Katharina Kubatzky


Affiliation: University of Heidelberg
Location: Heidelberg, Germany
Bacterial protein toxins and immune evasion.
Rho GTPase, JAK-STAT and cytokine receptor signalling












  1. Hildebrand D, Heeg K, Kubatzky K. Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependent. Infect Immun. 2011;79:220-8 pubmed publisher
    ..These results suggest that the osteoclastic properties characteristic for PMT may result from a cross talk between bone cells and lymphoid cells and that B cells might be an important target of Pasteurella multocida. ..
  2. Kubatzky K, Ruan W, Gurezka R, Cohen J, Ketteler R, Watowich S, et al. Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor. Curr Biol. 2001;11:110-5 pubmed
    ..Thus, efficient signal transduction through EpoR and possibly other preformed receptor oligomers may be determined by the dynamics of TM self assembly. ..
  3. Kubatzky K, Liu W, Goldgraben K, Simmerling C, Smith S, Constantinescu S. Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function. J Biol Chem. 2005;280:14844-54 pubmed
    ..This structure is important for EpoR function because replacement of this motif by consecutive leucines rendered the receptor constitutively active. ..
  4. Orth J, Aktories K, Kubatzky K. Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin. J Biol Chem. 2007;282:3050-7 pubmed
    ..Because constitutive activation of STATs has been found in a number of cancers, our findings offer a new mechanism for a carcinogenic role of PMT. ..
  5. Fueller F, Kubatzky K. The small GTPase RhoH is an atypical regulator of haematopoietic cells. Cell Commun Signal. 2008;6:6 pubmed publisher
    ..The recent generation of RhoH knockout mice showed a defect in thymocyte selection and TCR signalling of thymic and peripheral T-cells. However, RhoH-deficient mice did not develop lymphomas or showed obvious defects in haematopoiesis. ..
  6. Entschladen F, Altschmied J, Baumgrass R, Behrmann I, Giehl K, Hermanns H, et al. Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology. Cell Commun Signal. 2010;8:2 pubmed publisher
    ..This report gives an overview of the presentations of the conference. ..
  7. Preuss I, Hildebrand D, Orth J, Aktories K, Kubatzky K. Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways. Cell Microbiol. 2010;12:1174-85 pubmed publisher
    ..Our data indicate that PMT is a highly potent anti-apoptotic agent, which supports the view of a carcinogenic potential of the toxin...
  8. Gündogdu M, Liu H, Metzdorf D, Hildebrand D, Aigner M, Aktories K, et al. The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression. Mol Cancer. 2010;9:225 pubmed publisher
    ..Low RhoH levels on the other hand led to an upregulation of IL3-dependent cell growth, STAT5 activity and an increase of CD123 surface expression, linking RhoH to a CD123/STAT5 phenotype that has been described in AML patients. ..
  9. Constantinescu S, Keren T, Russ W, Ubarretxena Belandia I, Malka Y, Kubatzky K, et al. The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem. 2003;278:43755-63 pubmed
    ..As unliganded EpoR forms TM-dependent but inactive homodimers, we propose that the EpoR can be activated to different extents by homodimeric gp55 proteins, depending on the conformation of the gp55 protein dimer in the TM region. ..

Detail Information


  1. Seubert N, Royer Y, Staerk J, Kubatzky K, Moucadel V, Krishnakumar S, et al. Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell. 2003;12:1239-50 pubmed
    ..The active and inactive conformations were independently identified by computational searches for low-energy TM dimeric structures. We propose a specific EpoR-activated interface and suggest its use for structural and signaling studies. ..
  2. Hildebrand D, Walker P, Dalpke A, Heeg K, Kubatzky K. Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activity. Cell Microbiol. 2010;12:1732-45 pubmed publisher
    ..Thus we hypothesize that P. multocida Toxin alters host cell signalling using mechanisms that have so far only been known to be employed by oncogenic viral kinases to avoid host immune defence mechanisms...
  3. Hildebrand D, Kubatzky K. Phospho-Flow Analysis of Primary Mouse Cells After HDAC Inhibitor Treatment. Methods Mol Biol. 2017;1510:233-243 pubmed
    ..We provide detailed protocols for the preparation of murine bone marrow cells and the staining of HDACi-treated cells, as well as an insight into the concepts of flow cytometry analysis. ..
  4. Schirmer B, Giehl K, Kubatzky K. Report of the Signal Transduction Society Meeting 2017-Metabolism in Health and Disease. Int J Mol Sci. 2018;19: pubmed publisher
    ..Various other aspects of signal transduction were intensively discussed in five additional workshops. Here, we give an overview of the various workshops and further aspects of the scientific program. ..
  5. Hildebrand D, Bode K, Rieß D, Cerny D, Waldhuber A, Römmler F, et al. Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathway. Cell Rep. 2014;9:910-7 pubmed publisher
    ..These findings show that macrophages can induce an IL-1?-initiated immune response independently of inflammasome activity. ..
  6. Kubatzky K. Pasteurella multocida and immune cells. Curr Top Microbiol Immunol. 2012;361:53-72 pubmed publisher
    ..Recently, more attention was drawn to the osteoimmunological effects of PMT and the interplay between bone and immune cells. This review summarises the knowledge of effects of P. multocida virulence factors on the host's immune system...
  7. Chakraborty S, Kloos B, Roetz N, Schmidt S, Eigenbrod T, Kamitani S, et al. Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts. Immunobiology. 2018;223:142-150 pubmed publisher
    ..As maturation of DC prevents their transdifferentiation into osteoclasts, we hypothesize that PMT, a potent osteoclastogenic toxin, fails to trigger osteoclastogenesis in DC due to its effect on DC maturation and IL-12 production...