G A Kullak Ublick

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain
    G A Kullak-Ublick
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    FEBS Lett 424:173-6. 1998
  2. ncbi request reprint Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
    G A Kullak-Ublick
    Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 109:1274-82. 1995
  3. ncbi request reprint Lipid peroxidation and mucin secretagogue activity in bile of gallstone patients
    C Jüngst
    University Hospital, Zurich, Switzerland
    Eur J Clin Invest 37:731-6. 2007
  4. ncbi request reprint Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
    G A Kullak-Ublick
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 120:525-33. 2001
  5. ncbi request reprint Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene
    G A Kullak-Ublick
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    Hepatology 26:991-7. 1997
  6. ncbi request reprint Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization
    G A Kullak-Ublick
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    J Hepatol 25:985-7. 1996
  7. pmc Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse
    P Georgiev
    Swiss Hepato Pancreato Biliary Centre, Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Zurich, Switzerland
    Gut 56:121-8. 2007
  8. pmc Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor
    D Jung
    Laboratory of Molecular Gastroenterology and Hepatology, University Hospital, CH 8091 Zurich, Switzerland
    Gut 53:78-84. 2004
  9. ncbi request reprint Constitutive rat multidrug-resistance protein 2 gene transcription is down-regulated by Y-box protein 1
    A Geier
    Department of Internal Medicine III, University Hospital, Aachen, Germany
    Biochem Biophys Res Commun 309:612-8. 2003
  10. ncbi request reprint [Role of nuclear receptors in hepatic and intestinal drug transport]
    G A Kullak-Ublick
    Abteilung für Klinische Pharmakologie und Toxikologie, Departement fur Innere Medizin, Universitatsspital Zurich
    Dtsch Med Wochenschr 128:389-93. 2003

Collaborators

  • U Beuers
  • Alan F Hofmann
  • C G Dietrich
  • ALLAN WOLKOFF
  • M Pontoglio
  • B Hagenbuch
  • G A Kullak-Ublick
  • P J Meier
  • D Jung
  • B Stieger
  • P Georgiev
  • C Jüngst
  • M G Ismair
  • G Paumgartner
  • M Oswald
  • A Geier
  • M Fried
  • V Cattori
  • L Landmann
  • K Fattinger
  • M V St-Pierre
  • K M Rentsch
  • C Reichel
  • N Hagenbuch
  • D Jungst
  • J J Eloranta
  • M I Eder
  • P A Clavien
  • B Zundt
  • N von Stillfried
  • N Sreejayan
  • A A Navarini
  • F Dahm
  • K S Lang
  • A Nocito
  • C von Ritter
  • W Jochum
  • F W Spelsberg
  • R Graf
  • A C Fantin
  • U Scheurer
  • C Gartung
  • T Gerloff
  • S Matern
  • A En-Nia
  • P R Mertens
  • S J Karpen
  • F Pizzagalli
  • L Gresh
  • K E Fattinger
  • R Huber
  • T Fisch
  • C Fahney
  • H Domdey
  • C D Schteingart

