Research Topics
Genomes and Genes | Christiane Kunert-KeilSummaryAffiliation: University of Greifswald Country: Germany Publications
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Publications
The survival and proliferation of fibroblasts on ceramic implants: an in vitro studyChristiane Kunert-Keil
Department of Orthodontics, Preventive and Paediatric Dentistry, Ernst Moritz Arndt University of Greifswald, 17475 Greifswald, Germany
Biomed Tech (Berl) 57:11-5. 2012..The good biocompatibility may be attributed to the homogenous surface of these implants, and these surfaces might hasten osseointegration...- The survival and proliferation of fibroblasts on biocomposites containing genetically modified flax fibers: An in vitro studyChristiane Kunert-Keil
Department of Orthodontics, Preventive and Paediatric Dentistry, Ernst Moritz Arndt University of Greifswald, Germany Electronic address
Ann Anat 194:513-7. 2012..In conclusion, the tested new "green composites" showed a good biocompatibility. The biocompatibility of composites from transgenic flax plant fibers producing PHB did not differ from composites of non-transgenic flax plant fibers... 
Caveolin-1, caveolin-3 and VEGF expression in the masticatory muscles of mdx miceChristiane Kunert-Keil
Department of Orthodontics, Preventive and Pediatric Dentistry, Ernst Moritz Arndt University of Greifswald, Germany
Folia Histochem Cytobiol 49:291-8. 2011..The angiogenesis seems to be unaffected in the jaw muscles of mdx mice. We speculate that the increased caveolin expression could cause extensive and efficient muscle regeneration...- Immunolocalization of glycodelin in human adenocarcinoma of the lung, squamous cell carcinoma of the lung and lung metastases of colonic adenocarcinomaChristiane Kunert-Keil
Department of Orthodontics, Ernst Moritz Arndt University of Greifswald, Rotgerberstrasse 8, Greifswald, Germany
Acta Histochem 113:798-802. 2011..Because these data validate the recent findings of Gd mRNA expression, it may be concluded that glycodelin plays an important role in the pathogenesis of lung cancer and lung metastases... - Morphological evaluation of bone defect regeneration after treatment with two different forms of bone substitution materials on the basis of BONITmatrixCh Kunert-Keil
Department of Orthodontics, Preventive and Pediatric Dentistry, Ernst Moritz Arndt University Greifswald, Germany
J Physiol Pharmacol 60:57-60. 2009..The present study showed that both biomaterials could stimulate bone regeneration, but the paste-like composite leads in comparison to granular BONITmatrix to an accelerated more comprehensive bone regeneration... - Increased expression of glycodelin mRNA and protein in rat lungs during ovalbumin-induced allergic airway inflammationChristiane Kunert-Keil
Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Karlsburg, Germany
Histochem Cell Biol 131:383-90. 2009..Induced glycodelin amounts in tissue, particularly in Clara cells and alveolar macrophages were found. The altered expression pattern of glycodelin may contribute to the pulmonary immune response in asthmatic inflammation... 
Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strainsChristiane Kunert-Keil
Ernst Moritz Arndt University of Greifswald, Institute of Pathophysiology, Greifswalder Str, 11C, D 17495 Karlsburg, Germany
BMC Genomics 7:159. 2006..To verify data sets with an independent method, we studied the occurrence of some of the transcripts by in situ hybridization...- Bone substitution materials on the basis of BONITmatrix® up-regulate mRNA expression of IGF1 and Col1a1Tomasz Gredes
Department of Orthodontics, Preventive and Pediatric Dentistry, Ernst Moritz Arndt University of Greifswald, Germany
Ann Anat 194:179-84. 2012..In conclusion, BONITmatrix(®) and OSSA NOVA stimulate the expression of growth factor IGF1, but only the granular dosage form is able to stimulate osteoblast differentiation... - Talin, vinculin and nestin expression in orofacial muscles of dystrophin deficient mdx miceAlexander Spassov
Department of Orthodontics, Faculty of Medicine, University of Greifswald, Rotgerberstr 8, 17489, Greifswald, Germany
Arch Immunol Ther Exp (Warsz) 60:137-43. 2012..The expression of nestin may serve as an indicator for the regeneration in the orofacial muscles... - Myogenic differentiation factor 1 and myogenin expression not elevated in regenerated masticatory muscles of dystrophic (mdx) miceAlexander Spassov
Department of Orthodontics, Faculty of Medicine, University of Greifswald, Greifswald, Germany
J Orofac Orthop 72:469-75. 2011..Patients suffering from DMD present characteristic malocclusions in association with orofacial dysfunctions. Investigating the role of MRFs in mdx masticatory muscles may help to develop preventive and therapeutic strategies for DMD... - Differential expression of myosin heavy chain isoforms in the masticatory muscles of dystrophin-deficient miceAlexander Spassov
Department of Orthodontics, Faculty of Medicine, University of Greifswald, Germany
Eur J Orthod 33:613-9. 2011..The different MyHC gene expression in mdx mice masticatory muscles may be seen as an adaptive mechanism to muscular dystrophy... - Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humansSilke Vogelgesang
Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
Pharmacogenetics 12:535-41. 2002..Our results provide the first evidence in human brain tissue that the accumulation of Abeta may be influenced by the expression of P-gp in blood vessels, and suggest that P-gp may influence the elimination of Abeta from brain... - Changes in condylar cartilage after anterior mandibular displacement in juvenile pigsTomasz Gredes
Department of Orthodontics, Faculty of Medicine, University of Greifswald, Greifswald, Germany
Arch Oral Biol 57:594-8. 2012..Adaptive remodelling of the mandibular condyle in response to mandibular advancement is the mechanism exploited by orthodontic forward displacement devices... - Increased oxidative stress in dystrophin deficient (mdx) mice masticatory musclesAlexander Spassov
Department of Orthodontics, Faculty of Medicine, University of Greifswald, Greifswald, Germany
Exp Toxicol Pathol 63:549-52. 2011..However, there is still a lack of data about the oxidative status in dystrophic masticatory muscles... - Histological changes in masticatory muscles of mdx miceAlexander Spassov
Department of Orthodontics, Faculty of Medicine, University of Greifswald, Rotgerber Str 8, 17475 Greifswald, Germany
Arch Oral Biol 55:318-24. 2010..Therefore, to determine the pathological changes in this animal model of DMD, we examined the masticatory muscles of the mdx mice for histological abnormalities including nuclei localization, fibre diameters, and collagen expression... - The influence of biocomposites containing genetically modified flax fibers on gene expression in rat skeletal muscleTomasz Gredes
Department of Orthodontics, Preventive and Pediatric Dentistry, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
Biomed Tech (Berl) 55:323-9. 2010..Furthermore, composites from transgenic flax plants producing PHB did not differ from composites of non-transgenic flax plants... - The expression of myogenic regulatory factors and muscle growth factors in the masticatory muscles of dystrophin-deficient (mdx) miceAlexander Spassov
Department of Orthodontics, Faculty of Medicine, University of Greifswald, Rotgerber Str 8, 17475, Greifswald, Germany
Cell Mol Biol Lett 16:214-25. 2011..The finding of gender-related differences in the mRNA expression of the examined factors may indicate the importance of hormonal influences on muscle regeneration... - Immunolocalization of glycodelin in the genital tract of ratsChristiane Kunert-Keil
Institute of Pathophysiology, Ernst Moritz Arndt University, Greifswalder Street 11C, 17495, Karlsburg, Germany
