue recovery...
  19. ncbi request reprint VEGF165 transfection decreases postischemic NF-kappa B-dependent myocardial reperfusion injury in vivo: role of eNOS phosphorylation
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    FASEB J 17:705-7. 2003
    ..Retroinfusion of liposomal VEGF cDNA reduces NF-kappaB-dependent postischemic inflammation and subsequent myocardial reperfusion injury, an effect mediated at least in part by enhanced eNOS phosphorylation...
  20. ncbi request reprint Therapeutic angiogenesis/arteriogenesis in the chronic ischemic rabbit hindlimb: effect of venous basic fibroblast growth factor retroinfusion
    Corinna Lebherz
    Department of Internal Medicine I, Klinikum Grosshadern, Munich, Germany
    Endothelium 10:257-65. 2003
    ....
  21. ncbi request reprint Hemodynamic and vascular effects of ventricular sourcing by stent-based ventricle to coronary artery bypass in patients with multivessel disease undergoing coronary artery bypass surgery
    Peter Boekstegers
    Department of Internal Medicine, Grosshadern University Hospital, Munich, Germany
    Circulation 112:I304-10. 2005
    ....
  22. ncbi request reprint SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization
    Georg Stachel
    Medizinische Klinik und Poliklinik I, Klinikum Groshadern, Ludwig Maximilians University and DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany
    Stem Cells 31:1795-805. 2013
    ..Recombinant versions of S1FG applied via catheters in combination with progenitor cell mobilization may be useful in the treatment of chronic ischemic syndromes requiring improved perfusion...
  23. doi request reprint Transcatheter aortic valve implantation in aortic coarctation
    Rene Schramm
    Clinic of Cardiac Surgery, Ludwig Maximilian University, Campus Grosshadern, Munich, Germany
    Thorac Cardiovasc Surg 61:336-9. 2013
    ..Subsequent procedures were uneventful and followed the standardized protocol. A 29 mm Edwards Lifescience transcatheter Sapien bioprosthesis was successfully implanted...
  24. doi request reprint Transfemoral access for valve in valve implantation of an Edwards Sapien XT valve in a stenotic tricuspid bioprosthesis under fluoroscopic guidance
    Martin Greif
    Department of Cardiology, Grosshadern, University of Munich, Munich, Germany
    Can J Cardiol 29:1014.e3-4. 2013
    ..Valve-in-valve implantation of an Edwards Sapien XT valve in a failing tricuspid bioprosthesis is feasible via transfemoral access without general anaesthesia or rapid pacing...
  25. doi request reprint NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37
    Achim Pfosser
    Medizinische Klinik I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Stem Cells 28:376-85. 2010
    ..We conclude that NF kappaB activation by LL37 or transient p65-transfection increases functionally relevant eEPC recruitment to ischemic muscle tissue via induction of PSGL-1 and E-selectin...
  26. ncbi request reprint Selective pressure-regulated retroinfusion of fibroblast growth factor-2 into the coronary vein enhances regional myocardial blood flow and function in pigs with chronic myocardial ischemia
    Georges von Degenfeld
    Internal Medicine I, Grosshadern, Grosshadern University Hospital, Munich, Germany
    J Am Coll Cardiol 42:1120-8. 2003
    ..This hypothesis was tested in a newly developed pig model with percutaneous induction of chronic ischemia...
  27. doi request reprint Transcatheter Edwards Sapien XT valve in valve implantation in degenerated aortic bioprostheses via transfemoral access
    Martin Greif
    Medizinische Klinik und Poliklinik I, Klinikum Grosshadern, University Hospital of Munich, Munich, Germany
    Clin Res Cardiol 101:993-1001. 2012
    ..We report of a case series of seven patients with dysfunctional bioprosthetic aortic heart valves who have been treated with TAVI via transfemoral access...
  28. doi request reprint Embryonic endothelial progenitor cell-mediated cardioprotection requires Thymosin beta4
    Christian Kupatt
    Medizinische Klinik I, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Trends Cardiovasc Med 18:205-10. 2008
    ..This review focuses on underlying mechanisms of acute cardioprotection provided by eEPCs and, in particular, Thymosin beta4...