Detail Information

Publications16

  1. ncbi request reprint Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain
    G A Kullak-Ublick
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    FEBS Lett 424:173-6. 1998
    ..Northern blot analysis showed widespread expression of OATP in human brain. These data identify OATP as the first known target protein of DHEAS in human liver and brain...
  2. ncbi request reprint Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
    G A Kullak-Ublick
    Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 109:1274-82. 1995
    ..Based on a recently cloned rat liver organic anion transporter, we attempted to clone the corresponding human liver organic anion transporting polypeptide...
  3. ncbi request reprint Lipid peroxidation and mucin secretagogue activity in bile of gallstone patients
    C Jüngst
    University Hospital, Zurich, Switzerland
    Eur J Clin Invest 37:731-6. 2007
    ..The aim of the study was to compare mucin concentration and mucin secretagogue activity with lipid peroxidation in gallbladder bile of patients with cholesterol or pigment stones...
  4. ncbi request reprint Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
    G A Kullak-Ublick
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 120:525-33. 2001
    ..We aimed to characterize the novel OATP-B with respect to tissue distribution and hepatocellular localization and to compare its substrate specificity with those of OATP-A, OATP-C, and OATP8...
  5. ncbi request reprint Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene
    G A Kullak-Ublick
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    Hepatology 26:991-7. 1997
    ..The up-regulation of OATP expression by taurocholate could serve to enhance the sinusoidal efflux of toxic intracellular compounds during chronic cholestasis...
  6. ncbi request reprint Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization
    G A Kullak-Ublick
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    J Hepatol 25:985-7. 1996
    ..The aim of this study was to clone the human OATP gene and to map its chromosomal localization by fluorescence in situ hybridization...
  7. pmc Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse
    P Georgiev
    Swiss Hepato Pancreato Biliary Centre, Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Zurich, Switzerland
    Gut 56:121-8. 2007
    ..Cholestasis is associated with high morbidity and mortality in patients undergoing major liver surgery, but the mechanisms responsible remain elusive. Increased ischaemic liver injury and inflammation may contribute to the poor outcome...
  8. pmc Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor
    D Jung
    Laboratory of Molecular Gastroenterology and Hepatology, University Hospital, CH 8091 Zurich, Switzerland
    Gut 53:78-84. 2004
    ..Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids...
  9. ncbi request reprint Constitutive rat multidrug-resistance protein 2 gene transcription is down-regulated by Y-box protein 1
    A Geier
    Department of Internal Medicine III, University Hospital, Aachen, Germany
    Biochem Biophys Res Commun 309:612-8. 2003
    ..Given the presence of putative binding sites for the Y-box binding protein YB-1 in the regulatory sequence, its trans-regulatory influence was analyzed...
  10. ncbi request reprint [Role of nuclear receptors in hepatic and intestinal drug transport]
    G A Kullak-Ublick
    Abteilung für Klinische Pharmakologie und Toxikologie, Departement fur Innere Medizin, Universitatsspital Zurich
    Dtsch Med Wochenschr 128:389-93. 2003
  11. ncbi request reprint Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
    M G Ismair
    Division of Clinical Pharmacology Toxicology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 121:1185-90. 2001
    ..The smaller isoforms CCK-8 and CCK-4 are rapidly taken up into hepatocytes, metabolized, and excreted into bile. Our aim was to identify and characterize the hepatocellular CCK-8 uptake system...
  12. ncbi request reprint Arterial and venous pharmacokinetics of intravenous heroin in subjects who are addicted to narcotics
    K M Rentsch
    Institute of Clinical Chemistry and the Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, , Switzerland
    Clin Pharmacol Ther 70:237-46. 2001
    ....
  13. ncbi request reprint Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis
    M Oswald
    Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany
    Liver 21:247-53. 2001
    ..Downregulation of OATP-C might be the consequence of impaired canalicular secretion of organic anions and could serve to reduce the organic anion load of cholestatic hepatocytes...
  14. ncbi request reprint Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver
    N Hagenbuch
    Department of Medicine, University Hospital, Zurich, Switzerland
    J Hepatol 34:881-7. 2001
    ..The hepatic clearance of drugs and cholephilic organic anions is stimulated by phenobarbital (PB). Our aim was to analyze the effects of PB on the expression of hepatocellular bile salt and organic anion transporters...
  15. ncbi request reprint Transport of bile acids in hepatic and non-hepatic tissues
    M V St-Pierre
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich CH-8091, Switzerland
    J Exp Biol 204:1673-86. 2001
    ..Recent advances that have fostered a more complete appreciation for the elaborate disposition of bile acids in humans are emphasized...
  16. ncbi request reprint Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha
    D Jung
    Division of Clinical Pharmacology and Toxicology, University Hospital, CH 8091 Zurich, Switzerland
    J Biol Chem 276:37206-14. 2001
    ..These data support a role for HNF1 alpha as a global regulator of liver-specific bile salt and organic anion transporter genes...