J Mol Histol 36:111-7. 2005..Whereas in the rat male reproductive tract glycodelin expression is slightly different from human or primate tissues, in organs of the rat female genital tract glycodelin expression is similar to humans and primates... - Osteogenic capacity of transgenic flax scaffoldsTomasz Gredes
Department of Orthodontics, Ernst Moritz Arndt University Greifswald, 17475 Greifswald, Germany
Biomed Tech (Berl) 57:53-8. 2012..The application of these linen membranes for bone tissue engineering should be proved in further studies... - Experimental and histological investigations of the bone using two different oscillating osteotomy techniques compared with conventional rotary osteotomyFriedhelm Heinemann
Department of Orthodontics, Preventive and Pediatric Dentistry, Ernst Moritz Arndt University of Greifswald, Germany
Ann Anat 194:165-70. 2012..Finally, presented results showed that sonic surgery performed with SONICflex(®) is an alternative osteotomy method and can be used as an alternative to the conventional bur method... - Orthodontic tooth movement into jaw regions treated with synthetic bone substituteTomasz Gedrange
Department of Orthodontics, Preventive and Paediatric Dentistry, Centre of Dentistry and Oral Health, Ernst Moritz Arndt University Greifswald Rotgerberstr 8, D 17489 Greifswald, Germany
Ann Acad Med Stetin 56:80-4. 2010..Another objective was to evaluate the method of experimental tooth movement using an animal model... - Transient receptor potential cation channels in normal and dystrophic mdx muscleJana Krüger
Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Greifswalder Street 11C, D 17495 Karlsburg, Germany
Neuromuscul Disord 18:501-13. 2008..However, a constant TRP channel expression in combination with the well described weaker Ca(2+)-handling system of mdx fibres may indicate an imbalance between Ca(2+)-influx and cellular Ca(2+)-control... - Molecular changes in the early phase of renin-dependent cardiac hypertrophy in hypertensive cyp1a1ren-2 transgenic ratsChristiane Kunert-Keil
Institute of Pathophysiology, University Medicine Greifswald, Germany
J Renin Angiotensin Aldosterone Syst 14:41-50. 2013..The cyp1a1ren-2 transgenic rat thus appears to be a valid model to investigate early changes in cardiac hypertrophy. This study points to roles for TRPC6, FK506BP, SERCA2, K(v)4.2, and K(v)4.3 in the development of cardiac hypertrophy... - Influence of BONITmatrix(®) and OSSA NOVA on the expression of bone specific genesTomasz Gredes
Department of Orthodontics, Ernst Moritz Arndt University of Greifswald, D 17475 Greifswald, Germany Electronic address
Ann Anat 194:524-8. 2012..In conclusion, it can be stated that only the granular dosage form of BONITmatrix(®) is able to stimulate osteoblast differentiation, whereas OSSA NOVA has no influence on the gene expression of osteoblasts... - Identification and functional analysis of genetic variants of the human beta-glucuronidase in a German population sampleMatthias Gratz
Institute of Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University Greifswald, Germany
Pharmacogenet Genomics 15:875-81. 2005..Taken together, the data indicate a rather limited influence of genetic factors on inter-individual variability in beta-glucuronidase activity... - Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigueBernd W Pritschow
Institute of Pathophysiology, University of Greifswald, Greifswald, Germany
Pflugers Arch 461:115-22. 2011..The latter effect was not observed with muscles from TRPV4(-/-) mice. We conclude that TRPV4 is functionally expressed in mouse skeletal muscle and that TRPV4 activation modulates resting Ca(2+) influx and muscle fatigue... - MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonistsPeter Meisel
Department of Pharmacology, Unit of Periodontology, Ernst Moritz Arndt University Greifswald, Germany
Clin Pharmacol Ther 79:62-71. 2006.... - Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expressionChristoph A Ritter
Peter Holz Research Center of Pharmacology and Experimental Therapeutics, Institute of Pharmacology, Ernst Moritz Arndt University, Greifswald, Germany
Br J Pharmacol 137:1100-6. 2002..Furthermore, overexpression of GSTA1-1 leads to a partial protection against cell cycle effects of busulfan and affects tissue factor expression... - Glutaminyl cyclase activity is a characteristic feature of human cerebrospinal fluidAnastassia Gontsarova
Institute of Pathophysiology, University of Greifswald, Karlsburg, Germany
Clin Chim Acta 389:152-9. 2008..However, proteins and peptides are potential substrates of proteases and other enzymes. Proteolysis and enzymatic modification may lead to their degradation and modification...