  29. ncbi request reprint CT-Angiography-Based Evaluation of the Aortic Annulus for Prosthesis Sizing in Transcatheter Aortic Valve Implantation (TAVI)-Predictive Value and Optimal Thresholds for Major Anatomic Parameters
    Florian Schwarz
    Institute for Clinical Radiology, Hospital of the Ludwig Maximilian University of Munich, Munich, Germany
    PLoS ONE 9:e103481. 2014
    ..To evaluate the predictive value of CT-derived measurements of the aortic annulus for prosthesis sizing in transcatheter aortic valve implantation (TAVI) and to calculate optimal cutoff values for the selection of various prosthesis sizes...
  30. ncbi request reprint Feasibility of dynamic CT-based adenosine stress myocardial perfusion imaging to detect and differentiate ischemic and infarcted myocardium in an large experimental porcine animal model
    Fabian Bamberg
    Department of Clinical Radiology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
    Int J Cardiovasc Imaging 30:803-12. 2014
    ..8 ± 26 vs. 88.2 ± 22 ml/100 ml/min, p = 0.002). In a large animal model, CT-derived parameters of myocardial perfusion may enable detection and differentiation of ischemic and infarcted myocardium. ..
  31. doi request reprint Myocardial CT perfusion imaging in a large animal model: comparison of dynamic versus single-phase acquisitions
    Florian Schwarz
    Department of Clinical Radiology, Ludwig Maximilians University, Munich, Germany
    JACC Cardiovasc Imaging 6:1229-38. 2013
    ..This study sought to compare dynamic versus single-phase high-pitch computed tomography (CT) acquisitions for the assessment of myocardial perfusion in a porcine model with adjustable degrees of coronary stenosis...
  32. doi request reprint Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model
    Rabea Hinkel
    Medizinische Klinik und Poliklinik I, Klinikum Groshadern, and German Center for Cardiovascular Research Munich Heart Alliance, Marchioninistrasse 15, Munich, Germany
    Circulation 128:1066-75. 2013
    ..Because the functional benefits of miR-92a inhibitors in larger preclinical models are not known, we assessed the therapeutic efficacy of miR-92a inhibition in a porcine model of ischemia and reperfusion...
  33. doi request reprint Accuracy of dynamic computed tomography adenosine stress myocardial perfusion imaging in estimating myocardial blood flow at various degrees of coronary artery stenosis using a porcine animal model
    Fabian Bamberg
    Department of Clinical Radiology, Ludwig Maximilians University, Munich, Germany
    Invest Radiol 47:71-7. 2012
    ....
  34. doi request reprint Reduction of pacemaker implantation rates after CoreValve® implantation by moderate predilatation
    Philipp Lange
    Department of Cardiology, Klinikum Grosshadern, University Hospital of Munich, Munich, Germany
    EuroIntervention 9:1151-7. 2014
    ....
  35. doi request reprint Molecular and cellular mechanisms of thymosin β4-mediated cardioprotection
    Rabea Hinkel
    Medizinische Klinik und Poliklinik I, Klinikum Groshadern, Ludwig Maximilians University, Munich, Germany
    Ann N Y Acad Sci 1269:102-9. 2012
    ..These protective effects are further enhanced through increased myocyte and endothelial cell survival accompanied by differentiation of epicardial progenitor cells...
  36. ncbi request reprint Adjuvant early and late cardioprotective therapy: access to the heart
    Rabea Hinkel
    Medizinische Klinik und Poliklinik I, Klinikum der LMU München, Marchioninistrase 15, Munich, Germany
    Cardiovasc Res 94:226-36. 2012
    ..Therefore, this review focuses on the current and future administration techniques for early and late post-myocardial infarction therapies...
  37. doi request reprint Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection
    Jan Horstkotte
    Medizinische Klinik und Poliklinik I, Munich Heart Alliance, Klinikum Grosshadern of the Ludwig Maximilians University, Munich, Germany
    Circulation 124:2892-902. 2011
    ..Here, we investigated whether mitochondrial thioredoxin reductase is protective against myocardial ischemia/reperfusion injury...
