Affiliation: University of Ulm
Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, et al
. Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNAÂ damage. EMBO J. 2015;34:624-40 pubmed publisher
Guo Y, Dorn T, Kühl S, Linnemann A, Rothe M, Pfister A, et al
. The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis. Dev Biol. 2019;: pubmed publisher
..In line with these observations we also found that Isl1, a critical regulator for specification of the common cardiac progenitor cell (CPC) population, acts upstream of Dkk1. ..
Pfister A, Keil M, KÃ¼hl M. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway. J Biol Chem. 2015;290:10905-18 pubmed publisher
..In summary, we provide evidence for a novel nucleolar stress-response pathway involving PPAN, NPM, and BAX to guarantee cell survival in a p53-independent manner. ..
Hempel A, Kuhl M. A Matter of the Heart: The African Clawed Frog Xenopus as a Model for Studying Vertebrate Cardiogenesis and Congenital Heart Defects. J Cardiovasc Dev Dis. 2016;3: pubmed publisher
..Additionally, we highlight advantages of modeling candidate genes derived from genome wide association studies (GWAS) in Xenopus and discuss commonly used techniques. ..
Sträng J, Schuler R, Kuhl M, Kestler H. Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in Xenopus laevis. J Theor Biol. 2017;429:82-94 pubmed publisher
..We present a model that faithfully recapitulates the activity of Wnt11 during dorso-ventral axis formation in Xenopus laevis on the basis of the Wnt switch behavior. ..
Hempel A, Kühl S, Rothe M, Rao Tata P, Sirbu I, Vainio S, et al
. The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. Dev Biol. 2017;424:28-39 pubmed publisher
..We here place Rcsd1 downstream of Wnt11 during cardiac development thereby providing a novel mechanism for how non-canonical Wnt signalling regulates vertebrate cardiogenesis. ..
Schwab J, Siegle L, Kühlwein S, Kuhl M, Kestler H. Stability of Signaling Pathways during Aging-A Boolean Network Approach. Biology (Basel). 2017;6: pubmed publisher
..Boolean networks can be inferred from time-series of gene expression data. This allows us to get insights into the changes of behavior of pathways such as NF- ? B signaling in aged organisms in comparison to young ones. ..