  38. ncbi request reprint Role of PARP on iNOS pathway during endotoxin-induced acute lung injury
    Rainer Kiefmann
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 30:1421-31. 2004
    ..Furthermore, PARP seems to aggravate tissue destruction by regulating the expression of respective genes...
  39. ncbi request reprint Gene therapy for ischemic heart disease
    Rabea Hinkel
    University Clinic Grosshadern, Internal Medicine I, 81377 Munich, Germany
    Expert Opin Biol Ther 11:723-37. 2011
    ..Ischemic heart disease and heart failure are characterized by an adverse remodeling of the heart, featuring cardiomyocyte hypertrophy, increased fibrosis and capillary rarification...
  40. ncbi request reprint Current concepts and applications of coronary venous retroinfusion
    Peter Boekstegers
    Medizinische Klinik I, Klinikum Grosshadern, Marchioninistr 15, 81377, Munich, Germany
    Basic Res Cardiol 99:373-81. 2004
    ....
  41. ncbi request reprint MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2
    Rabea Hinkel
    1 Medizinische Klinik und Poliklinik I, Klinikum Grosshadern, 81377 Munich, Germany 2 DZHK German Center for Cardiovascular Research, partner site Munich Heart Alliance, 80802 Munchen, Germany 3
    Nat Commun 5:3970. 2014
    ..We conclude that MRTF-A promotes microvessel growth (via CCN1) and maturation (via CCN2), thereby enabling functional improvement of ischaemic muscle tissue. ..
  42. pmc Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia
    Di Qin
    Medizinische Klinik und Poliklinik I, Klinikum Groshadern, Munich, Germany
    PLoS ONE 8:e61831. 2013
    ..We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors...
  43. ncbi request reprint Retroinfusion-supported stenting in high-risk patients for percutaneous intervention and bypass surgery: results of the prospective randomized myoprotect I study
    Tilmann Pohl
    Department of Internal Medicine I, Grosshadern University Hospital, Munich, Germany
    Catheter Cardiovasc Interv 62:323-30. 2004
    ....
  44. doi request reprint Effectiveness of automated quantification of pulmonary perfused blood volume using dual-energy CTPA for the severity assessment of acute pulmonary embolism
    Felix G Meinel
    Institute for Clinical Radiology, Ludwig Maximilians University Hospital Munich, Marchioninistr 15, 81377 Munich, Germany
    Invest Radiol 48:563-9. 2013
    ....
  45. ncbi request reprint Sick Sinus Syndrome in HCN1-Deficient Mice
    Stefanie Fenske
    Center for Integrated Protein Science CIPS M and Zentrum für Pharmaforschung, Department Pharmazie S F, S C K, S I H H, E B, F A, R B, V H, C P, M B, C A W S and Medizinische Klinik und Poliklinik I, Klinikum Großhadern C K, P L, T Z, Ludwig Maximilians University, Munich, Germany DZHK German Center for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany C K, P L, T Z, M B, C A W S Max Planck Institut für Psychiatrie München, Germany C T W and School of Physics and Astronomy, University of Manchester, UK H Z
    Circulation 128:2585-94. 2013
    ..Although the pathologies of acquired SND have been studied extensively, little is known about the molecular and cellular mechanisms that cause congenital SND...
  46. ncbi request reprint Three-dimensional printing of models for preoperative planning and simulation of transcatheter valve replacement
    Daniel Schmauss
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    Ann Thorac Surg 93:e31-3. 2012
    ..Therefore, we decided to fabricate three-dimensional models to evaluate the potential effects of these constructs for previous surgical planning and simulation of the transcatheter valve replacement...
  47. pmc An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
    Rembert Koczulla
    Hospital of the University of Marburg, Department of Internal Medicine, Philipps Universtät Marburg, Marburg, Germany
    J Clin Invest 111:1665-72. 2003
    ..Taken together, these findings demonstrate that LL-37/hCAP-18 is a multifunctional antimicrobial peptide with a central role in innate immunity by linking host defense and inflammation with angiogenesis and arteriogenesis...